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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo pan-pan ma Xiao-Long Ye Ming-Lin pan Bo Hang Jian-Hua mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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Neuroendocrine tumour of the descending part of the duodenum complicated with schwannoma:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5770-5775页

作者： Lu Zhang Chi Zhang Shu-Yan Feng pan-pan ma Shuo Zhang Qian-Qian Wang Department of Gastroenterology The First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND No known case of neuroendocrine tumour(NET)with schwannoma has been *** SUMmaRY A 63-year-old female presented to our hospital with nausea and *** gastrointestinal endoscopy revealed a mass in the descending part of the *** ultrasound gastroscopy,we found that the tumour originated from the submucosa and showed low *** removed the tumour by electrocoagulation and sent it for pathological *** Immunohistochemical results showed that the mass was a rare NET with neurilemmoma.

关键词： Neuroendocrine tumour Schwannoma Duodenum Endoscopy Immunohistochemistry Trap with current Case report

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Achieving high strength and rapid degradation in Mg-Gd-Ni alloys by regulating LPSO phase morphology combined with extrusion

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Journal of magnesium and Alloys 2024年第6期12卷 2312-2326页

作者： Kai ma Jingfeng Wang Yinhong Peng Chaoneng Dai Yuanlang pan Ye Wang Danqian Wang Jinxing Wang Yanlong ma Fusheng pan College of materials Science and Engineering Chongqing UniversityChongqing 400044PR China National Engineering Research Center for magnesium Alloys Chongqing 400044PR China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331PR China College of materials Science and Engineering Chongqing University of TechnologyChongqing 400054PR China

In this study,Mg-13.2Gd-4.3Ni alloys containing continuous bulk-shaped long-period stacking ordered(LPSO),lamellar LPSO,and a small amount of eutectic phase were prepared,and the evolution of microstructure at different extrusion temperatures and its influence on mechanical and degradation properties as well as corrosion mechanism were *** before extrusion can effectively promote the precipitation of lamellar LPSO in ***400 with higher volume fraction of non-DRXed grains exhibited higher strength,which was mainly due to strong texture,high dislocation density,and high volume fraction of lamellar *** EX420 with higher volume fraction of DRXed grains showed higher degradation rate,which was mainly due to the higher density of grain *** EX400 exhibited excellent comprehensive properties with tensile yield strength(TYS)of 334 MPa,ultimate tensile strength(UTS)of 484 MPa and elongation(EL)of 7.4%,ultimate compressive strength(UCS)of 638 MPa and compressive yield strength(CYS)of 443 MPa,degradation rate of 86.1 mg/cm^(2)/h at 93℃in 3 wt.%KCl solution.

关键词： Mg-Gd-Ni alloys LPSO Mechanical properties Degradation rate

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Numerical Analysis on Charging Performance of the macro-Encapsulating Combined Sensible-Latent Heat Storage System with Structural Parameters

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Journal of Thermal Science 2024年第3期33卷 1026-1036页

作者： WANG Wei pan Zhenfei WANG Jingfu WU Yuting ma Chongfang Key Laboratory of Enhanced Heat Transfer and Energy Conservation Ministry of EducationCollege of Energy and Power EngineeringBeijing University of TechnologyBeijing100124China Key Laboratory of Heat Transfer and Energy Conversion Beijing MunicipalityCollege of Energy and Power EngineeringBeijing University of TechnologyBeijing100124China

For combined sensible-latent heat storage system(CSLHS)(termed as the hybrid configuration),macro encapsulation can effectively solve the leakage problem of ***,due to the poor thermal conductivity of PCMs,the charging performance of the hybrid configuration slightly increases compared to the solid structure(with only sensible materials).Meanwhile,the natural convection in the PCMs zone could improve the charging ***,how to improve natural convection intensity is a key issue for the CSLHS by macro *** is found that adding fins can significantly enhance natural convection and accelerate the melting of *** this paper,we proposed the hybrid configuration with fins built-in by macro encapsulation,and analyzed its charging performance with different fin structural parameters in the PCM zone by CFD *** the case,the sensible heat storage material is high-temperature concrete and the PCM is a low-melting-point mixed molten *** analyzed the effects of fin number,fin length and fin thickness on the charging performance of the hybrid configuration *** the result,the charging performance increases with the fin number,but the increase rate gradually *** the fin number is 6,the charging performance increases by 20.18%compared to the situation without *** charging performance increases gradually with the fin *** with the hybrid configuration without fin,for each 10 mm increase in fin length,its charging performances increase by 4.09%,5.26%,7.02%,8.77%,11.70%,and 15.79%,*** from number and length of fins,the effect of thickness on the charging performance is very *** the fin thickness increased from 1 mm to 4 mm,the charging performance only increased by 2.3%.It indicates that the main reason for the improving the charging performance is to increase the natural convection intensity by dividing the PCM zone through *** results show that the charging performance

关键词： macro-encapsulation hybrid configuration natural convection structural parameter charging performance

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Molecular Generation and Optimization of Molecular Properties Using a Transformer Model

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Big Data Mining and Analytics 2024年第1期7卷 142-155页

作者： Zhongyin Xu Xiujuan Lei Mei ma Yi pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 12365,1503,and 1570 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.

关键词： molecular optimization transformer matched Molecular Pairs(MMPs) logD solubility

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Shale Fracturability Graphic Template Based onMixed Analytic Hierar-chy Process andMutation Theory

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Energy Engineering 2024年第7期121卷 1921-1943页

作者： Sichen Li Dehua Liu Liang Cheng pan ma College of Petroleum Engineering Yangtze UniversityWuhan430100China Hubei Drilling and Recovery Engineering for Oil and Gas Key Laboratory Wuhan430100China

Due to the depletion of conventional energy reserves,there has been a global shift towards non-conventional energy *** oil and gas have emerged as key *** resources have dense and heterogeneous reservoirs,which require hydraulic fracturing to *** process depends on identifying optimal fracturing layers,also known as‘sweet spots’.However,there is currently no uniform standard for locating these sweet *** paper presents a new model for evaluating fracturability that aims to address the current gap in the *** model utilizes a hierarchical analysis approach and a mutation model,and is distinct in its use of original logging data to generate a fracturability evaluation *** this paper’s shale fracturing sweet spot evaluation method based on a two-step mutation model,four wells in different blocks of Fuling and Nanchuan Districts in China were validated,and the results showed that the proportion of high-yielding wells on the sweet spot line could reach 97.6%,while the proportion of low-producing wells was only 78.67%.Meanwhile,the evaluation results of the model were compared with the microseismic data,and the matching results were consistent.

关键词： Shale reservoir hydraulic fracturing analytic hierarchy process mutation model microseismic

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In situ thermoresponsive supramolecular assembly for switchable circularly polarized luminescence

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Science China Chemistry 2024年第7期67卷 2362-2372页

作者： Menghan pan Gong Zhang Haotian ma Xiaoxiao Cheng Jieai Li Wei Zhang State and Local Joint Engineering Laboratory for Novel Functional Polymeric materials Jiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu 241000China

The dynamic regulation of circularly polarized luminescence(CPL)holds profound significance in various fields,such as highlevel information storage and *** we developed a chiral amphiphilic molecule,CPSB-GLU-PEG350(CGP),composed of aggregation-induced emission(AIE)chromophores(Z)-4-(1-cyano-2-phenylvinyl)benzoic acid(CPSB),a chiral linker Glutamic acid and polyethylene glycol(PEG)thermoresponsive *** the self-assembled supramolecular system formed by CGP,we have achieved in-situ temperature-responsive chiral structures,facilitating the thermal control switch of the CPL *** dynamics simulations demonstrate the distinct behaviors of AIE and PEG units during the temperature-variable assembly ***,by co-assembling achiral dye molecules with CGP,we have expanded the color range of the temperature-responsive CPL assembly system in situ and confirmed the occurrence of circularly polarizedF?rster resonance energy transfer(C-FRET)phenomenon in this process,which successfully enriched the strategies for in-situ CPL control in aqueous *** addition,the contactless radiative energy transfer of CPL can also be realized in this system,exhibiting more flexible temperature regulation of the CPL *** study provides a convenient and universal strategy for the construction of dynamically smart chiroptical materials.

关键词： circularly polarized luminescence in-situ thermoresponsive supramolecular assembly energy transfer

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Orientation and Decision-making for Soccer Based on Sports Analytics and AI:A Systematic Review

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 37-57页

作者： Zhiqiang Pu Yi pan Shijie Wang Boyin Liu Min Chen Hao ma Yixiong Cui the School of Artificial Intelligence University of Chinese Academy of Sciences the Institute of Automation Chinese Academy of Sciences the Nanjing Artificial Intelligence Research of IA the School of Sports Engineering Beijing Sport University

Due to ever-growing soccer data collection approaches and progressing artificial intelligence(AI) methods, soccer analysis, evaluation, and decision-making have received increasing interest from not only the professional sports analytics realm but also the academic AI research community. AI brings gamechanging approaches for soccer analytics where soccer has been a typical benchmark for AI research. The combination has been an emerging topic. In this paper, soccer match analytics are taken as a complete observation-orientation-decision-action(OODA) *** addition, as in AI frameworks such as that for reinforcement learning, interacting with a virtual environment enables an evolving model. Therefore, both soccer analytics in the real world and virtual domains are discussed. With the intersection of the OODA loop and the real-virtual domains, available soccer data, including event and tracking data, and diverse orientation and decisionmaking models for both real-world and virtual soccer matches are comprehensively reviewed. Finally, some promising directions in this interdisciplinary area are pointed out. It is claimed that paradigms for both professional sports analytics and AI research could be combined. Moreover, it is quite promising to bridge the gap between the real and virtual domains for soccer match analysis and decision-making.

关键词： Artificial intelligence(AI) decision-making football review soccer sports analytics

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Investigation into the roles of interfacial H_(2)O structure in catalytic oxidation of HCHO and CO over CuMnO_(2) catalysts

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Journal of Environmental Sciences 2024年第3期137卷 310-320页

作者： Chunyan ma Jushuang pan Cheng Chen Yuanyuan Dong Feng Yao Fengbang Wang maoyong Song Key Laboratory of Environmental Nanotechnology and Health Effects Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China No.52 Institute of China North Industries Group Yantai Branch Co.Ltd. Yantai 264000China

The rapid deactivation of cost-effective MnO_(2)-based catalysts in humid air limits their application in practice,and the identification of the role of water in an oxidation process is significant for developing water-resistant MnO_(2)-based ***,CuMnO_(2)showed a20.3%HCHO conversion in 10 hr at room temperature in humid air with relative humidity of 40%,but deactivated in 3 hr in dry *** excellent activity and stability of HCHO oxidation in humid air were attributed to the positive effect of H_(2)O on HCHO oxidation to the H_(2)O-HOCH_(2)OH supermolecule assemblies via hydrogen bonds formed on CuMnO_(2).H_(2)O-HOCH_(2)OH supermolecule assemblies tend to be oxidized to carbonate,which is further oxidized to CO_(2).Furthermore,CuMnO_(2)exhibited a much poorer activity of CO oxidation in humid air,but the CO conversion was still 100%in 10 hr in dry air.H_(2)O showed a competitive adsorption effect to CO on CuMnO_(2).CuMnO_(2)could be applied in HCHO elimination in humid air and CO elimination in dry air.

关键词： H_(2)O-HOCH_(2)OH supermolecule HCHO oxidation Humid air CuMnO_(2) CO oxidation

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Laser ablation mechanism and performance of glass fiber-reinforced phenolic composites:An experimental study and dual-scale modelling

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Chinese Journal of Aeronautics 2024年第8期37卷 470-485页

作者： Ran BI Pengfei SHEN Longyu ZHU Zhengzheng ma Chuyang LUO Yongfeng LI Lijian pan Shanghai Key Laboratory of Lightweight Composite Donghua UniversityShanghai 201620China Shanghai High Performance Fibers and Composites Center(Province-Ministry Joint) Center for Civil Aviation CompositesDonghua UniversityShanghai 201620China AVIC Composite Corporation Ltd Beijing 101300China

Both experimental and simulation approaches were employed to investigate the laser ablation mechanism and performances of Glass Fiber Reinforced Phenolic Composites(GFRP).During the ablation process,the difference in thermal conductivities of the glass fibers and the resin matrix as well as their discrepant physical and chemical reactions form a conical ablation *** formation of a residual carbon layer effectively mitigates the ablation rate in the thickness direction.A higher power density results in a faster ablation rate,while a longer irradiation time leads to a larger ablation pit *** account for the variation in thermal conductivity between the fiber and resin,a macro-mesoscale model was developed to differentiate the matrix from the fiber *** element analysis revealed that laser irradiation leads to phenolic decomposition,glass fiber melting vaporization,and residual carbon skeleton *** dual-scale model exhibits precise prediction capabilities concerning the laser ablation process of GFRP,and its accuracy is confirmed through the comparison of simulation and experimental results for the GFRP laser ablation *** model provides a feasible method for performance evaluation and lifetime prediction of GFRP subjected to continuous wave laser irradiation.

关键词： Polymer-matrix composites Continuous-wave laser Microstructural analysis Ablation mechanism Finite element method

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