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Uveitis in autoimmune hepatitis:A case report

World Journal of Gastroenterology 2006年第10期12卷 1637-1640页

作者： Roberto Giulio Romanelli Giorgio La Villa Fabio Almerigogna Francesco Vizzutti Elena Di Pietro Valentina Fedi paolo gentilini Giacomo Laffi Department of Internal Medicine University of Florence-School of Medicine Viale Morgagni85-50134 FlorenceItaly

In this case report we describe for the first time an association between autoimmune hepatitis （AIH） and uveitis, without any doubts about other possible etiologies, such as HCV, since all the old reports describe the association of AIH with iridocyclitis before tests for HCV-related hepatitis could be available. A 38-year-old businessman with abnormal liver function tests and hyperemia of the bulbar conjunctiva was admitted to the hospital. Six years before admission, the patient presented with persistent fever, arthralgias, conjunctival hyperemia, leukocytosis and increased ESR, referred to acute rheumatic fever. The presence of systemic diseases, most commonly associated with uveitis, was investigated without results and the patient was then treated with topical corticosteroids. His symptoms resolved. A test for anti-nuclear antibodies was positive, at a titre of 1：320, with a speckled and nucleolar staining pattern. Liver ultrasound showed mild hepatomegaly with an increased echostructure of the liver. Percutaneous liver biopsy was performed under ultrasound assistance. Histological examination showed necroinflammation over the portal, periportal and Iobular areas, fibrotic portal tracts, with periportal fibrosis and occasional portal-to-portal bridgings, but intact hepatic architecture. Some hepatocytes showed barely discernible granules of hemosiderin in the Iobular area. Bile ductules had not any significant morphological alterations. METAVIR score was A2-F3, according to the modified HAI grading/fibrosis staging. The patient was diagnosed to have AIH with mild activity and fibrosis and was discharged on 25 mg prednisone, entering clinical and biochemical remission, further confirming diagnosis. After discharge the patient continued to have treatment with corticosteroids as an outpatient at a dose of 5 mg. On January 2002 the patient was readmitted to the hospital. A test for anti-nuclear antibodies was positive, at a titre of 1：320, with a speckled and nucle

关键词： Autoimmune hepatitis Uveitis

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Long-term albumin infusion improves survival in patients with cirrhosis and ascites: An unblinded randomized trial

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World Journal of Gastroenterology 2006年第9期12卷 1403-1407页

作者： Roberto Giulio Romanelli Giorgio La Villa Giuseppe Barletta Francesco Vizzutti Fabio Lanini Umberto Arena Vieri Boddi Roberto Tarquini Pietro Pantaleo paolo gentilini Giacomo Laffi Department of Internal Medicine University of Florence School of Medicine FlorenceItaly Department of Heart and Vessels University of Florence School of Medicine FlorenceItaly Department of Public Health University of Florence School of Medicine FlorenceItaly Giacomo Laffi Department of Internal Medicine University of Florence School of Medicine Florence Italy

AIM： To investigate the effects of long-term albumin administration on survival, recurrence of ascites and onset of other complications. METHODS： One hundred consecutive patients admitted for first-onset ascites were randomized to receive diuretics plus human albumin 25 g/wk in the first year and 25 g every two wk thereafter （group 1） or diuretics alone （group 2）. The primary endpoint was survival without liver transplantation. Secondary endpoints were recurrence of ascites and occurrence of other complications. RESULTS： Median follow-up was 84 （2-120） mo. Albu- min-treated patients had significantly greater cumulative survival rate （Breslow test= 7.05, P= 0.0078） and lower probability of ascites recurrence （51% versus 94%, P〈0.0001）. Chronic albumin infusion resulted in a mean increase in survival of 16 mo. CONCLUSION： Long-term albumin administration after first-onset ascites significantly improves patients＇ survival and decreases the risk of ascites recurrence.

关键词： Long-term albumin administration after first-onset ascites significantly improves patients' survival and decreases the risk of ascites recurrence.

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Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis

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World Journal of Gastroenterology 2013年第34期19卷 5671-5677页

作者： Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo gentilini Gilberto Poggioli paolo Gionchetti Massimo Campieri Fernando Rizzello Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) University of Bologna

AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were *** underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of *** patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 *** endoscopists evaluated in a blinded manner the number and size of duodenal *** GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman ***>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and *** examined area was divided into 3 segments:duodenal bulb,second and third portion *** specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular *** was classified according to the updated Vienna ***:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was *** polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was *** 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal *** mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was *** agreement was ***>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in t

关键词： Familial adenomatous polyposis Ileal pouch-anal anastomosis Duodenal polyps Eviendep

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