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Optimal therapy for HIV infection containment and virions inhibition

Infectious disease Modelling 2024年第1期9卷 10-26页

作者： paolo di giamberardino Daniela Iacoviello Muhammad Zubair Dept.of Computer Control and Management EngineeringSapienzaUniversity of RomeVia Ariosto 2500185RomeItaly

Prevention and early diagnosis are the best and most effective ways for defeating *** is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to become ***,research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is *** recent years,the presence of virus reserves located in various parts of the body,including the brain,has been *** possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied,proposing optimal control strategies.

关键词： Epidemic modeling HIV-AIDS Optimal control

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Early estimation of the number of hidden HIV infected subjects: An extended Kalman filter approach

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Infectious disease Modelling 2023年第2期8卷 341-355页

作者： paolo di giamberardino Daniela Iacoviello Dept.of Computer Control and Management EngineeringSapienzaUniversity of RomeVia Ariosto 2500185RomeItaly

In the last decades several epidemic emergencies have been affecting the world,influencing the social relationships,the economics and the *** particular,starting in the early 080,the Acquired Immunodeficiency Syndrome,AIDS,is representing one of the most worrying sanitary emergency,that has caused up to now more than 25 million of dead *** infection is caused by the Human Immunodeficiency Virus,HIV,that may be transmitted by body fluids;therefore with wise behaviours the epidemic spread could rapidly be *** sanitary emergency is peculiar for the long incubation time:it can reach even 10 years,a long period in which the individual can unconsciously infect other *** identification of the number of infected unaware people,mandatory to define suitable containment measures,is here obtained by using the extended Kalman filter applied to a noisy model in which,reasonably,only the number of infected diagnosed patients is *** simulations and real data analysis support the effectiveness of the approach.

关键词： Epidemic modeling Infection spread HIV-AIDS Extended Kalman filter

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