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Robotic-assisted microsurgery in andrology: a systematic review

Asian Journal of Andrology 2023年第4期25卷 454-461页

作者： konstantinos Douroumis Eleftherios Spartalis konstantinos Stravodimos panagiotis k levis Gerasimos Tsourouflis Dimitrios Dimitroulis Nikolaos I Nikiteas Hellenic Minimally Invasive and Robotic Surgery(MIRS)Study Group National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 15bGoudiAthens 11527Greece First Department of Urology National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece Second Department of Propaedeutic Surgery National and Kapodistrian University of AthensMedical SchoolAgiou Thoma 17GoudiAthens 11527Greece

Robot-assisted surgery is the gold standard of treatment in many fields of urology. In this systematic review, we aim to reportits usage in andrology and to evaluate any advantages. A systematic search of the PubMed and Cochrane Library databases wasconducted to identify articles referring to robotic-assisted microsurgery in andrology. The search strategy was in line with thePreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook. Thearticles were then reviewed by two authors. A qualitative analysis of the articles that met the inclusion criteria was ***-one articles that met the inclusion criteria were reviewed. The first results for robot-assisted vasovasostomy (RAVV) areencouraging as excellent patency rates, short operative times, and learning curves were achieved. Interestingly, patency rates weregreater in some case series for RAVV than for microsurgical vasovasostomy, with a statistically significant difference. In addition,robot has been shown to be of great use in bypassing fibrotic changes in cases of iatrogenic vasal injuries, difficulties encounteredwith traditional microsurgery. In addition, the feasibility of robot-assisted microsurgery has been proven for varicocelectomy andmicrosurgical denervation of the spermatic cord, with acceptable improvement in sperm parameters and pain, respectively. Thecurrent evidence suggests that there are potential advantages of the use of robots in andrology. However, for robotic surgery tobecome incorporated into the daily use of the andrologists, large, multicenter randomized trials are needed. As robotics systemsare becoming standard in urology practice, it is reasonable for one to believe that they will also find their place in andrology.

关键词： andrology male infertility robotic surgical procedures varicocele vasovasostomy

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A Note on Pad Approximants Pairs as Limits of Algebraic Polynomials Pairs of Weighted Best Approximation in Orlicz Spaces

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Analysis in Theory and Applications 2015年第3期31卷 253-259页

作者： F.E.levis Departamento de Matemtica Universidad Nacional de Río Cuarto

In this short note, we show the behavior in Orlicz spaces of best approximations by algebraic polynomials pairs on union of neighborhoods, when the measure of them tends to zero.

关键词： Best approximation pair Pad′e approximant pair Orlicz spaces.

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FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1884-1894页

作者： Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark levis Amy Duffield Yu Hu Donald Small Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Pediatrics Johns Hopkins University School of MedicineBaltimoreMDUSA

Tyrosine kinase inhibitors(TkIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other *** investigated the combination of FLT3 TkIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia *** combination of a FLT3 TkI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML *** also re-sensitized FLT3 TkI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPk pathway *** treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to *** treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from *** with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased *** findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TkI mainly through the dissociation of BIM and BCL-2 and also decreased BIM *** study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TkI therapy in FLT3/ITD AML treatment.

关键词： FLT3 drugs alone treatment BIM

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Climate System Response to the Toba Mega Eruption

Climate System Response to the Toba Mega Eruption

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International Conference on Continental Volcanism

作者： Caspar M. Ammann Alan Robock Samuel levis Climate and Global Dynamics Division National Center for Atmospheric Research1850 Table Mesa DriveBoulderCO 80307-3000USA Center for Environmental Prediction Department of Environmental SciencesRutgers University14 College Farm RoadNew BrunswickNJ 08901-8551USA Climate and Global Dynamics Division National Center for Atmospheric Research1850 Table Mesa DriveBoulderCO 80307-3000USA

＜正＞Large explosive volcanic eruptions have repeatedly imposed significant radiative forcing onto the Earth’s climate system during historical times. The optical effects following eruptions such as Tambora （1815） or krakatau （1883）, and, most recently, the eruption of Pinatubo （1991）, have generated attention around the world. The volcanic aerosol also left a clearly detectable climate signal through a general large scale cooling and changes in atmospheric circulation. The global hydrologic cycle has been temporarily slowed down

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甲醇在Pd(Ⅲ)面上的吸附和热解离

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分子催化 1990年第1期4卷 1-12页

作者：蒋致诚 R.J.levis N.Winograd 中国科学院兰州化学物理研究所宾夕法尼亚州立大学化学系

用XPS和静态SIMS研究了110～600k温度范围内甲醇在Pd(111)面上的吸附和解离表面化学反应。实验结果表明,甲醇在Pd(111)面上的热解离反应途径依赖于其初始暴露量。在110k低温下,暴露量为1.5L时达到单层饱和吸附。在此暴露量以下,甲醇在... 详细信息

用XPS和静态SIMS研究了110～600k温度范围内甲醇在Pd(111)面上的吸附和解离表面化学反应。实验结果表明,甲醇在Pd(111)面上的热解离反应途径依赖于其初始暴露量。在110k低温下,暴露量为1.5L时达到单层饱和吸附。在此暴露量以下,甲醇在表面的热解离占主导地位,其解离的中间吸附物种有CH_3ads、CH_3Oads和H_2Oads。这表明在Pd(111)面上,不仅甲醇中O-H键,而且C-O键也被活化。而在初始暴露量大于1.5L时,甲醇从表面的热脱附趋于主导地位。Pd(111)面上相对稳定的中间吸附物种CH_3ads的存在可能有助于理解Pd催化剂在合成CH_3OH、CH_4、CH_3OCH_3和CH_3CH_3反应中的催化作用机理。

关键词：甲醇吸附热解离钯催化剂

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Retrospective analysis of chronic hepatitis C in untreated patients with nonlinear mixed effects model

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Journal of Biomedical Science and Engineering 2008年第2期1卷 85-90页

作者： Jian Huang kathleen O’Sullivan John levis Elizabeth kenny-Walsh Orla Crosbie Liam Fanning Department of Gastroenterology and Hepatology University Hospital Cork Molecular Virology Department of Medicine Hospital Cork University Statistical Consultancy Unit University College Cork Statistical Consultancy Unit University College Cork Ireland

It is well known that viral load of the hepatitis C virus (HCV) is related to the efficacy of interferon therapy. The complex biological parameters that impact on viral load are essentially unknown. The current knowledge of the hepatitis C virus does not provide a mathematical model for viral load dynamics within untreated patients. We car-ried out an empirical modelling to investigate whether different fluctuation patterns exist and how these patterns (if exist) are related to host-specific factors. Data was prospectively col-lected from 147 untreated patients chronically infected with hepatitis C, each contributing be-tween 2 to 10 years of measurements. We pro-pose to use a three parameter logistic model to describe the overall pattern of viral load fluctua-tion based on an exploratory analysis of the data. To incorporate the correlation feature of longitu-dinal data and patient to patient variation, we introduced random effects components into the model. On the basis of this nonlinear mixed ef-fects modelling, we investigated effects of host-specific factors on viral load fluctuation by in-corporating covariates into the model. The pro-posed model provided a good fit for describing fluctuations of viral load measured with varying frequency over different time intervals. The aver-age viral load growth time was significantly dif-ferent between infection sources. There was a large patient to patient variation in viral load as-ymptote.

关键词： Logistic model Viral load Viral genotype Mixed effects modelling

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C^3系统效能的模型与测试

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舰船指挥控制系统 1990年第3期 15-23页

作者： levis,AH 梁锦培

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猪生产及管理系统”专栏三:妊娠母猪舍之经济学评估

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国外畜牧学（猪与禽） 2013年第11期33卷 18-25页

作者：毛慧 Donald G.levis 俄亥俄州立大学

妊娠母猪的各种饲养方法其经济学很少受到养猪业的关注.最常见的妊娠母猪饲养方法是室内单体限位栏.采用这一方法的主要原因是：（1）工作人员可以更加轻松地管理更多母猪的喂食、疫苗接种、配种、单个动物的转移等作业;（2）可以减少... 详细信息

妊娠母猪的各种饲养方法其经济学很少受到养猪业的关注.最常见的妊娠母猪饲养方法是室内单体限位栏.采用这一方法的主要原因是：（1）工作人员可以更加轻松地管理更多母猪的喂食、疫苗接种、配种、单个动物的转移等作业;（2）可以减少母猪间的身体攻击;（3）工作人员可以更容易地控制母猪所需的环境指标;（4）在较小的范围内,可以饲养更多的母猪;（5）由于能更好地控制排便区,母猪的总体卫生状况可得到改善;（6）每头存栏母猪的繁殖性能得到提高.

关键词：经济学评估妊娠母猪母猪舍饲养方法工作人员疫苗接种环境指标卫生状况

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