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Clock genes:Their role in colorectal cancer

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World Journal of Gastroenterology 2014年第8期20卷 1986-1992页

作者： Theodoros Karantanos George theodoropoulos Dimitrios Pektasides Maria Gazouli First Department of Propaedeutic Surgery School of MedicineUniversity of Athens11725 AthensGreece Second Pathology Department School of MedicineUniversity of Athens11725 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11725 AthensGreece

Clock genes create a complicated molecular time-keeping system consisting of multiple positive and negative feedback loops at transcriptional and translational levels. This circadian system coordinates and regulates multiple cellular procedures implicated in cancer development such as metabolism, cell cycle and DNA damage response. Recent data support that molecules such as CLOCK1, BMAL1 and PER and CRY proteins have various effects on c-Myc/p21 and Wnt/β-catenin pathways and influence multiple steps of DNA damage response playing a critical role in the preservation of genomic integrity in normal and cancer cells. Notably, all these events have already been related to the development and progression of colorectal cancer (CRC). Recent data highlight critical correlations between clock genes’ expression and pathogenesis, progression, aggressiveness and prognosis of CRC. Increased expression of positive regulators of this circadian system such as BMAL1 has been related to decrease overall survival while decreased expression of negative regulators such as PER2 and PER3 is connected with poorer differentiation, increased aggressiveness and worse prognosis. The implications of these molecules in DNA repair systems explain their involvement in the development of CRC but at the same time provide us with novel targets for modern therapeutic approaches for patients with advanced CRC.

关键词： Clock genes Colorectal cancer Development Prognosis

Undefined familial colorectal cancer

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 12-20页

作者： Constantinos Pantelis Zambirinis George theodoropoulos Maria Gazouli First Propaedeutic Surgical Department Hippocration University HospitalSchool of MedicineUniversity of Athens Department of Biology School of MedicineUniversity of Athens

Colorectal cancer(CRC),one of the most common cancers of the world,is actually a spectrum of several subtypes,with different molecular profiles,clinicopathological characteristics and possibly separate pathways of *** is estimated that in approximately 25-35 of cases,a familial component exists,so they are classified as familial CRC(fCRC).However the known hereditary CRC syndromes justify only up to *** rest are attributed to some inherited genetic predisposition passed to offspring through lowpenetrance genes,which in the proper environmental setting can bring on ***,part of the familial clustering may be attributed to *** of the complexity regarding the etiology of CRC,the clinician is sometimes faced with obscure patient data,and cannot be sure if they are dealing with fCRC or sporadic *** elucidation of what is going on with the as yet "undefined" portion of CRC will aid not only in the diagnosis,classification and treatment of CRC,but more importantly in the proper adjustment of the screening guidelines and in genetic counselling of patients.

关键词： Colorectal cancer Familial Undefined Type X Polymorphisms

Midventricular Takotsubo syndrome

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Journal of Geriatric Cardiology 2020年第5期17卷 303-304页

作者： Konstantinos C theodoropoulos Ioannis Felekos Chris Abell Nicholas D Palmer Turab Ali Department of Cardiology Liverpool Heart and Chest Hospital NHS Foundation TrustLiverpoolUK

A 78-year-old woman with a background of type 2 diabetes mellitus,hyperlipidaemia and hypertension experienced sudden onset severe chest pain while in the emergency department,after a stressful emotional *** pain last... 详细信息

关键词： Left ventriculography Midventricular Takotsubo syndrome

Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients

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World Journal of Gastroenterology 2010年第39期16卷 4938-4943页

作者： Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A theodoropoulos Elias Castanas Elias A Kouroumalis Liver Research Laboratory Medical SchoolUniversity of Crete Department of Gastroenterology University Hospital of Heraklion Department of Pathology University Hospital of Heraklion Department of Biochemistry Medical SchoolUniversity of Crete Department of Experimental Endocrinology Medical SchoolUniversity of Crete Liver ResearchLaboratory Medical SchoolUniversity of Crete

AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)***:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent *** were correlated with clinical data,histology,and ***:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 *** ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative *** had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative *** positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ***:The presence of ANEA and anti-gp210 identifies a subgroup of PBC pati

关键词： Primary biliary cirrhosis Antimitochondrial antibodies Antinuclear antibodies Antibodies against nuclear envelope antigens Anti-gp210 antibodies

Mitral pseudostenosis due to a large left atrial myxoma

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Journal of Geriatric Cardiology 2018年第3期15卷 244-245页

作者： Konstantinos C theodoropoulos Giovanni Masoero Gianpiero Pagnano Nicola Walker Alexandros Papachristidis Mark J Monaghan Department of Cardiology King's College Hospital NHS Foundation Trust. King's College London London UK

Myxomas are benign cardiac tumours that are mostly （75%） located in the left atrium, but they also can be found in the right atrium （15%-20%）, in the right ventricle （4%） and in the left ventricle （3%）.

关键词： Mitral stenosis Myxoma Transesophageal echocardiography

Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease

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World Journal of Gastroenterology 2009年第41期15卷 5224-5227页

作者： George E theodoropoulos Dimitrios Linardoutsos Dimitrios Tsamis Paraskevas Stamopoulos Dimitrios Giannopoulos Flora Zagouri Nikolaos V Michalopoulos First Department of Propaedeutic Surgery Hippocration University Hospital Department of Pathology Hippocration University Hospital Department of Clinical Therapeutics Alexandra Hospital

We report a case of jejunoileal intussusception in a 42-year-old patient with Crohn's disease caused by a gastrointestinal stromal tumor. The patient complained of vague diffuse abdominal pain for a period of 4 mo. Intussusception was suspected at computer tomography and magnetic resonance imaging scans. Segmental resection of the small intestine was performed. Pathological examination of the surgical specimen revealed a gastrointestinal stromal tumor as well as aphthous ulcerations and areas of inflammation, which were characteristic of Crohn's disease. This is the f irst report of small bowel intussusception due to a gastrointestinal stromal tumor coexisting with Crohn's disease.

关键词： Gastrointestinal stromal tumor Crohn's disease Intussusception

Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

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World Journal of Clinical Cases 2021年第8期9卷 1785-1792页

作者： Dimitra Ioanna Lampropoulou Konstantinos Laschos Gerasimos Aravantinos Konstantinos Georgiou Konstantinos Papiris George theodoropoulos Maria Gazouli Dimitrios Filippou Medical Oncology General Oncology Hospital of Kifissia“Agioi Anargiroi”Athens 14564Greece 1st Department of Propaedeutic Surgery Hippokration General Hospital of AthensAthens Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Endoscopic Surgery Department Hippokration General HospitalAthens 11527Greece Basic Medical Sciences Athens Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Anatomy and Surgical Anatomy Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

BACKGROUND Cholangiocarcinoma(CCA)represents a rare but highly aggressive malignancy that is often challenging to diagnose,especially in early *** role of existing tumor biomarkers for CCA diagnosis,remains controversial due to their low sensitivity and *** evidence has implicated long non-coding ribonucleic acid polymorphisms with cancer susceptibility in a variety of tumor *** association between long non-coding ribonucleic acid homeobox protein transcript antisense intergenic ribonucleic acid(HOTAIR)polymorphisms and CCA risk has not been reported *** To investigate the influence of HOTAIR variants on the risk of CCA *** We conducted a case-control study in which three HOTAIR single nucleotide polymorphisms(rs920778,rs4759314 and rs7958904)were genotyped in a Greek *** study population included 122 CCA patients(80 males and 42 females)and 165 healthy *** polymorphisms under investigation were examined in peripheral blood *** HOTAIR rs4759314 AG and GG genotypes were associated with a significantly increased CCA risk[P=0.004,odds ratio:3.13;95%confidence interval:1.65-5.91 and P=0.005,odds ratio:12.31;95%confidence interval:1.48-101.87,respectively].However,no significant associations of HOTAIR rs920778,and rs7958904 were ***,we found no significant associations between rs4759314 AA genotype and CCA *** HOTAIR rs4759314 AG and GG genotypes may be implicated with CCA development and may serve as a potential diagnostic biomarker.

关键词： Cholangiocarcinoma Homeobox protein transcript antisense intergenic ribonucleic acid polymorphisms Rs920778 Rs4759314 Rs7958904

Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn's disease

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World Journal of Gastroenterology 2014年第13期20卷 3609-3614页

作者： Diamantis Thomas Maria Gazouli Theodoros Karantanos Stella Rigoglou Georgios Karamanolis Konstantinos Bramis George Zografos George E theodoropoulos Colorectal Unit 1st Department of Propaedeutic Surgery"Hippokrateio" HospitalSchool of MedicineUniversity of Athens11527 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11527 AthensGreece Gastroenterology Unit 2nd Department of Surgery"Aretaieio" HospitalUniversity of AthensAthens 11527Greece

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD).

关键词： Crohn’ s disease, Treatment response, Infliximab, Polymorphisms

Exosomal noncoding RNAs in cholangiocarcinoma:Laboratory noise or hope?

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World Journal of Gastrointestinal Surgery 2020年第10期12卷 407-424页

作者： Konstantinos Laschos Dimitra Ioanna Lampropoulou Gerasimos Aravantinos Maria Piperis Dimitrios Filippou George theodoropoulos Maria Gazouli Department of Medical Oncology General Oncology Hospital of Kifissia“Agioi Anargiroi”Athens 14564Greece Radiation Therapy Department IatropolisAthens 15231Greece Department of Anatomy and Surgical Anatomy Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece 1st Propaedeutic University Surgery Clinic Hippocratio General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Basic Medical Sciences Laboratory of BiologyMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Currently,extracellular vesicles and particularly exosomes have gained a lot of research interest due to their unique roles in several biological *** RNAs(microRNAs,long noncoding RNAs and circular RNAs)represent a class of functional RNA with distinct regulatory roles in tumorigenesis and cancer *** is a rare but highly aggressive type of malignancy that is very challenging to diagnose,especially in early stages;surgical resection still represents the sole potentially curative treatment ***,there is an urgent need for the discovery of novel diagnostic and prognostic ***,we provide a comprehensive review of the most recent discoveries that focus on exosomal noncoding RNAs in cholangiocarcinoma with the aim to identify new molecular players that could be used as biomarkers and therapeutic targets.

关键词： :Cholangiocarcinoma Long noncoding RNAs MicroRNAs Circular RNAs Piwi-interacting RNAs Exosomes Extracellular vesicles