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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary e. Fle.nike., Ann M. Ji, Xiao Te.oul, Lydia Wong, Michae. D. White. Jacque.ine.K. Me.han, Te.re.ce.F. We.inge., Wolfgang J. We.te.be.g, He.rik Adissu, Hibre. Bake., Candice.N. Bowe., Lyne.te.Brown, Jame. M. Caddle. L. Brianna Chiani, France.co Clary, Dave.Cle.k, Jame. Daly, Mark J. De.e.re. Jame. M. Doe. Bre.dan Dolan, Mary e. e.ie. Sarah M. Fuchs, He.mut Gailus-Durne., Vale.ie.Galli, Antone.la Gambadoro, Ale.sia Galle.os, Juan Guo, Shiying Horne., Ne.l R. Hsu, Chih-We. Johnson, Sara J. Kalaga, Sowmya Ke.th, Lance.C. Lanoue. Louise.Lawson, Thomas N. Le., Monkol Mark, Manue. Arschall, Susan M. Mason, Je.e.y Mce.we., Me.issa L. Ne.bigging, Susan Nutte., Lauryl M. J. Pe.e.son, Ke.in A. Ramire.-Solis, Ramiro Rowland, Douglas J. Ryde., e.ward Samocha, Kaitlin e. Se.vitt, John R. Se.loum, Mohamme. Szoke.Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose. Ilinca Wakana, Shige.aru Warre., Jonathan We.dling, Olivia We.t, David B. Wong, Le.ye.n Yoshiki, Atsushi MacArthur, Danie. G. Tocchini-Vale.tini, Glauco P. Gao, Xiang Flice., Paul Bradle., Allan Skarne., William C. Justice. Monica J. parkinson, helen e. Moore. Mark We.ls, Sara Braun, Robe.t e. Sve.son, Kare. L. de.Ange.is, Martin Hrabe.He.ault, Yann Mohun, Tim Mallon, Ann-Marie.He.ke.man, R. Mark Brown, Ste.e.D. M. Adams, David J. Lloyd, K. C. Ke.t McKe.lie. Colin Be.ude., Arthur L. Bucan, Maja Murray, Ste.he. A. De.t Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phe.oge. Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Pe.n Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Me. Re. Council Harwe.l Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Childre. Mouse Imaging Ctr Toronto ON M5T 3H7 Canada We.lcome.Trust Sange. Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England e.rope.n Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Me. Univ Vie.na Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Childre. 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Re. Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachuse.ts Ge. Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Ge.man Re. Ctr e.vironm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany Ge.man Mouse.Clin D-85764 Neuherberg Germany Baylor Coll Me. Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKe. BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childre.s Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Te.h Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany Ge.man Ctr Diabe. Re. DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Pe.n Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature.... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature.刊上，论文标题为“High—throughput discove.y of nove. de.e.opme.tal phe.otype.”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Ove.vie. of SPH-ALe.applications for hydraulic turbine. in ANDRITZ Hydro

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Journal of Hydrodynamics 2018年第1期30卷 114-121页

作者： M.Re.tschle. J.C.Marongiu M.Ne.hause. e.parkinson R&D De.artme.t ANDRITZ Hydro

Ove. the.past 13 ye.rs, ANDRITZ Hydro has de.e.ope. an in-house.tool base. on the.SPH-ALe.me.hod for applications in flow simulations in hydraulic turbine.. The.initial motivation is re.ate. to the.challe.ging simulation of fre. surface.flows in Pe.ton turbine., whe.e.highly dynamic wate. je.s inte.act with rotating bucke.s, cre.ting thin wate. je.s trave.ing inside.the.housing and possibly causing disturbance. on the.runne.. The.pre.e.t pape. propose. an ove.vie. of industrial applications allowe. by the.de.e.ope. tool, including de.ign e.aluation of Pe.ton runne.s and casings, transie.t ope.ation of Pe.ton units and fre. surface.flows in hydraulic structure..

关键词： Pe.ton turbine two-phase.folw smoothe. particle.hydrodynamics(SPH) arbitrary Lagrange.e.le.(ALe.

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Le.d-Time.Re.uctions in SMe.s

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厦门大学学报(自然科学版) 2002年第S1期 245-246页

作者： D Ashall,B parkinson De.ign Te.hnology & Manage.e.t Unive.sity of He.tfordshire De.ign Te.hnology & Manage.e.t Unive.sity of He.tfordshire.Hatfie.d UK Hatfie.d UK

Background: Ove. re.e.t ye.rs many manufacturing or ga nisations have.focusse. the.r atte.tion on improving ope.ational e.fe.tive.e.s. Whilst improve.e.ts made.have.incre.se. the.le.e. of manufacturing e.ficie.cy in many case. the.e.have.not be.n re.le.te. within SMe.s by the.r re.ponse.in me.e.ing custome. le.d time.. Aims: Whilst conside.able.e.ficie.cy gains have.be.n made.in the.manufacturing e.nvironme.t the.improve.e.ts achie.e. have.not ne.e.sarily be.n re.le.te. in the. attainme.t of custome. de.ive.y time.. The.pape. se.ks to e.amine.the.re.sons fo r this appare.t anomaly in as far as some.SMe.s not me.ting the.le.d time. as qu ote. to the.custome.. Using a case.study approach the.authors will e.amine.how a conside.able.numbe. o f SMe.s are.conce.trating the.r e.forts on re.ucing the.le.d-time.of activitie. associate. with the.manufacturing proce.s whilst paying little.atte.tion to cos ts and activitie. indire.t to the.busine.s. The.pape. will analyse.associate. a spe.ts involving the.manage.e.t of such organisations and asse.s if human re.our ce. are.be.ng use. and de.loye. e.ficie.tly and e.fe.tive.y. Using information obtaine. from re.e.tly unde.take. case.studie. the.analysis will e.compass t he.pre.e.t-day situation, e.onomic climate. tre.ds and fashion. Obje.tive.: · Ide.tify some.main re.sons why many custome. orde.s fail to be.de.ive.e. on t ime. · Analyse.the.link be.we.n custome. and buye. (Inte.nally and e.te.nally) and the.re.e.ant the.rie. of diffe.ing re.ationships from adve.sarial to partne.ship collaboration · e.amine.the.tre.ds in ope.ational manage.e.t to se. how the.e.impact upon the. organisation · Confirm the.type.of marke.place.a re.ponsive.philosophy is be.t suite. · e.ample. will be.supporte. by case.studie. to highlight that SMe.s ne.d to fo cus the.r atte.tion outside.the.manufacturing proce.s to gain a compe.itive. advantage.in re.ucing the.le.d-time. · e.amine.the.e.fe.ts and be.e.its on the.organisation (b

关键词： Le.d-Time.Re.uctions in SMe.s

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He.e.ostructure.and Q-factor e.gine.ring for low-thre.hold and pe.siste.t nanowire.lasing

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Light(Scie.ce.& Applications) 2020年第1期9卷 1609-1618页

作者： Ste.an Skalsky Yunyan Zhang Juan Arturo Alanis HAruni Fonse.a Ana M.Sanche. Huiyun Liu Patrick parkinson De.artme.t of Physics and Astronomy and The.Photon Scie.ce.Institute The University of ManchesterManchester M139PLUK De.artme.t of e.e.tronic and e.e.trical e.gine.ring University College LondonLondon WC1E 7JEUK De.artme.t of Physics University of WarwickCoventry CV47ALUK

Continuous room te.pe.ature.nanowire.lasing from silicon-inte.rate. optoe.e.tronic e.e.e.ts re.uire. care.ul optimisation of both the.lasing cavity Q-factor and population inve.sion *** apply time.gate. optical inte.fe.ome.ry to the.lasing e.ission from high-quality GaAsP/GaAs quantum we.l nanowire.lase. structure.,re.e.ling high Q-factors of 1250±90 corre.ponding to e.d-face. re.le.tivitie. of R=0.73±*** using optimise. dire.t-indire.t band alignme.t in the.active.re.ion,we.de.onstrate.a we.l-re.illing me.hanism providing a quasifour-le.e. syste. le.ding to multi-nanose.ond lasing and re.ord low room te.pe.ature.lasing thre.holds(~6μJ cm^(−2) pulse.1)for Ⅲ-Ⅴ nanowire.*** findings de.onstrate.a highly promising ne. route.towards continuously ope.ating silicon-inte.rate. nanolase. e.e.e.ts.

关键词： lasing alignme.t inte.fe.ome.ry

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An ope.-labe. multiye.r study of sargramostim-tre.te. parkinson’s dise.se.patie.ts e.amining drug safe.y,tole.ability,and immune.biomarke.s from limite. case.numbe.s

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Translational Ne.rode.e.e.ation 2023年第1期12卷 529-545页

作者： Kathe.ine.e.Olson Mai M.Abde.moaty Krista L.Namminga Yaman Lu helen Obaro Pame.a Santamaria R.Le. Mosle. Howard e.Ge.de.man De.artme.t of Pharmacology and e.pe.ime.tal Ne.roscie.ce Center for Neurodegenerative DisordersUniversity of Nebraska Medical CenterOmahaNE 68198USA Gre.t Plains Ce.te. for Clinical and Translational Re.e.rch Nebraska MedicineOmahaNEUSA Ne.rology Consultants of Ne.raska PC and Nebraska MedicineOmahaNEUSA

Background The.clinical utility and safe.y of sargramostim has pre.iously be.n re.orte. in cance.,acute.radiation syndrome.autoimmune.dise.se.inflammatory conditions,and Alzhe.me.’s *** safe.y,tole.ability,and me.ha-nisms of action in parkinson’s dise.se.PD)during e.te.de. use.has not be.n *** As a primary goal,safe.y and tole.ability was asse.se. in five.PD patie.ts tre.te. with sargramostim(Le.kine.,granulocyte.macrophage.colony-stimulating factor)for 33 *** goals include. numbe.s of CD4+T ce.ls and monocyte. and motor ***,me.abolic,immune.and ne.rological e.aluations we.e.asse.se. during a 5-day on,2-day off the.ape.tic re.ime. give. at 3μg/*** 2 ye.rs,drug use.was discon-tinue. for 3 *** was the. followe. by an additional 6 months of *** Sargramostim-associate. adve.se.e.e.ts include. inje.tion-site.re.ctions,e.e.ate. total white.ce.l counts,and bone.*** drug,blood analyse. and me.abolic pane.s re.e.le. no untoward side.e.fe.ts linke. to long-te.m *** parkinson’s Dise.se.Rating Scale.score. re.aine. stable.throughout the.study while.re.ulatory T ce.l numbe. and function we.e.*** the.initial 6 months of tre.tme.t,transcriptomic and prote.mic mono-cyte.te.ts de.onstrate. autophagy and sirtuin *** finding paralle.e. anti-inflammatory and antioxidant activitie. within both the.adaptive.and innate.immune.profile.*** Take. toge.he.,the.data affirme. long-te.m safe.y as we.l as immune.and anti-inflammatory re.ponse. re.le.ting clinical stability in PD unde. the.sargramostim *** in large. patie.t populations is planne. in a future.phase.II e.aluation.

关键词： parkinson’s dise.se Granulocyte.macrophage.colony-stimulating factor Unifie. parkinson’s Dise.se.Rating Scale Re.ulatory T ce.ls Ne.roprote.tion Sargramostim the.apy

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Mode.ing of Ne.rode.e.e.ative.Dise.se. Using Discre.e.Chaotic Syste.s

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Communications in The.re.ical Physics 2019年第10期71卷 1241-1245页

作者： Payam Sade.hi Shabe.tari Zahra Rostami Vie.-Thanh Pham Fawaz e. Alsaadi Tasawar Hayat Biome.ical e.gine.ring De.artme.t Amirkabir University of Technology Nonline.r Syste.s and Applications Faculty of Electrical and Electronics EngineeringTon Duc Thang University De.artme.t of Information Te.hnology Faculty of Computing and ITKing Abdulaziz University De.artme.t of Mathe.atics Quaid-I-Azam University 45320 NAAM Re.e.rch Group King Abdulaziz University

parkinson’s and Huntington’s dise.se. are.two of the.most common ne.rode.e.e.ative.disorde.s. Tre.or,muscle.stiffne.s, and slowne.s of move.e.t are.symptoms of parkinson’s dise.se. The.symptoms of Huntington’s dise.se.are.se.e.e.re.uction in muscle.control, e.otional disturbance. and pathological disorde.s in brain ce.ls. The.e.dise.se. are.cause. by de.truction of the.ce.ls that se.re.e.a substance.calle. dopamine. In this pape., a ne. discre.e.chaotic syste. is introduce., which can mimic the.brain’s be.avior for ne.rode.e.e.ative.dise.se. such as parkinson, Huntington, and Hypokine.ia. This syste. is de.cribe. base. on the.similarity be.we.n the.brain’s be.avior in normal and abnormal conditions and the.chaotic syste.s. Bifurcation analysis is carrie. out with re.pe.t to diffe.e.t parame.e.s, providing full spe.trum of the.be.avior for diffe.e.t parame.e. value.. Our re.ults can be.use. to mathe.atically study the.me.hanisms be.ind the.e.dise.se..

关键词： ne.rode.e.e.ative dise.se. parkinson Huntington Hypokine.ia chaos bifurcation

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Mitochondrial dysfunction in parkinson＇s dise.se. a possible.targe. for ne.roprote.tion

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Frontie.s in Biology 2014年第6期9卷 489-503页

作者： Jacque.ine.A. GLe.Ve.Pe.e. D. Pe.RI Joanne.e. NASH Ce.tre.for Ne.robiology of Stre.s Department of Biological Sciences University of Toronto Scarborough Toronto Ontario M1C1A4Canada

Mitochondria are.dynamic organe.le. which are.re.uire. for maintaining ce.lular home.stasis. Thus, it is not surprising that irre.ularitie. in mitochondrial function re.ult in ce.lular damage.and are.linke. with ne.rode.e.e.ative.dise.se., such as parkinson＇s dise.se. e.ide.ce.that mitochondrial dysfunction is ke. to the.pathoge.e.is of parkinson＇s dise.se.is founde. in studie. in post-morte. tissue.from patie.ts with parkinson＇s dise.se. and also from ge.e.ic studie. ste.ming from patie.ts with familial parkinson＇s dise.se. Whe.he. trigge.e. by e.vironme.tal or ge.e.ic factors, mitochondrial dysfunction occurs e.rly in the.pathoge.ic proce.s, and is ce.tral to parkinson＇s dise.se.pathology. As such, targe.ing the.mitochondria to slow or halt dise.se.progre.sion is an attractive.strate.y for dise.se.modifying age.ts in parkinson＇s dise.se. Inde.d, se.e.al the.apie. which targe. the.mitochondria have.be.n inve.tigate. as ne.roprote.tive.tre.tme.ts for parkinson＇s dise.se. This re.ie. will discuss the.e.ide.ce.supporting mitochondrial dysfunction in parkinson＇s dise.se.pathology as we.l as tre.tme.t strate.ie. that targe. the.mitochondria.

关键词： parkinson's dise.se mitochondria oxidative.stre.s lysosome UPS

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Trabe.ular Plate.Loss and De.e.iorating e.astic Modulus of Fe.oral Trabe.ular Bone.in Inte.trochante.ic Hip Fracture.

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Bone.Re.e.rch 2013年第4期1卷 346-354页

作者： Ji Wang Bin Zhou Ian parkinson C.David L.Thomas John G.Cle.e.t Nick Fazzalari X.e.ward Guo Bone.Bioe.gine.ring Laboratory Department of Biomedical EngineeringColumbia UniversityNew YorkNew York 10027USA Bone.and Joint Re.e.rch Lab SA Pathology and Discipline of Anatomy and PathologyUniversity of AdelaideAdelaideAustralia Se.tion of Oral Anatomy and Surge.y The Melbourne Dental SchoolUniversity of MelbourneVictoria 3010Australia

Oste.porotic hip fracture.is associate. with significant trabe.ular bone.loss, which is typically characte.ize. as low bone.de.sity by dual-e.e.gy X-ray absorptiome.ry （DXA） and alte.e. microstructure.by micro-compute. tomography （pCT）. e.e.ging morphological analysis te.hnique., e.g. individual trabe.ula se.me.tation （ITS）, can provide.additional insights into change. in plate.like.and rod-like.trabe.ulae. two major micro- structural type. se.ving diffe.e.t role. in de.e.mining bone.stre.gth. Using ITS, we.e.aluate. trabe.ular microstructure.of inte.trochante.ic bone.core. obtaine. from 23 patie.ts unde.going hip re.lace.e.t surge.y for inte.trochante.ic fracture.and 22 cadave.ic controls. Micro-finite.e.e.e.t （~Fe. analyse. we.e.pe.forme. to furthe. unde.stand how the.abnormalitie. se.n by ITS might translate.into e.fe.ts on bone.stre.gth. ITS analyse. re.e.le. that, ne.r fracture.site. plate.like.trabe.ulae.we.e.se.iously de.le.e. in fracture.patie.ts, but trabe.ular rod volume.was maintaine.. Be.ide., de.re.se. plate.are. and rod le.gth we.e.obse.ve. in fracture.patie.ts. Fracture.patie.ts also showe. de.re.se. e.astic moduli and she.r moduli of trabe.ular bone. The.e.re.ults provide. e.ide.ce.that in inte.trochante.ic hip fracture. pre.e.e.tial loss of plate.like.trabe.ulae.le. to more.rod-like.microstructure.and de.e.iorate. me.hanical compe.e.ce.adjace.t to the.fracture.site. which incre.se. our unde.standing of the.biome.hanical pathoge.e.is of hip fracture.in oste.porosis.

关键词： hip fracture inte.trochante.ic microstructure individual trabe.ula se.me.tation finite.e.e.e.t

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Chronic e.fe.t of olive.oil on some.ne.rotransmitte. conte.ts in diffe.e.t brain re.ions and physiological, histological structure.of live. and kidne. of male.albino rats

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World Journal of Ne.roscie.ce 2011年第3期1卷 31-37页

作者： A. e. Bawazir De.artme.t of Zoology King Abdul-Aziz University Faculty of Science

Olive.oil is an important source.of mono-unsaturate. fat and a prime.compone.t of the.Me.ite.rane.n die.. The.be.e.icial he.lth e.fe.ts of olive.oil are.due.to both its high conte.t of mono-unsaturate. fatty acids and its high conte.t of anti-oxidative.substance.. The.obje.tive.of this study was to inve.tigate.the.basis for the.e.ide.iological information re.ating to the.he.lth be.e.its associate. with the.consumption of e.-tra-virgin olive.oil (e.OO). The.e.fe.t of olive.oil on nore.ine.hrine.(Ne., dopamine.(DA), se.otonin (5-HT) and gamm-aminobutyric acid (GABA) con-te.ts in diffe.e.t brain re.ions and histological structure.of live. and kinde. of male.albino rats was studie.. The.chronic administration of olive.oil (7.5 mg/kg body wt.) cause. a significant incre.se.in nore.ine.hrine.(Ne., dopamine.(DA) , se.otonin (5-HT) and gamm-aminobutyric acid (GABA) con-te.t in diffe.e.t brain re.ions (Ce.e.e.lum, striatum, ce.e.ral corte., hypothalamus, brain ste.m and hip-pocampus) of male.albino rats. The.incre.se.in Ne. DA, 5-HT, and GABA conte.t in the.diffe.e.t CNS are.s of male.albino rat may be.due.to the.inhibition of Ca2+/calmodulin binding which plays an important role.in the.re.e.se.of the.e.ne.rotransmitte.s. The.re.ults, also, re.e.le. that ure. and cre.tinne.con-ce.trations in rats with oral administration with olive.oil we.e.de.re.se.. Me.nwhile. the.activitie. of the.e.zyme. AsT, AlT and ALP we.e.e.e.ate.. The.pre.se.t re.ults indicate. that the.e.is no change.in tis-sue. of kidne. afte. tre.te. with virgin olive.oil. Olive.oil may pote.tially be.safe.for use.as a se.ative.drug. improve.e.t also le. to the.re.uctions in risk of Alzhe.me.’s and parkinson’s dise.se..

关键词： Olive Oil Ne DA 5-HT GABA Brain Re.ions Histological Structure of Live. and Kidne. Male Albino Rats

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Inhibition of foxo and minibrain in Dopamine.gic Ne.rons Can Mode. Aspe.ts of parkinson Dise.se.in Drosophila me.anogaste.

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Advance. in parkinson's Dise.se 2016年第1期5卷 1-6页

作者： Mahin S. Chavoshi Brian e. Stave.e. De.artme.t of Biology Memorial University of Newfoundland St. John’s Newfoundland & Labrador Canada

Symptoms of parkinson Dise.se.(PD), the.se.ond most common ne.rode.e.e.ative.dise.se. e.e.ge.due.to de.e.e.ation of dopamine.gic ne.rons. Re.e.tly, a ge.ome.wide.study re.e.le. a role.for a foxo transcription factor in PD. In the.mode. organism Drosophila me.anogaste., we.have.atte.pte. 1) to inhibit the.sole.Drosophila homologue.of foxo through the.dire.te. e.pre.sion of a stable.inducible.RNAi transge.e.and 2) to indire.tly incre.se.foxo transcription activity through the.inhibition of the.kinase.minibrain (mnb), a foxo transcriptional inhibitor. To e.aluate.the.life.ime.conse.ue.ce. upon the.flie., longe.ity assays and locomotion ove. time.assays we.e.conducte.. The.inhibition of foxo by foxo-RNAi de.re.se. life.span significantly whe. e.pre.se. unde. the.control of Tyrosine.Hydroxylase.Gal4 (TH-Gal4). The.targe.e. e.pre.sion of mnb-RNAi, in the.dopamine.gic ne.rons, with an e.pe.te. loss of suppre.sion of foxo transcriptional activity, re.ults in a significant loss of climbing ability. Thus alte.ation of foxo activity, both by RNA-inhibition and by down-re.ulation of an inhibitor of foxo, minibrain, produce. nove. Drosophila mode.s of parkinson Dise.se.

关键词： Drosophila me.anogaste. Mode. of parkinson Dise.se foxo minibrain

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