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Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport

World Journal of Gastroenterology 2010年第47期16卷 5958-5964页

作者： Matteo Pedrelli Camilla Pramfalk paolo parini Division of Clinical Chemistry Department of Laboratory Medicine Molecular Nutrition Unit Biosciences and Nutrition Karolinska Institutet at Karolinska University Hospital Huddinge

Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. Thyroid hormones (THs) affect growth, develop- ment, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRα and TRβ, and several isoforms (e.g. TRα1, TRα2, TRβ1, and TRβ2). Activation of TRα1 affects heart rate, whereas activation of TRβ1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRβ1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRβ1-modulating thyromimetics on RCT in various animal models and in humans.

关键词： Cardiovascular disease Cholesterol Lipoprotein metabolism Reverse cholesterol transport Thyroid hormones Thyroid hormone receptors

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胆固醇结石病人肝脏脂质代谢异常的分子生物学研究

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外科理论与实践 2007年第5期12卷 414-421页

作者：蒋兆彦姜翀弋胡海所广军 paolo parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权张圣道上海交通大学医学院附属瑞金医院外科上海消化外科研究所上海东方医院外科 Division of Hepatology and Gastroenterology Department of MedicineKarolinska University Hospital Huddinge141 86 StockholmSweden Department of Pathology Section on Lipid SciencesWake Forest University School of MedicineWinston-SalemNorth Carolina27157

目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋... 详细信息

目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。

关键词：胆固醇结石基因表达载脂蛋白类脂质累积病分子生物学

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Intestinal infarction by internal hernia in Petersen's space after laparoscopic gastric bypass

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World Journal of Gastroenterology 2014年第43期20卷 16349-16354页

作者： Massimiliano Fabozzi Riccardo Brachet Contul paolo Millo Rosaldo Allieta General and Laparoscopic Surgery Department "Umberto Parini" Aosta Valley Regional Hospital11100 AostaItaly

Intestinal occlusion by internal hernia is not a rare complication(0.2%-5%)after Laparoscopic Roux-en-Y-GBP(LGBP)with higher morbidity and mortality related to mesenteric vessels *** our Center,from October 2009 to April 2013 we have had 17 pts treated for internal hernia on 412 LGBP(4.12%).Clinical case:28-year-old woman,operated of LGBP(BMI=49;comorbidity:diabetes mellitus and arthropathy)about 10mo before,was affected by recurrent abdominal pain with alvus alteration lasting for a *** vomiting,she went to first aid Unit of a peripheric hospital where she made blood tests,RX and US of abdomen that resulted normal so she was discharged with flu like syndrome *** 3 d the patient contacted our Center since her symptoms got worse and was *** tests showed an alteration of hepatic enzymes and *** abdominal computed tomography(CT)showed the presence of fluid in perisplenic,peri-hepatic areas and in pelvis and a"target like imagine"of"clustered ileal loops"with a superior mesenteric vein(SMV)thrombosis involving the Portal *** the operation,we found a necrosis of80 cm of ileus(about 50 cm downstream the jejuno-jejunal anastomosis)due to an internal hernia through Petersen’s space causing a SMV *** necrotic bowel was removed,the internal hernia was reduced and Petersen’space was sutured by not-absorbable running *** anticoagulant therapy was begun in the post-operative time and the patient was discharged after 28 ***:The internal hernia diagnosis is rarely confirmed by preoperative exams and it is obtained in most cases by laparoscopy but the improvement of technologies and the discover of"new"CT signs interpretation can address to an early laparoscopic treatment for high suspicion cases.

关键词： Intestinal infarction Internal hernia Petersen's hernia Laparoscopic gastric bypass Portomesenteric thrombosis

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