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Chinese Chemical Letters 2010年第3期21卷 337-340页

作者： Ma, Yong Jun pan, yu ying Wang, Wei Feng Yang, Mei Xia Zhou, Min NW Normal Univ Coll Chem & Chem Engn Key Lab Ecoenvironm Related Polymer Mat Minist EducKey Lab Polymer Mat Gansu Prov Lanzhou 730070 Peoples R China

The electrocatalytic oxidation of methanol at the platinum electrode modified with Eu-Fe cyanide-bridged binuclear complexes (Eu-Fe film) was investigated for the first time by cyclic *** with the bare platinum electrode,the results showed that the modified electrode had excellent electrocatalytic activity for the oxidation of methanol;the oxidation peak potential shifted more negatively and the peak current increased about twenty *** electrooxidation of methanol at the modified elect...

关键词： Methanol Electrocatalysis Cyanide-bridged binuclear complexes Europium Chemically modified electrode

Multi-physical fields distribution in billet during helical electromagnetic stirring:A numerical simulation research

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China Foundry 2024年第1期21卷 51-59页

作者： Dong pan Qing-tao Guo Kai-lun Zhang Fu-zhi yu yu-ying Li yu-bao Xiao State Key Laboratory of Metal Materials for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

Electromagnetic stirring is one of the widely applied techniques to modify the quality of casting *** from conventional rotate stirring,the helical stirring is more professional in assisting multi-dimensional flow of molten metal and eliminating solidification *** this study,the single-winding helical stirring(SWHS)was introduced,offering advantages such as smaller volume and lower electromagnetic shielding compared to traditional helical stirring *** a comprehensive numerical simulation,the stirring parameters of SWHS were adjusted to yoke inclination angle of 43°and frequency of 12 *** higher electromagnetic force and flow velocity in drawing direction,as well as the lower temperature gradient induced by the SWHS,are positive factors for homogeneous solidification of *** experimental results on Al-8%Si alloy and 0.4%C-1.1%Mn steel demonstrate that compared to rotate stirring,the SWHS process can induce better billet quality and is more effective in accelerating the equiaxed expansion and reducing element *** SWHS process can enhance the equiaxed ratio of the billet by 58.3%and reduce segregation degree of carbon element by 10.97%.Consequently,SWHS holds great promise as a potential approach for improving the quality of continuous casting billets.

关键词： billet electromagnetic stirring helical solidification element segregation numerical simulation

基于一种矩阵和权重改进的MW-Apriori算法探讨名老中医李培旭教授治疗慢性肾脏病蛋白尿用药规律

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世界中西医结合杂志 2024年第2期19卷 240-247页

作者：于子洋张艳燕马笑凡崔伟锋潘玉颖李星锐北京中医药大学中医学院北京100048 河南医学高等专科学校河南郑州451191 河南省中西医结合医院河南郑州450004

目的通过一种改进Apriori算法对名老中医李培旭教授运用中医药治疗慢性肾脏病蛋白尿中药处方配伍及规律进行分析,以期对临床治疗有指导作用。方法收集2018年1月—2021年1月期间李培旭教授诊治慢性肾脏病蛋白尿临床数据建立数据库,运用... 详细信息

目的通过一种改进Apriori算法对名老中医李培旭教授运用中医药治疗慢性肾脏病蛋白尿中药处方配伍及规律进行分析,以期对临床治疗有指导作用。方法收集2018年1月—2021年1月期间李培旭教授诊治慢性肾脏病蛋白尿临床数据建立数据库,运用基于矩阵和权重改进的MW-Apriori算法,进行统计分析其中用药规律及药物组合特点,从而得出核心证型和核心处方。结果共收集处方1239张,病例391例,涉及到药物共214味,其中使用频次>10次的有135味,累计使用频次17467次,药物种类共21类,使用频次排名前5类分别为清热药、补虚药、利水药、解表药、活血药,性味归经方面,使用较多为寒性、平性及甘味药。在药物组合关联规则中显示连翘-金银花组合是所有药物组合中出现频次最高,甘草作为单味药物出现频次最高,且关联性最强,关联性较强药物为:金银花、连翘、黄柏、生地、黄芪、柴胡、泽泻、当归、白芍、蒲公英,总结出常见证型9种,常用药物50味,并从中得出核心证型及核心处方各4种,核心药物24味。结论通过对李培旭教授治疗慢性肾脏病数据分析,肾病蛋白尿的原发病较多,病机以湿热致肾闭精泄,本虚标实,虚实错杂,病程冗长,湿热(毒)蕴结为基本证型,治疗以祛邪通闭、益气养阴为主,选药多注重寒性、平性及甘味药物,研究得出核心证型和核心处方较为准确客观反映李教授学术思想,对临床具有一定指导意义。

关键词：慢性肾脏病蛋白尿中医药关联规则核心证型核心处方

Semi-Varying Coefficient panel Data Model with Technical Indicators Predicts Stock Returns in Financial Market

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Journal of Systems Science & Complexity 2024年第4期37卷 1638-1652页

作者： HU Xuemei pan ying LI Xiang School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067China Chongqing Key Laboratory of Social Economy and Applied Statistics Chongqing 400067China Research Center for Economy of Upper Reaches of the Yangtse River Chongqing Technology and Business UniversityChongqing 400067China

Accurately predicting stock returns is a conundrum in financial *** this conundrum can bring huge economic benefits for investors and also attract the attention of all circles of *** this paper the authors combine semi-varying coefficient model with technical analysis and statistical learning,and propose semi-varying coefficient panel data model with individual effects to explore the dynamic relations between the stock returns from five companies:CVX,DFS,EMN,LYB,and MET and five technical indicators:CCI,EMV,MOM,ln ATR,ln RSI as well as closing price(ln CP),combine semi-parametric fixed effects estimator,semi-parametric random effects estimator with the testing procedure to distinguish fixed effects(FE) from random effects(RE),and finally apply the estimated dynamic relations and the testing set to predict stock returns in December 2020 for the five *** proposed method can accommodate the varying relationship and the interactive relationship between the different technical indicators,and further enhance the prediction accuracy to stock returns.

关键词： Fixed effects random effects semi-varying coefficient panel data model stock returns technical indicators

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江苏省天然温泉场所水中微生物调查

环境与健康杂志 2024年第1期41卷 24-27页

作者：汪庆庆陈小岳何智敏沈淼潘莹宇丁震江苏省疾病预防控制中心环境与健康所江苏南京210009 常州市疾病预防控制中心食品与环境疾病科南通市疾病预防控制中心环境卫生与放射防护科淮安市洪泽区疾病预防控制中心公共卫生科南京市江宁区疾病预防控制中心公共卫生科

目的了解江苏省天然温泉场所温泉水中微生物污染现况、分布特征及其影响因素,探讨温泉水微生物污染的控制措施。方法于2021年调查江苏省4市8家温泉场所基本情况,检测温泉水中6种微生物的污染情况和分布特征,鉴定异养菌的细菌种群,分析... 详细信息

目的了解江苏省天然温泉场所温泉水中微生物污染现况、分布特征及其影响因素,探讨温泉水微生物污染的控制措施。方法于2021年调查江苏省4市8家温泉场所基本情况,检测温泉水中6种微生物的污染情况和分布特征,鉴定异养菌的细菌种群,分析理化因素、消毒措施、管理措施对微生物超标的影响。结果温泉水中菌落总数、异养菌、大肠杆菌、耐热大肠菌群、嗜肺军团菌、铜绿假单胞菌合格率或阳性率分别为86.5%、35.1%、83.8%、13.5%、8.1%、24.3%,异养菌鉴定出6个菌属;室内温泉池中菌落总数高于其它场所(χ^(2)=12.838,P<0.05),总大肠菌群、耐热大肠菌群、军团菌仅在室内温泉池和室外温泉池有超标,异养菌和铜绿假单胞菌在所有水体均超标;水温和池水循环使用对微生物超标均有影响,水温≥40℃时菌落总数、异养菌、总大肠菌群、耐热大肠菌群合格率升高(χ^(2)分别为4.912、4.609、6.098、4.912,P<0.05),循环使用的温泉水菌落总数和嗜肺军团菌合格率降低(χ^(2)分别为5.025、3.909,P<0.05)。结论温泉场所水中微生物存在不同程度超标现象,建议对温泉水采用适宜的消毒措施,控制温泉水更换频率,将温泉场所纳入公共场所卫生监管范畴。

关键词：温泉菌落总数异养菌总大肠菌群耐热大肠菌群嗜肺军团菌铜绿假单胞菌

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei Xin-yu Wang Hai-Tao Tang Fei-Hu Cui yun-Qi Wu ying-Ming pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying Wu Hong Chen Fan Zhang pan Guo Haili Qin Huai-Ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

Chiral Phenol-2NO Ligand Cooperation with Achiral Organic Base in the Zn(II)-Catalyzed Asymmetric Alkylation Reaction of Indoles

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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu yu-Heng Wang Xi-Rui Wang pan Hu Bo-Wen pan Wen-Jing Zhang Zi-yue Chen ying Zhou Xiong-Li Liu National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2999-3014页

作者： yun Yang Qingya Liu Meng Wang Lang Li Yan yu Meng pan Danrong Hu Bingyang Chu ying Qu Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens,including prolonged circulation in the bloodstream,specific cell recognition and targeting capabilities,and potential for ***,we introduce a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM *** microporous Prussian blue nanoparticles(MPB NPs)serving as both a photothermal sensitizer and carrier for 3-bromopyruvate(3BP),these nanoparticles are cloaked in a genetically programmable cell membrane displaying variants of signal regulatory proteinα(SIRPα)with enhanced affinity to *** a result,MPB-3BP@CM NPs inherit the characteristics of the original cell membrane,exhibiting an extended circulation time in the bloodstream and effectively targeting CD47 on the cytomembrane of colorectal cancer(CRC)***,blocking CD47 with MPB-3BP@CM NPs enhances the phagocytosis of CRC cells by ***,3BP,an inhibitor of hexokinase II(HK2),suppresses glycolysis,leading to a reduction in adenosine triphosphate(ATP)levels and lactate ***,it promotes the polarization of tumor-associated macrophages(TAMs)towards an anti-tumor M1 ***,integration with MPB NPs-mediated photothermal therapy(PTT)enhances the therapeutic efficacy against *** advantages make MPB-3BP@CM NPs an attractive platform for the future development of innovative therapeutic approaches for ***,it introduces a universal approach for engineering disease-tailored cell membranes for tumor therapy.

关键词： CD47 colorectal cancer

Recent advances on bismuth oxyhalides for photocatalytic CO_(2)reduction

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Journal of Environmental Sciences 2024年第6期140卷 183-203页

作者： Liangpang Xu Jimmy C.yu ying Wang Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Photocatalytic conversion of CO_(2)into fuels such as CO,CH_(4),and CH_(3)OH,is a promising approach for achieving carbon *** oxyhalides(BiOX,where X=Cl,Br,and I)are appropriate photocatalysts for this purpose due to the merits of visible-light-active,efficient charge separation,and easy-to-modify crystal structure and surface *** practical applications,multiple strategies have been proposed to develop high-efficiency BiOX-based *** review summarizes the development of different approaches to prepare BiOX-based photocatalysts for efficient CO_(2)*** the review,the fundamentals of photocatalytic CO_(2)reduction are ***,several widely used modification methods for BiOX photocatalysts are systematacially discussed,including heterojunction construction,introducing oxygen vacancies(OVs),Bi-enrichment,heteroatom-doping,and morphology ***,the challenges and prospects in the design of future BiOX-based photocatalysis for efficient CO_(2)reduction are examined.

关键词： Bismuth oxyhalides Photocatalysis CO_(2)reduction Modification methods