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Toughening additive manufactured Zr-based bulk metallic glass composites by martensite phase transformation

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Journal of Materials Science & Technology 2024年第3期170卷 95-102页

作者： Pengcheng Zhang Cheng Zhang jie pan Di Ouyang Lin Liu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Additive manufacturing technology based on laser powder bed fusion(LPBF)offers a novel approach for fabricating bulk metallic glass(BMG)products without restriction in size and ***,the BMGs prepared by LPBF usually suffered from less plasticity and poorer fracture toughness as compared to their cast counterparts due to partial crystallization in heat-affected zones(HAZs).Since crystallization in HAZs is hard to avoid completely in LPBF BMGs,it is desirable to design a suitable alloy system,in which only ductile crystalline phase,instead of brittle intermetallics,is formed in *** unique structure could effectively increase the toughness/plasticity of the LPBF *** achieve this goal,a quaternary BMG system with a composition of Zr_(47.5)Cu_(45.5)Al_(5)Co_(2)is adopted and subjected to *** is found that nearly a single phase of B_(2)-ZrCu is precipitated in HAZs,while a fully amorphous phase is formed in molten pools(MPs).This B_(2)phase reinforced BMG composite exhibits excellent mechanical properties with enhanced plasticity and ***,it is easy to modulate the mechanical properties by altering the amount of the B_(2)phase via adjusting the laser energy ***,the best combination of strength,plasticity,and notch toughness is obtained in the BMG composite containing 27.4%B_(2)phase and 72.6%amorphous phase,which exhibits yield strength(σ_(s))of 1423 MPa,plastic strain(ε_(p))of 4.65%,and notch toughness(K_(q))of 53.9 MPa m 1/***,a notable strain-hardening is also *** improvement of plasticity/toughness and appearance of strain-hardening behavior are mainly due to the martensite phase transformation from the B_(2)phase to the Cm phase during plastic deformation(i.e.,the phase transformation-induced plasticity effect).The current work provides a guide for making advanced BMGs and BMG composites by additive manufacturing.

关键词： Laser powder bed fusion Bulk metallic glass composites Phase transformation-induced plasticity Deformation mechanism

Effect of power supply parameters on discharge characteristics and sterilization efficiency of magnetically driven rotating gliding arc

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Plasma Science and Technology 2024年第9期26卷 61-68页

作者： Shaohua QIN Meizhi WANG Jun DU Lanlan NIE jie pan School of Physics and Electronics Shandong Normal UniversityJinan 250014People’s Republic of China School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution *** is widely used in medical,food,and environmental protection *** air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma *** this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus *** with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding *** using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding *** on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply *** results revealed that the MDRGA process can be divided into three stages:starting,gliding,and *** voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone *** this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc ***,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was ***,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device.

关键词： plasma magnetically driven rotating gliding arc sterilization

Nanoscale“precision strike”:Tumor microenvironment-responsive smart micelles for efficient targeted drug delivery

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Nano Research 2024年第9期17卷 8360-8367页

作者： Dong Wan Yarong Song Xiujuan Lu Yanfeng Huang Jianxin Zhang Yonghui Liu Yi Liu jie pan School of Chemistry Tiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China

To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric *** micelles were synthesized with copolymers composed of TPGS_(3350)-PVGLIG-DOX(TPD)and FA-SS-DOX(FSD),which endow them with tumor-targeted drug delivery ***_(3350)contributes to extending the circulation of micelles in body,augmenting their accumulation in tumor tissues via the enhanced permeability and retention(EPR)*** localized the tumor site,matrix metalloproteinase 2(MMP2)cleaves the PVGLIG peptide moiety within the micelles,thereby releasing TPGS_(3350)and exposing the targeting ligand of *** approach enables the subsequent internalization of the micelles by tumor cells through folate receptor-mediated *** internalization,the high intracellular concentration of glutathione(GSH)triggers the reduction of the disulfide bond within the FA-SS-DOX,leading to the release of the anticancer-drug doxorubicin(DOX),which promotes apoptosis in the tumor cells and enhances the efficacy of chemotherapy.

关键词： cancer peptide micelle dual-responsive folate

Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

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World Journal of Diabetes 2024年第1期15卷 34-42页

作者： jie Chen Wan-Chao Zhang Xiao-Qiang Tang Ruo-Han Yin Tao Wang Xiao-Yu Wei Chang-jie pan Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Department The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these *** differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving *** To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with *** The clinical data of inpatients from January 2022 to December 2022 were analyzed *** to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in *** The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT

关键词： Acute coronary syndrome Type-2 diabetes mellitus Total bilirubin Major adverse cardiovascular events

Trends in Respiratory Infectious Pathogens in Children Under the Age of 14—Xiamen City,Fujian Province,China,2017-2023

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China CDC weekly 2024年第8期6卷 143-147页

作者： Jiali Cao jie pan Xiaoqing Yang Jumei Liu Min Zhu Zeyu Zhao Ling Chen Tianmu Chen Huiming Ye Department of Laboratory Medicine Fujian Key Clinical Specialty of Laboratory MedicineWomen and Children’s HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Department of Pediatrics Women and Children's HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina

Summary What is already known about this topic?Respiratory infections pose a significant burden on public *** recent outbreaks occurring in various locations,there is limited information available on the prevalence tr... 详细信息

关键词： Xiamen spite Fujian

Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor (CAR) via dephosphorylation of the EGFR signaling pathway

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Journal of Biomedical Research 2024年第4期38卷 382-396页

作者： Muhammad Zubair Hafiz jie pan Zhiwei Gao Ying Huo Haobin Wang Wei Liu Jian Yang Department of Pharmacology Nanjing Medical UniversityNanjingJiangsu 211166China

The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer *** in vivo experiments were conducted on nude and ICR *** a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver *** the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ *** in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)*** with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 ***,other CAR target genes also showed a significant increase in the *** up-regulation of murine CAR was observed in the liver tissues of both nude and ICR *** findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator *** of the ERK1/2 signaling pathway was also observed in ***,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and *** the nude mice,T-AⅢ also inhibited EGFR *** results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.

关键词： timosaponin AⅢ CAR metabolism enzyme ERK1/2 signaling pathway EGFR signaling pathway

Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor(CAR) via dephosphorylation of the EGFR signaling pathway

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The Journal of Biomedical Research 2024年第04期 382-396页

作者： Muhammad Zubair Hafiz jie pan Zhiwei Gao Ying Huo Haobin Wang Wei Liu Jian Yang Department of Pharmacology Nanjing Medical University

The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ) on drug-metabolizing enzymes during anticancer therapy. The in vivo experiments were conducted on nude and ICR mice. Following a 24-day administration of T-AⅢ, the nude mice exhibited an induction of CYP2B10, MDR1, and CYP3A11 expression in the liver tissues. In the ICR mice, the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢadministration. The in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6, MDR1, and CYP3A4, along with constitutive androstane receptor(CAR) activation. Treatment with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 expression. Furthermore, other CAR target genes also showed a significant increase in the expression. The up-regulation of murine CAR was observed in the liver tissues of both nude and ICR mice. Subsequent findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation, with this effect being partially reversed by the ERK activator *** of the ERK1/2 signaling pathway was also observed in vivo. Additionally, T-AⅢinhibited the phosphorylation of EGFR at Tyr1173 and Tyr845, and suppressed EGF-induced phosphorylation of EGFR, ERK,and CAR. In the nude mice, T-AⅢ also inhibited EGFR phosphorylation. These results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway.

关键词：

考古成果在原创性临展策划中的创新实践:“从广州出发——‘南海Ⅰ号’与海上丝绸之路”策展回顾

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中国博物馆 2024年第1期 42-47,130,131页

作者：潘洁南越王博物院广州510030

考古成果与博物馆展示紧密关联,考古学科理论与研究成果在原创性临展的创新实践中具有至关重要的指导作用。2023年,南越王博物院策划并主办了“从广州出发——‘南海Ⅰ号’与海上丝绸之路”展,依托“南海Ⅰ号”最新考古研究成果,以“透... 详细信息

考古成果与博物馆展示紧密关联,考古学科理论与研究成果在原创性临展的创新实践中具有至关重要的指导作用。2023年,南越王博物院策划并主办了“从广州出发——‘南海Ⅰ号’与海上丝绸之路”展,依托“南海Ⅰ号”最新考古研究成果,以“透物见人”的理念为策展导向,通过多学科综合研究方法,以全新的视角向观众展示了“南海Ⅰ号”的航行路径与海上贸易景象。这种将古代货物生产基地—商品集散地—贸易路线联系起来的海上丝绸之路主题展,为考古成果指导博物馆展览创新提供了良好借鉴。

关键词：博物馆考古成果转化原创性临展南海Ⅰ号海上丝绸之路

金融体系赋能海洋经济高质量发展的机制与路径

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产经评论 2024年第3期15卷 86-94页

作者：潘捷北京大学经济学院—广东金融高新技术服务区广东金融学院经济贸易学院

新时期金融体系如何推动海洋经济新旧动能转换、赋能海洋经济高质量发展是各界广泛关注的热点议题。结合新质生产力理论和金融理论分析表明,金融体系中的蓝色金融、绿色金融、科技金融、产业链金融以及数字普惠金融等金融类型能够通过... 详细信息

新时期金融体系如何推动海洋经济新旧动能转换、赋能海洋经济高质量发展是各界广泛关注的热点议题。结合新质生产力理论和金融理论分析表明,金融体系中的蓝色金融、绿色金融、科技金融、产业链金融以及数字普惠金融等金融类型能够通过支持海洋科技创新、促进海洋产业转型升级,推动海洋经济高质量发展。进一步的案例研究发现,广东省通过出台系列金融支持政策进行金融工具创新,不断满足涉海企业融资需求,发挥金融优化资源配置功能。因此,可以通过加快发展海洋科技金融推动海洋科技创新、创新海洋金融模式加快海洋产业转型升级、构建多元化金融体系等路径,更充分地发挥金融体系对海洋经济高质量发展的赋能效应。

关键词：金融体系海洋经济海洋产业新质生产力高质量发展