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A breakthrough in liver regeneration for treatment of liver cancer

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Cancer Biology & Medicine 2021年第3期18卷 631-634页

作者： Hao xu Yisheng pan Ning Zhang Division of General Surgery Peking UniversityPeking University First HospitalBeijing 100034China Translational Cancer Research Center Peking UniversityPeking University First HospitalBeijing 100034China

The liver is the largest solid organ,and it is involved in multiple biological processes,including energy metabolism,protein synthesis,and *** physiological or pathological conditions,the liver can regrow to normal size even after resection of 90%of the liver volume because of its strong regeneration *** in diet,viral infection(HBV and/or HCV)。

关键词： metabolism liver breakthrough

Underwater Cable Localization Method Based on Beetle Swarm Optimization Algorithm

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IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1893-1895页

作者： Wenchao Huang Zhijun pan Zhezhuang xu College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

Dear Editor,This letter concerns the localization of three-core underwater cables which are widely deployed for offshore energy *** is a non-trivial problem,since the external magnetic field of threecore underwater cables is variable which reduces the accuracy of *** solve this problem,in this letter,an approximate equation is firstly derived to formulate the external magnetic field of a three-core armored underwater cable by considering the seafloor environments and the structure of three-core cables.

关键词： underwater letter trivial

Testing the Coincidence Problem with Strong Gravitational Lens,Type Ia Supernovae and Hubble Parameter Observational Data

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Research in Astronomy and Astrophysics 2022年第11期22卷 214-222页

作者： Jingwang Diao Yu pan Wenxiao xu School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China

In this paper,we use three different kinds of observational data,including 130 strong gravitational lensing(SGL)systems,type Ia supernovae(SNeIa:pantheon and Union2.1)and 31 Hubble parameter data points(H(z))from cosmic chronometers to constrain the phenomenological model(ρ_(x)∝ρ_(m)a^(ξ)).By combining these three kinds of data(Union2.1+SGL+H(z)),we get the parameter value at the confidence interval of 2σ,Ω_(X,0)=0.69±0.34,ω_(x)=−1.24±0.61,ξ=3.8±3.9 and H_(0)=70.22±0.86 kms^(−1) Mpc^(−1).According to our results,we find that theΛCDM model is still the model which is in best agreement with the observational data at present,and the coincidence problem is not *** addition,the Ω_(X) and Ω_(m) have the same order of magnitude in 00.645,it is necessary to introduce the dark energy interacting with dark matter.

关键词： (cosmology:)cosmological parameters (cosmology:)dark energy cosmology:observations

Three Series Theorem for Independent Random Variables under Sub-linear Expectations with Applications

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Acta Mathematica Sinica,English Series 2019年第2期35卷 172-184页

作者： Jia pan xu Li Xin ZHANG School of Mathematical Sciences Zhejiang University

In this paper, motived by the notion of independent and identically distributed random variables under the sub-linear expectation initiated by Peng, we establish a three series theorem of independent random variables under the sub-linear expectations. As an application, we obtain the Marcinkiewicz's strong law of large numbers for independent and identically distributed random variables under the sub-linear expectations. The technical details are different from those for classical theorems because the sub-linear expectation and its related capacity are not additive.

关键词： Sub-linear expectation capacity Rosenthal's inequality Kolmogorov's three series theorem Marcinkiewicz's strong law of large numbers

Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III

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Chinese Journal of Natural Medicines 2024年第4期22卷 291-292页

作者： DU Jinfa LIAO pan LU xu State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700China Medical Botanical Garden China Pharmaceutical UniversityNanjing 210009China

Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its natural sources are extremely limited,as it is derived exclusively from the bark of endangered genus Taxus plants,which contain paclitaxel in very low concentrations(0.01%−0.05%)[2-3].Recent advances in synthetic biology present promising opportunities to enhance paclitaxel levels in Taxus cell cultures or to enable the reconstitution of its production in heterologous hosts,such as yeast or tobacco(Nicotiana benthamiana).

关键词： Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution

Design and Mechanical Performance Analysis of a New Wheel Propeller

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Chinese Journal of Mechanical Engineering 2011年第5期24卷 805-812页

作者： GAO Fudong pan Cunyun xu Haijun ZUO Xiaobo College oJ＇Mechatronic Engineering and Automation National University of Defense Technology Changsha 410073 China

Nowadays,how to enhance the maneuverability of autonomous underwater vehicles（AUVs） is an important issue in the domain of international navigation in that most AUVs just have a single function of underwater navigation or submarine movement,while the design of thrusters is the key of solving the *** multi-moving state autonomous underwater vehicle in this paper can achieve four functions,such as wheels,legs,thrust,and course control depend on the characteristics of spatial deflexion and continual circumgyratetion of the flexible transmission shaft.A new wheel propeller for the multi-moving state autonomous underwater vehicle is presented through analyzing the mechanical characteristics of the ducted propeller and the contracted and loaded tip（CLT） *** the computational fluid dynamics（CFD） method is used to simulate numerically different propellers open-water performance by using the Reynolds-averaged Navier-Stokes（RANS） equations and Reynolds stress model（RSM） based on sub-domains hybrid *** predicted thrust coefficients,torque coefficients and pressure of the propellers agree well with the experimental data of their open-water *** good consistency shows that the numerical method has good accuracy in the prediction of propeller open-water performance,which guides to design the wheel ***,for the sake of ensuring the security and stability of the AUV when it is moving on the ground,finite element method is used to simulate numerically the intensity and vibration *** proposed final wheel propeller D4-70（WPD4-70） has preferable open-water performance and intensity characteristics,which can realize the agile maneuverability of the multi-moving state autonomous underwater vehicle.

关键词： wheel propeller numerical calculation computational fluid dynamics finite element method

A switchable concentrating photovoltaic/concentrating solar power(CPV/CSP)hybrid system for flexible electricity/thermal generation

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Science China(Technological Sciences) 2023年第8期66卷 2332-2345页

作者： pan XinYu YUAN MengDi JU Xing xu Chao Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

Due to the intermittency and indeterminacy of solar irradiance,balancing energy supply and load demand remains a *** paper proposed a switchable hybrid system that combines concentrating photovoltaic/concentrating solar power(CPV/CSP)technology with thermal energy storage(TES)to achieve flexible electricity and thermal generation by adjusting the incident solar flux of photovoltaic(PV).The hybrid system can directly transfer surplus solar energy into high-quality heat for storage using a rotatable PV/heat *** simulated results demonstrated that the hybrid system effectively improves power generation,optimally utilizes TES capacity,and reduces the levelized cost of electricity(LCOE).Over a selected seven-day period,the single-junction(1J)Ga As solar cells used in the hybrid system sustainably satisfied the load demand for more than five days without grid supplement,outperforming the CSP plant by an additional two *** hybrid system utilizing the 1J Ga As with the base configuration of solar multiple(SM)of 1.26 and TES capacity of 5 h improved the annual power production and renewable penetration(RP)by 20.8%and 24.8%compared with the conventional CSP plant,*** hybrid plant with monosilicon and a configuration of SM(1.8),PV ratio(1),and TES capacity(6 h)achieved an optimal LCOE of11.52$ct/k Wh and RP of 75.5%,which is 8.8%lower and 12.1%higher than the CSP plant,respectively.

关键词： concentrated photovoltaic concentrated solar power hybrid system flexible electricity/thermal ratio techno-economic analysis

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A complexity-reduced fast successive cancellation list decoder for polar codes

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Science China(Information Sciences) 2018年第2期61卷 138-148页

作者： Qingyun xu Zhiwen pan Nan LIU Xiaohu YOU National Mobile Communications Research Laboratory Southeast University

A multi-bit decision for polar codes based on a simplified successive cancellation(SSC) decoding algorithm can improve the throughput of polar decoding. A list algorithm is used to improve the errorcorrecting performance. However, list decoders are highly complex compared with decoders without a list algorithm. In this paper, a low-complexity list decoder is proposed, where path-splitting operations for a multi-bit decision can be avoided, if the decoding reliability exceeds a threshold. The threshold is determined based on the reliability of subchannels and positions of decoding nodes. Path splitting rules are designed for multi-bit decision processes, and a complexity-reduced list decoder is proposed based on this. Results show that the number of survival paths can be greatly reduced at the cost of negligible deterioration in block error performance. Thus, the computational complexity can be significantly reduced, especially for a high signal-to-noise ratio(SNR) region.

关键词： polar codes low-complexity decoder splitting-reduced multi-bit decision list decoder

Development and verification of large deformation model considering stiffness deterioration and shear dilation effect in FLAC^(3D)

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International Journal of Mining Science and Technology 2018年第6期28卷 959-967页

作者： Wang Ruijie Li Chong xu Jinhai pan Lijin School of Mines China University of Mining and Technology Key Laboratory of Deep Coal Resource Mining (CUMT) Ministry of Education State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology

The existing constitutive models of rock with strain softening cannot successfully reflect the damageinduced anisotropy and nonlinearity of the post-peak failure behavior under progressive loading. In order to better reflect the nonlinear stress-strain behavior of rock, especially for the post-peak failure behavior,with expected stiffness degradation and large deformation, a modified constitutive model of rock considering stiffness degradation and dilatation behavior at large deformation was proposed in this study. This study analyzes and discusses various attenuation parameters in the proposed nonlinear plastic constitutive model using FLAC^(3D) software. The excavation-induced stress in rocks was calculated by FLAC^(3D) using the Mohr-Coulomb model, conventional strain model, and the proposed modified model. The obtained results of these models were analyzed and compared with field data. This study shows that the simulated results using the proposed new constitutive model matched much more closely with the measured field data, with an average error less than 5%. This new model can successfully reflect the damage-induced stiffness degradation at large deformation, and can provide a theoretical basis for stability design and evaluation of underground excavation.

关键词： Stiffness degradation Dilatancy behavior Nonlinearity Post-peak failure behavior Deep soft rock roadway FLAC^3D