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New and Better Practices for City Regeneration

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Journal of Civil Engineering and Architecture 2018年第4期12卷 262-272页

作者： Maria paola Gatti Giorgio Cacciaguerra Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoVia Mesiano 77Trento 38123Italy

By failing to incorporate quality and environmental concerns the criteria applied for the territorial and functional development of cities are no longer *** the on-going search for guidelines and strategic measures,the need for the re-densification and the restoration of a degraded urban fabric has emerged at various *** rationally planned,such actions can help reduce the costs inherent in uncontrolled land consumption by favouring a renewed and more effective functional *** follows that the recovery and maintenance of the extant heritage and its functional reconversion are part and parcel of the foregoing measures for urban enhancement and ***,in Italy regeneration operations are difficult to implement:they are often promoted but usually fail to *** criteria exist to advance real solutions?To provide incentives for regeneration actions,improve the quality of urban areas and the built environment,and engender a virtuous process in the national economy,new strategies must be defined at the various action levels(planning,design,and building,management).Experts,politicians,administrators and society as a whole must be involved in a much wider process that will lead to regulatory,organizational and associated changes.

关键词： Regeneration urban enhancement requalification re-densification.

Complex Regulation of Prolyl-4-Hydroxylases Impacts Root Hair Expansion

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Molecular Plant 2015年第5期8卷 734-746页

作者： Silvia M. Velasauez Martiniano M. Ricardi Christian Peter Poulsen Ai Oikawa Adiphol Dilokpimol Adnan Halim Silvina Mangano Silvina paola Denita Juarez Eliana Marzol Juan D. Salgado Salter Javier Gloazzo Dorosz Cecilia Borassi Svenning Rune Moller Rafael Buono Yukiko Ohsawa Ken Matsuoka Marisa S. Otegui Henrik V. Scheller Naomi Geshi Bent Larsen Petersen Norberto D. lusem Jose M. Estevez Instituto de Fisiologfa Biologia Molecular y Neurociencias (IFIBYNE-CONICET) Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires C1428EGA Argentina VKR Research Centre Department of Plant and Environmental Sciences University of Copenhagen DK-1871 Frededksberg C Denmark Joint BioEnergy Institute Feedstocks Division Lawrence Berkeley National Laboratory 5885 Hollis Street Emeryville CA 94608 USA Copenhagen Center for Glycomios Department of Cellular and Molecular Faculty of Health and Medical Sciences University of CopenhagenDK-2200 Copenhagen N Denmark Department of Botany University of Wisconsin Madison WI 53706 USA RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan Laboratory of Plant Nutrition Faculty of Agriculture Kyushu University Hakozaki 6-10-1 Higashi-ku Fukuoka 812-8581 Japan Departamento de Fisiologia Biologia Molecular y Celular Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires C1428EGAArgentina These authors contributed equally to the article. Present address: Fungal Physiology CBS-KNAW Fungal Biodiversity Center Uppsalalaan 8 Utrecht 3584 CT The Netherlands Present address: The Danish Stem Cell Center The Panum Institute Blegdamsvej 3B DK-2200 Copenhagen Denmark

Root hairs are single cells that develop by tip growth, a process shared with pollen tubes, axons, and fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In addition to polysaccharides, plant cell walls are composed of hydroxyproline-rich glycoproteins （HRGPs）, which include several groups of O-glycoproteins, including extensins （EXTs）. Proline hydroxylation, an early post-translational modification （PTM） of HRGPs catalyzed by prolyl 4-hydroxylases （P4Hs）, defines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that P4H5, and to a lesser extent P4H2 and P4H13, are pivotal for root hair tip growth. Second, we demonstrate that P4H5 has in vitro preferred specificity for EXT substrates rather than for other HRGPs. Third, by P4H promoter and protein swapping approaches, we show that P4H2 and P4H13 have interchangeable functions but cannot replace P4H5. These three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and P4H13. Finally, we explore the impact of deficient proline hydroxylation on the cell wall architec- ture. Taken together, our results support a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HRGPs, is required for proper cell wall self-assembly and hence root hair elongation in Arabidopsis thaliana.

关键词： enzymology cell expansion cell walls protein targeting proline hydroxylation root hairs

New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review

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World Journal of Orthopedics 2014年第2期5卷 80-88页

作者： Giuseppe Musumeci paola Castrogiovanni Rosalia Leonardi Francesca Maria Trovato Marta Anna Szychlinska Angelo Di Giunta Carla Loreto Sergio Castorina Department of Bio-Medical Sciences Human Anatomy and Histology Section School of Medicine University of Catania 95123 Catania Italy Department of Medical and Surgical Sciences Ⅱ Dental Unity University of Catania 95123 Catania Italy Department of Medical and Pediatric Sciences Internal Medicine Division University of Catania 95123 Catania Italy Fondazione Mediterranea ‘‘G.B. Morgagni’’ 95125 Catania Italy

In this paper review we describe benefits and disadvantages of the established methods of cartilage regeneration that seem to have a better long-term *** illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineering, through mesenchymal stem cells and biomaterials,and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair *** articular cartilage has low capacity to repair itself,and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, result-ing in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to implement clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubM ed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the wellknown tissue engineering methods for the treatment of knee osteoarthritis.

关键词： Cartilage Repair Mesenchymal stem cells Scaffolds Tissue engineering Osteoarthritis

Pedestrians Mobility on Public Sidewalks Evaluated by the IAAPE Method

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Journal of Civil Engineering and Architecture 2017年第8期11卷 789-799页

作者： Karla Conceicao Pereira Alcindo Neckel Henrique Aniceto Kujawa Mauricio Kunz Grace Cardoso Lauro André Ribeiro Caliane Christie Oliveira de Almeida Silva Pamela Gnoatto paola Pol Saraiva Juliana Frighetto Tales Goncalves Visentin School of Architecture and Urbanism of Faculdade Meridional (IMED) Group of Studies and Research on Urban Mobility (NEPMOUR) Passo Fundo/RS. CEP: 99070-220 Brazil School of Psychologyof Faculdade Meridional (IMED) Group of Studies and Research on Urban Mobility (NEPMOUR) Passo Fundo/RS. CEP: 99070-220 Brazil

This research aims to evaluate walkability as a strategy of urban mobility in relation to physical characteristics of accessibility and attractiveness from public sidewalks characteristics in the city of Passo Fundo/RS-Brazil using the IAAPE （indicators of attraction and pedestrian accessibility） method. The concept of walkability corresponds to the simple act of walking in a pleasant way along the footpaths. Therefore, the IAAPE method was used, which considers aspects of connectivity, comfort, conviviality, coexistence, convenience, clarity and commitment in relation to the space evaluated. In this study, 40 adults, elderly, pregnant and wheelchair subjects were interviewed for evaluating the importance criteria on public sidewalks for a given type of user. In general, reduced sidewalk dimensions and obstacle presence are the main displacement hurdles in most of the cases analyzed. Thus, improvements are needed to avoid stress situations that arise from daily routine, to encourage physical activities, accessibility, and the emergence of meeting and leisure points.

关键词： Walkability mobility public sidewalks IAAPE life quality.

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纸上一千零一夜

现代装饰（家居） 2012年第3期 72-75页

作者： Jurianne Matter paola Paronetto HAY DRILL DESIGN Godeleine de Rosamel Philippe Balayn 陈菡

纸,是古往今来的文人墨客情感和思想的载体。但是纸并不是只在一个领域发光发热。在老家,人们会用纸糊在窗户上;小时候我对装着SMZ药片的纸袋子特别感兴趣,因为上面有我唯一能看懂的"每次半片";国家下发"限塑令"后,各种纸质包装犹如雨... 详细信息

纸,是古往今来的文人墨客情感和思想的载体。但是纸并不是只在一个领域发光发热。在老家,人们会用纸糊在窗户上;小时候我对装着SMZ药片的纸袋子特别感兴趣,因为上面有我唯一能看懂的"每次半片";国家下发"限塑令"后,各种纸质包装犹如雨后春笋,虽然环保与否人们还在争论。在设计师眼里,纸是灵感和道具,他们让纸前面的量词不再只是"张",而纸的背后都是他们的情绪和故事……

关键词：你喜欢线把不知道这个世界讲述者话则秋刀鱼色彩运用网格线距离感

Combination of a <i>Lactobacillus</i>-Based Probiotic and Organic Acids Decrease Egg to Chick Weight Loss and Reduce <i>Salmonella</i>spp. Counts in the Litter of Commercial Broiler Breeders

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Food and Nutrition Sciences 2019年第8期10卷 1011-1020页

作者： Matias A. Michel Fernando A. Revidatti Ricardo J. Fernández Martín L. Sindik paola Sanz Xochitl Hernandez-Velasco Juan D. Latorre Billy M. Hargis Guillermo Tellez-Isaias Facultad de Ciencias Veterinarias Universidad Nacional del Nordeste Corrientes Argentina Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Cd. de Mexico México Department of Poultry Science University of Arkansas Fayetteville AR USA

The effects of supplementing a blend of organic acids (OA) and a lactic acid bacteria (LAB) based-probiotic on egg to chick weight loss (%) and Salmonella spp. recovery counts in the litter of commercial broiler breeders were examined in three independent trials during the years 2013, 2014 and 2015. In each trial, ten thousand birds were divided into two groups of 5000 birds (4500 females and 500 males in each group): Control non-treated group, receiving regular water or treated group, receiving OA and probiotic in the drinking water from 25 to 35 weeks of age. During the ten weeks of evaluation, one thousand fertile eggs or hatched chickens in each trial respectively, were evaluated to obtained, hatching set weight, transferred egg weight, and hatching chick weight, to estimate the difference between egg to chick weight loss (%). Besides, in trial 2 (2014) and trial 3 (2015), litter samples were collected to evaluate Salmonella spp. counts. The supplementation of OA and probiotic during ten consecutive weeks significantly decreased the egg to chick weight loss (%) when compared with the control non-treated groups in all three trials evaluated. Interestingly, at the end of the trials 2 and 3, no counts of Salmonella spp. in the litter were detected. In contrast, control-non treated groups resulted in 4.30 and 4.24 Log10 of Salmonella spp. in trials two and three respectively. The results of the present study suggest that supplementation of OA and a LAB-probiotic for ten consecutive weeks decrease the egg to chick weight loss (%) and reduce Salmonella spp. counts in the litter of commercial broiler breeders. Higher initial body weight in broiler chickens and reduction of Salmonella spp., clearly justify the use of the combination of these products, as alternatives to antibiotics.

关键词： Broiler Breeder Organic Acid Probiotic Salmonella Litter

An uncommon cause of abdominal pain in a child: Meckel diverticulum

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Journal of Acute Disease 2017年第5期6卷 229-231页

作者： Anna Chiara Iolanda Contini Tamara Caldaro Giovanni Federici di Abriola Erminia Romeo Valerio Balassone Francesca Rea Filippo Torroni paola De Angelis Simona Faraci Giulia Angelino Renato Tambucci Luigi Dall'Oglio Digestive Surgery and Endoscopy Unit Bambino GesùChildren HospitalIRCCS00165 RomeItaly

Meckel diverticulum, a common congenital anomaly of the small intestine, can be responsible of several complications due to the presence of ectopic gastric mucosa and represents a challenge for diagnosis. We present the case of a 11-year boy suffering from intestinal pain and bleeding in which radiological examinations unexpectedly raised the suspicion of Meckel diverticulum. The diagnosis was confirmed using 99mTc-pertechnetate scintigraphy. At surgery, a fistulous tract between Meckel diverticulum and an inflamed appendix was found. The authors discuss the role of medical nuclear imaging which, notwithstanding its limitations, is of fundamental importance to achieve a correct and timely diagnosis. This is of particular relevance in unusual cases, as the one presented, in which Meckel diverticulum is found concurrently with other intestinal abnormalities.

关键词： Appendix Meckel Scintigraphy

穿心莲内酯对小鼠巨噬细胞活化及特异性抗体应答的影响

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穿心莲内酯对小鼠巨噬细胞活化及特异性抗体应答的影响

切断了的联系:中国女性的他者描述和本土形象

第五届全国中医药免疫学术研讨会——暨环境·免疫与肿瘤防治综合交叉会议

作者：王维王静刘春红 ITALIANI,paola BORASCHI,Diana 马世平瞿涤中国药科大学中药药理教研室复旦大学上海医学院生物医学研究院医学分子病毒学教育部/卫生部重点实验室病复旦大学上海医学院原微生物研究所复旦大学上海医学院病原微生物研究所意大利国立研究院生物医学技术研究所免疫生物学组细胞因子实验室

目的:研究穿心莲内酯对小鼠天然免疫和适应性免疫应答的影响。方法:小鼠腹腔巨噬细胞体外培养,经LPS诱导向M1活化或IL-4诱导向M2活化,同时以穿心莲内酯(10μg/ml)处理;利用real-time PCR检测巨噬细胞活化相关的M1和M2类细胞因子基因转... 详细信息

目的:研究穿心莲内酯对小鼠天然免疫和适应性免疫应答的影响。方法:小鼠腹腔巨噬细胞体外培养,经LPS诱导向M1活化或IL-4诱导向M2活化,同时以穿心莲内酯(10μg/ml)处理;利用real-time PCR检测巨噬细胞活化相关的M1和M2类细胞因子基因转录水平(M1:IL-1β,IL-18,IL-12等;M2:IL-1Ra,IL-18B P,IL-10等),流式细胞术检测巨噬细胞活化及抗原提呈功能相关的细胞表面分子(CD40,CD80,CD86,MHC等)。用乙肝表面抗原(HBsAg)免疫小鼠,同时腹腔注射给予穿心莲内酯(1mg/kg);利用ELISA方法检测anti-HBsAg,ELISPOT法检测分泌IL-4的脾淋巴细胞数量。结果:穿心莲内酯单独处理巨噬细胞24小时后使其偏向M2活化(IL-12/IL-10比例从0.78降低至0.12),处理LPS激活的巨噬细胞抑制其向M1分化(IL-12/IL-10比例从30.97降低至10.77),处理IL-4激活的巨噬细胞促进其向M2分化(IL-12/IL-10比例从0.32降低至0.15);并且穿心莲内酯下调了LPS激活的巨噬细胞表面分子CD40,CD80,CD86及MHC I的表达。HBsAg免疫的小鼠给予穿心莲内酯后血清特异性抗体anti-HBs滴度下降,分泌IL-4的脾淋巴细胞数量减少。结论:穿心莲内酯可调节小鼠的天然免疫和适应性免疫应答,调节巨噬细胞的活化并减少特异性抗体的产生。

关键词：穿心莲内酯免疫调节巨噬细胞细胞因子抗体

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全球史评论 2019年第1期 45-87,361页

作者：曾佩琳陈昊天(译) 美国西北大学亚洲语言和文化学系首都师范大学历史学院

本文分析了20世纪之交,作为"中国通"或者说作为中国专家的西方女性笔下对中国女性的描述。这些文本均可被归为性别实践,其来源囊括了回忆录、传教士报道、照片和绘画,无疑维系了帝国主义、殖民主义和传教事业,但其重点和意义也超越了这... 详细信息

本文分析了20世纪之交,作为"中国通"或者说作为中国专家的西方女性笔下对中国女性的描述。这些文本均可被归为性别实践,其来源囊括了回忆录、传教士报道、照片和绘画,无疑维系了帝国主义、殖民主义和传教事业,但其重点和意义也超越了这些话语。西方女性运用了所谓"跨国家庭生活"的方式,在中国找到了一个特权舞台,在这里,她们可以充分发挥自己的潜力,而不必向由男性主导的父权社会证明自己的正当性。在西方女性运用大量的修辞形象和话语转义来描绘中国,以求迎合西方读者时,这些作品也展现出西方女性通过书写中国女性来体现自身独特性并重塑自我的多重愿景。这也许有助于理解西方女性如何塑造中国的东方主义形象,以及她们在这一过程中所起的作用。这些维多利亚时代由西方女性执笔的有关中国女性的书籍,并不仅仅是不寻常而杰出的人物所书写的娱乐性作品,抑或是传教事业的一部分。相反,它们澄清并阐明了跨国文化互动的复杂驱动力,无论在过去还是当下,这一驱动力仍然在中国、西方、女性、种族和性别等领域中发挥着作用。

关键词：中国女性西方女性写作 20世纪之交东方主义