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Distinctive characteristics and functions of multiple mitochondrial Ca^(2+) influx mechanisms

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Science China(Life Sciences) 2011年第8期54卷 763-769页

作者： shi pan shin-Young RYU Shey-shing SHE~ Center for Translational Medicine Department of Medieine Thomas Jefferson University Philadelphia PA 19107 USA Department of Physiology Seoul National University College of Medicine Seoul 110-799 Republic of Korea

Intracellular Ca2+ is vital for cell *** of Ca2+ homeostasis contributes to human diseases such as heart failure,neuron-degeneration,and *** ensure an effective intracellular Ca2+ dynamics,various Ca2+ transport proteins localized in different cellular regions have to work in *** central role of mitochondrial Ca2+ transport mechanisms in responding to physiological Ca2+ pulses in cytosol is to take up Ca2+ for regulating energy production and shaping the amplitude and duration of Ca2+ transients in various *** the discovery that isolated mitochondria can take up large quantities of Ca2+ approximately 5 decades ago,extensive studies have been focused on the functional characterization and implication of ion channels that dictate Ca2+ transport across the inner mitochondrial *** mitochondrial Ca2+ uptake sensitive to non-specific inhibitors ruthenium red and Ru360 has long been considered as the activity of mitochondrial Ca2+ uniporter(MCU) .The general consensus is that MCU is dominantly or exclusively responsible for the mitochondrial Ca2+ *** multiple Ca2+ influx mechanisms(e.g.L-,T-,and N-type Ca2+ channel) have their unique functions in the plasma membrane,it is plausible that mitochondrial inner membrane has more than just MCU to decode complex intracellular Ca2+ signaling in various cell *** the last decade,four molecular identities related to mitochondrial Ca2+ influx mechanisms have been *** are mitochondrial ryanodine receptor,mitochondrial uncoupling proteins,LETM1(Ca2+ /H+ exchanger) ,and MCU and its Ca2+ sensing regulatory subunit ***,we briefly review recent progress in these and other reported mitochondrial Ca2+ influx pathways and their differences in kinetics,Ca2+ dependence,and pharmacological *** potential physiological and pathological implications are also discussed.

关键词： mitochondrial calcium channels calcium transport mitochondria heart ryanodine receptor

KBH_4/BiCl_3──A New and Facile Reduction System for the Conversion of Aromatic Nitro Compounds to Primary Ammes

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Chinese Chemical Letters 1996年第11期7卷 981-983页

作者： pan, shi Feng Ren, Ping Da Dong, Ting Wei Department of Chemistry Fudan University Shanghai 200433

s: Vinous aromatic nitro compounds could be selectively and rapidly reduced to the corresponding amines in excellent yields by potassium borohydride - bismuth chloride/ethanol-water, a new and facile reductive system.

关键词： system the Conversion reduction Amines

Allosteric conformational changes of G proteins upon its interaction with membrane and GPCR

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Chinese Chemical Letters 2022年第2期33卷 747-750页

作者： Longmei Li Jin Zhang Wenjing Sun Weimin Gong Changlin Tian pan shi Chaowei shi Hefei National Laboratory of Physical Science at Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China Department of Chemical Physics at School of Chemistry and Materials Sciences University of Science and Technology of ChinaHefei 230027China

Current resolved structures of GPCRs and G protein complexes provided important insights into G protein activation. However, the binding or dissociation of GPCRs with G protein is instantaneous and highly dynamic in the intracellular environment. The conformational dynamic of G protein still needs to be addressed. In this study, we applied ^(19)F solution NMR spectroscopy to monitor the conformational changes of G protein upon interact with detergent mimicking membrane and receptor. Our results show that there are two states equilibria in the G_(α)in apo states. The interaction of G_(α)with detergents will accelerate this conformational transformation and induce a state that tends to bind to GPCRs. Finally, the G_(α)proteins presented a fully activation state when they coupled to GPCRs.

关键词： 19F solution NMR G protein-coupled receptors Conformational dynamics G protein

Puerarin attenuates angiotensin Ⅱ-induced cardiac fibroblast proliferation via the promotion of catalase activity and the inhibition of hydrogen peroxide-dependent Rac-1 activation

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Chinese Journal of Natural Medicines 2018年第1期16卷 41-52页

作者： CHEN Gang pan shi-Fen CUI Xiang-Li LIU Li-Hong Department of Pharmacy Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

The aims of the present study were to evaluate the effects of puerarin on angiotensin II-induced cardiac fibroblast proliferation and to explore the molecular mechanisms of action. Considering the role of H202 in nicotinamide adenine dinucleotide phosphate （NADPH） oxidase activation, we hypothesized that modulating catalase activity would be a potential target in regulating the redox-sensitive pathways. Our results showed that the activation of Rac 1 was dependent on the levels of intracellular H202. Puerarin blocked the phosphorylation of extracellular regulated protein kinases （ERK）1/2, abolished activator protein （AP）-1 binding activity, and eventually attenuated cardiac fibroblast proliferation through the inhibition of H202-dependent Racl activation. Further studies revealed that angiotensin II treatment resulted in decreased catalase protein expression and enzyme activity, which was disrupted by puerarin via the upregulation of catalase protein expression at the transcriptional level and the prolonged protein degradation. These findings indicated that the anti-proliferation mechanism of puerarin was mainly through blocking angiontensin II-triggered downregu- lation of catalase expression and H202-dependent Racl activation.

关键词： Angiontensin II Puerarin Catalase Hydrogen peroxide

Calculation and Spectra Analysis of Horizontal Acceleration Correction(HACC)for Airborne Gravimetry

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Geo-Spatial Information Science 2004年第3期7卷 204-209页

作者： shi pan SUN Zhongmiao XIAO Yun Xi’an Research Institute of Surveying and Mapping Xi’an 710054China 不详

On the basis of a sinusoidal model of the disturbed horizontal acceleration,the spectrum characteristics of misaligned angle and horizontal acceleration correction are *** an airborne gravimetry test,the misaligned angle of platform and horizontal acceleration correction are *** are 5′and 3 mGal,respectively,when the flight is stable.

关键词： airborne gravimetry airborne gravimeter horizontal acceleration correction misaligned angle of the platform GPS

A hybrid rendering algorithm for textile objects

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Science in China(Series F) 2009年第3期52卷 490-499页

作者： ZHANG MingMin pan ZhiGeng shi JiaoYing WANG Peng MI QingFeng State Key Laboratory of CAD & CG Zhejiang University Hangzhou 310027 China

Although realistic textile rendering has been widely used in virtual garment and try-on systems, a robust method to simulate textile with a realistic appearance and high fidelity is yet to be established. We propose to use a novel hybrid geometric- and image-based rendering （GIBR） method to achieve photo realistic representation of textile products. The image-based technique, with its radiance synthesis algorithm, enables us to recover the reflectance properties of textile in an environment photo, and thus can render the appearance of textile material. The geometry-based technique, with its traditional illumination model of assigning illumination parameters extracted from the original scene （such as radiance and chroma dispatch）, makes it possible to interactively manipulate 3D virtual objects in the ＂real＂ environment. Our realistic textile rendering method has advantages over the traditional ones in its easiness to implement and its wide range of applications.

关键词： realistic rendering image and geometry hybrid radiance synthesis

A Barbier type reaction promoted by in situ formed active metal bismuth from NaBH_4 and BiCl_3 in aqueous media

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Chinese Journal of Chemistry 1996年第5期14卷 462-466页

作者： REN,Ping-Da pan,shi-Feng DONG,Ting-Wei WU,shi-HuiDepartment of Chemistry,Pudan University,Shanghai 200433,China Department of Chemistry Fudan University Shanghai 200483 China

In the presence of active metal bismuth (Bi) which was prepared from the combination of bismuth trichloride and sodium borohydride,aldehydes have been found to react with allyl bromide in aqueous media,and the corresp... 详细信息

关键词： Barbier type reaction aqueous medium reaction active metal bismuth

Optimizing Two-Phase Flow Heat Transfer:DCS Hybrid Modeling and Automation in Coal-Fired Power Plant Boilers

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Frontiers in Heat and Mass Transfer 2024年第2期22卷 615-631页

作者： Ming Yan Caijiang Lu pan shi Meiling Zhang Jiawei Zhang Liang Wang Technical Supervision Center Huadian Electric Power Research Institute Co.Ltd.Hangzhou310030China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu611756China School of Management Science&Real Estate Chongqing UniversityChongqing400044China

In response to escalating challenges in energy conservation and emission reduction,this study delves into the complexities of heat transfer in two-phase flows and adjustments to combustion processes within coal-fired *** a fusion of hybrid modeling and automation technologies,we develop soft measurement models for key combustion parameters,such as the net calorific value of coal,flue gas oxygen content,and fly ash carbon content,within theDistributedControl System(DCS).Validated with performance test data,thesemodels exhibit controlled root mean square error(RMSE)and maximum absolute error(MAXE)values,both within the range of *** into their respective automatic control systems,thesemodels optimize two-phase flow heat transfer,finetune combustion conditions,and mitigate incomplete ***,this paper conducts an in-depth exploration of the generationmechanismof nitrogen oxides(NOx)and low oxygen emission reduction technology in coal-fired boilers,demonstrating a substantial reduction in furnace exit NOx generation by 30%to 40%and the power supply coal consumption decreased by 1.62 g/(kW h).The research outcomes highlight the model’s rapid responsiveness,enabling prompt reflection of transient variations in various economic indicator *** provides a more effective means for real-time monitoring of crucial variables in coal-fired boilers and facilitates timely combustion adjustments,underscoring notable achievements in boiler *** research not only provides valuable and practical insights into the intricacies of two-phase flow heat transfer and heat exchange but also establishes a pioneering methodology for tackling industry challenges.

关键词： Two-phase flow coal-fired boiler oxygen content of flue gas carbon content in fly ash hybrid modeling automation control

THE PULPING AND PAPERMAKING CHARACTERISTICS OF YOUNG *** AND ***

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Journal of Northeast Forestry University 1993年第1期4卷 41-47页

作者： Liu Changen Zhang Yingsheng Zhang shi pan Zhicao Northeast Forestry University 1. Northeast Forestry University China

5, 10, 15, and 20 year old Larix gmelini and Betula platyphylla were used as pulping raw material in the research. The examination of young L. gmelini and B. Platyphyllafibrous structures showed that the fiber length and ratio of length to width of 5 years old L. gmelini noticeably differed from that of mature L. gmelini. but that of 5 year old B. platyphyllawere nearby equal to that of mature B. platyphylla. The research results indicated that 15 years old B. platyphylla and 20 year old L. gmelini were best suited to pulping among the eight experimental raw materials; 10 years old B. platyphylla and 15 year old L. gmelini were optimal to the ratio of beating degree increment and corresponding beating time. The pulp characteristics of 15 year old B. platyphylla and 20 year old L. gmelini were similar to those of mature wood, and it was feasible to consider 15 years to B. platyphylla and 20 years to L. gmelini as their rotation period; 10 years and 15 years as their thinning cycles for the papermaking forest base.

关键词： Larch Birch pulping papermaking