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Journal of Encapsulation and Adsorption Sciences 2017年第3期7卷 121-126页

作者： Tessy López Juan C. Manrique-Arias paola ramírez Pamela Larraza Francisco Rodríguez Reinoso Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco CdMx México Unidad Radiofarmacia-Ciclotrón Facultad de Medicina Universidad Nacional Autónoma de México CdMx México Departamento de Química Universidad de Alicante Espa&ntilde a

In recent years Copper-64 in the chemical form of copper chloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64CuCl2, the nanoparticles Cu(acac)2/F-TiO2 were mixed with 64CuCl2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac)2/F-TiO2. The “in vivo” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.

关键词： PET Therapy Nanoparticles Functionalized Titania (F-Tio2) Titanium Acetylacetonate [Cu (AcAc)2] Cu(Acac)2/F-Tio2 PET Lesion Detection Imaging

Sol-Gel Silica Matrix as Reservoir for Controlled Release of Paracetamol: Characterization and Kinetic Analysis

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Journal of Encapsulation and Adsorption Sciences 2016年第2期6卷 47-55页

作者： Tessy López Mayra Álvarez paola ramírez Gustavo Jardón Miriam López Guadalupe Rodriguez Itzel Ortiz Octavio Novaro Laboratorio de Nanotecnología y Nanomedicina Universidad Autónoma Metropolitana-Xochimilco México D.F. México Laboratorio de Nanotecnología Instituto Nacional de Neurología y Neurocirugía “MVS” México D.F. México Department of Chemical and Biomolecular Engineering Tulane University New Orleans USA Instituto de Física Universidad Nacional Autónoma de México Circuito de la Investigación s/n México D.F. México

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m2/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO2 materials were proved to be a suitable system for controlled release of paracetamol.

关键词： Sol-Gel Growth Nanostructures Biomaterials Surface Properties

HVOF-sprayed HAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

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Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John Henao Astrid L.Giraldo-Betancur paola Forero-Sossa Diego German Espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana T.Estrada-Moo Idelfonso E.Pech-Pech CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDESI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution

Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in an impacted environment

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Marine Life Science & Technology 2024年第1期6卷 126-142页

作者： Elisa Banchi Erwan Corre paola Del Negro Mauro Celussi Francesca Malfatti National Institute of Oceanography and Applied Geophysics OGS TriesteItaly FR2424 Station Biologique de RoscoffPlateforme ABiMS(Analysis and Bioinformatics for Marine Science)Sorbonne Universite CNRS29680 RoscoffFrance Department of Life Sciences University of TriesteTriesteItaly

Bacteria living in sediments play essential roles in marine ecosystems and deeper insights into the ecology and biogeochemistry of these largely unexplored organisms can be obtained from‘omics’***,we characterized metagenome-assembled-genomes(MAGs)from the surface sediment microbes of the Venice Lagoon(northern Adriatic Sea)in distinct sub-basins exposed to various natural and anthropogenic *** were explored for biodiversity,major marine metabolic processes,anthropogenic activity-related functions,adaptations at the microscale,and biosynthetic gene *** from 126 MAGs,a non-redundant dataset of 58 was compiled,the majority of which(35)belonged to(Alpha-and Gamma-)*** the broad microbial metabolic repertoire(including C,N,and S metabolisms)the potential to live without oxygen emerged as one of the most important *** was also found as a successful *** analysis showed that different MAGs encoded the same metabolic patterns(e.g.,C fixation,sulfate oxidation)thus suggesting metabolic *** and toxic compounds resistance genes were coupled,a condition that could promote the spreading of these genetic *** showed a high biosynthetic potential related to antimicrobial and biotechnological classes and to organism defense and interactions as well as adaptive strategies for micronutrient uptake and cellular *** results highlighted that bacteria living in an impacted environment,such as the surface sediments of the Venice Lagoon,may benefit from metabolic plasticity as well as from the synthesis of a wide array of secondary metabolites,promoting ecosystem resilience and stability toward environmental pressures.

关键词： Antibiotic resistance PAHs Biosynthetic gene clusters Microscale Mobilome Resistome

Alternative therapeutic strategies in diabetes management

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World Journal of Diabetes 2024年第6期15卷 1142-1161页

作者： Alessia Annicchiarico Barbara Barile Cinzia Buccoliero Grazia paola Nicchia Giacomina Brunetti Department of Biosciences Biotechnologies and EnvironmentUniversity of Bari Aldo MoroBari 70125Italy

Diabetes is a heterogeneous metabolic disease characterized by elevated blood glucose levels resulting from the destruction or malfunction of pancreaticβcells,insulin resistance in peripheral tissues,or both,and results in a non-sufficient production of *** adjust blood glucose levels,diabetic patients need exogenous insulin administration together with medical nutrition therapy and physical *** the aim of improving insulin availability in diabetic patients as well as ameliorating diabetes comorbidities,different strategies have been *** first approaches included enhancing endogenousβcell activity or transplanting new *** protocol for this kind of intervention has recently been optimized,leading to standardized *** is indicated for diabetic patients with severe hypoglycemia,complicated by impaired hypoglycemia awareness or exacerbated glycemic *** has been associated with improvement in all comorbidities associated with diabetes,quality of life,and ***,different trials are ongoing to further improve the beneficial effects of ***,to overcome some limitations associated with the availability of islets/pancreas,alternative therapeutic strategies are under evaluation,such as the use of mesenchymal stem cells(MSCs)or induced pluripotent stem cells for *** cotransplantation of MSCs with islets has been successful,thus providing protection against proinflammatory cytokines and hypoxia through different mechanisms,including exosome *** use of induced pluripotent stem cells is recent and requires further *** advantages of MSC implantation have also included the improvement of diabetes-related comorbidities,such as wound *** the number of advantages of the direct injection of MSCs,new strategies involving biomaterials and scaffolds have been developed to improve the efficacy of mesenchymal cell delivery with promising resul

关键词： Diabetes Pancreas/islet transplantation Mesenchymal stem cells Induced pluripotent stem cells Exosomes Scaffolds

Methane cracking in molten tin for hydrogen and carbon production—a comparison with homogeneous gas phase process

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 155-166页

作者： Emmanuel Busillo Benedetta de Caprariis Maria paola Bracciale Vittoria Cosentino Martina Damizia Gaetano Iaquaniello Emma Palo Paolo De Filippis Chemical Engineering Department Sapienza University of RomeRome 00184Italy NextChem S.p.A. Rome 00156Italy

Methane cracking is considered a bridge technology between gray and green hydrogen production *** this work an experimental study of methane cracking in molten tin is *** tests were conducted in a quartz reactor(i.d.=1.5 cm,L=20 cm)with capillary injection,varying temperature(950–1070℃),inlet methane flow rate(30–60 mL·min^(-1))and tin height(0–20 cm).The influence of the residence time in the tin and in the headspace on methane conversion and on carbon morphology was *** conversions obtained in tin and in the empty reactor were measured and compared with results of detailed kinetic simulations(CRECK).Furthermore,an expression of a global kinetic constant for methane conversion in tin was also *** highest conversion(65%at Q_(0)=30 mL·min^(-1) and t=1070℃)is obtained for homogeneous gas phase reaction due to the long residence time(70 s),the presence of tin leads to a sharp decrease of residence time(1 s),obtaining a conversion of 35%at 1070℃,thus meaning that tin owns a role in the *** characterization(scanning electron microscopy,raman)reported a change in carbon toward sheet-like structures and an increase of the carbon structural order in the presence of molten tin media.

关键词： methane cracking molten media H2 production carbon morphology

Transition process in children with chronic liver diseases:what is the challenging point?

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 854-856页

作者： Anna Di Sessa Giusy Capasso paola Tirelli Emanuele Miraglia Del Giudice Pierluigi Marzuillo Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaplesItaly

Pediatric chronic liver diseases encompass a wide spectrum of hepatopathies with a relevant health medical and financial burden(1,2).In addition to inherited disorders(e.g.,Alagille syndrome,metabolic disorders,etc.),there are numerous chronic liver conditions including metabolic dysfunction-associated steatotic liver disease(MASLD)and autoimmune liver diseases affecting morbidity,quality of life,and life expectancy of these young patients(3,4).To complicate matters,the exact prevalence of childhood chronic liver diseases is still unknown since their asymptomatic course especially in the early stages but increasing rates are reported worldwide(1,5,6).Moreover,management of these chronic conditions represents a great challenge for clinicians as it requires a lifelong multi-disciplinary approach(1).Worthy of note,advances in the knowledge of pathophysiological mechanisms underlying liver diseases greatly improved their natural history with increased survival rates into adulthood(1,3).Given that,adult hepatologists are increasingly dealing with most of these conditions(3).

关键词： Chronic liver diseases children transition adult

Nrf2 and Her3 co-expression in cholangiocarcinoma:Possible biological pathways for potential therapeutic approach

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 317-321页

作者： paola Parente Valentina Angerilli Giuseppe Zamboni Angelo Sparaneo Fabiola Fiordelisi Leonarda Di Candia Matteo Fassan Paolo Graziano Pathology Unit Fondazione IRCCS Casa Sollievo della Sofferenza71013San Giovanni Rotondo(Foggia)Italy Department of Medicine(DIMED) Surgical Pathology UnitUniversity of Padua35128Padua(Padua)Italy Pathology Unit IRCCS Ospedale Sacro Cuore Don Calabria37024Negrar(Verona)Italy Laboratory of Oncology Fondazione IRCCS Casa Sollievo della Sofferenza71013San Giovanni Rotondo(Foggia)Italy Veneto Institute of Oncology IOV-IRCCS 35124Padua(Padua)Italy

To the Editor:Cholangiocarcinomas(CCAs)are heterogeneous group of malignancies,encompassing intrahepatic CCA(iCCA),and extrahepatic CCA(eCCA);they are also classified into common hepatic duct cholangiocarcinoma(CHDCCA),choledocus extrapancreatic cholangiocarcinoma(EPCCA)and choledocus intrapancreatic cholangiocarcinoma(IPCCA)and,finally,gallbladder carcinoma(GBCCA).CCAs are relatively uncommon but.

关键词： carcinoma gallbladder Nrf2

Discovering genetic biomarkers for targeted cancer therapeutics with eXplainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty Elizabeth Gutierrez-Chakraborty Cristian Rodriguez-Aguayo Hakan Başağaoğlu Gabriel Lopez-Berestein paola Amero School of Civil and Environmental Engineering and Construction Management The University of Texas at San AntonioSan AntonioTexasUSA Department of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most prevalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted

May ChatGPT be a tool producing medical information for common inflammatory bowel disease patients’questions?An evidencecontrolled analysis

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World Journal of Gastroenterology 2024年第1期30卷 17-33页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Marina Cipullo Giovanna Palladino Giuseppe Imperio Andrea Ventura Salvatore Auletta paola Ciamarra Alessandro Federico Division of Hepatogastroenterology Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy

Artificial intelligence is increasingly entering everyday *** language model(LLM)systems such as Chat Generative Pre-trained Transformer(ChatGPT)have become potentially accessible to everyone,including patients with inflammatory bowel diseases(IBD).However,significant ethical issues and pitfalls exist in innovative LLM *** hype generated by such systems may lead to unweighted patient trust in these ***,it is necessary to understand whether LLMs(trendy ones,such as ChatGPT)can produce plausible medical information(MI)for *** review examined ChatGPT’s potential to provide MI regarding questions commonly addressed by patients with IBD to their *** the review of the outputs provided by ChatGPT,this tool showed some attractive potential while having significant limitations in updating and detailing information and providing inaccurate information in some *** studies and refinement of the ChatGPT,possibly aligning the outputs with the leading medical evidence provided by reliable databases,are needed.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Chat Generative Pre-trained Transformer Large language model Artificial intelligence