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Neural Regeneration Research 2015年第9期10卷 1409-1412页

作者： Sandra Moreno Maria paola Cerù Department of Science-LIME University Roma Tre Department of Life Health and Environmental Sciences University of L’AquilaCoppito (AQ) Italy

Peroxisome proliferator activated receptors： In the early 1990s, seminal work on rodent liver demonstrated that the hypolipidemic effect of xenobiotics, referred to as peroxisome proliferators, was mediated by a member of steroid hormone receptor superfamily, thus designated peroxisome proliferator-activated receptors （PPARs）（Issemann and Green, 1990; Dreyer et al., 1992）. The research field opened by this discovery led to the identification of three isotypes, namely PPARa （NR1C1）, PPAR[3/6 （NRIC2）, PPARy （NRIC3）, in a wide range of tissues. All these receptors act as ligand-activated transcription factors, binding lipid molecules with different, though overlapping, specificity.

关键词： PPAR a promising therapeutic target is PPAR

APolygonal Discontinuous Galerkin Formulation for Contact Mechanics in Fluid-Structure Interaction Problems

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Communications in Computational Physics 2021年第6期30卷 1-33页

作者： Stefano Zonca paola FAntonietti Christian Vergara MOX Dipartimento di MatematicaPolitecnico di MilanoItaly LABS Dipartimento di ChimicaMateriali e Ingegneria Chimica“Giulio Natta”Politecnico di MilanoItaly

In this work,we propose a formulation based on the Polygonal Discontinuous Galerkin(PolyDG)method for contact mechanics that arises in fluid-structure interaction *** particular,we introduce a consistent penalization approach to treat the frictionless contact between immersed structures that undergo large *** key feature of the method is that the contact condition can be naturally embedded in the PolyDG formulation,allowing to easily support polygonal/polyhedral *** proposed approach introduced a fixed background mesh for the fluid problem overlapped by the structure grid that is able to move independently of the fluid *** assess the validity of the proposed approach,we report the results of several numerical experiments obtained in the case of contact between flexible structures immersed in a fluid.

关键词： Polygonal Discontinuous Galerkin method fluid-structure interaction contact mechanics

Bedrock geology interacts with altitude in affecting leaf growth and foliar nutrient status of mountain vascular plants

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Journal of Plant Ecology 2017年第5期10卷 839-850页

作者： Renato Gerdol Roberta Marchesini paola Iacumin Department of Life Sciences and Biotechnology University of FerraraCorso Ercole I d’Este 32I-44121 FerraraItaly Department of Physics and Earth Sciences University of ParmaViale delle Scienze 158/AI-43124 ParmaItaly

Aims Altitude is often used as a proxy for ascertaining how warming affects plant growth and leaf level ***,we have a poor understanding of how the effects of altitude-related warming varies across ***,this study examined the independ-ent and interactive effects of altitude and geology and species on plant growth and foliar nutrient *** We determined leaf growth rates and concentrations of major nutrients(nitrogen,N and phosphorus,P)in leaves of five spe-cies across two altitudinal gradients(1200-2200 m)in the Dolomites(south-eastern Alps,Italy).the two transects were located on carbonate bedrock and silicate bedrock,*** also determined concentrations of inorganic and organic N and P forms in soils,andδ15N signature in leaves and *** Findings Foliar N concentrations were unrelated to bedrock *** negative foliarδ^(15)N signature suggested that organic N was the primary source of N supply across the *** P concentrations were strongly affected by bedrock geology and their altitudinal patterns depended on the concentrations of organic and inorganic P forms in the *** and organic P appeared to be the main sources of P *** growth rates increased with higher altitude on silicate bedrock and decreased with higher altitude on carbonate bedrock and presented a significant positive correlation with foliar N:*** conclusion,bedrock geology inter-acted with altitude in controlling the foliar nutrient status mainly owing to availability of soil P and its effect on foliar nutrient stoichiometry.

关键词： altitude mycorrhiza plant functional type soil chemistry ^(15)N

An Adaptive hp-DG-FE Method for Elliptic Problems: Convergence and Optimality in the 1D Case

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Communications on Applied Mathematics and Computation 2019年第3期1卷 309-331页

作者： paola Antonietti Claudio Canuto Marco Verani MOX-Dipartimento di Matematica Politecnico di MilanoP.zza Leonardo Da Vinci 3220133 MilanItaly Dipartimento di Scienze Matematiche Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TurinItaly

We propose and analyze an hp-adaptive DG-FEM algorithm, termed hp-ADFEM, and its one-dimensional realization, which is convergent, instance optimal, and h- and p-robust. The procedure consists of iterating two routines:one hinges on Binev's algorithm for the adaptive hp-approximation of a given function, and finds a near-best hp-approximation of the current discrete solution and data to a desired accuracy;the other one improves the discrete solution to a finer but comparable accuracy, by iteratively applying D?rfler marking and h refinement.

关键词： Elliptic problem Discontinuous Galerkin method hp-adaptivity Convergence and optimality

Tackling cisplatin resistance in ovarian cancer: what can we do?

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Cancer Drug Resistance 2021年第4期4卷 755-757页

作者： paola Perego Molecular Pharmacology Unit Department of Applied Research and Technological DevelopmentFondazione IRCCS Istituto Nazionale dei TumoriMilan 20133Italy

Ovarian cancer is a complex disease mainly consisting of epithelial cancer which comprises various histological *** most frequent one is high-grade serous ovarian *** prognosis of this disease is poor because most women are diagnosed with advanced *** many patients respond to first-line Pt-based therapy,the development of resistance limits the efficacy of *** therapeutic strategies to improve the efficacy of ovarian carcinoma treatment are emerging from both basic and translational research *** this Special Issue,approaches to improve the armamentarium to fight ovarian carcinoma are presented,thereby providing an overview of selected aspects of ovarian cancer biology that can be exploited to improve *** this context,a re-evaluation and optimization of already tested strategies such as intra-peritoneal therapy together with a deep investigation of the recently acquired knowledge on factors(e.g.,E3 ubiquitin ligases)and features[Cancer Stem Cells(CSCs)]contributing to drug resistance may provide useful insights to tackle cisplatin resistance.

关键词： cisplatin cancer resistance

The inflammasomes in health and disease:from genetics to molecular mechanisms of autoinflammation and beyond

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Cellular & Molecular Immunology 2011年第2期8卷 135-145页

作者： Cristina Conforti-Andreoni paola Ricciardi-Castagnoli Alessandra Mortellaro Singapore Immunology Network(SIgN) Agency for ScienceTechnology and Research(A*STAR)ImmunosSingapore

Nucleotide-binding oligomerization domain(NOD)-containing protein-like receptors(NLRs)are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen *** NLRs form the framework for cytosolic platforms called inflammasomes,which orchestrate the early inflammatory process via IL-1b *** and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a variety of autoinflammatory ***,the activity of certain inflammasomes is associated with susceptibility to infections as well as autoimmunity and *** this review,we will discuss how identifying the genetic characteristics of inflammasomes is assisting our understanding of both autoinflammatory diseases as well as other immune system-driven disorders.

关键词： autoinflammatory diseases polymorphisms NLRs NLRP3

Hepcidin modulation in human diseases: From research to clinic

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World Journal of Gastroenterology 2009年第5期15卷 538-551页

作者： Alberto Piperno Raffaella Mariani paola Trombini Domenico Girelli Department of Clinical Medicine and Prevention University of Milano-Bicocca Monza 20052 Italy Centre for Diagnosis and Treatment of Hemochromatosis and Iron Overload Diseases San Gerardo Hospital Monza 20052 Italy Department of Clinical and Experimental Medicine University of Verona Verona 37100 Italy

By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need. In recent years there has been important advancement in our knowledge of hepcidin regulation that also has implications for understanding the physiopathology of some human disorders. Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a reliable assay of the hormone in biological fluids. Measurement of hepcidin in biological fuuids can improve our understanding of iron diseases and be a useful tool for diagnosis and clinical management of these disorders. We reviewed the literature and our own research on hepcidin to give an updated status of the situation in this rapidly evolving fi eld.

关键词：红血球生成血色沉着病贫血病缺铁临床

When Heritage Is Rural: Environmental Conservation, Cultural Interpretation and Rural Renaissance in Chinese Listed Villages

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Built Heritage 2019年第2期3卷 64-80页

作者： Anna-paola Pola World Heritage Institute of Training and Research for the Asia and the Pacific Region under the Auspice of UNESCO(WHITRAP) ShanghaiChina

This article argues that China’s growing attention towards villages in recent years has contributed to transforming the concept of built heritage and helped in disseminating a holistic idea of territory that has prepared the ground for the environmental turn the country is now *** conceptual transformation was carried on by a number of converging-although independent-initiatives from different governmental institutions and has been driven by different factors,most importantly,the need to mend the development gap between urban and rural areas,and the wish to rediscover the cultural heritage of the *** Chinese experience in village preservation was conceived as an important component of a much wider corpus of measures,driven by the rural revitalisation discourse,and should therefore be situated within this broader conceptual *** perspective leads to a distinctive approach to the concept of heritage and outlines a type of protection‘with Chinese characteristics’that will increasingly influence the international *** on three years of field observations and desk analysis,the article highlights some of the characters that define the Chinese experience in village preservation,analysing the most important national lists of villages and examining various cases.

关键词： rural development rural heritage beautiful villages historic cultural villages traditional villages eco-villages rural tourism rural revitalisation

Mallory-Weiss syndrome from giant gastric trichobezoar: A case report

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 972-977页

作者： Eva Lieto Annamaria Auricchio Maria paola Belfiore Giovanni Del Sorbo Gabriele De Sena Vincenzo Napolitano Alessio Ruggiero Gennaro Galizia Francesca Cardella Department of Translational Medical Sciences University of Campania L.VanvitelliNapoli 80138CampaniaItaly Department of Precision Medicine University of Campania L.VanvitelliNapoli 80138CampaniaItaly

BACKGROUND Mallory-Weiss syndrome(MWS),representing a linear mucosal laceration at the gastroesophageal junction,is a quite frequent cause of upper gastrointestinal bleeding,usually induced by habitual *** subsequent cardiac ulceration in this condition is likely due to the concomitance of increased intragastric pressure and inappropriate closure of the gastroesophageal sphincter,collectively inducing ischemic mucosal ***,MWS is associated with all vomiting conditions,but it has also been described as a complication of prolonged endoscopic procedures or ingested foreign *** SUMMARY We described herein a case of upper gastrointestinal bleeding in a 16-year-old girl with MWS and chronic psychiatric distress,the latter of which deteriorated following her parents’*** patient,who was residing on a small island during the coronavirus disease 2019 pandemic lockdown period,presented with a 2-mo history of habitual vomiting,hematemesis,and a slight depressive ***,a huge intragastric obstructive trichobezoar was detected and discovered to be due to a hidden habit of continuously eating her own hair;this habit had persisted for the past 5 years until a drastic reduction in food intake and corresponding weight loss *** relative isolation in her living status without school attendance had worsened her compulsory *** hair agglomeration had reached such enormous dimensions and its firmness was so hard that its potential for endoscopic treatment was judged to be *** patient underwent surgical intervention instead,which culminated in complete removal of the *** According to our knowledge,this is the first-ever described case of MWS due to an excessively large trichobezoar.

关键词： Mallory-Weiss syndrome Upper gastrointestinal bleeding Trichobezoar Ringworm Psychiatric distress Case report

Neoarchean atmospheric chemistry and the preservation of S-MIF in sediments from the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 207-226页

作者： Alice Bosco-Santos William Patrick Gilhooly Ⅲ paola de Melo-Silva Fotios Fouskas Amaury Bouyon João Gabriel Motta Mauricio Rigoni Baldim Wendell Fabricio-Silva Pascal Philippot Elson Paiva Oliveira Department of Geology and Natural Resources University of CampinasCampinasSP 13083855Brazil Department of Earth Sciences Indiana University-Purdue University IndianapolisIndianapolisINUSA Institut de Physique du Globe de Paris Universitéde ParisCNRS-UMR 715475005 Paris Cedex 05France Vizlab-X-Reality and GeoInformatics Lab UNISINOSSão LeopoldoRS 93022-750Brazil Geosciences Department Federal University of Mato GrossoCuiabáMTBrazil Geosciences Institute University of BrasiliaBrasíliaDistrito Federal 70910-900Brazil Institute of Geography and Geology University of Würzburg97074 WürzburgGermany Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance Institute of Astronomy Geophysicsand Atmospheric SciencesUniversity of São PauloRua do Matão 1226São PauloBrazil

Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric *** ranges in Δ^(33)S that expanded into larger fractionations leading up to the Great Oxygenation Event(GOE;2.45–2.2 Ga)are disproportionately represented by sequences from the Kaapvaal and Pilbara *** patterns of S-MIF attenuation and enhancement may differ from the timing and magnitude of minor sulfur isotope fractionations reported from other cratons,thus obscuring local for global sulfur cycling *** expanding the Δ^(33)S record to include the relatively underrepresented São Francisco Craton in Brazil,we suggest that marine biogeochemistry affected S-MIF preservation prior to the *** an early Neoarchean sequence(2763–2730 Ma)from the Rio das Velhas Greenstone Belt,we propose that low δ^(13)Corg(<-30‰)and dampened Δ^(33)S(-0.4‰to-0.7‰)in banded iron formation reflect the marine diagenetic process of anaerobic methane *** overlying black shale(TOC up to 7.8%)with higher δ^(13)Corg(-33.4‰to-19.2‰)and expanded Δ^(33)S(2.3‰±0.8‰),recorded oxidative sulfur cycling that resulted in enhance preservation of S-MIF input from atmospheric sources of elemental *** sequence culminates in a metasandstone,where concomitant changes to more uniform δCorg(-30‰to--25‰),potentially associated with the RuBisCO I enzyme,and near-zero Δ^(33)S(-0.04‰to 0.38‰)is mainly interpreted as evidence for local oxygen *** placed in the context of other sequences worldwide,the Rio das Velhas helps differentiate the influences of global atmospheric chemistry and local marine diagenesis in Archean biogeochemical *** data suggest that prokaryotic sulfur,iron,and methane cycles might have an underestimated role in pre-GOE sulfur minor isotope records.

关键词： S-MIF preservation Archean atmospheric chemistry GOE São Francisco Craton