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Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease

Neural Regeneration Research 2017年第10期12卷 1680-1686页

作者： Shan Hui Yu Yang Wei-jun Peng Chen-xia Sheng Wei Gong Shuai Chen pan-pan xu Zhe Wang Department of Integrated Chinese and Western Medicine Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Geriatric Medicine Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Bushen Tiansui decoction is composed of six traditional Chinese medicines：Herba Epimedii,Radix Polygoni multiflori,Plastrum testudinis,Fossilia Ossis Mastodi,Radix Polygalae,and Rhizoma Acorus *** Bushen Tiansui decoction is effective against amyloid beta（Aβ） toxicity,we hypothesized that it would reduce hippocampal synaptic damage and improve cognitive function in Alzheimer＇s *** test this hypothesis,we used a previously established animal model of Alzheimer＇s disease,that is,microinjection of aggregated Aβ25–35 into the bilateral brain ventricles of Sprague-Dawley *** found that long-term（28 days） oral administration of Bushen Tiansui decoction（0.563,1.688,and 3.375 g/m L;4 m L/day） prevented synaptic loss in the hippocampus and increased the expression levels of synaptic proteins,including postsynaptic density protein 95,the N-methyl-D-aspartate receptor 2 B subunit,and *** results suggested that Bushen Tiansui decoction can protect synapses by maintaining the expression of these synaptic *** Tiansui decoction also ameliorated measures reflecting spatial learning and memory deficits that were observed in the Morris water maze（i.e.,increased the number of platform crossings and the amount of time spent in the target quadrant and decreased escape latency） following intraventricular injections of aggregated Aβ25–35 compared with those measures in untreated Aβ_（25–35）-injected ***,these results provided evidence that further studies on the prevention and treatment of dementia with this traditional Chinese medicine are warranted.

关键词： nerve regeneration neurodegeneration Bushen Tiansui decoction Alzheimer's disease synaptic plasticity amyloid β synaptic proteins Shank1 N-methyl-D-aspartate receptor 2B subunit postsynaptic density protein 95 Morris water maze neural regeneration

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Genome-wide analysis of hippocampal transfer RNA-derived small RNAs identifies new potential therapeutic targets of Bushen Tiansui formula against Alzheimer’s disease

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Journal of Integrative Medicine 2021年第2期19卷 135-143页

作者： Zhe-yu Zhang Chun-hu Zhang Jing-jing Yang pan-pan xu Peng-ji Yi Mu-li Hu Wei-jun Peng Department of Integrated Traditional Chinese&Western Medicine the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Integrated Traditional Chinese&Western Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Scientific Research the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

Objective:Bushen Tiansui formula(BSTSF),a traditional Chinese medicine prescription,has been widely used to treat Alzheimer’s disease(AD).However,the mechanisms underlying its effects remain largely *** this study,a rat AD model was used to study the effects of BSTSF on cognitive performance and expression of transfer RNA-derived small RNAs(tsRNAs)in the hippocampus,to determine whether treatment of AD with BSTSF could regulate the expression of tsRNAs,a novel small non-coding ***:To generate a validated AD model,oligomeric amyloid-β_(1-42)(Aβ_(1-42))was injected intracerebroventricularly into *** Morris water maze(MWM)test was used to evaluate rat cognitive performance,and tsRNA-sequencing was conducted to examine tsRNA expression in the rat *** targets were validated by quantitative real-time polymerase chain reaction(qRT-PCR).Bioinformatic analyses were conducted to investigate the biological function of candidate ***:The learning and memory deficits of Aβ_(1-42)-induced AD rats,assessed by MWM tests,were clearly ameliorated by BSTSF treatment.A total of 387 tsRNAs were detected in the rat *** them,13 were significantly dysregulated in AD rats compared with sham control rats,while 57 were markedly altered by BSTSF treatment,relative to untreated AD rats(fold change>2 and P<0.05).Moreover,six BSTSF treatment-related tsRNAs were identified and validated by *** analyses indicated that the six treatment-related tsRNAs had potential therapeutic roles,via multiple signaling pathways and Gene Ontology biological functions,including cyclic adenosine monophosphate and retrograde endocannabinoid ***:This study identified a previously uncharacterized mechanism underlying the effects of BSTSF in alleviating the learning and memory deficits in Aβ_(1-42)-induced AD rats,demonstrating that tsRNAs are potential therapeutic targets of BSTSF in the treatment of AD.

关键词： Traditional Chinese medicine Alzheimer’s disease Endocannabinoids Hippocampus Small non-coding RNAs Transfer RNA

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Effects of B segregation on Mo-rich phase precipitation in S31254 super-austenitic stainless steels:Experimental and first-principles study

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Chinese Physics B 2022年第11期31卷 445-454页

作者： pan-pan xu Jin-Yao Ma Zhou-Hua Jiang Yi Zhang Chao-Xiong Liang Nan Dong Pei-De Han 无 College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China Taiyuan Iron and Steel(Group)Company Ltd Taiyuan 030024China School of Metallurgy Northeastern UniversityShenyang 110167China

Precipitation in super-austenitic stainless steels will significantly affect their corrosion resistance and hot *** effects of Cr and Mo on precipitation behaviors were mainly achieved by affecting the driving force for precipitation,especially Mo has a more substantial promotion effect on the formation of theσphase than *** the present study,B addition to the S31254 super-austenitic stainless steels shows an excellent ability to inhibit *** effect of B on the precipitation behaviors was investigated by microstructure characterization and theoretical *** experimental observation shows that the small addition of B inhibits the formation of theσphase along grain boundaries and changes from continuous to intermittent ***,the inhibitory effect increased obviously with the increase of B *** influence of B addition was theoretically analyzed from the atomic level,and the calculation results demonstrate that B can inhibit the formation ofσphase precipitates by suppressing Mo migration to grain *** is found that B and Mo are inclined to segregate atΣ5 andΣ9 grain boundaries,with B showing the most severe grain boundary segregation *** B distribution at the grain boundary before precipitation begins,the segregation of Mo and Cr will be ***,B’s occupation will induce a high potential barrier,making it difficult for Mo to diffuse towards grain boundaries.

关键词： super-austenitic stainless steel precipitate segregation boron

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Study on the effect of clopidogrel combined with ezetimibe in the treatment of cerebral infarction

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Journal of Hainan Medical University 2019年第20期25卷 48-53页

作者： Kang Zhao Yu-Meng Zhao pan-pan xu Ying-Qi Zhang The First Hospital of Hebei Medical University Department of Emergency Medicine The Second Medicine of Hebei Medical University Psychosomatic Medicine 050000 ShijiazhuangHebei

Objective:To investigate the effect of clopidogrel combined with ezetimibe on cerebral ***:110 patients with acute cerebral infarction treated in our hospital from January 2016 to December 2018 were selected as study object. The clinical case data were retrospectively analyzed. According to different treatment options, they were divided into the observation group (using clopidogrel combined with ezetimibe,n=41), the control group 1 (treated with clopidogrel,n=39) and the control group 2 (using clopidogrel combined with atorvastatin,n=30). Finally, the serum levels of folic acid (FA), ferritin, troponin I (cTnI), the blood lipid levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and internal carotid artery intima-media thickness (IMT) of three groups were compared. The National Institutes of Health Stroke Scale (NIHSS) score, Barthel score and efficacy of three groups were compared. Results: (1) There were no significant differences in the serum levels( FA, ferritin cTnI), the serum lipid levels (HDL-C, LDL-C, TC, TG), IMT, NIHSS scores, and Barthel scores between three groups (P>0.05).mAfter treatment, the FA and HDL-C values of control group 2 were higher than those of the control group 1 (P0.05).Conclusions:The combination of clopidogrel and ezetimibe in the treatment of cerebral infarction c

关键词： clopidogrel ezetimibe cerebral infarction effectiveness safety

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连续性血液透析滤过对四氯化碳模型大鼠肝肾肠功能的保护作用

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世界华人消化杂志 2023年第18期31卷 766-772页

作者：包美美许盼盼吴春丽金华市人民医院血透室浙江省金华市321000

背景四氯化碳(carbon tetrachloride,CCl_(4))中毒是化工从业人员常见的中毒类型,但目前尚无特效的临床药物能治疗此类中毒导致的肝、肾、肠损伤.目的探索连续性血液透析滤过(continuous blood purification,CBP)对口服CCl4中毒大鼠肝... 详细信息

背景四氯化碳(carbon tetrachloride,CCl_(4))中毒是化工从业人员常见的中毒类型,但目前尚无特效的临床药物能治疗此类中毒导致的肝、肾、肠损伤.目的探索连续性血液透析滤过(continuous blood purification,CBP)对口服CCl4中毒大鼠肝、肾、肠功能的保护作用及其潜在干预机制.方法将斯泼累格·多雷大鼠分为对照组、模型组(CCl4)和CBP治疗组(CCl_(4)+CBP),利用CCl4灌胃建立大鼠模型.收集外周血用于检测白细胞和中性粒细胞数以及血清尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)、C反应蛋白(C-reactive protein,CRP)、谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(alanine aminotransferase,AST)、D-乳酸(D-lactic acid,D-LA)、肠性脂肪酸结合蛋白(intestinal fatty acid binding protein,I-FABP)和降钙素(procalcitonin,PCT)的水平.将收集的肝肾肠组织进行相关病理检测,免疫组化法和免疫印迹法检测核转录因子(nuclear transcription factor-κB,NF-κB)通路的相对表达水平.结果CBP处理可显著降低CCl_(4)引起的白细胞和中性粒细胞增多(P<0.05)以及血清BUN、Cr、CRP、ALT、AST、D-LA、I-FABP和PCT的水平的增高(P<0.05),并降低肾脏组织中损伤标记物中性粒细胞明胶酶相关脂质运载蛋白的表达以及肝、肾、肠相关病理形态改变.免疫组化和免疫印迹法检测显示,CBP处理能降低CCl4引起的NF-κB通路激活(P<0.05).结论CBP对CCl4引起的肝、肾、肠损伤具有保护效果,其可能通过降低CCl_(4)引起NF-κB通路激活从而改善肝、肾、肠损伤的症状.

关键词：连续性血液透析滤过四氯化碳(CCl_(4)) 大鼠多器官衰竭 NF-κB通路

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基于行扫描测量的运动目标压缩成像

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物理学报 2017年第1期66卷 76-83页

作者：王盼盼姚旭日刘雪峰俞文凯邱棚翟光杰中国科学院国家空间科学中心复杂航天系统电子信息技术重点实验室北京100190 中国科学院大学北京100190 北京理工大学物理学院量子技术研究中心北京100081

运动目标成像在实际应用中具有重要作用,而如何获取高质量运动目标图像是该领域研究中的一个热点问题.本文采用行扫描采样的方式,通过构造运动测量矩阵,建立一种基于压缩感知理论的运动物体成像模型,并通过仿真及实验,验证了该模型对于... 详细信息

运动目标成像在实际应用中具有重要作用,而如何获取高质量运动目标图像是该领域研究中的一个热点问题.本文采用行扫描采样的方式,通过构造运动测量矩阵,建立一种基于压缩感知理论的运动物体成像模型,并通过仿真及实验,验证了该模型对于恢复运动物体图像信息的可行性.实验结果证明,该方法可获得高质量的运动物体成像.通过引入图像质量评价标准,分析了运动物体成像质量与速度之间的关系.将该方法与普通压缩感知算法进行比较,结果证明,在相同速度下,该方法的成像质量更高.该方法在无人机对地观测、产品线视频监测等领域有着很好的应用前景.

关键词：压缩感知运动目标成像行扫描测量矩阵

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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依托度酸大鼠在体肠吸收动力学

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沈阳药科大学学报 2010年第9期27卷 754-758页

作者：孙佳轶郭盼潘裕生许莺聂淑芳潘卫三沈阳药科大学药学院辽宁沈阳110016

目的考察依托度酸在大鼠各肠段的吸收动力学特征。方法运用大鼠在体单向灌流技术考察依托度酸在大鼠各肠段的吸收动力学特征;采用高效液相色谱法(HPLC)测定灌流液中依托度酸的含量;从药物质量浓度、吸收部位、灌流速度、pH值4个方面对... 详细信息

目的考察依托度酸在大鼠各肠段的吸收动力学特征。方法运用大鼠在体单向灌流技术考察依托度酸在大鼠各肠段的吸收动力学特征;采用高效液相色谱法(HPLC)测定灌流液中依托度酸的含量;从药物质量浓度、吸收部位、灌流速度、pH值4个方面对依托度酸的各肠段吸收特性进行考察;利用重量法计算动力学参数。结果灌流速度和一定范围内的pH值(5.4～7.4)对药物吸收速率常数(ka)和表观吸收系数(Papp)影响显著;一定范围内的药物浓度对ka和Papp无显著影响;十二指肠、空肠、回肠和结肠的ka值分别为(0.082 7±0.003 8)、(0.077 5±0.004 5)、(0.073 3±0.006 4)、(0.064±0.009 3)min-1。结论依托度酸在大鼠肠道的吸收呈现一级动力学特征,且吸收机制为被动扩散。依托度酸在整个肠道均有吸收。

关键词：依托度酸单向灌流法在体肠吸收重量法

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Rho与中枢神经系统轴突再生

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生物化学与生物物理进展 2004年第4期31卷 296-298页

作者：于盼盼徐晓明陆佩华上海第二医科大学神经生物学实验室上海200025

Rho是小分子质量GTP酶Rho家族成员 ,在细胞的一些信号转导途径中起着分子开关的作用 .Rho能通过作用于肌动蛋白骨架系统引起轴突生长锥塌陷 ,从而抑制轴突生长 .研究表明 ,Nogo A、MAG、OMgp等髓鞘源性的轴突再生抑制分子均可通过激活Rh... 详细信息

Rho是小分子质量GTP酶Rho家族成员 ,在细胞的一些信号转导途径中起着分子开关的作用 .Rho能通过作用于肌动蛋白骨架系统引起轴突生长锥塌陷 ,从而抑制轴突生长 .研究表明 ,Nogo A、MAG、OMgp等髓鞘源性的轴突再生抑制分子均可通过激活Rho介导的信号转导途径抑制轴突再生 .

关键词： Rho GTP酶中枢神经系统轴突再生信号转导

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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng xu Jing-Kai Wang Bo Chen Hao xu Deng pan Yu-Yang Ma Kun pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

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