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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho pablo D rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Preliminary results of a new intrastromal corneal ring segment as a tissue saving procedure in photorefractive keratectomy to correct moderate to high myopia

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1955-1960页

作者： Sandro Coscarelli pablo rodrigues Guilherme Rocha Leonardo Torquetti Ennio Coscarelli Eye Clinic Belo Horizonte 30140-001Brazil Escola Paulista de Medicina Sao Paulo 04023-062Brazil Hospital de Olhos de Brasilia Brasilia 70200-670Brazil Center of Excellence in Ophthalmology Para de Minas 35660-051Brazil

AIM:To evaluate the clinical results after implantation of a new intrastromal corneal ring segment(ICRS)associated with photorefractive keratectomy(PRK)to correct high myopia(HM)patients with thin ***:We evaluated 42 eyes of 23 HM patients that had ICRS implantation followed by *** mean age of patients was 29.1±7.12 y(range 18 to 40 years old).Uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),keratometry,spherical equivalent,pachymetry,and aberrometry were compared using ANOVA with repeated measurements evaluated preoperatively and at last follow-up visit after the *** refractive predictability and simulated/real corneal ablation were also ***:The mean follow-up time after PRK was 6.8±1.6 *** mean preoperative UCVA improved from 20/800 preoperative to 20/100 after ICRS and 20/35 after *** mean preoperative BCVA was 20/25(range from 20/30 to 20/20)and remained unchanged after ICRS *** the PRK the mean BCVA was 20/25(range from 20/30 to 20/20).The mean spherical equivalent decreased from-7.25±1.12(range-5.00 to-9.00)preoperatively to-3.32±1.0(range-2.00 to-5.00)postoperatively(P<0.001)after ICRS implantation and decreased from-2.44±1.51 preoperatively to 0.32±0.45(range-0.625 to 0.875)postoperatively(P<0.001)after *** change in BCVA and topographic astigmatism was statistically significant(P<0.0001).CONCLUSION:ICRS in HM associated with PRK can be a tissue saving procedure and an alternative surgical option for correction of moderate to high myopia.

关键词： high myopia intrastromal corneal ring segments photorefractive keratectomy

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Internet of things:Conceptual network structure,main challenges and future directions

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Digital Communications and Networks 2023年第3期9卷 677-687页

作者： Leonardo B.Furstenau Yan pablo Reckziegel rodrigues Michele Kremer Sott Pedro Leivas Michael S.Dohan José Ricardo López-Robles Manuel J.Cobo Nicola Luigi Bragazzi Kim-Kwang Raymond Choo Department of Industrial Engineering Federal University of Rio Grande do SulPorto Alegre 90035-190Brazil University of Santa Cruz do Sul Av.Independencia2293Santa Cruz do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Lakehead University Thunder BayONP7B 5E1Canada Academic Unit of Accounting and Management Autonomous University of ZacatecasCalle Comercio y Administracion S/NFracc.ProgresoC.P.98066ZacatecasZacatecasMexico Department of Computer Science and Artificial Intelligence University of Granada18071 GranadaSpain York University ONM3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Internet of Things(IoT)is a key technology trend that supports our digitalized society in applications such as smart countries and smart *** this study,we investigate the existing strategic themes,thematic evolution structure,key challenges,and potential research opportunities associated with the *** this study,we conduct a Bibliometric Performance and Network Analysis(BPNA),supplemented by an exhaustive Systematic Literature Review(SLR).Specifically,in BPNA,the software SciMAT is used to analyze 14,385 documents and 30,381 keywords in the Web of Science(WoS)database,which was released between 2002 and *** results reveal that 31 clusters are classified according to their importance and development,and the conceptual structures of key clusters are presented,along with their performance analysis and the relationship with other *** thematic evolution structure describes the important cluster(s)over *** the SLR,23 documents are *** SLR reveals key challenges and limitations associated with the *** expect the results will form the basis of future research and guide decision-making in the IoT and other supporting industries.

关键词： Internet of things Strategic intelligence Industry 4.0 SciMAT Bibliometric analysis Science mapping

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The Harvesting of the Endangered Palm Euterpe edulis in the Brazilian Atlantic Forest: The Case of Linear Canopy Openings

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Journal of Geoscience and Environment Protection 2023年第12期11卷 151-162页

作者： pablo José Francisco Pena rodrigues Mariana de Andrade Iguatemy Talita Reis Instituto de Pesquisas Jardim Botanico do Rio de Janeiro Rua Pacheco Le&#227o Rio de Janeiro Brazil

The palm Euterpe edulis was historically very exploited by humans and even today, many individuals are cut down by collectors to harvest the edible palm hearts. The ecological aspects of this anthropogenic pressure and its related effects are poorly understood. Here we investigate if linear canopy openings in a fragment of Brazilian Atlantic Forest can cause edge effects and facilitate predatory harvesting by humans. We sampled in Tinguá Biological Reserve (Southeastern Brazil) native palm populations at forest edges adjacent to two linear canopy openings, and in the forest interior far from any edge. Our 8-year monitoring showed that the linear canopy openings negatively affected the palm populations reducing its density and regeneration mainly on edges, but no local extinction was observed. Thus, the direct human impact from harvesting, adverse survival conditions on edges and interspecific competition causes population declines with no local extinction, so this suggests that E. edulis may resist even under strong anthropogenic pressure.

关键词： Extinction Exploitation Forest Product Species Survival Sustainability

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The effect of water-level fluctuations on swamp forest colonization by seedlings of <i>Tabebuia cassinoides</i>DC. (Bignoniaceae)

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Open Journal of Ecology 2011年第3期1卷 63-64页

作者： Mariana de Andrade Iguatemy pablo José Francisco Pena rodrigues 不详

Establishment of Tabebuia cassinoides seedlings is related to water-level fluctuations in southeastern Brazil swamp forests. Nine years of annual monitoring of 48 individuals established during a drought in November 1997, when the swamp was unflooded, suggested that their establishment depends on this unpredictable event. This conclusion is further sustained by the wide variability of the seedling cohort size structure, and the fascicular root conformation that holds the shoots erect.

关键词： Tropical Rain Forest Wetland Seedling Establishment Safe Site Root Morphology

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Does Linear Canopy Openings in a Lowland Atlantic Tropical Forest Cause Edge Effects on Seedling Communities?

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Open Journal of Ecology 2014年第15期4卷 945-949页

作者： pablo J. F. Pena rodrigues Mariana A. Iguatemy Marcelo T. Nascimento Instituto de Pesquisas Jardim Botanico do Rio de Janeiro Rio de Janeiro-RJ Brazil Universidade Estadual do Norte Fluminense Darcy Ribeiro Campos dos Goytacazes-RJ Brazil

Edge effects and linear canopy openings may change ecological patterns and processes on forests. Here we investigate if these openings in a lowland Brazilian Atlantic forest cause edge effects on seedlings. We sampled seedling communities at forest edges near to two linear canopy openings (gas pipeline and power line) and in interiors far from edges. Comparisons between the seedling communities were performed to access edge effects. Density and basal area patterns were compared using, hierarchical two-way ANOVAs and the number of newly germinated seedlings, mortality and resprouts were compared by one-way ANOVAs. The results showed that edge effects of linear canopy openings affect seedling communities leading to low densities on edges that showed less favorable conditions for arrival, establishment and initial survival. The basal area patterns were not affected by edge effects apparently by the resistance of the seedlings that have more than 4 mm diameter. Therefore, linear canopy openings caused edge effects, which determine low seedling densities on edges. However this pattern is not due to increase mortality on these edges, but probably caused by the reduction on germination and establishment.

关键词： Forest Regeneration Fragmentation Disturbance Human-Modified Habitats Secondary Forests

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Edge Effects of Oil Pipeline Canopy Openings on Tree Community Structure and Dynamics in a Montane Atlantic Forest

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Journal of Geoscience and Environment Protection 2016年第7期4卷 132-140页

作者： pablo J. F. Pena rodrigues Leticia R. Melo Rodolfo C. R. de Abreu Mariana A. Iguatemy Instituto de Pesquisas Jardim Botanico do Rio de Janeiro Rio de Janeiro-RJ Brazil

The Atlantic forest has historically been severely deforested, and only fragments currently remain that are subject to a wide variety of anthropogenic impacts, including edge effects that can cause structural and functional degradation. The Tinguá Biological Reserve-RJ comprises approximately 26,000 hectares of well-preserved Atlantic Forest, but it is subject to impacts caused by two canopy openings along oil pipelines. Comparisons were made between pipeline edges and forest interiors to evaluate edge effects on the structure and dynamics of those tree communities. Tree densities were higher along forest edges, apparently increasing over time. Tree basal areas, on the other hand, have decreased along edges due to higher mortality rates. Linear canopy opening edges showed higher densities of small trees, while the interior had more very large trees, indicating changes in successional processes and community structural patterns due to edge effects.

关键词： Fragmentation Disturbance Human-Modified Habitats Linear Canopy Openings Human Impact

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Effect of Osmotic Stress on the Initial Development of Bean Seedlings

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American Journal of Plant Sciences 2014年第13期5卷 1973-1982页

作者： pablo Diego Silva Cabral Leonardo N.S.dos Santos Henrique Duarte Vieira Tais Cristina Bastos Soares Cintia Aparecida Bremenkamp Weverton Pereira rodrigues University of North Rio de Janeiro State Darcy Ribeiro Rio de JaneiroBrazil Faculty of Agricultural Engineering University of CampinasSao PauloBrazil Agricultural Sciences Center Federal University of Espirito SantoVictoriaBrazil Instituto Capixaba de Pesquisa e Extensao Rural—INCAPER VictoriaBrazil

One of the methods to determine the tolerance of plants to water stress is the observation of germination of seeds under stress induced in laboratory conditions. Thus, the aim was to evaluate the response of four common bean cultivars to water deficit simulated under laboratory conditions. Two common landrace genotypes acquired from farmers (FORT 07 and FORT 08) and two commercial cultivars, IAPAR 81 and Serrano were evaluated. The different levels of water deficit were induced with mannitol solution. The experimental design was completely randomized and a factorial scheme 5 × 4 (osmotic potential x genotypes), with four replications. The characteristics: primary root protrusion, seed vigor, normal and abnormal seedling, seedling and root length, fresh and dry weight of seedling and root were evaluated. By reducing the osmotic potential seedling vigor bean was more affected than the primary root protrusion. Regardless of cultivar, there was a significant and progressive reduction in the normal seedlings percentage from potential -0.3 MPa. The IAPAR 81 and FORT 07 cultivars showed higher tolerance to water deficit compared to other cultivars.

关键词： Phaseolus vulgaris L. Mannitol Water Stress

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