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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil Sharma Amos Lal Rahul Kashyap Vikas Bansal Juan Pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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Trusted Cluster-Based Communication for Wireless Sensor Network Using Meta-Heuristic Algorithms

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Computer Systems Science & Engineering 2023年第5期45卷 1935-1951页

作者： pankaj Kumar Sharma Uma Shankar Modani Department of Computer Engineeing Mahila Engineering CollegeAjmerIndia Department of E&C Engineering Engineering CollegeAjmerIndia

The mobile transient and sensor network’s routing algorithm detects available multi-hop paths between source and destination ***,some methods are not as reliable or trustworthy as ***,finding a reliable method is an important factor in improving communication *** further enhancement of protected communication,we suggest a trust cluster based secure routing(TCSR)framework for wireless sensor network(WSN)using optimization ***,we introduce an efficient cluster formation using a modified tug of war optimization(MTWO)algorithm,which provides loadbalanced clusters for energy-efficient data ***,we illustrate the optimal head selection using multiple design constraints received signal strength,congestion rate,data loss rate,and throughput of the *** parameters are optimized by a butterfly optimal deep neural network(BO-DNN),which provides first-level security towards the selection of the best head ***,we utilize the lightweight signcryption to encrypt the data between two nodes during data transmission,which provides second-level *** model provides an estimation of the trust level of each route to help a source node to select the most secure *** nodes of the network improve reliability and security by maintaining the reliability *** results showed that the proposed scheme achieved 45.6%of delivery ratio.

关键词： Trust model WSN secure routing cluster formation load-balanced clusters

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Trends in major and minor meteorological variables and their influence on reference evapotranspiration for mid Himalayan region at east Sikkim, India

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Journal of Mountain Science 2016年第2期13卷 302-315页

作者： Shweta yadav Proloy DEB Sonu KUMAR Vanita PANDEY pankaj Kumar PANDEY Water Engineering and Management Asian Institute of TechnologyPathumthani 12120Thailand Centre for Water Climate and Land-Use(CWCL)Faculty of Science and Information TechnologySchool of Environmental and Life SciencesUniversity of NewcastleCallaghanNewcastle 2308Australia Department of Agricultural Engineering Northeastern Regional Institute of Science and TechnologyNirjuliArunachal Pradesh 791109India Department of Soil and Water Engineering College of Agricultural Engineering and Post Harvest TechnologyRanipoolSikkim 737135India

Estimation of evapotranspiration(ET) for mountain ecosystem is of absolute importance since it serves as an important component in balancing the hydrologic *** present study evaluates the performance of original and location specific calibrated Hargreaves equation(HARG) with the estimates of Food and Agricultural Organization(FAO)Penman Monteith(PM) method for higher altitudes in East Sikkim,*** results show that the uncalibrated HARG model underestimates ET_0 by 0.35 mm day^(-1) whereas the results are significantly improved by regional calibration of the *** addition,this paper also presents the variability in the trajectory associated with the climatic variables with the changing climate in the study *** Mann-Kendall(MK) test was used to investigate and understand the mean monthly trendof eight climatic parameters including reference evapotranspiration(ET_0) for the period of *** of ET_0 was estimated for the calculations done by FAO PM *** outcomes of the trend analysis show significant increasing(p ≤ 0.05) trend represented by higher Z-values,through MK test,for net radiation(Rn),maximum temperature(Tmax) and minimum temperature(Tmin),especially in the first months of the ***,significant(0.01 ≥ p ≤0.05) decreasing trend in vapor pressure deficit(VPD)and precipitation(P) is observed throughout the *** trend in sunshine duration,VPD and ET_0 is found in spring(March- May) and monsoon(June –November) *** result displays significant(0.01≤ p ≤ 0.05) decreasing ET_0 trend between(June- December) except in July,exhibiting the positive relation with VPD followed by sunshine duration at the ***,the study emphasizes the importance of trend analysis of ET_0 and other climaticvariables for efficient planning and managing the agricultural practices,in identifying the changes in the meteorological parameters and to accurately assess the hydrologic water balance of the hilly regions.

关键词：参考作物蒸散量气候变化喜马拉雅地区印度水文循环农业组织区域标定日照时数

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Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis

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World Journal of Clinical Cases 2022年第1期10卷 91-103页

作者： pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen yadav Usha Dutta Neelam Varma Manavjit Singh Sandhu Rakesh Kochhar Department of Radiodiagnosis Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Hematology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Surgical Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient *** role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this *** To assess the value of WBC and NLR in predicting response to PCD in *** This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December *** and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall *** and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after *** was calculated by dividing the number of neutrophils by the number of *** association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was *** trend of WBC and NLR was also assessed post *** One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final *** was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)*** pain to PCD interval was 24±69.89 *** was successful in 109 patients(group 1)and 46 patients(group 2)who failed to *** was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ *** WBC and NLR showed an overall decreasing *** was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,*** a cut-off value of 9.87 fo

关键词： Acute pancreatitis Percutaneous catheter drainage White blood cell Neutrophil-lymphocyte ratio Necrotic collection

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Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

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Organic Chemistry Frontiers 2022年第2期9卷 572-592页

作者： Yaseen Hussain Tamanna Manisha Sharma Akshay Kumar pankaj Chauhan Department of Chemistry Indian Institute of Technology JammuJagtiNH-44Nagrota BypassJammu181221 J&KIndia Department of Chemistry DAV UniversityPathankot-Jalandhar RoadJalandhar 144001PunjabIndia

Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended *** organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and *** has also opened the window for developing complex domino reactions involving the 1,6-addition *** advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple *** review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.

关键词： domino asymmetric stereo

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Multi-scale coupling analysis of urbanization and ecosystem services supply-demand budget in the Beijing-Tianjin-Hebei region, China

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Journal of Geographical Sciences 2023年第2期33卷 340-356页

作者： ZHANG Fan XU Ning WANG Chao GUO Mingjing pankaj KUMAR Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China School of Economics and Management China University of GeosciencesWuhan 430074China Key Laboratory of Land and Resources Strategy Research Ministry of Natural Resources of the People’s Republic of ChinaBeijing 100812China Research Center of Resource and Environmental Economics China University of GeosciencesWuhan 430074China Department of Geography Delhi School of EconomicsUniversity of DelhiNew Delhi 110021India

Rapid economic development and human activities have severely affected ecosystem *** of the spatial distribution of areas of rapid urbanization is the basis for optimizing urban-ecological spatial *** paper evaluated the spatial distribution of urbanization in the Beijing-Tianjin-Hebei(BTH)region,and then quantified the ecosystem services(ES)budget in the region based on an ES supply and demand *** results showed that(1)urbanization patterns in the BTH region were relatively stable from 2000 to 2015,with clear patterns of low levels of urbanization in the northwest and high levels in the southeast;(2)areas with positive ES budget values were found throughout the region,except in built-up areas,with high ES supply areas concentrated in the northwest,and high ES demand areas in the southeast;(3)at both the county and prefecture-city levels,urbanization had negative,positive,and negative correlations with ES supply,demand,and budget,respectively;(4)the coupling coordination degree(CCD)increased,with high CCD values in the *** on these results,policy recommendations include strengthening rational land-use planning and ecosystem management,promoting the coordinated development of the economy and ecological function,and coordinating the provision of production-life-ecological functions.

关键词： urbanization ecosystem services supply-demand coupling Beijing-Tianjin-Hebei region

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DIC Based Strain and Damage Analysis of Large Scale Steel to Composite Adhesive Joints Subjected to Tension and Compression Loading

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中国海洋工程:英文版 2023年第4期37卷 588-597页

作者： pankaj R.JAISWAL Rahul Iyer KUMAR Richard TRUMPER Wim DE WAELE Soete Laboratory Department of ElectromechanicalSystems and Metal Engineering(EMSME)Ghent UniversityGhent 9052Belgium BAE systems London SW1Y 5ADUnited Kingdom

This paper reports an experimental study of the mechanical response to tensile and compressive force of large scale steel to composite joints adhesively bonded with a thin layer of vinylester *** one specimen,the length of the reinforcing fibres in contact with the steel substrate has been reduced by saw cutting at both ends of the *** damaged specimen and four intact specimens were subjected to quasi-static tensile testing;six specimens were used for compression *** strain distribution at the composite surface and at the steel to hardwood connection of the specimen was monitored by digital image correlation(DIC).DIC allowed identifying the onset of damage in the tensile tested joints near the interface of the composite layer and the steel-hardwood *** tensile and compression tested specimens failed due to significant peel strain concentration at the composite near the connection of steel and *** average strength of a specimen tested in compression was about 66%higher than the average strength of a specimen tested in *** strain concentration zone in the damaged specimen was away from the introduced saw *** a result the damaged and intact tensile specimens showed the same failure strength and *** specimens failed by adhesive failure between the composite-hardwood interface.

关键词： vinylester resin multi-material joint strain damage digital image correlation.

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Spatial distribution of fossil fuel derived CO_(2) over India using radiocarbon measurements in crop plants

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Journal of Environmental Sciences 2023年第2期124卷 19-30页

作者： Rajveer Sharma Ravi Kumar Kunchala Sunil Ojha pankaj Kumar Satinath Gargari Sundeep Chopra Inter University Accelerator Centre New Delhi 110067India Centre for Atmospheric Sciences Indian Institute of Technology DelhiNew Delhi 110016India

Examining the contribution of fossil fuel CO_(2) to the total CO_(2) changes in the atmosphere is of primary concern due to its alarming levels of fossil fuel emissions over the globe,specifically developing *** radiocarbon represents an important observational constraint and utilized to trace fossil fuel derived CO_(2)(CO_(2ff))in the *** the first time,we have presented a detailed analysis on the spatial distribution of fossil fuel derived CO_(2)(CO_(2ff))over India using radiocarbon(Δ14C)measurements during three-year *** shows that theΔ14C values are varying between 29.33‰ to-34.06‰ across India in the year 2017,where highest value belongs to a location from Gujarat while lowest value belongs to a location from *** on the14C patterns,spatial distributions of CO_(2ff) mole fractions have been determined over India and the calculated values of CO_(2ff) mole fractions are varying between 4.85 ppm to 26.59 ppm across *** is also noticed that the highest CO_(2ff) mole fraction is observed as 26.59 ppm from a site in ***_(2ff) mole fraction values from four high altitude sites are found to be varied between 4.85 ppm to 14.87 *** of sampling different crop plants from the same growing season and different crop plant organs(grains,leaves,stems)on theΔ14C and CO_(2ff) have been *** and intra seasonal variations in theΔ14C and CO_(2ff) mole fractions have also been analyzed from a rural location(Dholpur,Rajasthan).

关键词： Carbon dioxide Crop plants Fossil fuel CO_(2) Radiocarbon measurements

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Optimized Resource Allocation and Queue Management for Traffic Control in MANET

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Computer Systems Science & Engineering 2023年第5期45卷 1323-1342页

作者： I.Ambika Surbhi Bhatia Shakila Basheer pankaj Dadheech Department of Computer Science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia Department of Information College of Computer Science and Information TechnologyKing Faisal University36362Saudi Arabia Department of Information Systems College of Computer and Information SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh11671Saudi Arabia Department of Computer Science&Engineering Swami Keshvanand Institute of TechnologyManagement&Gramothan(SKIT)Jaipur302017RajasthanIndia

A set of mobile devices that employs wireless transmission for communication is termed Mobile Ad hoc Networks(MANETs).Offering better communication services among the users in a centralized organization is the primary objective of the *** to the features of MANET,this can directly End-to-End Delay(EED)the Quality of Service(QoS).Hence,the implementation of resource management becomes an essential issue in *** paper focuses on the efficient Resource Allocation(RA)for many types of Traffic Flows(TF)in *** Mobile Ad hoc Networks environments,the main objective of Resource Allocation(RA)is to process consistently available resources among terminals required to address the service requirements of the *** three categories improve performance metrics by varying transmission rates and simulation *** solving that problem,the proposed work is divided into Queue Management(QM),Admission Control(AC)and *** effective QM,this paper develops a QM model for elastic(EL)and inelastic(IEL)Traffic *** research paper presents an AC mechanism for multiple TF for effective *** work presents a Resource Allocation Using Tokens(RAUT)for various priority TF for effective ***,nodes have three cycles which are:Non-Critical Section(NCS),Entry Section(ES)and Critical Section(CS).When a node requires any resources,it sends Resource Request Message(RRM)to the *** and inelastic TF priority is determined using Fuzzy Logic(FL).The token holder selects the node from the inelastic queue with high priority for allocating the *** Network Simulator-2(NS-2),simulations demonstrate that the proposed design increases Packet Delivery Ratio(PDR),decrease Packet Loss Ratio(PLR),minimise the Fairness and reduce the EED.

关键词： MANET resource allocation end-to-end delay fuzzy logic QoS

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Improved Multi-Path Routing for QoS on MANET

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Computer Systems Science & Engineering 2023年第6期45卷 2521-2536页

作者： M.Vargheese Surbhi Bhatia Shakila Basheer pankaj Dadheech Department of Computer Science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityAl HasaSaudi Arabia Department of Information Systems College of Computer and Information SciencePrincess Nourah bint Abdulrahman UniversityP.O.BOX 84428Riyadh11671Saudi Arabia Department of Computer Science&Engineering Swami Keshvanand Institute of TechnologyManagement&Gramothan(SKIT)Jaipur302017RajasthanIndia

A Mobile Ad hoc NETwork(MANET)is a self-configuring network that is not reliant on *** paper introduces a new multipath routing method based on the Multi-Hop Routing(MHR)*** is the consecutive selection of suitable relay nodes to send information across nodes that are not within direct range of each *** to ensure good MHR leads to several negative consequences,ultimately causing unsuccessful data transmission in a *** research work consists of three *** first to attempt to propose an efficient MHR protocol is the design of Priority Based Dynamic Routing(PBDR)to adapt to the dynamic MANET environment by reducing Node Link Failures(NLF)in the *** is achieved by dynamically considering a node’s mobility parameters like relative velocity and link duration,which enable the next-hop *** method works more efficiently than the traditional *** the second stage is the Improved Multi-Path Dynamic Routing(IMPDR).The enhancement is mainly focused on further improving the Quality of Service(QoS)in MANETs by introducing a QoS timer at every node to help in the QoS routing of *** QoS is the most vital metric that assesses a protocol,its dynamic estimation has improved network performance *** method uses distance,linkability,trust,and QoS as the four parameters for the next-hop *** is compared against traditional routing *** Network Simulator-2(NS2)is used to conduct a simulation analysis of the protocols under *** proposed tests are assessed for the Packet Delivery Ratio(PDR),Packet Loss Rate(PLR),End-to-End Delay(EED),and Network Throughput(NT).

关键词： Multi-path routing quality of service node-link failure packet delivery ratio

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