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China's Tibet 2000年第1期11卷 26-27页

作者： pamela LOGAN

Determinants of inequality in health care seeking for childhood illnesses:insights from Nairobi informal settlements

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Global Health Journal 2022年第4期6卷 198-203页

作者： Nicholas Ngomi Christopher Khayeka-Wandabwa Thaddaeus Egondi pamela AMarinda Tilahun Nigatu Haregu School of Pure and Applied Health Sciences Murang'a University of TechologyP.O.Box 75-10200MurangaKenya Laboratory of Genetics Wageningen University&Research6700 HB WageningenNetherlands Drugs for Neglected Diseases initiative(DNDi) P.O.Box 21936-00505NairobiKenya Department of Food Science and Nutrition School of Agricultural Sciencesthe University of ZambiaLusakaZambia Nossal Institute for Global Health Melbourne School of Population and Global Healththe University of MelbourneMelbourne 3000Australia

Background:An in-depth understanding of patterns of inequities in healthcare seeking among the urban residents is critical in identifying appropriate interventions *** study evaluates determinants of inequality in health care seeking for childhood illnesses among informal settlement residents in Nairobi,***:Data from the second Nairobi Cross-Sectional Slum Survey(NCSS 2012)was *** inequality in seeking health care for childhood diarrhea as the prototype illness was assessed using concentration index(CI).The wealth index based on the household possessions and amenities was used as a measure for socioeconomic ***:A total of 2027 qualified women were included in this *** 16.6% of children born of younger mothers aged<20 years had diarrhea and a similar proportion of children(16.3%)was observed among mothers who were *** CI of-0.026 on health care seeking for diarrhea among children points to significant inequality among the urban poor(95% confidence interval:-0.028 to-0.023).Conclusion:Occupation of parents,age of mothers,ethnicity,marital status and children's age were major deter-minants with regard to disease outcome and to a broader extent inequality in health care seeking for childhood *** bottom top community health invigoration strategies in health information awareness and services access would be instrumental.

关键词： Diarrhea Childhood illnesses Socio-economic status Informal settlement Kenya

The Promise Chen Kaige's Flight of Cinematic Fancy

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China Today 2006年第3期55卷 52-55页

作者： pamela Lord

Chen Kaige’s latest film has set a new box office record for Chinese film,and looks bound for international success.

关键词：中国电影评论《无极》陈凯歌

Construction and Application of Efficient Ac-Ds Transposon Tagging Vectors in Rice

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Journal of Integrative Plant Biology 2009年第11期51卷 982-992页

作者： Shaohong Qu Jong-Seong Jeont Pieter B.F. Ouwerkerk Maria Bellizzi Jan Leach pamela Ronald Guo-Liang Wang Department of Plant Pathology Ohio State University Columbus OH 43210 USA Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China Department of Plant Pathology University of California Davis CA 95616 USA Graduate School of Biotechnology and Plant Metabolism Research Center Yongin 446-701 Korea Institute of Biology Leiden University Clusius Laboratory RA Leiden 2300 The Netherlands Bioagdcultural Sciences and Pest Management Colorado State University Fort Collins CO 80523 USA Crop Gene Engineering Key Laboratory of Hunan Province and Pre-State Key Laboratory of Crop Germplasm Renovation and Resource Utilization Hunan Agricultural University Changsha 410128 China

Transposons are effective mutagens alternative to T-DNA for the generation of insertional mutants in many plant species including those whose transformation is inefficient. The current strategies of transposon tagging are usually slow and labor-intensive and yield low frequency of tagged lines. We have constructed a series of transposon tagging vectors based on three approaches：（i） AcTPase controlled by glucocorticoid binding domain/VP16 acidic activation domain/Gal4 DNA-binding domain （GVG） chemical-inducible expression system; （ii） deletion of AcTPase via Cre-lox site-specific recombination that was initially triggered by Ds excision; and （iii） suppression of early transposition events in transformed rice callus through a dual-functional hygromycin resistance gene in a novel Ds element （HPT-Ds）, We tested these vectors in transgenic rice and characterized the transposition events. Our results showed that these vectors are useful resources for functional genomics of rice and other crop plants. The vectors are freely available for the community,

关键词： Ac-Ds transposable element glucocorticoid binding domain/VP16 acidic activation domain/Gal4 DNA-binding domain-inducible expression Cre-lox site-specific recombination rice.

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Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo

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Bone Research 2019年第4期7卷 388-398页

作者： Marietta Landgraf Christoph ALahr Alvaro Sanchez-Herrero Christoph Meinert Ali Shokoohmand pamela MPollock Dietmar WHutmacher Abbas Shafiee Jacqui AMcGovern Centre in Regenerative Medicine Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia School of Biomedical Science Institute of Health and Biomedical InnovationTranslational Research InstituteQueensland University of TechnologyBrisbaneAustralia Australian Research Council(ARC)Training Centre in Additive Biomanufacturing Queensland University of TechnologyBrisbaneAustralia UQ Diamantina Institute Translational Research InstituteThe University of QueenslandBrisbaneQLDAustralia

Advanced prostate cancer(PCa)is known for its high prevalence to metastasize to bone,at which point it is considered *** significant effort,there is no animal model capable of recapitulating the complexity of PCa bone *** humanized mouse model for PCa bone metastasis used in this study aims to provide a platform for the assessment of new drugs by recapitulating the human–human cell interactions relevant for disease development and *** humanized tissueengineered bone construct(hTEBC)was created within NOD-scid IL2rgnull(NSG)mice and was used for the study of experimental PC3-Luc bone *** was confirmed that PC3-Luc cells preferentially grew in the hTEBC compared with murine *** translational potential of the humanized mouse model for PCa bone metastasis was evaluated with two clinically approved osteoprotective therapies,the non-species-specific bisphosphonate zoledronic acid(ZA)or the human-specific antibody Denosumab,both targeting Receptor Activator of Nuclear Factor Kappa-Β***,but not Denosumab,significantly decreased metastases in hTEBCs,but not murine *** results highlight the importance of humanized models for the preclinical research on PCa bone metastasis and indicate the potential of the bioengineered mouse model to closely mimic the metastatic cascade of PCa cells to human ***,it will enable the development of new effective antimetastatic treatments.

关键词： metastasis PC3 drugs

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TRANSFORMATIONAL CHANGE

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Beijing Review 2019年第40期62卷 22-23页

作者： pamela Tobey National Bureau of Statistics

October 1 marked the 70th anniversary of the founding of the People's Republic of China. During the past seven decades, tremendous changes have taken place in China's society, economy, standard of living and international status. To put its achievements into perspective, Beijing Reviewbreaks down the numbers behind China's development across a wide sphere of sectors.

关键词： People's Republic of China international status Beijing

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莫西沙星

中国实用内科杂志 2002年第10期22卷 635-638页

作者： pamela A Hunter Maxim Medical Magdalen CentreThe Oxford Science Park

莫西沙星（Bay12-8039）是由拜耳公司研发的一种新型的氟喹诺酮类药物，并已经经过FDA的批准在美国上市。莫西沙星具有良好的药物代谢动力学特性。每日1次，口服400mg即可使血浆和组织浓度持续高于大疗分呼吸道致病菌的MIC_(90)。

关键词：莫西沙星光毒性杀菌活性抗菌谱

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OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice

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Molecular Plant 2008年第3期1卷 446-458页

作者： Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas pamela C. Ronald Department of Plant Pathology University of California Davis CA 95616 USA Present address: Monsanto Corporation Davis CA 95616 USA Present address: USDA-ARS Appalachian Fruit Research Station Kearneysville WV 25430 USA

The rice Xa21 gene, which confers resistance to the bacterial pathogen Xanthomonas oryzae pv. oryzae （Xoo）, encodes a receptor-like kinase, Few components involved in transducing the Xa21-mediated defense response have yet been identified. Here, we report that XA21 binds to a WRKY transcription factor, called OsWRKY62. The OsWRKY62 gene encodes two splice variants （OsWRKY62.1 and OsWRKY62.2）. OsWRKY62.1：smGFP2 and OsWRKY62.2：smGFP2 fusion pro- teins partially localize to the nucleus. Transgenic plants overexpressing OsWRKY62.1 are compromised in basal defense and Xa21-mediated resistance to Xoo. Furthermore, overexpression of OsWRKY62.1 suppresses the activation of defenserelated genes. These results imply that OsWRKY62 functions as a negative regulator of innate immunity in rice, and serves as a critical mediator of both basal and race-specific defense responses.

关键词： rice OsWRKY62 Xa21 defense response.

INTERNATIONAL ACCESS TO THE CHINESE MEDICAL LITERATURE THROUGH MEDLINE

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中华医学杂志(英文版) 1993年第4期106卷 243-249页

作者： pamela L.Moriearty 陈受彬 Department of Psychiatry Southern Illinois University School of MedicineSpringfieldIL 62794-9230USA Department of International Affairs Sun Yat-Sen University of Medical SciencesGuangzhou 510089

This article reviews, for authors publishing in the Chinese literature, the characteristics of MEDLINE users, the format of MEDLINE citations and the main retrieval strategies used with the system. References were retrieved and data collected through MEDLINE searches of the database 1988-June 1992. Thirty-six indexed journals from the People's Republic of China (PRC) were analyzed. The items of a MEDLINE citation are described. Titles of Chinese journals are listed in English as well as Chinese in the annual "List of Serials Indexed" of Index Medicus. Articles from journals in the PRC are indexed at the China MEDLARS Center, Beijing, PRC. For the 36 journals analyzed, 12 530 citations appeared in MEDLINE during the search period. Basic search strategies are described. Users doing author searches may have difficulties with common Chinese surnames, especially if only one given name initial is used. Journal searches of specialty journals, as well as address field searches for publications from a particular institution, may be helpful to scientists planning a visit to China. Effective use of MEDLINE has become an opportunity and responsibility for scientists and physicians over the world. Suggestions for preparation of English titles and abstracts to assure optimal information transfer and retrieval efficiency are: think about your audience; do not waste words; include key features in the title; be consistent with names and affiliations; use MeSH terms; include important non-MeSH terms in text; use structured abstracts; and obtain MEDLINE printouts of your own citations.

关键词： CD-ROM INFORMATION ONLINE

Viral hepatitis update: Progress and perspectives

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World Journal of Gastroenterology 2021年第26期27卷 4018-4044页

作者： María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado pamela Valva Virology Institute CONICETSchool of Medical SciencesNational University of CórdobaCordoba X5016Argentina Multidisciplinary Institute for Investigation in Pediatric Pathologies(IMIPP)CONICET-GCBA Laboratory of Molecular BiologyPathology DivisionRicardo Gutiérrez Children’s HospitalCABA C1425Buenos AiresArgentina Institute of Biomedical Investigations in Retrovirus and AIDS(INBIRS) School of MedicineUniversity of Buenos AiresCONICETCABA C1121ABGBuenos AiresArgentina

Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and *** the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and *** review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research *** hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food *** the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine *** hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and *** hepatitis D virus,we describe diagnostic methodology,pathogenesis,and ***,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus