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Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity

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Chinese Journal of Natural Medicines 2016年第3期14卷 227-231页

作者： LI jie-Hong pan jie-tao YIN Yong-Qin Department of Traditional Chinese Medicinal Chemistry Guangdong Pharmaceutical University

In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.

关键词： Ipomoea cairica Resin glycoside Simonic acid A a-Glucosidase

Synergistic effect of silicon availability and salinity on metal adsorption in a common estuarine diatom

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Journal of Environmental Sciences 2025年第2期148卷 364-374页

作者： Fengyuan Chen jie Ma Ke pan SZU-HKUST Joint PhD Program in Marine Environmental Science Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Department of Ocean Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Increasing nitrogen and phosphorus discharge and decreasing sediment input have made silicon(Si)a limiting element for diatoms in *** in nutrient structure and salinity fluctuation can greatly affect metal uptake by estuarine ***,the combined effects of Si and salinity on metal accumulation in these diatoms have not been *** this study,we aimed to investigate how salinity and Si availability combine to influence the adsorption of metals by a widely distributed diatom Phaeodactylum *** data indicate that replete Si and low salinity in seawater can enhance cadmium and copper adsorption onto the diatom *** the single-cell level,surface potential was a dominant factor determining metal adsorption,while surface roughness also contributed to the highermetal loading capacity at lower *** a combination of noninvasive micro-test technology,atomic force microscopy,X-ray photoelectron spectroscopy,and Fourier transform infrared spectroscopy,we demonstrate that the diversity and abundance of the functional groups embedded in diatom cell walls vary with salinity and Si *** results in a change in the cell surface potential and transient metal *** study provides novel mechanisms to explain the highly variable metal adsorption capacity of a model estuarine diatom.

关键词： Diatom Metal adsorption Silicon Salinity Functional group Surface potential

Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： Xin LI Yibo ZHOU tao ZHAO Xingjian HE Yanhong pan State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material CyclingCentre for Research and Education on Biological Evolution and Environment and Frontiers ScienceSchool of Earth Sciences and EngineeringNanjing UniversityNanjing210023China Institute of Palaeontology Yunnan Key Laboratory of Earth System ScienceYunnan Key Laboratory for PalaeobiologyYunnan UniversityKunming650500China

Mammalian hair,as a key feature related to endothermy,physical protection,and camouflage,has a long geohistorical record that dates back even to the ***,the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep *** address this,we conducted taphonomic experiments to simulate the transformation process of black *** changes in the morphological structure,microscopic characteristics,and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy,Fourier transform infrared(FTIR)spectroscopy,and Raman *** results revealed that damage to the morphology of hair began at a mild temperature(150–175℃),and hair transformed into a fluid-like mass at a relatively high temperature(200℃).In addition,the morphological structure of melanosomes had relatively greater preservation potential than keratins did,and the microscopic features of melanosomes were persistently *** Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature *** the chemical signals were not lost completely,the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200℃),whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable,even at high temperatures(>200℃).These results were confirmed by principal component analysis(PCA)and principal component analysis linear discriminant analysis(PCA–LDA).In addition,the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid),which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

Tribo-piezoelectric hybrid nanogenerator based on temporary solution template process

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Science China(Technological Sciences) 2025年第2期68卷 97-105页

作者： Jinxian ZHANG Peng pan Zhengchun YANG jie HE Peifeng ZENG College of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300382China

In this study,a friction piezoelectric hybrid nanogenerator(HNG)with a sponge-like structure was developed.A novel temporary solution template process was proposed to create smaller,uniformly distributed pores within the sponge structure,allowing for the complete volatilization of the porous agent without causing structural *** output voltage of the porous HNG structure was nearly twice that of its solid structure,demonstrating superior electrical output performance.A peak-to-peak open circuit voltage of 168 V,a short circuit current density of 36.41μA cm^(-2),and a maximum power density of 32 W m^(-2) were obtained at a load resistance of 200 MΩ by periodically compressing an HNG with a dimension of 0.8 cm×0.8 *** generated electricity was sufficient to directly illuminate 180 tandem white LEDs and power small electronic *** addition,this study shows that the HNG could detect electrical signals from different parts of the human body during movement,suggesting significant potential for applications in energy harvesting and motion sensing.

关键词： PDMS hybrid nanogenerator triboelectric piezoelectric flexible composites

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin Hu Mengfan Wang pan Shang Ziyan Liu tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

Investigation into enhanced performance of toluene and Hg0 stimulative abatement over Cr-Mn oxides co-modified columnar activated coke

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Journal of Environmental Sciences 2025年第2期148卷 88-106页

作者： Jiajie Wang jie Liu Lei Gao Dong Xie Caiting Li Liping Xiang Huiyu Xiong Jiaqi Xie Tianren Zhang Yueguo pan School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China National&Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings Hengyang 421001China Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province Hengyang 421001China College of Environmental Science and Engineering Hunan UniversityChangsha 410082China

In this study,a string of Cr-Mnco-modified activated coke catalysts(XCryMn1-y/AC)were prepared to investigate toluene and Hg0 removal *** characterizations including XRD,TEM,SEM,in situ DRIFTS,BET,XPS and H_(2)-TPR showed that 4%Cr0.5Mn0.5/AC had excellent physicochemical properties and exhibited the best toluene and Hg0 removal efficiency at 200◦*** varying the experimental gas components and conditions,it was found that too large weight hourly space velocity would reduce the removal efficiency of toluene and *** O_(2) promoted the abatement of toluene and Hg0,the inhibitory role of H_(2)O and SO_(2) offset the promoting effect of O_(2) to some *** significantly inhibited Hg0 removal,resulting from that toluene was present at concentrations orders of magnitude greater than mercury’s or the catalyst was more prone to adsorb toluene,while Hg0 almost exerted non-existent influence on toluene *** mechanistic analysis showed that the forms of toluene and Hg0 removal included both adsorption and oxidation,where the high-valent metal cations and oxygen vacancy clusters promoted the redox cycle of Cr^(3+)+Mn^(3+)/Mn^(4+)+Cr^(6+)+Mn^(2+),which facilitated the conversion and replenishment of reactive oxygen species in the oxidation process,and even the CrMn1.5O4 spinel structure could provide a larger catalytic interface,thus enhancing the adsorption/oxidation of toluene and ***,its excellent physicochemical properties make it a costeffective potential industrial catalyst with outstanding synergistic toluene and Hg0 removal performance and preeminent resistance to H_(2)O and SO_(2).

关键词： Toluene Element mercury Cr-Mn oxides Activated coke

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi jie pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-Ling Li tao Zhou Hong Cai tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-pan Yang Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China School of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal UniversityGuilin 541004China

Studying molecular recognition in aqueous environments is crucial for understanding biological ***,we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine *** subtle modifications can significantly affect the binding properties of these receptors,which is similar to the mutations in biological *** theoretical calculations and molecular recognition experiments demonstrated that these“mutations”have an impact on the hydrophobicity and charge distribution of the hosts,consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv tao Long Hui-Wen pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study