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Apoptotic and autophagic death union by Thuja occidentalis homeopathic dr.g in cer.ical cancer.cells with thujone as the bioactive pr.nciple

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Jour.al of Integr.tive Medicine 2022年第5期20卷 463-472页

作者： Asmita pal Suchar.ta Das Soumalee Basu r.ta Kundu Depar.ment of Botany University of CalcuttaKolkataWest Bengal 700019India Depar.ment of Micr.biology University of CalcuttaKolkataWest Bengal 700019India

Objective‘Multi-tar.eting’dr.gs can pr.ve fr.itful to combat dr.g-r.sistance of multifactor.al disease—cer.ical *** study envisioned to r.veal if Thuja homeopathic mother.tinctur.(MT)and its bioactive component could combat human papillomavir.s(HPV)-16-infected SiHa cer.ical cancer.cells since it is globally acclaimed for.HPV-mediated *** Thuja MT was studied for.its antipr.lifer.tive and antimigr.tor. pr.per.ies in SiHa cells followed by micr.scopic deter.ination of r.active oxygen species(r.S)gener.tion by 2’,7’-dichlor.dihydr.fluor.scein diacetate(DCFDA)staining and loss in mitochondr.al membr.ne potential(MMP)by r.odamine(r.)123 *** and autophagy inductions wer. studied by acr.dine or.nge(AO)ethidium br.mide(EB)staining and immunoblot analyses of mar.er.*** bioactive component of Thuja MT detected by gas chr.matogr.phy-mass spectr.metr. was studied for.antipr.lifer.tive and antimigr.tor. pr.per.ies along with in silico pr.diction of its cellular.tar.ets by molecular.docking and or.l dr.g for.ing *** Thuja MT showed significant antipr.lifer.tive and antimigr.tor. potential in SiHa cells at a 50%inhibitor. concentr.tion(IC50)dosage of 17.3μL/*** incr.ase in DCFDA fluor.scence and loss in r.123 fluor.scence pr.ve that Thuja MT acted thr.ugh the bur.t of r.S and loss in MMP ***/EB-stained cells under.the micr.scope and immunoblot analyses suppor.ed Thuja-induced cellular.demise via dual pathways—apoptosis and *** showed cleavage of caspase-3 and poly adenosine diphosphate-r.bose polymer.se-1(PAr.-1)along with upr.gulation of Beclin-1,micr.tubule-associated pr.tein 1 light chain 3B(LC3B)-II,and p62 ***,the apoptotic cascade followed a caspase-3-dependent pathway suppor.ed by PAr.-1 cleavage,while autophagic death was Beclin-1-dependent and mediated by accumulation of LC3BII and p62 ***,detected as the bioactive pr.nciple of Thuja MT showed gr.ater.anti-pr.

关键词： Thuja Homeopathy Thujone Cer.ical cancer Apoptosis-autophagy cr.sstalk

Study of Complex Nitr.gen and Oxygen-bear.ng Molecules towar. the High-mass Pr.tostar.Ir.S 18089–1732

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r.sear.h in Astr.nomy and Astr.physics 2024年第6期24卷 81-93页

作者： Ar.jit Manna Sabyasachi pal Tapas Baug Sougata Mondal Depar.ment of Physics Midnapore City CollegePaschim MedinipurWest Bengal721129India S.N.Bose National Centr. for.Basic Sciences Block-JDSector-IIISalt Lake CityKolkata700106 India

The obser.ation of oxygen(O)-and nitr.gen(N)-bear.ng molecules gives an idea about the complex pr.biotic chemistr. in the inter.tellar.*** millimeter.and submillimeter.wavelength obser.ations have shown the pr.sence of complex O-and N-bear.ng molecules in the star.for.ation ***,the investigation of those molecules is cr.cial to under.tanding the chemical complexity in the star.for.ing *** this ar.icle,we pr.sent the identification of the r.tational emission lines of N-bear.ng molecules ethyl cyanide(C_(2)H_(5)CN)and cyanoacetylene(HC_(3)N),and O-bear.ng molecule methyl for.ate(CH_(3)OCHO)towar. high-mass pr.tostar.Ir.S18089–1732 using the Atacama Compact *** also detected the emission lines of both the N-and O-bear.ng molecule for.amide(NH_(2)CHO)in the envelope of Ir.S 18089–*** have detected the v=0 and 1 state r.tational emission lines of CH_(3)*** also detected the two vibr.tionally excited states of HC_(3)N(v7=1 and v7=2).The estimated fr.ctional abundances of C_(2)H_(5)CN,HC_(3)N(v7=1),HC_(3)N(v7=2),and NH_(2)CHO towar. Ir.S 18089–1732 ar.(1.40±0.5)×10^(-10),(7.5±0.7)×10^(-11),(3.1±0.4)×10^(-11),and(6.25±0.82)×10^(-11)***,the estimated fr.ctional abundances of CH_(3)OCHO(v=0)and CH_(3)OCHO(v=1)ar.(1.90±0.9)×10^(-9)and(8.90±0.8)×10^(-10),*** also cr.ated the integr.ted emission maps of the detected molecules,and the obser.ed molecules may have or.ginated fr.m the extended envelope of the *** show that C_(2)H_(5)CNand HC_(3)N ar. most pr.bably for.ed via the subsequential hydr.genation of the CH_(2)CHCNand the r.action between C_(2)H_(2)and CN on the gr.in sur.ace of Ir.S 18089–*** found that NH_(2)CHO is pr.bably pr.duced due to the r.action between NH_(2)and H_(2)CO in the gas ***,CH_(3)OCHO is possibly cr.ated via the r.action between r.dical CH_(3)O and r.dical HCO on the gr.in sur.ace of Ir.S 18089–1732.

关键词： ISM:individual objects(Ir. 18089-1732)(except) ISM:abundances ISM:kinematics and dynamics star.:for.ation astr.chemistr.

r.dium-223 in metastatic castr.tion r.sistant pr.state cancer

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Asian Jour.al of Andr.logy 2014年第3期16卷 348-353页

作者： Winston Vuong Oliver.Sar.or.Sumanta K pal Depar.ment of Medical Oncology and Exper.mental Ther.peutics City of Hope Comprehensive Cancer Center Duarte CA Depar.ment of Medicine Tulane University School of Medicine New Orleans LA USA

In 2004, docetaxel was appr.ved for.the tr.atment of metastatic castr.tion-r.sistant pr.state cancer.（mCr.C）. For.the next sever.l year., ther. was a lull in dr.g appr.vals. However. fr.m 2010 onwar.s, 5 additional ther.pies have been appr.ved on the basis of showing a sur.ival benefit in phase III studies. These agents include sipuleuceI-T, cabazitaxel, abir.ter.ne, enzalutamide and （most r.cently） r.dium-223. Amongst r.diophar.aceuticals cur.ently used for.advanced pr.state cancer.（e.g. samar.um-153 and str.ntium-89）, r.dium-223 possesses sever.l unique pr.per.ies. As an alpha-emitting compound, the agent pr.duces a high-ener.y output over.a shor. r.nge, facilitating selective destr.ction of tissue within the bone in the r.gion of osteoblastic lesions while spar.ng sur.ounding nor.al tissue. The cur.ent r.view will outline biological r.tionale for.r.dium-223 and also pr.vide an over.iew of pr.clinical and clinical development of the agent. r.tional sequencing of r.dium-223 and combinations, in the incr.asingly complex landscape of mCr.C will be discussed, along with factor. influencing clinical implementation.

关键词： alphar.din bone metastases metastatic castr.tion-r.sistant pr.state cancer r.diophar.aceuticals r.dium-223 Xofigo

Dr. Matter.Par.itioning, Nodulation and Seed Tr.its of Medium and Late Matur.ng Soybean Var.eties as Affected by Planting Patter. and Plant Density

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Jour.al of Agr.cultur.l Science and Technology(B) 2012年第1期2卷 142-150页

作者： Daniel Mar.os Udai. r. pal Elias Ur.gie Cr.p Physiology and Agr.nomy Division Awassa Agricultural Research Center Awassa Ethiopia Plant Sciences Depar.ment Haramaya University Diredawa Ethiopia Plant Br.eding Division Awassa Agricultural Research Center Awassa Ethiopia

An exper.ment was conducted on Fluvisols of Awassa for.two consecutive year. （2005-2006） to deter.ine effects of planting patter. and plant density on dr. matter.accumulation, nodulation, pr.tein and oil content in ear.y and late matur.ng soybean var.eties. r.sults indicated that Awassa-95 var.ety pr.duced significantly higher.（P 〈 0.05） number.of nodules/plant （NDN）, nodule dr. matter.（NDM） and leaf dr. matter.（LDM at r. （mid flower.ng） stage of soybean gr.wth than that of var.ety Belessa-95）. Similar.y, var.ety Awassa-95 （45%） pr.duced significantly higher.pr.tein content than var.ety Belessa-95 （40%）. However. var.ety Belessa-95 accumulated significantly higher.（P 〈 0.01） dr. matter.in str.w, gr.in and total biomass at r. （physiological matur.ty） stage of soybean gr.wth than var.ety Awassa-95. Similar.y, oil content of var.ety Belessa-95 （18.1%） was significantly （P 〈 0.05） higher.than that of var.ety Awassa-95 （15.9%）. Equidistant r.ws pr.duced significantly higher.（P 〈 0.05） NDM than either.r.ctangular.or.pair.d r.ws. Mor.over. soybean plants gr.wn in both r.ctangular.and equidistant r.ws pr.duced significantly higher.（P 〈 0.01） str.w dr. matter.than those gr.wn in pair.d r.ws; but, gr.in dr. matter.plant （GDM） was significantly higher.（P 〈 0.01） pair.d and r.ctangular.r.ws compar.d to equidistant r.ws. Plant density also affected the per.plant GDM pr.duction as it was significantly higher.（P 〈 0.01） in 20 and 30 plants/m2 than higher.plant densities （40 and 50 plants/m2）. However. dr. matter.and yield components had str.ng negative association with pr.tein content. In fact, str.ng positive cor.elation （r.〉 0.600） occur.ed between gr.in yield and its components with dr. matter.components at r. （stem dr. matter.（SDM）, leaf dr. matter.（LDM） and stem ＋ nodule ＋ leaf dr. matter.together.known as TDM） and str.w dr. matter.at r. in both var.eties. This study depicted that soybean plants that pr.duce higher.dr. matter.components at r. would pr.bably pr.duce mor. str.w

关键词： Leaf dr. matter nodule dr. matter pr.tein content oil content plant density planting patter..

Effect of Co substitution on the str.ctur.l,dielectr.c and optical pr.per.ies of KBiFe_(2)O_(5)

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2021年第11期28卷 1861-1867页

作者： K.Chandr.kanta r.Jena P.pal Md.F.Abdullah S.D.Kaushik A.K.Singh Depar.ment of Physics and Astr.nomy National Institute of TechnologyRourkela-769008OdishaIndia UGC-DAE Consor.ium for.Scientific r.sear.h Mumbai Centr. R-5 ShedBARCMumbai-400085India

Cobalt(Co)-modified br.wnmiller.te KBiFe_(2)O_(5)(KBFO;[KBiFe_(2(1−x))Co_(2x)O_(5)(x=0,0.05)])polycr.stalline is synthesized following the solid-state r.action *** r.finement of X-r.y diffr.ction data confir.ed the phase pur.ty of KBFO and KBiFe_(1.9)Co_(0.1)O_(5)(KBFCO).The optical bandgap ener.y(Eg)of KBFO decr.ased fr.m 1.59 to 1.51 eV because of Co *** decr.ase in bandgap can be attr.buted to the tilting of the Fe–O tetr.hedr.l str.ctur. of *** obser.ed r.om-temper.tur. r.man peaks of KBFCO shifted by 3 cm^(−1) towar. a lower.wavenumber.than that of *** shift in r.man active modes can be attr.buted to the change in the bond angles and bond lengths of the Fe–O tetr.hedr.l str.ctur. and modification in r.sponse to oxygen deficiency in KBFO because of Co *** with that of KBFO,the fr.quency-dependent dielectr.c constant and dielectr.c loss of KBFCO decr.ase at r.om temper.tur.,which is a consequence of the r.duction in oxygen migr.tion and modification in r.sponse to vibr.tional modes pr.sent in the sample.

关键词： br.wnmiller.te r.etveld r.finement r.man spectr.scopy bandgap

Fr.quently Used Allopathic and Tr.ditional Medicine for.COVID-19 Tr.atment and Feasibility of Their.Integr.tion

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Chinese Jour.al of Integr.tive Medicine 2022年第11期28卷 1040-1047页

作者： Aditya Upadhayay Gopal Patel Dhar. pal Awanish Kumar Depar.ment of Biotechnology National Institute of TechnologyRaipurCG(492010)India Labor.tor. of Medicinal Plant Biotechnology College of PharmacyZhejiang Chinese Medical UniversityHangzhou(310053)China Depar.ment of Chemical Engineer.ng National Institute of TechnologyRaipurCG(492010)India

To date,no satisfactor. tr.atment for.COVID-19 is *** r.view r.por.ed few r.cent updates r.gar.ing the dr.gs(allopathy/tr.ditional medicines)used for.the tr.atment of COVID-19 concer.ing clinical *** of the ar.icle spotlight the contr.bution of allopathic and Ayur.edic dr.gs to the scientific basis for.utilization as a potential ther.py against COVID-19 infection and pr.vide new insights on the integr.tion of allopathy and tr.ditional *** advocated the combination of these two systems of tr.atment will ascer.ain their.integr.tions,and ther. would be a good possibility and scope for.developing a model of integr.tion in the management of *** discussion may help r.sear.her.,physicians,and healthcar. policymaker. to encour.ge for.effective and integr.ted use of allopathic and Ayur.edic medicines to contr.l the COVID-19 pandemic mor. effectively.

关键词： COVID-19 allopathy tr.ditional medicine integr.tion pr.mising ther.py

Enantioselective ir.dium-catalyzed allylic substitution with a r.for.atsky r.agent: dir.ct constr.ction of β-ster.ogenic homoallylic ester.

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Science China Chemistr. 2024年第11期67卷 3791-3797页

作者： Debasis pal Kir.na DVeer.nna Yuk Fai Wong PAndr.w Evans Depar.ment of Chemistr. Queen’s University90 Bader LaneKingstonK7L 3N6Canada Xiangya School of Phar.aceutical Sciences Central South UniversityChangsha410013China

The r.for.atsky r.agent der.ved fr.m ethyl br.moacetate cir.umvents the challenge associated with the dir.ct r.gio-and enantioselective ir.dium-catalyzed allylic alkylation with an unstabilized aliphatic ester.enolate. Notably, this wor. r.pr.sents the fir.t example of using a r.for.atsky r.agent in a metal-allyl r.action, which per.its the dir.ct constr.ction of enantioenr.ched β-ster.ogenic homoallylic ester. without pr.activation of the pr.nucleophile or.post-r.action modification of the pr.duct(e.g., ther.al decar.oxylation of a 1,3-dicar.onyl). Mor.over. the pr.cess allows the coupling of a br.ad r.nge of ster.cally and electr.nically diver.e electr.philes bear.ng ar.l, heter.ar.l and alkenyl der.vatives, including the significantly mor. challenging alkyl-substituted allylic car.onates. The ver.atility of the ester.pr.duct is exemplified by a ser.es of functional gr.up manipulations and the development of a concise and efficient enantioselective total synthesis of the natur.l pr.duct,(+)-descur.inolide A. Finally, mechanistic studies indicate that the zinc enolate behaves as a soft nucleophile that under.oes outer.spher. alkylation.

关键词： allylic substitution asymmetr.c catalysis mechanistic studies natur.l pr.duct synthesis r.for.atsky r.agent

Ther.al Pr.per.ies of Ni–Cr.Si–B–Fe Based Inter.ayer.Mater.al and Its Application in TLP Bonding of IN 718 Super.lloy

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Acta Metallur.ica Sinica(English Letter.) 2020年第12期33卷 1666-1680页

作者： U.K.Tar.i P.S.r.bi Sukhomay pal Depar.ment of Mechanical Engineer.ng IIT GuwahatiGuwahati 781039India

A new Ni–Cr.Si–B–Fe fi ller.mater.al is pr.par.d for.tr.nsient liquid-phase(TLP)bonding of Inconel 718 super.lloy by mechanical alloying *** melting temper.tur. r.nge of the fi ller.mater.al and its activation ener.y of melting ar. deter.ined by diff er.ntial scanning calor.metr. *** activation ener.y and melting temper.tur. of the alloy powder.decr.ase with incr.asing milling *** 718 alloy was joined via TLP by using the newly developed fi ller.*** eff ect of TLP bonding temper.tur. and time on micr.str.ctur.l evolution and mechanical pr.per.ies of the joint was *** distinct micr.str.ctur.l r.gions wer. obser.ed in the bonding ar.a:isother.al solidifi cation zone consisting of a single-phase solid solution,diff usion aff ected zone consisting of extensive diff usion-induced pr.cipitates of metallic bor.de,and unaff ected base *** ultimate shear.str.ngth and micr.har.ness of the TLP-bonded joint incr.ase with bonding time and temper.tur..

关键词： Tr.nsient liquid-phase(TLP)bonding Kissinger.plot Mechanical alloying Inconel 718

Pipes with Tr.pezoidal Cut Twisted Tape Inser.s in the Laminar.Flow r.gime:Nusselt Number.and Fr.ction Coefficient Analysis

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Fluid Dynamics & Mater.als Pr.cessing 2023年第2期19卷 501-511页

作者： Shr.kant Ar.nr.o Thote Netr. pal Singh Depar.ment of Mechanical Engineer.ng Oriental UniversityIndore453555India

The ther.al behavior.of pipes with a twisted tape inside(used to enhance heat tr.nsfer.thr.ugh the tube wall)is studied in the laminar.flow *** is used as the wor. fluid with the cor.esponding r.ynolds Number.spanning the inter.al 200–*** is found that in such conditions the‘Nusselt Number.(Nu)gr.dually incr.ases with r.ducing the tape twist r.tio,wher.as the fr.ction factor.is detr.mentally affected by the pr.sence of the tape(as witnessed by the compar.son with the companion case wher. a plain tube is consider.d).In par.icular.it is shown that the heat tr.nsfer.efficiency can be impr.ved by near.y 69%if tape inser.s with a r.latively low twist r.tio ar. *** the basis of these findings,it is concluded that loose fit tape inser.s ar. super.or.to tight fit tapes in ter.s of heat tr.nsfer.and ease of r.placement.

关键词： Fr.ction factor laminar.flow Nusselt Number tr.pezoidal-cut twisted tape