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小学生时代（大嘴英语） 2019年第7期 30-32页

作者： pamela love d Evi Gstottner(图) 不详

I drew a hopscotch With some chalk Outside where My neighbors walk.

关键词： Hopscotch hopscotch neighbors

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Sharing Song

小学生时代（大嘴英语） 2024年第9期 18-21页

作者： pamela love Laura Montenegro(图) 不详

Sing a song of sharing Apples in a tree:Some for squirrels,and some for birds,And some of them for me.

关键词： some birds Apple

Making Sense of Hospital Project MisPerformance: Over Budget, Late, Time and Time Again—Why? And What Can Be done About It?

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Engineering 2022年第5期8卷 183-201页

作者： Peter E.d.love Lavagnon A.Ika School of Civil and Mechanical Engineering Curtin UniversityPerthWA 6845Australia Telfer School of Management University of OttawaOttawaON KIN 6N5Canada

Hospital projects worldwide often experience misperformance,showing a tendency to exceed their estimated cost,miss their deadline,suffer quality problems,and yield benefit *** this ubiquitous problem,this paper aims to make sense of this phenomenon by addressing the following research question:How can we make sense of hospital project misperformance,and what can be done to mitigate its occurrence?We use an illustrative case study approach and the analytical lens of sense-making to examine the misperformance of three mega-hospital *** research reveals issues such as scope changes,an inability to adapt and respond to risk and uncertainty,ineffectual project management and governance,and optimism bias,which combine to impact project performance *** suggest that the two prominent theoretical perspectives dominating the literature in this field fall short of adequately explaining hospital project *** provide suggestions for improving the procurement process of hospitals and submit there is a need to develop a robust and balanced theory of project misperformance.

关键词： Cost Hospital Optimism bias Procurement Project management Performance Sense-making

Alcohol-induced alterations of the hepatocyte cytoskeleton

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World Journal of Gastroenterology 2010年第11期16卷 1358-1365页

作者： Blythe d Shepard pamela L Tuma department of Biology The Catholic University of America

The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease.

关键词： Ethanol Hepatotoxicity Tubulin Actin Keratin

Alcohol-induced protein hyperacetylation: Mechanisms and consequences

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World Journal of Gastroenterology 2009年第10期15卷 1219-1230页

作者： Blythe d Shepard pamela L Tuma department of Biology The Catholic University of America 620 Michigan Avenue NE Washington DC 20064 United States

Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylationo This reversible, post- translational modification on the E-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcohol- induced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specific substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will first list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function.

关键词： Ethanol Hepatotoxicity Acetylation deacetylases Acetyltransferases

Forecasting the impacts of chemical pollution and climate change interactions on the health of wildlife

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Current Zoology 2015年第4期61卷 669-689页

作者： pamela d. NOYES Sean C. LEMA department of Environmental & Molecular Toxicology Environmental Health Sciences Center Sinnhuber Aquatic ResearchLaboratory Oregon State University Corvallis OR USA Biological Sciences department Center for Coastal Marine Sciences California Polytechnic State University San Luis Obispo CA 93407 USA

Global climate change is impacting organisms, biological communities and ecosystems around the world. While most research has focused on characterizing how the climate is changing, including modeling future climatic conditions and predicting the impacts of these conditions on biodiversity, it is also the case that climate change is altering the environmental impacts of chemical pollution. Future climate conditions are expected to influence both the worldwide distribution of chemicals and the toxi- cological consequences of chemical exposures to organisms. Many of the environmental changes associated with a warming global climate （e.g., increased average - and possibly extreme - temperatures; intense periods of drier and wetter conditions; reduced ocean pH; altered salinity dynamics in estuaries） have the potential to enhance organism susceptibility to chemical toxicity. Addi- tionally, chemical exposures themselves may impair the ability of organisms to cope with the changing environmental conditions of the shifting climate. Such reciprocity in the interactions between climate change and chemicals illustrates the complexity inherent in predicting the toxicological consequences of chemical exposures under future climate scenarios. Here, we summarize what is currently known about the potential reciprocal effects of climate change and chemical toxicity on wildlife, and depict current approaches and ongoing challenges for incorporating climate effects into chemical testing and assessment. Given the rapid pace of new man-made chemistries, the development of accurate and rapid methods to evaluate multiple chemical and non-chemical stressors in an ecologically relevant context will be critical to understanding toxic and endocrine-disrupting effects of chemical pollutants under future climate scenarios [Current Zoology 61 （4）： 669-689, 2015].

关键词： Global wanning Toxicology Metals Endocrine disruptors Risk assessment

Sensory Phenotypic and Molecular Identification of Aromatic Rice Accessions Cultivated in Benin

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Advances in Bioscience and Biotechnology 2024年第3期15卷 195-206页

作者： Chimène Nadège Mahoussi Nanoukon Koffi david Montcho Hambada deless Edmond Fulgence Thiémélé Bignon Meyrix pamela Franzel Loumedjinon Babatoundé Franel Carel Wenceslas Affolabi Amed Sèmèvo Havivi Kéllya Laurinzo déguénon Grâce Finagnon Vitoekpon Arielle Bankole Lambert Gustave djedatin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Bio-technologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Biotechnologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture Kétou Benin Genetics Teaching and Research Unit Department of Biochemistry-Genetics Peleforo GON COULIBALY University Korhogo C&#244te d’Ivoire

Rice is one of the most widely cultivated cereals in the world, and its aroma is increasingly in demand. With the advancement of research, a major rice flavor gene has been identified on rice chromosome 8. It encodes non-functional betaine aldehyde dehydrogenase leading to the accumulation of 2-acetyl-1-pyrroline which is the major olfactory compound that confers the fragrant character to rice. The aroma of rice is considered a special trait of enormous economic importance that determines the prime price in world trade. To satisfy the needs of the population and reduce rice imports into Benin, we conducted this study to identify aromatic rice accessions grown in Benin. Seventy-two rice accessions collected across Benin were PCR amplified with three SSR markers RM 7049, Aro 7, and RM 223, linked to the fgr (fragrance of rice) aroma gene. Molecular analysis revealed that 12 of the 72 accessions, namely Bagou 19, Bagou 22, Tchaka 34, Foun 15, Tchaka 41, Nana 32, Kan 61, Kung 69, Kung 67, Bagou 20, Agbab 101 and Koum 55 possess the fgr gene and can be considered as aromatic rice accessions. A sensory phenotypic test using KOH was carried out on rice accessions carrying fgr gene. Of the twelve positives, only one had the smell of aromatic rice, like the Azucena control. These results show that Benin also has aromatic rice varieties that can be sold on national and international markets.

关键词： Aromatic Rice 2-Acetyl-1-Pyrroline SSR Markers Benin

Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma

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World Journal of Gastroenterology 2012年第11期18卷 1208-1215页

作者： Cesar Toledo Carola E Matus Ximena Barraza pamela Arroyo pamela Ehrenfeld Carlos d Figueroa Kanti d Bhoola Maeva del Pozo Maria T Poblete Laboratorio de Patologia Celular Instituto de AnatomiaHistologia y PatologiaUniversidad Austral de ChileValdivia Box 567Chile Servicio de Anatomia Patologica Hospital Base Lung Institute of Western AustraliaCentre for Asthma and Allergy Research InstituteUniversity of Western Australia

AIM： To determine the expression of HER2 and bradykinin B1 receptors （B1R） in the two pathogenic models of gallbladder cancer： the metaplasia dysplasia carcino ma and the adenoma carcinoma pathways.METHOdS： Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue. Expression of both receptors was studied in biopsy samples from 92 patients （6 males and 86 females; age ranging from 28 to 86 years, mean 56 years）. High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridization. Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS： HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium. On the contrary, there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia （22/24; 91.7%） and carcinoma in situ （9/10; 90%）, the lesions that displayed a significantly high proliferation index. Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in s/tu was not accompanied by HER2 gene amplification. A similar result was observed in invasive carcinomas （0/12）. The B1R distribution pattern mirrored that of HER2 except that B1R was additionally observed in the adenomas. The B1R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia （24/24; 100%） and carcinoma in situ （10/10; 100%） and in the epithelial cells of adenomas. In contrast, both HER2 （4/12; 33%） and B1R （1/12; 8.3%） showed a low expression in inva- sive gallbladder carcinomas.CONCLUSION： The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis,

关键词： Bradykinin BI receptor HER2 Gallbladderadenoma Gallbladder dysplasia Intestinal metaplasia Gallbladder cancer

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph d.Tan Gary John V.Mercado Patricia E.Cabrera Paulita pamela P.Astudillo Rolando Enrique d.domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines department of Ophthalmology Manila Doctors HospitalManila 1000Philippines department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pd those from the Visayas(Pd on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Heating Up the Environmental Context of Chemical Pollution： Ecotoxicology in a Changing Global Climate

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Current Zoology 2015年第4期61卷 614-616页

作者： pamela d. NOYES Sean C. LEMA Guest Editors department of Environmental & Molecular Toxicology Sinnhuber Aquatic Research Laboratory Oregon State University Corvallis OR USA Biological Sciences department Center for Coastal Marine Sciences California Polytechnic State University San Luis Obispo CA USA

Humans and wildlife are exposed to an ever-increasing array of man-made chemicals that are now meas-ured in every habitat on our planet from the Earth＇s highest mountain peaks to sediments in the deep ocean （e.g., Farrington and Takada, 2014; Quiroz et al., 2009; Veron et al., 1987; Villa et al., 2006）. In addition to the expanding variety of synthetic chemistries in use, there are many substances that are components of the Earth that may through human activities concentrate at high- levels or be released into the environment in forms that enhance their bioavailability, exposure, and toxicity potential.

关键词：光环境生态毒理学全球气候化学污染加热化学物质人类活动生物利用度