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Search for the doubly charmed baryon ?cc+

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Science China(Physics,Mechanics & Astronomy) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： R. Aaij C. Abellán Beteta T. Ackernley B. Adeva M. Adinolfi H. Afsharnia C. A. Aidala S. Aiola Z. Ajaltouni S. Akar j. Albrecht F. Alessio M. Alexander A. Alfonso Albero Z. Aliouche G. Alkhazov P. Alvarez Cartelle S. Amato Y. Amhis L. An L. Anderlini A. Andreianov M. Andreotti F. Archilli A. Artamonov M. Artuso K. Arzymatov E. Aslanides M. Atzeni B. Audurier S. Bachmann M. Bachmayer j. j. Back P. Baladron Rodriguez V. Balagura W. Baldini j. Baptista Leite R. j. Barlow S. Barsuk W. Barter M. Bartolini F. Baryshnikov j. M. Basels G. Bassi B. Batsukh A. Battig A. Bay M. Becker F. Bedeschi I. Bediaga A. Beiter V. Belavin S. Belin V. Bellee K. Belous I. Belov I. Belyaev G. Bencivenni E. Ben-Haim A. Berezhnoy R. Bernet D. Berninghoff H. C. Bernstein C. Bertella A. Bertolin C. Betancourt F. Betti I. Bezshyiko S. Bhasin j. Bhom L. Bian M. S. Bieker S. Bifani P. Billoir M. Birch F. C. R. Bishop A. Bitadze A. Bizzeti M. Bj?rn M. P. Blago T. Blake F. Blanc S. Blusk D. Bobulska j. A. Boelhauve O. Boente Garcia T. Boettcher A. Boldyrev A. Bondar N. Bondar S. Borghi M. Borisyak M. Borsato j. T. Borsuk S. A. Bouchiba T. j. V. Bowcock A. Boyer C. Bozzi M. j. Bradley S. Braun A. Brea Rodriguez M. Brodski j. Brodzicka A. Brossa Gonzalo D. Brundu A. Buonaura C. Burr A. Bursche A. Butkevich j. S. Butter j. Buytaert W. Byczynski S. Cadeddu H. Cai R. Calabrese L. Calefice L. Calero Diaz S. Cali R. Calladine M. Calvi M. Calvo Gomez P. Camargo Magalhaes P. Campana A. F. Campoverde Quezada S. Capelli L. Capriotti A. Carbone G. Carboni R. Cardinale A. Cardini I. Carli P. Carniti L. Carus K. Carvalho Akiba A. Casais Vidal G. Casse M. Cattaneo G. Cavallero S. Celani j. Cerasoli A. j. Chadwick M. G. Chapman M. Charles P. Charpentier G. Chatzikonstantinidis C. A. Chavez Barajas M. Chefdeville C. Chen S. Chen A. Chernov V. Chobanova S. Cholak M. Chrzaszcz A. Chubykin V. Chulikov P. Ciambrone M. F. Cicala X. Cid Vidal G. Ciezarek P. E. L. Clarke M. Clemencic H. V. Clif j. Closier j. L. Cobbledick V. Coco j. A. B. Coelho j. Cogan E. Cogneras L. Nikhef National Institute for Subatomic Physics Physik-Institut Universit?t Zürich Oliver Lodge Laboratory University of Liverpool Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela H.H. Wills Physics Laboratory University of Bristol Université Clermont Auvergne University of Michigan Ann Arbor United States INFN Sezione di Milano University of Cincinnati Fakult?t Physik Technische Universit?t Dortmund European Organization for Nuclear Research (CERN) School of Physics and Astronomy University of Glasgow ICCUB Universitat de Barcelona Department of Physics and Astronomy University of Manchester Petersburg Nuclear Physics Institute NRC Kurchatov Institute (PNPI NRC KI) Cavendish Laboratory University of Cambridge Universidade Federal do Rio de janeiro (UFRj) Université Paris-Saclay INFN Sezione di Firenze INFN Sezione di Ferrara Physikalisches Institut Ruprecht-Karls-Universit?t Heidelberg Institute for High Energy Physics NRC Kurchatov Institute (IHEP NRC KI) Syracuse University Yandex School of Data Analysis Aix Marseille Univ Laboratoire Leprince-Ringuet CNRS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Institute of Physics Ecole Polytechnique Fédérale de Lausanne (EPFL) Department of Physics University of Warwick Centro Brasileiro de Pesquisas Físicas (CBPF) Imperial College London INFN Sezione di Genova National University of Science and Technology “MISIS” I. Physikalisches Institut RWTH Aachen University INFN Sezione di Pisa INFN Sezione di Cagliari Institute of Nuclear Physics Moscow State University (SINP MSU) Institute of Theoretical and Experimental Physics NRC Kurchatov Institute (ITEP NRC KI) INFN Laboratori Nazionali di Frascati LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité Universita degli Studi di Padova Universita e INFN Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences School of Physics and Technology Wuhan University University of Birmingham Università di Modena e Reggio Emilia Department of Physics U

A search for the doubly charmed baryon ?cc+with the decay mode ?cc+→Ξc+K-π+is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb-1. No significant signal is observed within the invariant mass range of 3.6 to 4.0 GeV/c2. Upper limits are set on the ratio R of the production cross-section times the total branching fraction of the ?cc+→Ξc+K-π+decay with respect to the Ξcc++→Λc+K-π+π+decay. Upper limits at 95% credibility level for R in the range 0.005 to 0.11 are obtained for diferent hypotheses on the ?cc+mass and lifetime in the rapidity range from 2.0 to 4.5 and transverse momentum range from 4 to 15 GeV/c.

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Identification of new genetic risk factors for prostate cancer

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Asian journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-jarai Graham G. Giles Ali Amin Al Olama Sarah K. jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. parker Christopher j. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles jameson Colin S. Cooper Dallas R. English john L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

人工关节感染一期翻修的生存率和失败原因:一项荟萃分析

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临床骨科杂志 2024年第5期27卷 639-639页

作者：胡孔足(摘译) 不详

为研究人工关节感染一期翻修术的生存率和失败原因,作者使用“一期翻修”“假体交换”“假体周围感染”“PjI”“一期”等词进行检索后的病例荟萃分析。共检索出24项研究,包括2062例全髋置换术后假体周围感染一期翻修和147例全膝置换术... 详细信息

为研究人工关节感染一期翻修术的生存率和失败原因,作者使用“一期翻修”“假体交换”“假体周围感染”“PjI”“一期”等词进行检索后的病例荟萃分析。共检索出24项研究,包括2062例全髋置换术后假体周围感染一期翻修和147例全膝置换术后假体周围感染一期翻修患者。男性占55%,平均年龄66.3岁,随访69.8个月。

关键词：荟萃分析一期翻修假体周围感染全膝置换术人工关节感染生存率失败原因

强化与标准血压控制对痴呆的影响:随机临床试验

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中华高血压杂志 2019年第4期27卷 367-367页

作者：刘青叶鹏 Williamson jD Pajewski NM Auchus AP Bryan RN Chelune G Cheung AK Cleveland ML Coker LH Crowe MG Cushman WC Cutler jA Davatzikos C Desiderio L Erus G Fine Lj Gaussoin SA Harris D Hsieh MK johnson KC Kimmel PL Tamura MK Launer Lj Lerner Aj Lewis CE Martindale-Adams j Moy CS Nasrallah IM nichols LO Oparil S Ogrocki PK Rahman M Rapp SR Reboussin DM Rocco MV Sachs BC Sink KM Still CH Supiano MA Snyder jK Wadley VG Walker j Weiner DE Whelton PK Wilson VM Woolard N Wright jT jr Wright CB SPRINT MIND investigators for theSPRINT research group

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开... 详细信息

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。

关键词：随机临床试验老年痴呆血压控制轻度认知障碍标准心血管事件治疗方法研究人员

Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages

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Bioactive Materials 2024年第11期41卷 657-671页

作者： Kamila Iskhakova Hanna Cwieka Svenja Meers Heike Helmholz Anton Davydok Malte Storm Ivo Matteo Baltruschat Silvia Galli Daniel Pröfrock Olga Will Mirko Gerle Timo Damm Sandra Sefa Weilue He Keith MacRenaris Malte Soujon Felix Beckmann julian Moosmann Thomas O'Hallaran Roger j.Guillory II D.C.Florian Wieland Berit Zeller-Plumhoff Regine Willumeit-Römer florian wieland berit zeller-plumhoffregine willumeit-römer1institute of metallic biomaterialshelmholtz zentrum hereongeesthachtgermany institute of materials physiscs helmholtz zentrum hereongeesthachtgermany deutsches elektronen-synchrotron desy hamburggermany department of prosthodontics faculty of odontologyuniversity of malmömalmösweden institute of coastal environmental chemistry helmholtz zentrum hereongeesthachtgermany molecular imaging north competence center kiel universitykielgermany the department of oral and maxillofacial surgery campus kiel ukshkielgermany department of biomedical engineering michigan technological universityusa department of microbiology and biochemistry michigan state universityusa joint department of biomedical engineering medical college of wisconsinusa institute of materials mechanics helmholtz zentrum hereongeesthachtgermany

Magnesium(Mg)–based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing,*** a suture *** to their mechanical properties and biocompatibility,they may replace titanium or stainless-steel implants,commonly used in orthopedic ***,patient safety has to be assured by finding a long-term balance between metal degradation,osseointegration,bone ultrastructure adaptation and element distribution in *** order to determine the implant behavior and its influence on bone and tissues,we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to permanent materials titanium and polyether ether *** implants were present in rat tibia for 10,20 and 32 weeks before sacrifice of the *** radiation-based micro computed tomography enables the distinction of features like residual metal,degradation layer and bone ***,X-ray diffraction and X-ray fluorescence yield information on parameters describing the bone ultrastructure and elemental composition at the bone-to-implant ***,with element specific mass spectrometry,the elements and their accumulation in the main organs and tissues are *** results show that Mg-xGd implants degrade in vivo under the formation of a stable degradation layer with bone remodeling similar to that of Ti after 10 *** accumulation of Mg and Gd was observed in selected organs,except for the interfacial bone after 8 months of ***,we confirm that Mg-5Gd and Mg-10Gd are suitable material choices for bone implants.

关键词： Biodegradable implants Bone ultrastructure Degradation Mg-based alloys

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利用数字技术提升阅读能力(英文)

开放教育研究 2012年第3期18卷 63-66页

作者：罗达·莫里斯阿林森·贝克尔托丽·凯茨里利·艾菲德霍莉·格思里金伯莉·哈珀凯特琳·约翰逊阿曼达·尼古斯凯瑟琳·谢尔曼金伯莉·谢里林赛·斯蒂芬斯玛丽·沃森俄克拉荷马基督教大学美国

利用数字技术帮助阅读有困难的读者日益成为保证读者参与的方法之一。2011年秋季学期,俄克拉荷马基督教大学职前教师利用笔记本电脑和iPad对阅读有困难的读者进行了辅导,并将辅导过程所用的iPad应用程序和网站分为以下几类:音素意识、... 详细信息

利用数字技术帮助阅读有困难的读者日益成为保证读者参与的方法之一。2011年秋季学期,俄克拉荷马基督教大学职前教师利用笔记本电脑和iPad对阅读有困难的读者进行了辅导,并将辅导过程所用的iPad应用程序和网站分为以下几类:音素意识、音韵、理解、词汇和流利度,以供其他教师分享。研究发现,如果辅导过程中以某些方式使用数字技术,学生更容易参与到阅读过程中。

关键词：数字技术阅读有困难的读者 iPad

母亲颗粒物空气污染暴露与足月出生体重:效应与异质性的多国评估

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环境与职业医学 2013年第6期30卷 470-470页

作者： Payam Dadvand jennifer parker Michelle L. Bell Matteo Bonzini Michael Brauer Lyndsey A. Darrow Ulrike Gehring Svetlana V. Glinianaia Nelson Gouveia Eun-hee Ha jong Han Leem Edith H. van den Hooven Bin jalaludin Bill M. jesdale johanna Lepeule Rachel Morello-Frosch Geoffrey G. Morgan Angela Cecilia Pesatori Frank H. Pierik Tanja Pless-Mulloli David Q. Rich Sheela Sathyanarayana juhee Seo Rémy Slama Matthew Strickland Lillian Tamburic Daniel Wartenberg Mark j. Nieuwenhuijsen Tracey j. Woodruff

[背景]越来越多的证据显示,母亲空气污染暴露与对胎儿生长的不良影响之间存在关联;但是,现有的文献并不一致。[目的]研究9个国家14个中心的数据,量化母亲颗粒物空气污染暴露与足月出生体重和低出生体重(LBW)之间的关联,并探讨此关联中... 详细信息

[背景]越来越多的证据显示,母亲空气污染暴露与对胎儿生长的不良影响之间存在关联;但是,现有的文献并不一致。[目的]研究9个国家14个中心的数据,量化母亲颗粒物空气污染暴露与足月出生体重和低出生体重(LBW)之间的关联,并探讨此关联中地点特征和暴露评估方法对中心之间异质性的影响。[方法]空气污染与妊娠结局国际合作(ICAPPO)的各中心采用共同的分析方案,对PM10和PM2.5(颗粒物≤10和2.5μm)与足月LBW和连续出生体重进行效应评估。采用meta分析将各个中心(~300万例出生)的效应评估结合起来,并采用meta回归分析在报告的效应评估中,中心特征和暴露评估方法对中心之间异质性的影响。[结果]随机效应meta分析显示,调整母亲的社会经济地位后,在整个妊娠期间,足月LBW与PM10[比值比(OR)=1.03;95%CI:1.01~1.05]和PM2.5[OR=1.10;95%CI:1.03~1.18]每增加10μg/m3呈正相关。在充分调整随机效应的meta分析中,作为一个连续性的结果,PM10暴露每增加10μg/m3与足月出生体重呈负相关(-8.9g;95%CI:-13.2^-4.6 g)。meta回归分析显示,具有较高平均PM2.5水平和PM2.5∶PM10比率的中心,以及采用时间暴露评估(与时空相比)的中心,所报告的关联更强。[结论]在研究人群中,母亲颗粒物污染暴露与足月LBW相关联。有3个地点特征和暴露评估方法学方面的不同导致各个中心报告的关联的差异。

关键词：空气污染胎儿生长异质性 ICAPPO 低出生体重 meta分析 meta回归多中心研究颗粒物妊娠

Seasonal and population differences in migration of Whimbrels in the East Asian–Australasian Flyway

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Avian Research 2020年第3期11卷 246-257页

作者： Fenliang Kuang jonathan TColeman Chris jHassell Kar‑Sin KLeung Grace Maglio Wanjuan Ke Chuyu Cheng jiayuan Zhao Zhengwang Zhang Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River EstuaryInstitute of Biodiversity ScienceSchool of Life SciencesFudan UniversityShanghai 200433China School of Chemistry and Life Sciences Chuxiong Normal University546 South Road of LuchengChuxiong 675000YunnanChina Queensland Wader Study Group 22 Parker StreetShailer ParkQLD 4128Australia Global Flyway Network PO Box 3089BroomeWA 6725Australia Hong Kong Waterbirds Ringing Group Hong Kong 999077China Australasian Wader Studies Group BroomeWA 6725Australia Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China.

Background:Conserving migratory birds is challenging due to their reliance on multiple distant sites at different stages of their annual life *** concept of“flyway”,which refers to all areas covered by the breeding,nonbreeding,and migrating of birds,provides a framework for international cooperation for *** the same flyway,however,the migratory activities of the same species can differ substantially between seasons and *** the seasonal and population differences in migration is helpful for understanding migration ecology and for identifying conservation ***:Using satellite‑tracking we tracked the migration of Whimbrels(Numenius phaeopus variegatus)from nonbreeding sites at Moreton Bay(MB)and Roebuck Bay(RB)in Australia in the East Asian-Australasian *** tests were used to analyze the strength of migration connectivity between the nonbreeding and breeding sites of MB and RB ***’s t test was used to compare the migration activities between the two populations and between northward and southward ***:During northward migration,migration distance and duration were longer for the MB population than for the RB *** distance and duration of the first leg flight during northward migration were longer for the MB population than for the RB population,suggesting that MB individuals deposited more fuel before departing from nonbreeding sites to support their longer nonstop *** RB population exhibited weaker migration connectivity(breeding sites dispersing over a range of 60 longitudes)than the MB population(breeding sites concentrating in a range of 5 longitudes in Far Eastern Russia).Compared with MB population,RB population was more dependent on the stopover sites in the Yellow Sea and the coastal regions in China,where tidal habitat has suffered dramatic ***,RB population increased while MB population decreased over the past decades,suggesting that loss of tidal habit

关键词： Conservation Flyway Migration Migration connectivity Stopover Tracking Yellow Sea

Residues important to the allosteric regulation on ligand binding affinity in β3 integrins

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医用生物力学 2009年第S1期24卷 20-20页

作者： jizhong Lou1,Wei Chen2,Mei-Yin Chou3,Cheng Zhu1,2,3,4(1parker H.Petit Institute for Bioengineering and Bioscience,2Woodruff School of Mechanical Engineering,and 3School of Physics,4Coulter Department of Biomedical Engineering,,Georgia Institute of Technology,GA,USA)

Integrins are heterodimers that mediate cell adhesion and transduce signals bidirectionally across the cell *** often exist in low affinity(or inactive) states for

关键词： Residues important to the allosteric regulation on ligand binding affinity in