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Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： Shikha sharma Gaurav kumar Nitin kumar Neeraj K.Sethiya Dheeraj Bisht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh Bhandari Uttarakhand Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

Background:Ayurvedic system of medicine is well established for prevention and treatment of renal *** are vast number of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum Buch.-*** Miq.,which has been known to exhibit diuretic ***:To investigate possible mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed by being divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were subjected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed by effectiveness exploration of putative bioactive compounds from *** against human carbonic anhydrase(hCA)enzyme using molecular docking ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have been ***,HPTLC reveals presence of carbohydrates,proteins,amino acids,steroids,alkaloids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of *** ***,molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A,Nor-cepharadione B,Galbelgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a key biomarker for diuretic)and score is comparable with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhibits signifi-cant diuretic *** activity may be correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular docking

Impact of phytoconstituents on oral health practices:a post COVID-19 observation

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Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： Harsh kumar Reena Singh Daljeet Singh Dhanjal Chirag Chopra Natália Cruz-Martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar Manickam Shahida Anusha Siddiqui Dinesh kumar Indu sharma Varun sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

Deep Learning-Based Mask Identification System Using ResNet Transfer Learning Architecture

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Computer Systems Science & Engineering 2024年第2期48卷 341-362页

作者： Arpit Jain Nageswara Rao Moparthi A.Swathi Yogesh kumar sharma Nitin Mittal Ahmed Alhussen Zamil S.Alzamil MohdAnul Haq Department of Computer Science and Engineering KoneruLakshmaiah Education FoundationVaddeswaram522302India Department of Computer Science and Engineering Sreyas Institute of Engineering and TechnologyHyderabad500068India University Centre for Research and Development Chandigarh UniversityMohali140413India Department of Computer Engineering College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Recently,the coronavirus disease 2019 has shown excellent attention in the global community regarding health and the *** Health Organization(WHO)and many others advised controlling Corona Virus Disease in *** limited treatment resources,medical resources,and unawareness of immunity is an essential horizon to *** all resources,wearing a mask is the primary non-pharmaceutical intervention to stop the spreading of the virus caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)*** countries made masks mandatory to prevent *** such enforcement,automatic and effective face detection systems are *** study presents a face mask identification approach for static photos and real-time movies that distinguishes between images with and without *** contribute to society,we worked on mask detection of an individual to adhere to the rule and provide awareness to the public or *** paper aims to get detection accuracy using transfer learning from Residual Neural Network 50(ResNet-50)architecture and works on detection *** experiment is tested with other popular pre-trained models such as Deep Convolutional Neural Networks(AlexNet),Residual Neural Networks(ResNet),and Visual Geometry Group Networks(VGG-Net)advanced *** proposed system generates an accuracy of 98.4%when modeled using Residual Neural Network 50(ResNet-50).Also,the precision and recall values are proved as better when compared to the existing *** outstanding work also can be used in video surveillance applications.

关键词： Transfer learning depth analysis convolutional neural networks(CNN) COVID-19

Comprehensive analysis of uncertainty quantification for the^(58)Ni(n,p)^(58)Co reaction cross section

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Chinese Physics C 2024年第9期48卷 170-175页

作者： Mahesh Choudhary Aman sharma Namrata Singh Mahima Upadhyay Punit Dubey A.Gandhi Akash Hingu G Mishra Sukanya De L.S.Danu Ajay kumar R.G.Thomas Saurav Sood Sajin Prasad S.Mukherjee I.N.Ruskov Yu.N.Kopatch A.kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest 077125Romania Department of Physics The Maharaja Sayajirao University of BarodaVadodara 390002India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Electrical Power Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for Nuclear Research(JINR) Dubna 141980Russia

In this study,we measured the^(58)Ni(n,p)^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)Ni(n,p)^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： ^(58)Ni(n p)^(58)Co reaction γ-ray spectroscopy uncertainty quantification of cross section covariance analysis

Tuning of Optical Properties via Annealing of Bismuth Ferrite (BiFeO3) Thin Films

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Open Journal of Composite Materials 2024年第3期14卷 124-131页

作者： Harish kumar Meena Khushbu Meena Reena Verma Karishma Jain Sushil kumar Jain Kedar Babu sharma Balram Tripathi Department of Physics S S Jain Subodh PG College Jaipur India Department of Physics University of Rajasthan Jaipur India Department of Physics School of Physical Sciences Manipal University Jaipur Jaipur India

In this study we are reporting annealing induced optical properties of bismuth ferrite (BiFeO3) thin films deposited on glass substrate via spin coating at 5000 rpm. The structural, optical and surface morphology of BiFeO3 (BFO) thin films have been studied via X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Optical absorption (UV-Vis) and Photoluminescence (PL) spectroscopy. XRD spectra confirm annealing induced phase formation of BiFeO3 possessing a rhombohedral R3c structure. The films are dense and without cracks, although the presence of porosity in BFO/glass was observed. Moreover, optical absorption spectra indicate annealing induced effect on the energy band structure in comparison to pristine BiFeO3. It is observed that annealing effect shows an intense shift in the UV-Vis spectra as diffuse absorption together with the variation in the optical band gap. The evaluated optical band gap values are approximately equal to the bulk band gap value of BiFeO3.

关键词： Optical Properties Annealing Ferroelectrics Photo Luminescence BFO Thin Films

Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire:An observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 33-39页

作者： Neha Jindal Anuraag Jena Krishan kumar Bijaya K Padhi Rajni sharma Vaneet Jearth Usha Dutta Vishal sharma Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Advanced Pediatric Centre Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The gastrointestinal symptom rating scale(GSRS)is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome(IBS)and peptic ulcer *** validated scale has questions on around 15 items and has been validated in patients with dyspepsia and *** To translate and validate the English version of the GSRS questionnaire to the Hindi *** The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian *** process involved various steps as per the World Health Organization methodology including initial forward translation,backward translation,and assessment by an expert *** pilot testing was followed by testing in healthy and diseased *** The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls(n=30,15 females)and diseased individuals(n=72,27 females).The diseased group included patients with functional dyspepsia and ***'s alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered *** questions significantly differentiated the diseased population from the healthy population(P value<0.05)in the translated Hindi version of the *** The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.

关键词： Irritable bowel syndrome Gut health Dyspepsia Symptoms Pain Constipation Diarrhoea

Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis:A pilot study

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World Journal of Cardiology 2024年第6期16卷 318-328页

作者： Ajay kumar Mishra Kannu Bansal Ibragim Al-Seykal Pradnya B Bhattad Anu Anna George Anil Jha Nitish sharma Jennifer Sargent Mark J Kranis Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Medicine Division of CardiologySaint Vincent HospitalWorcesterMA 01608United States Division of Cardiovascular Medicine Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Embolic events reported in up to 80%of *** of>10 mm size are associated with increased embolic events and poor *** is a paucity of literature on the association of multiple vegetations with *** To study the echocardiographic(ECHO)features and outcomes associated with the presence of multiple *** In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom 67 with vegetation were *** demographic,clinical,laboratory,and ECHO parameters were *** that were studied included recurrent admission,embolic phenomenon,and *** Twenty-three(34%)patients were noted to have multiple vegetations,13(56.5%)were male and 10(43.5%)were *** mean age of these patients was ***(35%)had a prior episode of *** features of moderate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacemaker lead(OR=4.8),impaired left ventricle(LV)relaxation(OR=4),and elevated pulmonary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of multiple *** these moderate to severe valvular regurgitation(P=0.028),pacemaker lead(P=0.039)and impaired relaxation(P=0.028)were statistically *** patients were noted to have an increased association of recurrent admissions(OR=3.6),recurrent bacteremia(OR=2.4),embolic phenomenon(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device removal(OR=4.8).Of this device removal(P=0.039)and recurrent admissions(P=0.017)were statistically *** This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple *** features of moderate to severe regurgitation,presence of pacemaker lead,impai

关键词： Endocarditis Echocardiography Vegetations Predictors Outcome

A randomized controlled trial on triamcinolone versus saline impregnated merocel post endoscopic sinus surgery:Our experience in a tertiary care centre

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 193-199页

作者： Ananya Sood Khushboo Goel SSanjeev Bhagat Dimple Sahni Dinesh kumar sharma Vishav Yadav Department of Otorhinolaryngology and Head&Neck Surgery Government Medical CollegePatialaPunjabIndia

Purpose:To assess the potential benefit of impregnating Merocel(a non-absorbable nasal dressing)with a topical steroid solution,for use as a direct and slow local delivery system of steroids after sinus surgery to improve postoperative wound ***:In this randomized controlled trial,40 patients with bilateral chronic rhinosinusitis with nasal polyposis were subjected to functional endoscopic sinus *** the completion of the surgery,Merocel packs were inserted in the bilateral nasal cavities and infiltrated with 4 mL triamcinolone(40 mg/mL)in one nasal cavity(treatment group)and 4 mL normal saline in the other(control group).Nasal packs were removed on the third postoperative day and postoperative healing assessment was done on postoperative Weeks 1,2,4,and *** findings were noted as per Lund Kennedy(LKES)and perioperative sinus endoscopy(POSE)scores and compared on both ***:Significant(P<0.05)improvement was noted in Lund Kennedy score for crusting and polyp at Week 12,for edema at Week 1,and nasal discharge at Weeks 1 and 12,but there was no significant improvement in scarring at any ***,the difference between the treatment and control arms was statistically significant at all postoperative visits except at Week ***,there was a significant improvement in POSE scores at Weeks 1,2,and 12 but not at Week ***:This study positively concludes that the nasal cavity packed with drug-soaked packs had less scarring and edema in the postoperative period and the overall wound healing was much better as compared to saline-soaked packs.

关键词： chronic rhinosinusitis functional endoscopic sinus surgery Lund Kennedy merocele perioperative sinus endoscopy triamcinolone

Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj kumar Ravindra kumar Garg Hardeep Singh Malhotra Imran Rizvi Rajesh Verma Praveen kumar sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert