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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues

Protein & Cell 2024年第8期15卷 594-611页

作者： Jian Wu Chaoye Wang Shuhui Sun Tianmin Ren Lijie pan Hongyi Liu Simeng Hou Shen Wu Xuejing Yan Jingxue Zhang Xiaofang Zhao Weihai Liu Sirui Zhu Shuwen Wei Chi Zhang Xu Jia Qi Zhang Ziyu Yu Yehong Zhuo Qi Zhao Chenlong Yang Ningli Wang beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China department of Neurosurgery Peking University Third HospitalCenter for Precision Neurosurgery and Oncology of Peking University Health Science CenterBeijing 100191China Spencer Center for Vision Research Byers Eye InstituteSchool of MedicineStanford UniversityPalo AltoCA 94304USA

The progressive degradation in the trabecular meshwork(TM)is related to age-related ocular diseases like primary open-angle ***,the molecular basis and biological significance of the aging process in TM have not been fully ***,we established a dynamic single-cell transcriptomic landscape of aged macaque TM,wherein we classified the outflow tissue into 12.cell subtypes and identified mitochondrial dysfunction as a prominent feature of TM ***,we divided TM cells into 13 clusters and performed an in-depth analysis on cluster O,which had the highest aging score and the most significant changes in cell proportions between the two ***,we found that the APOE gene was an important differentially expressed gene in cluster O during the aging process,highlighting the close relationship between cell migration and extracellular matrix regulation,and TM *** work further demonstrated that silencing the APOE gene could increase migration and reduce apoptosis by releasing the inhibition on the PI3K-AKT pathway and downregulating the expression of extracellular matrix components,thereby increasing the aqueous outflow rate and maintaining intraocular pressure within the normal *** work provides valuable insights for future clinical diagnosis and treatment of glaucoma.

关键词： single-cell transcriptomic atlas macaque trabecular meshwork ocular outflow tissue aging

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ATP-dependent retrograde axonal transport of P2.3 receptor in primary sensory neurons

ATP-dependent retrograde axonal transport of P2X3 receptor i...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bin WANG~1,Xu-Qiao CHEN~1,Cheng-Biao WU~2.Jin pan~1,Bo YUAN~3,Yuan-Yuan SU~1,Xing-Yu JIANG~3, Xu ZHANG~4,Lan BAO~(1,*) 1 Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for biological {2.,Chinese Academy of {2.,Shanghai 2.0031,China 2.department of Neuro{2.,School of Medicine,university of California,San Diego,La Jolla,California 92.93- 0662.USA 3 National Center for Nanoscience and Technology,beijing 100080,China 4 Institute of Neuroscience and State Key Laboratory of Neuroscience,Institutes for biological {2.,Chinese Academy of {2.,Shanghai 2.0031,China

Objective P2. receptors are ATP-gated cation channels and play variable roles in pathophysiological *** P2. receptors,P2.

关键词： primary sensory neuron P2.3 receptor axonal retrograde transport

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Lipid rafts mediates ATP-induced endocytosis,signal transduction and retrograde transport of P2.3 receptor

Lipid rafts mediates ATP-induced endocytosis,signal transduc...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Qiao CHEN~(1,#),Bin WANG~(1,#),Chengbiao WU~2.Jin pan~1,Bo YUAN~3,Yuan-Yuan SU~1,Xing-Yu JIANG~3,Xu ZHANG~4 Lan BAO~(1,*) 1 Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for biological {2.,Chinese Academy of {2.,Shanghai 2.0031,China 2.department of Neuro{2.,School of Medicine,university of California,San Diego,La Jolla,California,USA 3National Center of Nanoscience and Technology,beijing 100190,China 4 Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for biological {2., Chinese Academy of {2.,Shanghai 2.0031,China

P2. receptors are a family of cation channels expressed in neurons and nonneuronal *** play a variety of roles including synaptic transmission,muscle contraction,neuronal secretion and inflammation response. Among P2. receptors,the P2. subtype is selectively expressed in dorsal root ganglion *** raft is a specialized membrane microdomain and participate many signal transduction *** report showed that P2. receptor is localized in the lipid rafts of DRG *** have found P2. receptor engaged in retrograde transport in the form of signaling *** we investigated the role of lipid rafts in a,B-MeATP-dependent endocytosis and signal transduction,and retrograde transport of P2. *** of lipid raft with MBCD or nystatin abolished ATP-dependent endocytosis of P2. receptor and ATP-induced ERK activation in P2. receptor-expressing HEK2.3 *** vivo sucrose gradient fractionation with vesicular pellets prepared from sciatic nerve axoplasm showed that abundant P2. receptor was localized in lipid raft *** transported P2. receptors were colocalized with the lipid raft marker caveolinla in sciatic *** terminal treatment with MPCD attenuated retrograde transport of P2. receptor in axon of dorsal root ganglion ***,lipid raft mediates ATP-induced endocytosis,signal transduction and retrograde transport of P2. receptor.

关键词： P2.3 receptor lipid raft endocytosis ERK retrograde transport

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Functional analysis of mutations in eukaryotic translation initiation factor 2.（eIF2.） in Chinese patients with vanishing white matter disease

Functional analysis of mutations in eukaryotic translation i...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xue-Rong LENG~1,Ye WU~1,Yan-Xia pan~2.Li DU~2.Jing-Min WANG~1,Zhi-Jie GAO~2.Jiong QIN~1,Xi-Ru WU~1,Yu-Wu JIANG~(1,*) 1 Pediatric department,Peking {2. First Hospital,{2.,100034,China 2.Shan Xi Medical {2. First Hospital,Taiyuan,030001,China

＜正＞Objective Vanishing white matter disease（VWM）,inherited with autosomal recessive manner,is supposed one of the most prevalent inherited leukoencephA10pathy in *** is the first known hereditary human disease due to the direct defects in translation initiation process,with the gene defects in EIF2.1-5,encoding the five subunits of eukaryotic translation initiation factor 2.（eIF2.α,β,γ,δ8 andε） respectively,which was identified in *** cases with VWM were reported in our unit first since *** pathogenesis of VWM is still far from well understood. Methods EIF2.1-5 mutation screening was performed in 12.Chinese children,who fulfilled the clinically diagnostic *** novel EIF2.5 mutations identified,in vitro functional study was carried out in transfected HEK2.3 cells. Results All patients presented with classical *** were identified in EIF2.5,EIF2.3 and *** novel mutations were found,including 7 missense mutations（EIF2.5:c.185A＞T,p.D62.;c.1004G＞C,p.C335S;c.112.A＞ G,p.N376D;EIF2.3:c.140G＞A,p.G47E;c.1037T＞C,p.I346T;EIF2.2.c.2.4 T＞A,p.V85E;c.92. G＞A,p.V308M）,1 nonsense mutation（EIF2.5:c.805C＞T,R2.9X）,and 1 deletion（EIF2.5:c.182.-1838del,p.S610-D613del）.EIF2.3 mutation, accounting for～2.%of total mutations found in this study,is more prevalent than previous reports in Caucasian population （7%）.Further functional study on five novel EIF2.5 mutations revealed that p.R2.6X and p.S610-D613del mutations result in significantly loss of the mutant *** amount of the mutant protein,as well as the interaction between the mutant eIF2.γand eIF2.γsubunits were not interfered by the three missense EIF2.5 mutations（p.D62.,p.C335S and p. N376D）.Conclusions VWM patients with mutations analysis confirmation are reported first in China in this *** novel EIF2. mutations were identified and unique mutation spectrum in Chinese patients was ***2.5 mutations, p.R2.6X and p.S610-D613del,are probably loss of function

关键词： Vanishing white matter disease(VWM) eukaryotic translation initiation factor2.(eIF2.) mutation

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New Record Ocean Temperatures and Related Climate Indicators in 2.2.

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Advances in Atmospheric sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHENG John ABRAHAM Kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU Fan WANG Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHENG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHEN Dakui WANG Licheng FENG Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Karina VON SCHUCKMANN Yuying pan Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China university of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA university of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human *** 2.2.,the sea surface temperature(SST)and upper 2.00 m ocean heat content(OHC)reached record *** 0–2.00 m OHC in 2.2. exceeded that of 2.2. by 15±10 ZJ(1 Zetta Joules=102. Joules)(updated IAP/CAS data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the *** with the onset of a strong El Niño,the global SST reached its record high in 2.2. with an annual mean of~0.2.℃ higher than 2.2. and an astounding>0.3℃ above 2.2. values for the second half of *** density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2.2..

关键词： ocean heat content salinity stratification global warming climate

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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic sciences Kashi UniversityKashi 844000China beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12.sheep *** testing between the inhabited altitudes and 34,2.8,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2.HBB-like,and HBBC,and(2.HBE1-like,HBE2.like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2.affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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Microbial biodegradation of microcystin-RR by bacterium Sphingopyxis sp. USTB-05

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Journal of Environmental sciences 2010年第2期22卷 168-175页

作者： Mulan Zhang Gang pan Hai Yan State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China department of biological Science and Technology School of Applied Science University of Science and Technology Beijing Bering 100083 China

A strain, USTB-05, isolated from Lake Dianchi, China, degraded the cyanobacterial toxin microcystin-RR （MC-RR） at the rate of 16.7 mg/L per day. Analysis of 16S rDNA sequence showed that the strain was Sphingopyxis sp. Enzymatic degradation pathways for MC-RR by Sphingopyxis sp. USTB-05 were identified. Adda-Arg peptide bond of MC-RR was cleaved and then a hydrogen and a hydroxyl were combined onto the NH2.group of Adda and the carboxyl group of arginine to form a linear molecule as intermediate product within the first few hours. Then, through dehydration reaction, two hydrogen of amino group on arginine reacted with adjacent hydroxyl on carbon to form a linear MC-RR with two small peptide rings as the final product after 2. hr. These biodegradation pathways were different from those reported for other strains, implying that MC-RR may undergo different transformations and different products were formed due to various bacteria in natural lakes and reservoirs.

关键词： microcystin-RR biodegradation Sphingopyxis sp. USTB-05 enzymatic pathways Lake Dianchi

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Spectroscopic study on transformations of dissolved organic matter in coal-to-liquids wastewater under integrated chemical oxidation and biological treatment process

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Journal of Environmental sciences 2018年第8期30卷 206-216页

作者： Siwei Peng Xuwen He Hongwei pan department of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450045China

A large amount of wastewater containing various toxic organic contaminants is produced during coal-to-liquids process. In this study, several spectroscopic methods were used to monitor the transformation of organic pollutants during an integrated chemical oxidation and biological process. The results showed that the hydrophobic acid fraction increased after Fenton oxidation, which was likely due to the production of small-molecule organic acids. Soluble microbial products were generated during biological treatment processes,which were degraded after ozonation; meanwhile, the hydrophilic base and acid components increased. Ultraviolet-visible spectroscopic analysis indicated that peaks at the absorption wavelengths of 2.0 and 2.4 nm, which are associated with aromatic substances, were detected in the raw water. The aromatic substances were gradually removed, becoming undetectable after biological aeration filter（BAF） treatment. Fourier transform infrared spectroscopy analysis revealed that the functional groups of phenols;benzene, toluene, ethylbenzene, and xylene（BTEX）; aromatic hydrocarbons; aliphatic acids;aldehydes; and esters were present in raw wastewater. The organic substances were oxidized into small molecules after Fenton treatment. Aromatic hydrocarbons were effectively removed through bioadsorption and biodegradation after BAF *** organic matter was reduced and finally became undetectable after anoxic–oxic treatment in combination with a membrane bioreactor. Four fluorescent components were fractionated and obtained via excitation–emission matrix parallel factor analysis（EEM-PARAFAC）. Dissolved organic matter fractionation in conjunction with EEM-PARAFAC was able to monitor more precisely the evolution of characteristic organic contaminants.

关键词： Coal-to-liquids wastewater Spectroscopic analysis Dissolved organic matter fractionation UV–visible spectrum Excitation–emission matrix parallel factor analysis (EEM-PARAFAC)

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From Proton Conductive Nanowires to Nanofuel Cells： A Powerful Candidate for Generating Electricity for Self-Powered Nanosystems

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Nano Research 2011年第11期4卷 1099-1109页

作者： Caofeng pan Jun Luo Jing Zhu beijing National Center for Electron Microscopy Laboratory of Advanced Materials State Key Laboratory of New Ceramics and FineProcessing Department of Material Science and Engineering Tsinghua University Beijing 100084 China

The likely goal of nanotectulology is the integration of individual nanodevices into a nanosystem, which includes the nanodevice（s）, power harvesting unit, data processing logic system, and possibly wireless communication unit. A nanosystem requires a nanoscale power source to make the entire package extremely small and high performance. The nanofuel and nanobiofuel cells developed here represent a new self-powering approach in nanotechnology, and their power output is high enough to drive nanodevices for performing self-powered sensing. This study shows the feasibility of building self-powered nanosystems for biological sciences, environmental monitoring, defense technology and even personal electronics.

关键词： Nation nanowire nanofuel cell nanobiofuel cell self-powered nanosystem

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低氧和氧化应激对不同来源间充质干细胞旁分泌的差异性影响

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中国组织工程研究 2024年第19期28卷 3024-3030页

作者：潘筱颖许永德刘志强邢晓雯杨勇长春中医药大学吉林省长春市130117 长春中医药大学附属医院泌尿外科吉林省长春市130021 首都医科大学附属北京友谊医院北京市100000 军事科学院军事医学科学院北京市100000

背景:间充质干细胞的生物学行为受所处生存微环境的影响,微环境条件预处理是调控间充质干细胞功能的重要手段。目的:对比氧化应激和低氧条件下脐带间充质干细胞、脂肪间充质干细胞旁分泌功能的差异,为治疗不同疾病选择适当的间充质干细... 详细信息

背景:间充质干细胞的生物学行为受所处生存微环境的影响,微环境条件预处理是调控间充质干细胞功能的重要手段。目的:对比氧化应激和低氧条件下脐带间充质干细胞、脂肪间充质干细胞旁分泌功能的差异,为治疗不同疾病选择适当的间充质干细胞预处理方式提供理论依据。方法:培养脐带间充质干细胞和脂肪间充质干细胞,分别加入不同浓度的H_(2.O_(2.或不同体积分数的O_(2.干预,检测细胞形态、增殖、活力和旁分泌因子表达。结果与结论:①普通培养环境下,脐带间充质干细胞中脑源性神经营养因子和转化生长因子β的表达水平显著高于脂肪间充质干细胞,而脂肪间充质干细胞中基质细胞衍生因子1α和肿瘤坏死因子刺激因子6的表达水平显著高于脐带间充质干细胞;②中低浓度水平(≤100μmol/L)H_(2.O_(2.对2.间充质干细胞活力的影响无显著差异,但H_(2.O_(2.浓度从50μmol/L增至100μmol/L使脐带间充质干细胞中血管内皮生长因子表达水平显著增高,脂肪间充质干细胞中碱性成纤维细胞生长因子、血管内皮生长因子、基质细胞衍生因子1α和白细胞介素10表达水平均显著升高;③体积分数1%O_(2.促进2.间充质干细胞增殖;体积分数1%O_(2.干预2. h后,2.间充质干细胞中基因表达水平均有升高,但脂肪间充质干细胞中血管内皮生长因子、白细胞介素10和肿瘤坏死因子刺激因子6的表达水平显著高于脐带间充质干细胞;④结果提示:低氧和氧化应激预处理可提高间充质干细胞旁分泌功能,但2.间充质干细胞对低氧和氧化应激的响应不同,治疗疾病可选择适合的间充质干细胞预处理方式进一步提升其治疗潜力。

关键词：脐带间充质干细胞脂肪间充质干细胞旁分泌氧化应激低氧

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