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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-yue Liu Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He peng-Jiao Ma Man-Tian Mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

基于阅读技巧识别和双通道融合机制的机器阅读理解方法

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自动化学报 2024年第5期50卷 958-969页

作者：彭伟胡玥李运鹏谢玉强牛晨旭中国科学院信息工程研究所北京100085 中关村实验室北京100080 中国科学院大学网络空间安全学院北京100085

机器阅读理解任务旨在要求系统对给定文章进行理解,然后对给定问题进行回答.先前的工作重点聚焦在问题和文章间的交互信息,忽略了对问题进行更加细粒度的分析(如问题所考察的阅读技巧是什么?).受先前研究的启发,人类对于问题的理解是一... 详细信息

机器阅读理解任务旨在要求系统对给定文章进行理解,然后对给定问题进行回答.先前的工作重点聚焦在问题和文章间的交互信息,忽略了对问题进行更加细粒度的分析(如问题所考察的阅读技巧是什么?).受先前研究的启发,人类对于问题的理解是一个多维度的过程.首先,人类需要理解问题的上下文信息;然后,针对不同类型问题,识别其需要使用的阅读技巧;最后,通过与文章交互回答出问题答案.针对这些问题,提出一种基于阅读技巧识别和双通道融合的机器阅读理解方法,对问题进行更加细致的分析,从而提高模型回答问题的准确性.阅读技巧识别器通过对比学习的方法,能够显式地捕获阅读技巧的语义信息.双通道融合机制将问题与文章的交互信息和阅读技巧的语义信息进行深层次的融合,从而达到辅助系统理解问题和文章的目的.为了验证该模型的效果,在FairytaleQA数据集上进行实验,实验结果表明,该方法实现了在机器阅读理解任务和阅读技巧识别任务上的最好效果.

关键词：机器阅读理解阅读技巧识别对比学习双通道融合机制

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坐立康复机器人的双目标轨迹综合设计

哈尔滨工程大学学报 2024年第5期45卷 974-981页

作者：苏鹏刘霖张力岳超李剑北京信息科技大学机电工程学院北京100192 国家康复辅具研究中心附属康复医院北京100176 北京邮电大学自动化学院北京100876

针对坐立功能障碍患者的康复训练问题,本文基于人体运动曲线的轨迹综合,设计了一种符合人机耦合性的坐立康复训练机器人。通过光学动作捕捉实验,采集人体坐立运动轨迹,选择以大腿运动轨迹作为机器人的设计目标;在六杆机构模型的基础上,... 详细信息

针对坐立功能障碍患者的康复训练问题,本文基于人体运动曲线的轨迹综合,设计了一种符合人机耦合性的坐立康复训练机器人。通过光学动作捕捉实验,采集人体坐立运动轨迹,选择以大腿运动轨迹作为机器人的设计目标;在六杆机构模型的基础上,基于双目标轨迹发生综合法,以大腿上近髋点与近膝点的轨迹作为机构复现的双目标轨迹,进行机构数学模型的分析计算,得出该六杆机构可实现空间内多组位置的精确轨迹综合;建立机器人三维模型,对其关键部件进行静力学仿真分析以及虚拟样机的运动仿真,验证机器人设计的可行性;进行了机器人辅助坐立实验,采集膝、髋关节的运动曲线,膝、髋关节轨迹最大偏移误差分别为12%、5.8%,整体拟合程度较好,表明所设计的机器人具有较好的人机运动协同特征。

关键词：坐立康复机器人运动曲线轨迹发生法人机协同

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Mg(BH_(4))_(2)储氢材料及性能研究进展

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广州化学 2021年第5期46卷 1-13页

作者：王玉放庞越鹏郑时有上海理工大学材料科学与工程学院上海200093

简单介绍了Mg(BH_(4))_(2)在固态储氢材料中的重要地位,重点综述了改善其储氢性能的方法。目前主要的方法有四大类:向Mg(BH_(4))_(2)中添加Ti基、Nb基、Ni基等过渡金属及其化合物添加剂形成具有催化作用的复合材料,通过纳米工程制备Mg(B... 详细信息

简单介绍了Mg(BH_(4))_(2)在固态储氢材料中的重要地位,重点综述了改善其储氢性能的方法。目前主要的方法有四大类:向Mg(BH_(4))_(2)中添加Ti基、Nb基、Ni基等过渡金属及其化合物添加剂形成具有催化作用的复合材料,通过纳米工程制备Mg(BH_(4))_(2)纳米颗粒,Mg(BH_(4))_(2)与其他金属氢化物、硼氢化物、铝氢化物等形成氢化反应复合材料,制备Mg(BH_(4))_(2)衍生物等,并对这些方法改进后的关键储氢性能数据进行对比。同时阐述了各种方法对Mg(BH_(4))_(2)性能影响的具体机理,为后续关于提升Mg(BH_(4))_(2)储氢性能的研究方向进行了展望。

关键词：硼氢化镁改性方法固态储氢综述

Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG peng CUI Yao-Ming MA Yan WANG Jian-Sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-Tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-Bo TANG Chao-yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk

Endoscopic“calabash”ligation and resection for small gastric mesenchymal tumors

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World Journal of Gastrointestinal Endoscopy 2024年第10期16卷 545-556页

作者： Xi-Min Lin yue-Ming peng Hao-Tian Zeng Jia-Xing Yang Zheng-Lei Xu Department of Gastroenterology The Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Nursing Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Gastric mesenchymal tumors(GMT)are identified as soft tissue neoplasms that arise from mesenchymal stem cells within the gastrointestinal *** pri-marily encompass gastric stromal tumors(GST),gastric leiomyomas,and gastric *** most GMT are benign,there are still potential malignant changes,especially ***,early surgical intervention is the primary treat-ment for *** have designed a simple endoscopic“calabash”ligation and resection(ECLR)procedure to treat *** efficacy and safety need to be com-pared with those of traditional endoscopic techniques,such as endoscopic sub-mucosal excavation(ESE).AIM To assess the safety and effectiveness of ECLR in managing small GMT(sGMT)with a maximum diameter≤20 mm by comparing to *** This retrospective analysis involved patients who were hospitalized in our institution between November 2021 and March 2023,underwent endoscopic resection,and received a pathological diagnosis of *** with a tumor diameter≤20 mm were chosen and categorized into two cohorts:Study and control *** study group was composed of patients treated with ECLR,whereas the control group was composed of those treated with *** on general clinical characteristics(gender,age,tumor diameter,tumor growth direction,tumor pathological type,and risk grade),surgery-related information(complete tumor resection rate,operation duration,hospitalization duration,hospitalization cost,and surgical complications),and postoperative follow-up were collected for both *** aforementioned data were subsequently analyzed and *** Five hundred and eighty-nine individuals were included,with 297 cases in the control group and 292 in the study *** propensity score matching,the final analysis incorporated 260 subjects in each *** findings indicated that the study group exhibited shorter operation duration and lowered medical expenses relative to the control ***,the study group rep

关键词： Endoscopic“calabash”ligation and resection Endoscopic submucosal excavation Gastric mesenchymal tumors Gastric stromal tumors Leiomyoma Schwannoma

CdSe/ZnS量子点和量子点-受体分子复合物的超快动力学研究

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光谱学与光谱分析 2024年第1期44卷 56-61页

作者：白西林彭越张雪东葛晶山西师范大学物理与信息工程学院山西太原030031 山西省光谱测量与分析重点实验室山西太原030031

量子点(QD)作为一种新型的半导体纳米发光材料,由于其独特的光学性质,如发光颜色可调、尺寸可调、激发光谱宽和发射光谱窄等优点,自被发现以来一直备受关注。相比于单量子点而言,核/壳量子点更为优异的光学性能使其成为光伏器件应用中... 详细信息

量子点(QD)作为一种新型的半导体纳米发光材料,由于其独特的光学性质,如发光颜色可调、尺寸可调、激发光谱宽和发射光谱窄等优点,自被发现以来一直备受关注。相比于单量子点而言,核/壳量子点更为优异的光学性能使其成为光伏器件应用中的理想材料,例如在量子点敏化太阳能电池中,Ⅰ型核/壳量子点太阳能电池器件表现出更高的稳定性和转换效率。然而,界面电荷转移和电荷复合过程如何影响器件性能一直是大家关注的焦点,相关方面认知的匮乏阻碍了量子点光伏器件的进一步发展。为了对电荷转移(CT)和复合过程有更加清晰的认识,通过利用飞秒时间分辨瞬态吸收(TA)光谱和量子化学计算相结合的方法,对Ⅰ型CdSe/ZnS核/壳量子点和三种量子点-电子受体分子(如1-氯蒽醌(1-CAQ)、蒽醌(AQ)和甲基紫(MV^(2+)))复合物的载流子动力学进行了全面而细致的研究。通过光谱分析表明,QD-MV^(2+)复合物发生了最快的电子转移(ET)和俄歇复合(AR)过程,并且ET速率与AR速率呈正相关关系。此外,根据Marcus ET理论和密度泛函理论计算,证明了电子受体的带隙和给受体之间的能级差作为驱动力是共同影响ET速率的关键因素。该研究为电子受体的选择提供了新的见解,对光伏器件的改进设计具有重要的指导意义。

关键词：量子点瞬态吸收光谱密度泛函理论电子转移

The Journey/DAO/TAO of Embodied Intelligence: From Large Models to Foundation Intelligence and Parallel Intelligence

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1313-1316页

作者： Tianyu Shen Jinlin Sun Shihan Kong Yutong Wang Juanjuan Li Xuan Li Fei-yue Wang College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and RoboticsCollege of EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China peng Cheng Laboratory Shenzhen 518000China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China IEEE

THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real *** this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].

关键词： Intelligence DAO TAO

Volatile Solid and Bury Period Influence on Odorous Material Production in Simulating Landfill Treatment

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Journal of Geoscience and Environment Protection 2024年第1期12卷 120-129页

作者： peng Lu Yuanyuan Zhang Linan Xing Ying Wang Hong Lu Dongbei yue Wei Cheng Jin Liu Department of Environmental Engineering Technology Beijing Polytechnic Beijing China Beijing Municipal Institute of City Management Beijing China Department of Environmental Science and Engineering Tsinghua University Beijing China Chinese Academy of Meteorological Sciences Beijing China China Meteorological Administration Beijing China

Odor pollution in landfill area has attracted more social attention in China. It is very important to control the generation of odor pollutants in situ. Analyzing odorous materials production form buried waste, simulated columns of different volatile solid (VS) content and different buried period waste were designed. Gas compounds produced from the columns were collected and analyzed by comprehensive two-dimensional gas chromatography (GC × GC) method. It has remarkable relationship between VS content and concentrations of odorous material. When VS content more than 40%, the total amount of odorous compounds increases remarkably. It can be inferred that reduced VS content of original waste may effective decreasing odorous materials production in landfill area. The old rubbish produced more odorous compounds than that of fresh one in simulated columns.

关键词： Volatile Solid Odorous Material Bury Period