检索结果-南通市图书馆

Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-Ming Wang Yu-Tao pan Chen-Song Yang Ming-Chong Liu sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi Zeng Dong-Bo Wang Xuan Fang Jia-Mu Cao Bing-Ke Zhang Jing-Wen pan Dong-Hao Liu Si-Hang Liu Shu-Jie Jiao Tian-Yuan Chen gang Liu Lian-Cheng Zhao Jin-Zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

氮肥运筹对水稻氮素吸收和稻田渗漏液氮素浓度影响

在线全文

学校读者我要写书评

暂无评论

农业环境科学学报 2009年第10期28卷 2145-2150页

作者：潘圣刚曹凑贵蔡明历翟晶王若函黄圣齐高艮亮农业部华中农业大学作物生理生态与栽培重点开放试验室湖北武汉430070

通过大田试验,设计3个不同氮肥水平(0、150、240kg N·hm-2)和两种不同施肥比例(基肥∶分蘖肥∶穗粒肥=40%∶30%∶30%、基肥∶分蘖肥∶穗粒肥=30%∶20%∶50%),研究了氮肥运筹对水稻氮素吸收和稻田渗漏液氮素浓度的影响。结果表明,稻田... 详细信息

通过大田试验,设计3个不同氮肥水平(0、150、240kg N·hm-2)和两种不同施肥比例(基肥∶分蘖肥∶穗粒肥=40%∶30%∶30%、基肥∶分蘖肥∶穗粒肥=30%∶20%∶50%),研究了氮肥运筹对水稻氮素吸收和稻田渗漏液氮素浓度的影响。结果表明,稻田渗漏液中NH4+-N、NO3--N和总N浓度在施肥后第3d达到最大、随后降低,在施氮后的第7d,分别降为峰值的5.6%～16.9%、13.8%～22.5%、22.5%～34.5%。施氮水平处于0～240kgN·hm-2时,水稻产量、氮素积累总量(total N accumulation,TNA)和稻田渗漏液NH4+-N、NO3--N和总N浓度随着氮素水平的提高而显著增加;在较高氮肥水平(240kgN·hm-2)下,与氮肥前移相比(基肥∶分蘖肥∶穗粒肥=40%∶30%∶30%),采用氮肥后移(基肥∶分蘖肥∶穗粒肥=30%∶20%∶50%)的施肥比例,水稻产量和成熟期TNA分别增加6.2%和16.4%,稻田渗漏液NO3--N及总N浓度分别降低8.9%和4.8%,而对NH4+-N浓度影响不显著,说明适宜的氮肥运筹可以增加水稻的产量和氮素吸收,减少氮素渗漏损失。

关键词：氮肥运筹水稻氮素吸收渗漏液

氮肥运筹对水稻养分吸收特性及稻米品质的影响

在线全文

学校读者我要写书评

暂无评论

植物营养与肥料学报 2010年第3期16卷 522-527页

作者：潘圣刚翟晶曹凑贵蔡明历王若涵黄胜奇李进山华中农业大学作物栽培与生理生态研究中心湖北武汉430070 江西省烟叶科学研究所江西南昌330029 随州市农业技术推广中心湖北随州441300

以水稻品种扬两优6号为材料,研究了田间条件氮肥运筹对水稻养分吸收及产量和品质的影响。结果表明,高氮处理(N240)成熟期氮素积累总量、磷素积累总量和钾素积累总量分别比中氮(N150)和低氮处理(N0)增加了21.5%、18.5%1、8.3%和134.6%、1... 详细信息

以水稻品种扬两优6号为材料,研究了田间条件氮肥运筹对水稻养分吸收及产量和品质的影响。结果表明,高氮处理(N240)成熟期氮素积累总量、磷素积累总量和钾素积累总量分别比中氮(N150)和低氮处理(N0)增加了21.5%、18.5%1、8.3%和134.6%、127.0%和82.7%;产量增加了10.4%和39.6%。在相同氮素水平下,采用B种施肥比例(基肥∶分蘖肥∶穗粒肥=30%∶20%∶50%),水稻成熟期氮素积累总量比A处理(基肥∶分蘖肥∶穗粒肥=40%∶30%∶30%)增加了15.4%,产量提高了7.3%。在高氮处理(N240)条件下,采用B施肥比例,蛋白质含量显著提高,直链淀粉显著降低,但提高了稻米的垩百度而使稻米外观品质变劣。

关键词：氮肥运筹养分吸收品质水稻

Revisiting the top-quark pair production at future e^(+)e^(−)colliders

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第4期48卷 82-88页

作者：马进王声权孙婷申建明吴兴刚 Department of Physics Guizhou Minzu UniversityGuiyang 550025China School of Physics and Electronics Hunan Provincial Key Laboratory of High-Energy Scale Physics and ApplicationsHunan UniversityChangsha 410082China Department of Physics Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China

In this study,we reanalyze the top-quark pair production at next-to-next-to-leading order(NNLO)in quantum chromodynamics(QCD)at future e^(+)e^(−)colliders using the Principle of Maximum Conformality(PMC)*** PMC renormalization scales inαs are determined by absorbing the non-conformalβterms by recursively using the Renormalization Group Equation(RGE).Unlike the conventional scale-setting method of fixing the scale at the center-of-mass energyμ_(r)=√s,the determined PMC scale Q_(⋆)is far smaller than the √sand increases with the √s,yielding the correct physical behavior for the top-quark pair production ***,the convergence of the pQCD series for the top-quark pair production is greatly improved owing to the elimination of the renormalon *** a typical collision energy of √s=500 GeV,the PMC scale is Q_(⋆)=107 GeV;the QCD correction factor K for conventional results is K∼1+0.1244+0.0102+0.0012−0.0087−0.0011+0.0184−0.0086+0.0002+0.0061−0.0003,where the first error is caused by varying the scaleμr∈[√s/2,2√s]and the second error is from the top-quark massΔm_(t)=±0.7 *** applying the PMC,the renormalization scale uncertainty is eliminated,and the QCD correction factor K is improved to K∼1+0.1507_(−0.0015)^(+0.0015)−0.0057_(−0.0000)^(+0.0001),where the error is from the top-quark massΔm_(t)=±0.7 *** PMC improved predictions for the top-quark pair production are helpful for detailed studies of the properties of the top-quark at future e^(+)e^(−)colliders.

关键词： top-quark lepton colliders Renormalization Group Equation QCD correction

黄土微观结构优先连通模型及其对优先渗流的意义

在线全文

学校读者我要写书评

暂无评论

岩土力学 2024年第6期45卷 1709-1719页

作者：潘网生赵恬茵李鑫黔南民族师范学院旅游与资源环境学院贵州都匀558000 石家庄铁道大学土木工程学院河北石家庄050043

开展黄土微观结构研究有助于揭示宏细观黄土体渗流、黄土滑坡滑动面形成机制和过程。构建了含裂隙和不含裂隙两类黄土微观结构连通模型,探讨了孔隙连通率p、孔隙变异系数λ、裂隙最大跨度ω及裂隙网络贯通率q等参数之间的关系,并通过黄... 详细信息

开展黄土微观结构研究有助于揭示宏细观黄土体渗流、黄土滑坡滑动面形成机制和过程。构建了含裂隙和不含裂隙两类黄土微观结构连通模型,探讨了孔隙连通率p、孔隙变异系数λ、裂隙最大跨度ω及裂隙网络贯通率q等参数之间的关系,并通过黄土微观结构扫描式电子显微镜试验和野外渗流试验对两类模型的连通阈值进行了验证。结果表明:裂隙的存在,特别是其跨度大小,对黄土孔隙形态大小及其分布特征具有重要影响;裂隙是优先流的重要通道,是较低孔隙率条件下发生黄土优先流的重要原因;黄土微观结构优先连通模型研究结论与黄土渗流试验结论基本吻合,揭示了泾阳南塬“漫灌式”灌溉行为对含裂缝的高陡边坡稳定性的不利影响以及东风村、蒋刘村等大型滑坡发生的根本原因。

关键词：黄土优先流连通性微观结构地理信息系统

Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第5期13卷 2653-2667页

作者： Han-sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Chih-Hsiung Wu You-Cheng Liao Jungshan Chang Min-Hsiung pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science&Technology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Institute of Biochemistry and Molecular Biology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Department of Surgery Taipei Medical University HospitalTaipei 110TaiwanChina Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Institute of Food Sciences and Technology National Taiwan UniversityTaipei 106TaiwanChina

Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosphoprotein(t-DARPP)has been reported to be involved in trastuzumab therapy resistance and promoting tumor *** evaluate the t-DARPP expression in BC,paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+BC tumor *** established 2 patient-derived xenografts(PDX)mice models to test the efficacy of trastuzumab,named model 1(non-responder)and model 2(responder).t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer ***,there is no response from the ***,mechanistic studies using transwell and western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins,enhance p95-HER2 expression and promote cell *** found that quercetin effectively reduced t-DARPP expression in HER2+BC *** t-DARPP ShRNA-suppressed cells,quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase *** conclusion,the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+BC patients has the potential as a biomarker for mitigating drug resistance.

关键词： p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer Quercetin Trastuzumab resistance Truncated isoform of dopamine-and cAMPregulated phosphoprotein

Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-gang Li Junliang Fu Fu-sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi Li Liang-ji Liu Jia-bing Tong Zhi-hui Lan Shu-guang Tian Qiao Li Xiang-li Tong Ji-feng Wu Zhen-gang Zhu Su-yun Li Jian-sheng Li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Traditional Chinese MedicineHefei 230012Anhui ProvinceChina Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese MedicineFuyang 236600Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western MedicineNanchang 330002Jiangxi ProvinceChina Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Zhengzhou 450046Henan ProvinceChina

Background Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effectively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD ***,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical ***,setting,participants and interventions A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:*** in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine *** patients were followed up for 3 *** outcome measures The primary outcome was time taken to symptom *** secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dyspnoea score,and quality of life(QOL)***,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the *** The time taken for effective stabilisation(P<0.05)and obvious stabilisation(P<0.01),and the duration of antibiotic use(P<0.05)were significantly shorter in the treatment group than in the control *** days 6,9,12 and 14 of treatment,clinical symptom and sign score decreased in both groups,particularly in the treatment group(P<0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P<0.01),with more significant reductions in the treatm

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine