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Numerical analysis of slope collapse using SPH and the SIMSAND critical state model

Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 169-179页

作者： Zhao Lu Zhuang Jin panagiotis kotronis Civil and Environmental Engineering University of MacaoMacaoChina Research and Development Center Shenzhen Foundation Engineering Co.Ltd.Shenzhen518000China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou510000China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen518000China Institut de Recherche en Génie Civil et Mécanique(GeM) École Centrale de NantesUniversitéde NantesRue de la NoëNantes44321France

Geological disasters such as slope failure and landslides can cause loss of life and ***,reproducing their evolution process is of great importance for risk assessment and *** recently developed SIMSAND critical state sand model combined with the smoothed particle hydrodynamics(SPH)method is adopted in this work to study slope failure under large *** illustrate the efficiency and accuracy of the SIMSAND-SPH approach,a series of slope collapse studies using the discrete element method(DEM)considering various particle shapes(***,tetrahedral and elongated)is adopted as *** parameters of the SIMSAND model are calibrated using DEM triaxial *** comparison to the DEM simulations,the runout distance and final slope height are well characterized with the SIMSAND-SPH approach with less computational *** comparisons show that the SIMSAND-SPH approach is highly efficient and accurate,which can be an alternative numerical tool to simulate real scale granular flow.

关键词： Granular material Smoothed particle hydrodynamics(SPH) Large deformations Landslide Critical state Slope failure Sand

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One-year outcomes of resveratrol supplement with aflibercept versus aflibercept monotherapy in wet agerelated macular degeneration

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1496-1502页

作者： Ioannis Datseris Nikolaos Bouratzis Charalambos kotronis Iordanis Datseris Malvina-Efthimia Tzanidaki Alexandros Rouvas Nikolaos Gouliopoulos Ophthalmological Institute OMMA Athens 11525Greece Specialized Eye Hospital“Ophthalmiatreion”Athinon Athens 10672Greece 2^(nd)Department of Ophthalmology Medical School of University of Athens“Attikon”University HospitalAthens 12462Greece

AIM:To determine the one-year outcomes of resveratrol oral supplement in patients suffering from wet age-related macular degeneration(AMD).METHODS:Fifty naïve and previously untreated patients suffering from wet AMD,were randomly assigned in two subgroups of 25 patients *** the participants were treated with 3 monthly intravitreal injections of 2.0 mg aflibercept(IAIs)followed by injections“according to need”,while in one group the patients also received daily two tablets of resveratrol oral *** to treatment initiation,a complete ophthalmological examination,including best corrected visual acuity(BCVA)and contrast sensitivity evaluation,optical coherence tomography(OCT)scans,fundus autofluorescence(FAF),fluorescein angiography,indocyanine green angiography,and OCT angiography(OCTA),was performed to every participant,while all of them completed the Hospital Anxiety and Depression Scale(HADS)questionnaire,in order to assess their quality of life(QoL)*** patients were assessed monthly for 1y with FAF,and OCT or OCTA;the main endpoints were the number IAIs,the changes in BCVA,in contrast sensitivity,and in patients’QoL ***:No significant differences were present between the groups regarding the baseline demographic and clinical *** the 12-month period,a similar number of IAIs was applied in both groups(4.52±1.00 vs 4.28±0.90,P=0.38),while the rest of the clinical data also did not differ significantly after the completion of the study ***,for HADS Depression(11.88±2.51 vs 8.28±1.54,P<0.001)and HADS Anxiety(11.92±2.52 vs 7.76±1.51,P<0.001)questionnaires values,the score was significantly better in patients who received resveratrol ***,a statistically significant difference was detected in the mean change from baseline values of contrast sensitivity(0.17±0.19 vs 0.35±0.24,P=0.005),HADS Depression(0.08±1.38 vs-3.88±1.48,P<0.001),and HADS Anxiety(0.36±1.98 vs-5.12±2.70,P<0.001)scores,in favour of the pati

关键词： wet age-related macular degeneration resveratrol aflibercept Hospital Anxiety and Depression Scale contrast sensitivity

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