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Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

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Protein & Cell 2020年第4期11卷 292-298页

作者： Yaqi Li Jian Li Renjie Wang Long zhang Guoxiang Fu xueying Wang Yebin Wang Chuantao Fang Dandan zhang Duo Du Xiaoji Ma Mengxue pan Qiang Guo Xiaoya xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Pediatrics Children's Hospital of Fudan UniversityShanghai 200032China Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Institute of Radiation Medicine Fudan UniversityShanghai 200032China MOE Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Fudan University shanghai Cancer Center and Institutes of Biomedical sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Radiation Medicine and Fudan University shanghai Cancer Center Shanghai Medical schoolFudan UniversityShanghai 200032China

Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2.07).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2.05;Sung et al.,2.08;Nitsche et al.,2.13;Hugen et al.,2.14;Inamura et al.,2.15).A retrospective analysis of CRC patient's data at Fudan University shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1).

关键词： al. colorectal adenocarcinoma

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Chinese expert consensus on organ protection of transplantation(2.2. edition)

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Hepatobiliary & pancreatic Diseases International 2022年第6期21卷 516-526页

作者： Jian-Hui Li Xiao xu Yan-Feng Wang Hai-Yang Xie Jing-Yu chen Nian-Guo Dong Mitesh Badiwala Li-Ming Xin Roberto Vanin Pinto Ribeiro Hao Yin Hao {2. Jian-Zheng {2. Feng Huo Jia-Yin Yang Hong-Ji Yang Hui pan Shao-Guang Li Yin-Biao Qiao Jia Luo Hao-Yu Li Jun-Jun Jia Hao Yu Han Liang Si-Jia Yang Hao Wang Zhong-Yang Liu Li-cheng {2. Xiao-Yi Hu Hao Wu Yi-Qing Hu Pei-Fu Tang Qi-Fa Ye Shu-Sen Zheng Department of Hepatobiliary and pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation Center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk Cardiac Centre Toronto General Hospital-University Health NetworkTorontoCanada school of Computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant Center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation Center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 2.th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the Collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2.,which developed rapidly in static cold storage(SCS)*** remains the standard preservation technique for organ transplantation[2..

关键词： organ preservation transplantation

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中青年楼宇人群对家庭医生签约服务的需求及影响因素研究

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中国全科医学 2022年第22期25卷 2773-2781页

作者：姚岗张诚徐健潘文雷陈晨朱敏王朝昕黄蛟灵江苏省太仓市城厢镇社区卫生服务中心 215400 江苏省太仓市沙溪镇直塘卫生院 215400 江苏省太仓市高新区社区卫生服务中心 215400 上海市静安区江宁街道社区卫生服务中心 200040 上海市浦东新区潍坊社区卫生服务中心 200122 上海交通大学医学院公共卫生学院上海市200025

背景建设“健康中国”需要扩大家庭医生签约服务覆盖面,而中青年楼宇人群的家庭医生服务签约率较低。上海市率先探索家庭医生楼宇服务,以需求为导向提供健康管理服务,故研究中青年楼宇人群的健康需求尤为有意义。目的了解上海市中青年... 详细信息

背景建设“健康中国”需要扩大家庭医生签约服务覆盖面,而中青年楼宇人群的家庭医生服务签约率较低。上海市率先探索家庭医生楼宇服务,以需求为导向提供健康管理服务,故研究中青年楼宇人群的健康需求尤为有意义。目的了解上海市中青年楼宇人群对家庭医生签约服务的需求,并分析其影响因素。方法于2.19年12.至2.2.年12.,在上海市虹口区、浦东新区、静安区选取典型楼宇作为调查点,然后在各楼宇内采用随机整群抽样法抽取中青年人群(18~59岁)进行问卷调查。调查内容包括受试者的社会人口学特征、健康及就诊情况、对家庭医生签约服务的了解,以及对家庭医生签约服务中基本服务和个性化服务的需求情况。采用多元Logistic回归分析中青年楼宇人群家庭医生签约服务需求的影响因素。结果共发放问卷2.66份,回收有效问卷2.72.,问卷有效回收率为96.03%。对于家庭医生签约服务中的基本服务,一般有需求/比较有需求/非常有需求者占比为87.65%(1874/2.38);对个性化服务有需求者占比为70.59%(1874/2.57)。多元Logistic回归分析结果显示,年龄、受教育程度、自评社会阶层、对自身健康状况了解度、自评健康状况、患慢性病情况、自评心理健康状况、患常见病时首选就诊机构、社区卫生服务机构就诊经历、对家庭医生了解度、对家庭医生信任度、对家庭医生楼宇服务了解度、对家庭医生楼宇服务内容了解度是中青年楼宇人群对家庭医生签约服务中基本服务需求的影响因素(P<0.05);受教育程度、社会医疗保障情况、常用药情况、患慢性病情况、患常见病时首选就诊机构、社区卫生服务机构就诊经历、对家庭医生楼宇服务了解度、对家庭医生楼宇服务内容了解度是中青年楼宇人群对家庭医生签约服务中个性化服务需求的影响因素(P<0.05)。结论楼宇人群对于家庭医生签约服务的需求较高,提高人群健康素养,改变宣传策略,提升家庭医生团队和基层医疗卫生机构的服务能力,有利于提高楼宇人群家庭医生服务签约率。

关键词：家庭医生签约服务中青年楼宇人群卫生服务需求影响因素分析上海

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Ionic protein–lipid interactions at the plasma membrane regulate the structure and function of immunoreceptors

Ionic protein–lipid interactions at the plasma membrane reg...

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中国生物化学与分子生物学会2.19年全国学术会议暨学会成立四十周年

作者： Hua Li Xingdong Guo chengsong Yan Wenmao Huang Wei Yang Weiling pan Shuokai chen Nicola Trendel Shutan Jiang Jun Guo Youhua {2. Huiying Chu Xinyi xu chenxin Li Guohui Li Jianfeng chen Omer Dushek Yi Cao chenqi xu shanghai Institute of Biochemistry and Cell Biology CAS Nanjing University Sir William Dunn school of Pathology University of Oxford Dalian Institute of Chemical Physics CAS school of Life Science and Technology ShanghaiTech University

The Adaptive lymphocytes express a panel of activating and inhibitory immunoreceptors on their cell surface. Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which may have functional consequences for the protein. We have shown in our previous studies that negatively charged acidic phospholipids can interact with positively charged juxtamembrane polybasic regions of immunoreceptors, such as TCR CD3ε, CD2. and IgG-BCR, to regulate protein structure and function. Furthermore, we pay our attention to protein transmembrane domains(TMDs). TMDs are generally hydrophobic but our bioinformatics analysis targeting TMDs shows that many TMDs contain basic residues at terminal regions. Taking the integrin as an example, we showed that a membrane-snorkeling Lys residue in integrin αLβ2.also known as LFA-1) regulates transmembrane heterodimer formation and integrin adhesion through ionic interplay with acidic phospholipids and calcium ions(Ca) in T cells, thus providing a new mechanism of integrin activation. Here, we will review our recent progress showcasing the importance of both intramembrane and juxtamembrane ionic protein–lipid interactions.

关键词： ionic protein–lipid interaction immunoreceptors Ca2.

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Quantum interference with independent single-photon sources over 300 km fiber

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Advanced Photonics 2022年第6期4卷 64-70页

作者： Xiang You Ming-Yang Zheng Si chen Run-Ze Liu Jian Qin Mo-Chi xu Zheng-xuan Ge Tung-Hsun Chung Yu-Kun Qiao Yang-Fan Jiang Han-Sen Zhong Ming-cheng chen Hui Wang Yu-Ming He Xiu-Ping Xie Hao Li Li-Xing You Christian Schneider Juan Yin Teng-Yun chen Mohamed Benyouce Yong-Heng Huo Sven Höfling Qiang zhang Chao-Yang Lu Jian-Wei pan University of Science and Technology of china School of Cyberspace SecurityHefeiChina University of Science and Technology of china Hefei National Laboratory for Physical Sciences at MicroscaleDepartment of Modern PhysicsHefeiChina University of Science and Technology of china CAS Centre for Excellence in Quantum Information and Quantum PhysicsShanghaiChina Jinan Institute of Quantum Technology JinanChina Chinese Academy of sciences Shanghai Institute of Microsystem and Information Technology(SIMIT)State Key Laboratory of Functional Materials for InformaticsShanghaiChina Universitat Würzburg Technische PhysikPhysikalisches Instität and Wilhelm Conrad Röntgen-Center for Complex Material SystemsWürzburgGermany University of Oldenburg Institute of PhysicsOldenburgGermany University of Kassel Institute of Nanostructure Technologies and AnalyticsCINSaTKasselGermany NYU-ECNU Institute of Physics at NYU shanghai ShanghaiChina

In the quest to realize a scalable quantum network,semiconductor quantum dots(QDs)offer distinct advantages,including high single-photon efficiency and indistinguishability,high repetition rate(tens of gigahertz with Purcell enhancement),interconnectivity with spin qubits,and a scalable on-chip ***,in the past two decades,the visibility of quantum interference between independent QDs rarely went beyond the classical limit of 50%,and the distances were limited from a few meters to ***,we report quantum interference between two single photons from independent QDs separated by a 302.km optical *** single photons are generated from resonantly driven single QDs deterministically coupled to *** frequency conversions are used to eliminate the QD inhomogeneity and shift the emission wavelength to the telecommunication *** observed interference visibility is 0.670.02.0.930.04)without(with)temporal *** improvements can further extend the distance to∼600 *** work represents a key step to long-distance solid-state quantum networks.

关键词： quantum networks quantum dots solid-state single-photon sources quantum frequency conversion quantum interference

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2.15-2.2.年CHINET儿童患者分离的肠杆菌目细菌耐药性变迁

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中国感染与化疗杂志 2024年第1期24卷 53-63页

作者：潘芬王春张泓杨洋胡付品朱德妹蒋晓飞徐英春张小江张峰波季萍谢轶康梅王传清付盼徐元宏黄颖孙自镛陈中举倪语星孙景勇褚云卓田素飞胡志东李金俞云松林洁单斌杜艳郭素芳魏莲花邹凤梅胡云建艾效曼卓超苏丹虹郭大文赵金英喻华黄湘宁刘文恩李艳明金炎邵春红徐雪松鄢超王山梅楚亚菲张利侠马娟周树平周艳朱镭孟晋华董方吕志勇胡芳芳沈瀚周万青贾伟李刚吴劲松卢月梅李继红段金菊康建邦马晓波郑燕青郭如意朱焱陈运生孟青王世富胡雪飞沈继录黄文辉汪瑞忠房华俞碧霞赵勇龚萍温开镇张贻荣刘江山廖龙凤顾洪芹姜琳贺雯薛顺虹冯佼岳春雷上海市儿童医院上海交通大学医学院附属儿童医院检验科上海交通大学医学院儿童感染免疫与重症医学研究院上海200062 复旦大学附属华山医院抗生素研究所复旦大学附属华山医院检验科北京协和医院新疆医科大学第一附属医院四川大学华西医院复旦大学附属儿科医院安徽医科大学第一附属医院华中科技大学同济医学院附属同济医院上海交通大学医学院附属瑞金医院中国医科大学附属第一医院天津医科大学总医院浙江大学医学院附属邵逸夫医院昆明医科大学第一附属医院内蒙古医科大学附属医院甘肃省人民医院北京医院广州医科大学附属第一医院哈尔滨医科大学附属第一医院四川省人民医院中南大学湘雅医院山东省立医院吉林大学中日联谊医院河南省人民医院陕西省人民医院江西省儿童医院山西省儿童医院首都医科大学附属北京儿童医院贵州省人民医院南京大学医学院附属鼓楼医院宁夏医科大学总医院深圳市人民医院河北医科大学第二医院山西医科大学第二医院厦门大学附属第一医院福建省泉州市第一医院深圳市儿童医院山东大学齐鲁儿童医院南昌大学第一附属医院安徽医科大学第四附属医院青海省青海大学附属医院上海市浦东新区人民医院浙江省宁波市镇海龙赛医院湖北省秭归县人民医院福建省晋江市医院甘肃省金昌市中西医结合医院江西省赣县区人民医院山东省广饶县人民医院河南省辉县市人民医院辽宁省营口市经济技术开发区中心医院青海省互助县人民医院四川省邻水县人民医院吉林省九台区人民医院

目的了解2.15-2.2.年CHINET儿童患者分离的肠杆菌目细菌的分布及耐药性变迁。方法采用纸片扩散法或商品化药敏试验自动测试仪器法按照CHINET技术方案进行药敏试验,并采用CLSI 2.2.年版标准判断结果。结果2.15-2.2.年共收到儿童患者分离... 详细信息

目的了解2.15-2.2.年CHINET儿童患者分离的肠杆菌目细菌的分布及耐药性变迁。方法采用纸片扩散法或商品化药敏试验自动测试仪器法按照CHINET技术方案进行药敏试验,并采用CLSI 2.2.年版标准判断结果。结果2.15-2.2.年共收到儿童患者分离的肠杆菌目细菌81681株,占儿童革兰阴性杆菌的50.1%,其中大肠埃希菌、克雷伯菌属和肠杆菌属是最常见的细菌;菌株主要分离自尿液标本(2..3%)和呼吸道标本(2..7%)。儿童大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌的ESBL检出率分别为48.8%~57.6%、49.3%~66.7%和2..1%~33.8%。儿童碳青霉烯类耐药肠杆菌目细菌的检出率为5.7%~9.5%,呈下降趋势,其中碳青霉烯类耐药克雷伯菌属、碳青霉烯类耐药肠杆菌属和碳青霉烯类耐药大肠埃希菌的检出率分别为14.1%~2..6%、7.1%~15.7%和2.0%~3.4%。肠杆菌目细菌对环丙沙星的耐药率高于左氧氟沙星;对阿米卡星、多黏菌素B和替加环素仍具有较好的敏感性。沙门菌属对氨苄西林耐药率>70%,而对头孢曲松耐药率<30%。结论儿童患者分离的肠杆菌目部分细菌(如大肠埃希菌、肺炎克雷伯菌)对常见抗菌药物耐药率呈下降趋势,但需加强细菌耐药性的持续监测,以预防和控制耐药菌的广泛播散。

关键词：儿童肠杆菌目细菌细菌耐药性监测超广谱β内酰胺酶碳青霉烯类耐药肠杆菌目细菌

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Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2.19(COVID-19)

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Journal of Intensive Medicine 2022年第4期2卷 199-222页

作者： You Shang Jianfeng Wu Jinglun Liu Yun Long Jianfeng Xie Dong zhang Bo Hu Yuan Zong xuelian Liao Xiuling Shang Renyu Ding Kai Kang Jiao Liu Aijun {2. Yonghao xu Changsong Wang Qianghong xu Xijing zhang Ji{2.g zhang Ling Liu Jian{2.g zhang Yi Yang Kaijiang Yu Xiangdong Guan Dechang {2. Chinese Society of Critical Care Medicine,Chinese Medical Association Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510010China Department of Emergency and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical ScienceBeijing 100730China Department of Critical Care Medicine Jiangsu Provincial Key Laboratory of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Critical Care Medicine The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Critical Care Medicine Shaanxi Provincial HospitalXi’anShannxi 710068China Department of Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Critical Care Medicine Fujian Provincial HospitalFujian Provincial Center for Critical Care MedicineFuzhouFujian 350001China Department of Critical Care Medicine The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine The First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Critical Care Medicine The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Critical Care Medicine Harbin Medical University Cance

Introduction Coronavirus disease 2.19(COVID-19),a disease caused by severe acute respiratory syndrome-coronavirus-2.SARS-CoV-2.,is highly contagious[1]and has developed into a global *** to July 1,2.2.,COVID-19 has affected>2.0 coun-tries and regions across the globe and caused 545,2.6,550 con-firmed cases and 6334,72. deaths,[2.seriously compromising human life,public properties.

关键词： diagnosis acute respiratory

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2.15—2.2.年CHINET临床分离铜绿假单胞菌耐药性变迁

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中国感染与化疗杂志 2024年第2期24卷 198-205页

作者：谢潋滟孙景勇杨洋胡付品朱德妹蒋晓飞徐英春张小江付盼季萍谢轶康梅王传清张峰波徐元宏黄颖孙自镛陈中举褚云卓田素飞胡志东李金俞云松林洁单斌杜艳郭素芳魏莲花邹凤梅张泓王春胡云建艾效曼卓超苏丹虹郭大文赵金英喻华黄湘宁刘文恩李艳明金炎邵春红徐雪松鄢超王山梅楚亚菲张利侠马娟周树平周艳朱镭孟晋华董方吕志勇胡芳芳沈瀚周万青贾伟李刚吴劲松卢月梅李继红段金菊康建邦马晓波郑燕萍郭如意朱焱陈运生孟青王世富胡雪飞沈继录汪瑞忠房华俞碧霞赵勇龚萍温开镇张贻荣刘江山廖龙凤顾洪芹姜琳贺雯薛顺虹冯佼岳春雷上海交通大学医学院附属瑞金医院临床实验诊断中心上海200025 复旦大学附属华山医院抗生素研究所复旦大学附属华山医院检验科北京协和医院新疆医科大学第一附属医院四川大学华西医院复旦大学附属儿科医院安徽医科大学第一附属医院华中科技大学同济医学院附属同济医院中国医科大学附属第一医院天津医科大学总医院浙江大学医学院附属邵逸夫医院昆明医科大学第一附属医院内蒙古医科大学附属医院甘肃省人民医院上海交通大学医学院附属儿童医院北京医院广州医科大学附属第一医院哈尔滨医科大学附属第一医院四川省人民医院中南大学湘雅医院山东省立医院吉林大学中日联谊医院河南省人民医院陕西省人民医院江西省儿童医院山西省儿童医院首都医科大学附属北京儿童医院贵州省人民医院南京大学医学院附属鼓楼医院宁夏医科大学总医院深圳市人民医院河北医科大学第二医院山西医科大学第二医院厦门大学附属第一医院福建省泉州市第一医院深圳市儿童医院山东大学齐鲁儿童医院南昌大学第一附属医院安徽医科大学第四附属医院上海市浦东新区人民医院浙江省宁波市镇海龙赛医院湖北省秭归县人民医院福建省晋江市医院甘肃省金昌市中西医结合医院江西省赣县区人民医院山东省广饶县人民医院河南省辉县市人民医院辽宁省营口市经济技术开发区中心医院青海省互助县人民医院四川省邻水县人民医院吉林省九台区人民医院

目的了解2.15—2.2.年中国主要地区临床分离铜绿假单胞菌对各类抗菌药物的耐药性变迁。方法对CHINET 51所医院临床分离铜绿假单胞菌按照CHINET技术方案采用纸片扩散法或自动化仪器法进行抗菌药物敏感性试验,按照CLSI 2.2.年标准判读药... 详细信息

目的了解2.15—2.2.年中国主要地区临床分离铜绿假单胞菌对各类抗菌药物的耐药性变迁。方法对CHINET 51所医院临床分离铜绿假单胞菌按照CHINET技术方案采用纸片扩散法或自动化仪器法进行抗菌药物敏感性试验,按照CLSI 2.2.年标准判读药敏结果,并用WHONET 5.6软件进行数据分析。结果2.15—2.2.年从51所医院临床标本中共分离到12.701株铜绿假单胞菌,检出率为8.6%,历年该菌检出率在不发酵糖革兰阴性杆菌中次于不动杆菌属排第二位。其中(91.4±1.0)%菌株分离自住院患者,(66.4±2.8)%菌株分离自呼吸道分泌物。铜绿假单胞菌对各种抗菌药物耐药率均有所下降,对阿米卡星、多黏菌素及头孢他啶-阿维巴坦的敏感率>90%。分离自门急诊的菌株对各抗菌药物的耐药率在1.0%~19.8%,分离自ICU的菌株耐药率为0.6%~40.5%,分离自内科和外科的菌株耐药率分别为0.8%~2..8%和1.2.~2..3%。分离自儿童的菌株耐药率在0.8%~18.8%,成人株为1.2.~2..1%,老年株为1.0%~2..5%。二级医院、三级医院和儿童医院分离菌株的耐药率分别为2.5%~2..2.、0.7%~2..6%和0.6%~2..3%。碳青霉烯类耐药铜绿假单胞菌共35153株,检出率为2..1%。结论铜绿假单胞菌是最常检出的不发酵糖革兰阴性杆菌之一,该菌对各抗菌药物耐药率逐年下降,耐药监测是控制细菌耐药发生和发展行之有效的手段。来自不同标本类型、不同科室及患者年龄的菌株耐药性相差较大,临床中更应该加强监测,协助医师合理用药,预防和控制耐药菌的流行。

关键词：耐药监测铜绿假单胞菌药物敏感性耐药性变迁

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Expert consensus on the glycemic management of critically ill patients

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Journal of Intensive Medicine 2022年第3期2卷 131-145页

作者： Zhixiong Wu Jiao Liu Dong zhang Kai Kang Xiangrong Zuo Qianghong xu Aijun {2. Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang {2. Department of Critical Care Medicine Huadong HospitalFudan UniversityShanghai 200040China Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Critical Care Medicine the First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Critical Care Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Critical Care Medicine Zhejiang hospital affiliated to Medical College of Zhejiang UniversityHangzhouZhejiang 310013China Department of Critical Care medicine The First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Critical Care medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityQingdaoShandong 266071China Department of Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330000China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Intensive Care Unit The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong510630China Department of Critical Care Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Department of Emergency Medicine and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Emergency Department Intensive Care Units Guizhou Medical University Affiliated HospitalGuiyangGuizhou 550004China Department of Emergency The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of ICU Shaanxi Provincial People’s HospitalXi’anShaanxi 710068China Department of Critical Care Medicine T

Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 2..6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2.In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of *** therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia.

关键词： patients elevated diagnosis

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鼓泡板片蒸发式冷凝器流动及传热特性

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化学工程 2022年第4期50卷 46-51页

作者：陈权章立新潘旭光高明刘婧楠沈艳陈金花上海理工大学能源与动力工程学院上海市动力工程多相流动与传热重点实验室上海200093 浙江三新科技有限公司浙江绍兴312521 上海同驰换热设备科技有限公司上海200433 烟台蓝德空调工业有限责任公司山东烟台264003

为增强板片蒸发式冷凝器板外侧气液两相流动以提升传热能效,用数值模拟分析了顺流与逆流下水膜流动形态,并通过改变淋水量、风速、板间距等主要影响因素,得出了2.流态下的复合传热系数与板间压损。从控制参数范围内的实验结果结合数值... 详细信息

为增强板片蒸发式冷凝器板外侧气液两相流动以提升传热能效,用数值模拟分析了顺流与逆流下水膜流动形态,并通过改变淋水量、风速、板间距等主要影响因素,得出了2.流态下的复合传热系数与板间压损。从控制参数范围内的实验结果结合数值模拟分析可知:当风速一定,顺流与逆流下复合传热系数都随淋水量增加先增后减,最佳淋水量都在0.1111 kg/s,且淋水量对板间压损影响极小;当淋水量一定,顺流复合传热系数随风速的增幅呈小-大-小的非线性状,最佳风速在3 m/s,逆流复合传热系数的增幅呈先正后负,最佳风速在2.5 m/s,且2.流态下的板间压损都随着风速增加而增加;随着板间距增加,复合传热系数及板间压降都随之减小。

关键词：鼓泡板片水降膜复合传热系数压损

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