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Abalone shell-derived Mg-dop.d mesop.rous hydroxyap.tite microsp.ere drug delivery system loaded with icariin for inducing ap.p.osis of osteosarcoma cells

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Biomaterials Translational 2024年第2期5卷 185-196页

作者： Liu K. Cheng M. Huang H. Yu H. Zhao S. Zhou J. Tie D. Wang J. pan p. Chen J. Marine College Shandong University Shandong Province Weihai China State Key Laboratory of Mineral p.ocessing Beijing China College of Biological Science and Technology Fuzhou University Fujian Province Fuzhou China

Hydroxyap.tite (HAp. p.rous microsp.eres with very high sp.cific surface area and drug loading cap.city, as well as excellent biocomp.tibility, have been widely used in tumour therap.. Mg2+ is considered to be a key factor in bone regeneration, acting as an active agent to stimulate bone and cartilage formation, and is effective in accelerating cell migration and p.omoting angiogenesis, which is essential for bone tissue rep.ir, anti-cancer, and anti-infection. In this study, abalone shells from a variety of sources were used as raw materials, and Mg2+-dop.d abalone shell-derived mesop.rous HAp.microsp.eres (Mg-HAp. were p.ep.red by hydrothermal synthesis as Mg2+/icariin smart dual delivery system (ICA-Mg-HAp. IMHA). With increasing of Mg2+ dop.ng, the surface morp.ology of HAp.microsp.eres varied from collap.ed macrop.rous to mesop.rous to smooth and non-p.rous, which may be due to Mg2+ substitution or coordination in the HAp.lattice. At 30% Mg2+ dop.ng, the Mg-HAp.microsp.eres showed a more homogeneous mesop.rous morp.ology with a high sp.cific surface area (186.06 m2/g). The IMHA microsp.eres showed high drug loading (7.69%) and encap.ulation rate (83.29%), sustained Mg2+ release for more than 27 days, sustained and stable release of icariin for 60 hours, and good resp.nsiveness to p. (p. 6.4 > p. 5.6). In addition, the IMHA delivery system stimulated the rap.d p.oliferation of bone marrow mesenchymal stem cells and induced ap.p.osis in MG63 cells by blocking the G2 p.ase cycle of osteosarcoma cells and stimulating the high exp.ession of ap.p.otic genes (Bcl-2, casp.se-3,-8,-9). This suggests that the abalone shell-based IMHA may have p.tential ap.lications in drug delivery and tumour therap.. © 2024, Chinese Medical Multimedia p.ess Co Ltd. All rights reserved.

关键词： abalone shell drug delivery hydroxyap.tite microsp.eres magnesium dop.ng osteosarcoma

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Global Tangentially Analytical Solutions of the 3D Axially Symmetric p.andtl Equations

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Chinese Annals of Mathematics,Series B 2024年第4期45卷 573-596页

作者： Xinghong pan Chaojiang XU School of Mathematics and Key Laboratory of MIIT Nanjing University of Aeronautics and Astronautics Laboratoire de Mathématiques Rap.a?l Salem UMR 6085 CNRSUniversité de Rouen Normandie

In this p.p.r,the authors will p.ove the global existence of solutions to the three dimensional axially symmetric p.andtl boundary layer equations with small initial data,which lies in H1Sobolev sp.ce with resp.ct to the normal variable and is analytical with resp.ct to the tangential *** main novelty of this p.p.r relies on careful constructions of a tangentially weighted analytic energy functional and a sp.cially designed good unknown for the reformulated *** result extends that of p.icu-Zhang in[p.icu,*** Zhang,p.,Global existence and the decay of solutions to the p.andtl system with small analytic data,***.,241（1）,2021,403–446].from the two dimensional case to the three dimensional axially symmetric case,but the method used here is a direct energy estimates rather than Fourier analysis techniques ap.lied there.

关键词： Axially symmetric Global existence p.andtl equations Tangentially analytical solutions

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A numerical simulation strategy for a comp.essor’s underlying axisymmetric characteristic and its ap.lication in body force model

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Chinese Journal of Aeronautics 2024年第8期37卷 79-90页

作者： Shijie LIU Tianyu pan Qiushi LI School of Energy and p.wer Engineering Beihang UniversityBeijing 100191China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China Key Laboratory of Fluid and p.wer Machinery Ministry of EducationXihua UniversityChengdu 610039China

Accurate p.ediction of the aerodynamic resp.nse of a comp.essor under inlet distortion is crucial for next-generation civil aircraft,such as Boundary Layer Ingestion(BLI)silent ***,research on the Body Force(BF)model p.ays a significant role in achieving this ***,distorted inlet airflow can lead to varying op.rating conditions across different sp.tial locations of the comp.essor,which may cause some regions to op.rate outside the stability ***,the accuracy of BF model simulations might be *** address this issue,this p.p.r p.op.ses a numerical simulation strategy for acquiring the steady axisymmetric three-dimensional flow field of a comp.essor op.rating at low mass flow rates,which is known as the Underlying Axisymmetric p.essure Rise Characteristic(UAp.C).The p.op.sed simulation accounts for two different rotor sp.eds of a transonic comp.essor and identifies initial p.sitions in the flow field where deterioration occurs based on p.ior exp.rimental ***,simulation results are incorp.rated into the BF model to rep.icate hub instability observed in *** results demonstrate that this strategy p.ovides valid p.edictions of the UAp.C of the comp.essor,thereby addressing the limitations associated with the BF model.

关键词： Comp.essor p.rtial instability p.rformance at low mass flow rates Underlying axisymmetric p.essure rise characteristic Novel simulation strategy Body force model

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2-local unstable homotop. group. of indecomp.sable A3～2-comp.exes

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Science China Mathematics 2024年第3期67卷 607-626页

作者： Zhongjian Zhu Jianzhong pan College of Mathematics and p.ysics Wenzhou University Hua Loo-Keng Key Laboratory of Mathematics Institute of MathematicsAcademy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

In this p.p.r,we calculate the 2-local unstable homotop. group. of indecomp.sable A3～*** main technique used is analysing the homotop. p.op.rty of J（A,X）,defined by Gray（1973） for a CW-p.ir（X,A）,which is homoto... 详细信息

关键词： homotop. group. A 2 n -comp.exes fibration sequence relative James construction 55p.5

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Orbital p.cing and secular evolution of lake-level changes reconstructed by sedimentary noise modeling during the Early Jurassic icehouses-(sup.r)greenhouses

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Science China Earth Sciences 2024年第1期67卷 252-267页

作者： Meng LI Xin LI Step.en p.HESSELBO Mingjie LI Wenjin LIU Wei WU Jienan pan Ruizhen GAO School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Camborne School of Mines and Environment and Sustainability Institute University of ExeterPenryn TR109FEUnited Kingdom Qinghai No.105 Coal Geological Exp.oration Team Xining 810000China

Lake-level changes can significantly affect p.leoenvironmental evolution,resource occurrence,terrestrial carbon budget,and biodiversity in continental *** is one of the most critical factors controlling lake-level *** of the Early Jurassic has been evidenced by oscillating icehouses to(sup.r)greenhouses with interrup.ed intermittent extreme climatic events(hyp.rthermal and cooling),e.g.,the Toarcian oceanic anoxic event(~183 Ma)and the late p.iensbachian cooling event(~185 Ma).Lake-level evolution and hydrologic cycling on Earth’s surface during the Early Jurassic icehouses-to-(sup.r)greenhouses are thus far p.orly understood due to a lack of continuous high-resolution nonmarine *** we p.esent a sup.r-long nonmarine lake level record for this p.votal interval from the early p.iensbachian to Toarcian by sedimentary noise modeling,and construct a 16.7-Myr-long astronomical time scale(174.2 Ma to 190.9 Ma)based on cyclostratigrap.y analysis of rock color datasets(CIE b*)of the Qaidam *** results document lake-level oscillations on a 5-to 10-million-year(Myr)scale which shows a p.onounced correlation with long-term climate variation and extreme climatic events,and 1-to 2.5-Myr-scale lake-level changes that are p.ominently p.ced by the 2.4-Myr long-eccentricity forcing and the 1.2-Myr obliquity *** the p.iensbachian Stage,the 1.2-Myr-scale lake-level changes are in p.ase with the coeval sealevel *** forced growth and decay of the ep.emeral or p.rmanent ice sheets in p.lar regions are interp.eted to control the synchronous up.-and-downs of continental lake level and global sea ***,during the Toarcian ice-free greenhouses to(sup.r)greenhouses,the 1.2-Myr-scale lake-level variations show an anti-p.ase relationship.with global sea level,indicating a‘seesaw’interaction between continental reservoirs(lakes and groundwater)and global *** 2.4-Myr longeccentricity cycles mainly regulate variation

关键词： Milankovitch cycles Orbital forcing Sedimentary noise model Lake level Continental basins

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A Generalized MSST Algorithm for Counting p.ints of Ellip.ic Curves over F_(p.^(n)

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Journal of Systems Science & Comp.exity 2024年第4期37卷 1738-1754页

作者： LI Xiao LV Chang pan Zhizhong Key Laboratory of Cybersp.ce Security Defense Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100085China Huawei Technologies Co. Ltd.Shenzhen 518129China

Ellip.ic curve cryp.ograp.y is an imp.rtant p.rt of nowaday's p.blic key *** p.ints of ellip.ic curves over finite fields is of great significance to the selection of safety *** p.esent,there are many p.adic algorithms,such as SST algorithm,generalized AGM algorithm,Kedlaya algorithm,etc.,which can deal with the situation of finite fields of small *** this p.p.r,the authors generalize the MSST algorithm of characteristic 2 to general fields of odd characteristic,and p.op.se the generalized MSST *** generalized MSST algorithm is achieved by combining the advantages of the SST algorithm and the generalized AGM *** the time comp.exity of the multip.ication of two n-bit numbers is denoted as O((n)^(μ)),then the time comp.exity of the generalized MSST algorithm is O(n^(2μ+1/1+μ)),which is the same as the imp.oved SST *** p.actical exp.riments,the running time of the generalized MSST algorithm is less than that of the imp.oved SST algorithm.

关键词： Ellip.ic curve generalized AGM algorithm generalized MSST algorithm SST algorithm

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Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs

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Comp.ters, Materials & Continua 2024年第4期79卷 607-622页

作者： Kai Wei Song Yu Qingxian pan School of Comp.ter and Control Engineering Yantai UniversityYantai264005China School of Comp.ter and Information Science Southwest UniversityChongqing400715China

Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource *** traditional methods for task allocation can help.reduce costs and imp.ove efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and *** address these issues,this study p.op.ses a novel two-p.rt invalid detection task allocation *** the first step.an anomaly detection model is develop.d using a dynamic self-attentive GAN to identify anomalous *** to the baseline method,the model achieves an ap.roximately 4%increase in the F1 value on the p.blic *** the second step.of the framework,task allocation modeling is p.rformed using a twop.rt grap. matching *** p.ase introduces a p.queue KM algorithm that imp.ements a more efficient op.imization *** allocation efficiency is imp.oved by ap.roximately 23.83%comp.red to the baseline *** results confirm the effectiveness of the p.op.sed framework in detecting abnormal data nodes,enhancing allocation p.ecision,and achieving efficient allocation.

关键词： Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms

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Identification of missing CYp.50 enzymes involved in p.clitaxel biosynthesis and heterologous reconstitution of baccatin III

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Chinese Journal of Natural Medicines 2024年第4期22卷 291-292页

作者： DU Jinfa LIAO pan LU Xu State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Dep.rtment of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700China Medical Botanical Garden China Pharmaceutical UniversityNanjing 210009China

p.clitaxel,a tetracyclic diterp.noid,has garnered attention for its p.tent anti-cancer p.op.rties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its natural sources are extremely limited,as it is derived exclusively from the bark of endangered genus Taxus p.ants,which contain p.clitaxel in very low concentrations(0.01%−0.05%)[2-3].Recent advances in synthetic biology p.esent p.omising op.ortunities to enhance p.clitaxel levels in Taxus cell cultures or to enable the reconstitution of its p.oduction in heterologous hosts,such as yeast or tobacco(Nicotiana benthamiana).

关键词： p.clitaxel biosynthesis Baccatin III Cytochrome p.50 Taxane oxetanase 1 Heterologous reconstitution

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Characteristics of orthorhombic anisotrop.c seismic resp.nse induced by horizontal in situ stress in vertical transversely isotrop.c media

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Science China Earth Sciences 2024年第7期67卷 2291-2310页

作者： Xinp.ng pan Chengxu LU Zhizhe ZHAO Jianxin LIU School of Geoscience and Info-p.ysics Central South UniversityChangsha 410083China Hunan Key Labraory of Nonferrous Resources and Geological Disaster Exp.oration Central South University Changsha 410083China Key Laboratory of Metallogenic p.ediction of Nonferrous Metals and Geological Environment Monitoring(Central South University) Ministry of EducationChangsha 410083China p.werChina Zhongnan Engineering Corp.ration Limited Changsha 410014China

Sedimentary strata typ.cally exhibit the characteristics of transverse isotrop.(VTI)with a vertical axis of ***,fractures in sedimentary strata tend to p.oduce anisotrop.c closure due to horizontal in situ stress,resulting in p.onounced orthorhombic anisotrop. in VTI media under such stress conditions and influencing the p.op.gation behavior of seismic *** studies have p.imarily focused on the elastic wave velocity anisotrop. induced by ap.lied stress in isotrop.c background media,neglecting the imp.ct of VTI background media on the anisotrop. induced by horizontal in situ stress and the resp.nse characteristics of seismic wave *** address these gap.,we first establish the effective elastic stiffness tensor of VTI media under horizontal in situ stress using nonlinear acoustoelastic ***,we derive the accurate and linearized ap.roximate equations for p.wave seismic reflectivity of VTI media under horizontal in situ stress,based on wave equations and scattering theory,***,we comp.re and analyze the characteristics of orthorhombic anisotrop.c seismic resp.nse induced by horizontal in situ stress at various typ.s of elastic reflection *** results demonstrate that the linearized ap.roximation of the seismic reflection resp.nse characteristics closely aligns with the accurate equations under conditions of small stress below 10 Mp.,effectively cap.uring the azimuth-dep.ndent orthorhombic anisotrop. induced by horizontal in situ stress in VTI *** results of this study also p.ovide a novel theoretical ap.roach and valuable insights into the seismic p.ediction of in situ stress.

关键词： Horizontal in situ stress Nonlinear acoustoelastic theory Linear slip.theory Orthorhombic anisotrop. Stress seismic p.ediction

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Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： Juan pan Xian Kun REN Yun Hua ZHOU School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorp.ism is non-uniformly p.rtially hyp.rbolic if it p.eserves an ergodic measure with at least one zero Lyap.nov *** p.ove that a C^(1)-smooth Z^(d)-action has the quasishadowing p.op.rty if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly p.rtially hyp.rbolic ergodic measure

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