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Tumor-associated myeloid cells:diversity and therapeutic targeting

Cellular & Molecular Immunology 2021年第3期18卷 566-578页

作者： Alberto Mantovani Federica Marchesi Sebastien Jaillon Cecilia Garlanda paola allavena Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoItaly Department of Biomedical Science Humanitas UniversityRozzanoItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK Department of Biotechnology and Translational Medicine University of MilanMilanItaly

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional *** tumor-associated macrophages(TAMs),which are more abundantly represented,and tumor-associated neutrophils(TANs)are known to sustain tumor cell growth and invasion,support neoangiogenesis and suppress anticancer adaptive immune *** recent decades,several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and *** of the most successful strategies have now reached the clinic and are being investigated in clinical *** this review,we provide an overview of the recent literature on the evergrowing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

关键词： tumor-associated macrophages tumor microenvironment macrophage targeting

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THE FRACTALKINE-RECEPTOR AXIS IMPROVES HUMAN COLORECTAL CANCER PROGNOSIS BY LIMITING TUMOR METASTATIC DISSEMINATION

THE FRACTALKINE-RECEPTOR AXIS IMPROVES HUMAN COLORECTAL CANC...

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第十一届全国免疫学学术大会

作者： Marco Erreni Imran Siddiqui Giulia Marelli Fabio Grizzi Paolo Bianchi Diego Morone Federica Marchesi Giuseppe Celesti Samantha Pesce Andrea Doni Cristiano Rumio Massimo G.Roncalli Luigi Laghi Alberto Mantovani paola allavena Dpt. Of Immunology and Inflammation IRCCS Humanitas Institute Lab. Of Gastroenterology IRCCS Humanitas Clinical Institute Dpt. Of Medical Biotechnology and Translational Medicine University of Milan Dpt. Of Pharmacology and Biomolecular Science University of Milan Humanitas University Dpt. of Pathology IRCCS Humanitas Clinical Institute

Human colorectal cancer(CRC)is a one of the most frequent neoplasia in Western countries and its metastatic progression is a major cause of cancer-related *** search of specific,clinically relevant,molecules upregulated in CRC,we performed a gene-profiling analysis in surgery-derived CRC samples and corresponding adjacent

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