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Preliminary results of a new intrastromal corneal ring segment as a tissue saving procedure in photorefractive keratectomy to correct moderate to high myopia

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1955-1960页

作者： Sandro Coscarelli pablo Rodrigues Guilherme Rocha Leonardo Torquetti Ennio Coscarelli Eye Clinic Belo Horizonte 30140-001Brazil Escola Paulista de Medicina Sao Paulo 04023-062Brazil Hospital de Olhos de Brasilia Brasilia 70200-670Brazil Center of Excellence in Ophthalmology Para de Minas 35660-051Brazil

AIM:To evaluate the clinical results after implantation of a new intrastromal corneal ring segment(ICRS)associated with photorefractive keratectomy(PRK)to correct high myopia(HM)patients with thin ***:We evaluated 42 eyes of 23 HM patients that had ICRS implantation followed by *** mean age of patients was 29.1±7.12 y(range 18 to 40 years old).Uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),keratometry,spherical equivalent,pachymetry,and aberrometry were compared using ANOVA with repeated measurements evaluated preoperatively and at last follow-up visit after the *** refractive predictability and simulated/real corneal ablation were also ***:The mean follow-up time after PRK was 6.8±1.6 *** mean preoperative UCVA improved from 20/800 preoperative to 20/100 after ICRS and 20/35 after *** mean preoperative BCVA was 20/25(range from 20/30 to 20/20)and remained unchanged after ICRS *** the PRK the mean BCVA was 20/25(range from 20/30 to 20/20).The mean spherical equivalent decreased from-7.25±1.12(range-5.00 to-9.00)preoperatively to-3.32±1.0(range-2.00 to-5.00)postoperatively(P<0.001)after ICRS implantation and decreased from-2.44±1.51 preoperatively to 0.32±0.45(range-0.625 to 0.875)postoperatively(P<0.001)after *** change in BCVA and topographic astigmatism was statistically significant(P<0.0001).CONCLUSION:ICRS in HM associated with PRK can be a tissue saving procedure and an alternative surgical option for correction of moderate to high myopia.

关键词： high myopia intrastromal corneal ring segments photorefractive keratectomy

Protein Shuttle between Nucleus and Cytoplasm:New Paradigms in the ABI5-dependent ABA Responses

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Molecular Plant 2019年第11期12卷 1425-1427页

作者： Inmaculada Sanchez-Vicente pablo Albertos Oscar Lorenzo Dpto.de Botanica y Fisiologia Vegetal Instituto Hispano-Luso de Investigaciones Agrarias(CIALE)Facultad de BiologiaUniversidad de SalamancaC/Rio Duero 1237185 SalamancaSpain Present address:Biotechnology in Horticultural Crops TU Munchen-WeihenstephanLiesel-Beckmann-Strasse 185354 FreisingGermany

Plant survival depends on seed germination,progression through post-germinative developmental checkpoints,and adaptation to abiotic *** these processes underlie a tightly controlled regulation by the stress hormone abscisic acid(ABA)at different levels,even though the main research focuses on changes in transcript and protein ***,protein fate undergoes complex readjustments that allow signal transduction to be integrated into physiological *** them,protein redox status,stability,capacity of oligomerization,formation of complexes,and subcellular compartmentalization become key points for plant reprogramming against stresses to acquire an optimal *** this Spotlight,we highlight and discuss the latest advances in dissecting the mechanisms driving protein dynamics of nucleocytoplasmic trafficking in the cell and its relevance for regulating the stability of ABI5 and the ABI5-dependent AB A signaling pathway(Figure 1).

关键词： Figure driving programming

The Case of the Carnian(Triassic) Conodont Genus Metapolygnathus Hayashi

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Journal of Earth Science 2015年第2期26卷 219-223页

作者： Ali Murat Kili pablo Plasencia Keisuke Ishida Francis Hirsch Department of Geological Engineering Balikesir University Department of Geology and ICBIBE University of ValenciaDr. Moliner 50. 46100 Burjassot Spain Laboratory of Geology Faculty of Sciences Tokushima University Laboratory of Geology Faculty of Sciences Naruto University

Successive evolutionary trends control the genera Paragondolella Mosher and Meta- polygnathus Hayashi over the about 20 Ma long Aegean-Tuvalian timespan. In consideration of their evolutionary criteria, these genera have been retained together with Carnepigondolella Kozur and the two new genera proposed herein, MazzaeUa （type species M. carnica） and Hayashiella （type species H. nodosa）. Mazzaella n. gen. represents a Late Julian side branch ofMetapolygnathus, harbouring a platform ornamentation similar to the several million years younger Tuvalian lineage of Carnepigondolella, issued from Hayashiella n. gen. that is intermediary between Metapolygnathus and CarnepigondoleUa, based on appearance and platform ornamentation.

关键词： Carnian conodont phylogeny evolutionary trend.

IMPACTS OF CONSTRUCTION RISKS ON COSTS IN LEED-CERTIFIED PROJECTS

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Journal of Green Building 2016年第4期11卷 163-181页

作者： Asli Pelin Gurgun David Arditi pablo Casals Vilar Department of Civil Engineering Yildiz Technical UniversityDavutpasa Campus34220IstanbulTurkey. Construction Engineering and Management Program Illinois Institute of TechnologyDepartment of CivilArchitectural and Environmental EngineeringAlumni Memorial HallRoom 229ChicagoIL 60616USA. Construction Engineering and Management Program Illinois Institute of TechnologyDepartment of CivilArchitectural and Environmental Engineering IL60616USA

Construction according to green principles rather than traditional methods poses a new set of risks to project *** risks should be appropriately identified and managed in order to prevent cost *** study aims to identify construction risks and their cost impacts in LEED-certified *** this purpose,thirteen risks were identified based on a literature survey and were categorized under four groups of issues:(i)consultant,contractor and subcon-tractor,(ii)material,product and process,(iii)legal,regulatory and contractual,and(iv)financial and economic.A survey was then administered to green build-ing design and construction practitioners in the *** assess the likelihood of occurrence of these risks and their respective impacts on project *** to the survey results,the risks associated with consultant,contractor and subcon-tractor issues have the highest expected impact on *** top five risk factors were determined as(1)contractors and subcontractors agreeing to standards that are not within their expertise and competence,(2)high cost of certification,(3)lack of expertise in new products/technologies,(4)doubts about the long-term viability and performance of new and untested products,materials and tech-nologies,and(5)inadequate definition of project parties’contractual roles and *** the cost impact of risks is of great value to owners and designers and *** the risks associated with LEED-certified projects and their cost impacts can be of benefit to all practitioners.

关键词： green construction LEED certification risk cost green risk management

Insights into the Tricholomatineae (Agaricales, Agaricomycetes): a new arrangement of Biannulariaceae and Callistosporium, Callistosporiaceae fam. nov., Xerophorus stat. nov., and Pleurocollybia incorporated into Callistosporium

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Fungal Diversity 2020年第2期101卷 211-259页

作者： Alfredo Vizzini Giovanni Consiglio Mauro Marchetti pablo Alvarado Department of Life Sciences and Systems Biology University of TorinoViale P.A.Mattioli 2510125 TurinItaly Institute for Sustainable Plant Protection(IPSP-SS Turin) C.N.R.Viale P.A.Mattioli2510125 TurinItaly Via Ronzani 61 Casalecchio di Reno40033 BolognaItaly Via Molise 8 56123 PisaItaly ALVALAB Dr.Fernando Bongera St.Severo Ochoa Bldg.S1.0433006 OviedoSpain

A new classification of the taxa formerly ascribed to Biannulariaceae(≡Catathelasmataceae),***(type),Callistosporium,Pleurocollybia,Macrocybe,Pseudolaccaria,Guyanagarika and Anupama is here *** inference of the Tricholomatineae based on the analysis of a combined dataset of nuclear genes including ITS,18S and 28S rDNA,tef1 and rpb2 data supports significantly a monophyletic origin of the aforementioned genera with the exception of Catathelasma,which is significantly related with Bonomyces and *** is therefore emended to include the clade formed by Catathelasma,Bonomyces and ***,the new family Callistosporiaceae is proposed to name the clade containing Callistosporium(=Pleurocollybia)and related *** of Callistosporium with distant lamellae,long hygrophoroid basidia and large amygdaliform spores are accommodated in the new genus ***,the new species Callistosporium pseudofelleum and Macrocybe sardoa are described,Clitocybe hesleri and *** are combined into Callistosporium and Pseudolaccaria,respectively,and Callistosporium olivascens *** is upgraded to species rank and combined into Xerophorus.

关键词： Basidiomycota Tricholomatoid clade Catathelasma clade Multigene phylogenetic analysis Taxonomy

Condition-dependence and sexual ornamentation： Effects of immune challenges on a highly sexually dimorphic grasshopper

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Insect Science 2018年第4期25卷 617-630页

作者： J. pablo Valverde Hendrik Eggert Joachim Kurtz Holger Schielzeth Department of Evolutionary Biology Bielefeld University Bielefeld Germany Institute for Evolution and Biodiversity Westfalische Wilhelms-Universitat Munster Munster Germany and 3 Department of Population Ecology Institute of Ecology Friedrich Schiller University Jena Germany Department of Population Ecology Institute of Ecology Friedrich Schiller University Jena Germany

Sexual ornaments contribute substantially to phenotypic diversity and it is particularly relevant to understand their evolution. Ornaments can assume the function of signals-of-quality that the choosy sex uses to evaluate potential mating partners. Often there are no obvious direct benefits and investment into mate choice is primarily rewarded by beneficial alleles that are inherited to the offspring. Inter-sexual communication via sexual ornaments requires honesty of the sexual signal, yet the question of what maintains honesty remains only partially solved. One solution is that honesty is maintained by trait expression being dependent on individual condition, since condition-dependent trait expression offers an effectively inexhaustible source of genetic variability. Here we test in the highly sexually dimorphic club-legged grasshopper Gomphocerus sibiricus if putative sexual ornaments, in particular the striking front-leg clubs, are more strongly affected by a lipopolysaccharide （LPS） immune challenge than putatively not sexually selected traits. Our results show overall little condition-dependent expression of morphological and song traits, with sexually selected traits exhibiting effects comparable to nonsexually selected traits （with the possible exception of stridulatory file length and syllable-to-pause ratio in advertisement songs）. Interestingly, field observations of individuals of lethally parasitized individuals suggest that a very strong environmental challenge can specifically affect the expression of the front-leg clubs. The presence of 1% of males in natural populations with missing or heavily deformed clubs plus 5% with minor club deformations furthermore indicate that there are risks associated with club development during final ecdysis and this might act as a filter against deleterious alleles.

关键词： Acrididae honest signaling Orthoptera phenotypic plasticity sexualselection

Lessons learned from requirements gathering for virtual reality simulators

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Virtual Reality & Intelligent Hardware 2021年第5期3卷 407-422页

作者： Vivian GÓMEZ Kelly PEÑARANDA pablo FIGUEROA Department of Systems and Computing Engineering Universidad de Los AndesBogotá7620001Colombia

Background This paper shows how current collaborative virtual environments(VEs)such as Mozilla Hubs and AltspaceVR can aid in the task of requirements gathering in VR for simulation and *** We performed a qualitative study on our use of these technologies in the requirements gathering of two *** Our results show that requirements gathering in virtual reality has an impact on the process of requirements *** report advantages and shortcomings that will be of interest to future *** example,we found that VR sessions for requirements gathering in current VEs could benefit from better pointers and better sound *** Current VEs are useful for the requirements gathering task in the development of VR simulators and VR training environments.

关键词： Human computer interaction Virtual environment Requirements gathering Globally dispersed teams VR simulators and training

A GIS-based methodology for the appraisal of historical,architectural,and social values in historic urban cores

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Frontiers of Architectural Research 2020年第4期9卷 900-913页

作者： Juan A.Garcia-Esparza pablo Altaba Tena Department of Mechanical Engineering and Construction Universitot Jaume I12071Castello de la PlanaSpain

Historic environments represent the evolution of materials and techniques that have been used for the construction these environments over the *** into the study of this field entails working not only on the crafts that have constructed these environ ments but also on the people who made,used,and reinterpreted them by learning about the craftsmen and the idiosyncrasies of the *** study has adopted several methodologies as referenee to examine the material and cultural reality of the rural region of Valencia,*** the adaptation of in ter national methodologies,researchers have carried out a digital database that compiles and maps out the results of the Local Character Assessment of ten Histotiric Urban Cores by incorporating the historical,architectural,and social values to reinforce the Territorial Heritage Action *** of the critical innovations adopted by this form of assessment is the compulsory integration of tangible and intangible heritage through the active involvement of users and *** innovation is to understand the values behind the dynamism and transformation of historic ***,this study advances theory and practice on the transmission of knowledge among artisans,researchers,and the population and how con temporary practices help acquire new meani ngs that overlap the past ones.

关键词： Historic environment Local Character Assessme nt Digital heritage GIS for heritage Heritage values

Phase separating Rho:a widespread regulatory function of disordered regions in proteins revealed in bacteria

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3203-3205页

作者： Eric Schumbera pablo Mier Miguel A.Andrade-Navarro Institute of Organismic and Molecular Evolution Faculty of BiologyJohannes Gutenberg University of Mainz55128 MainzGermany

A recent study published in Science by Krypotou et *** the role of an intrinsically disordered region(IDR)in the transcription termination Rho protein from Bacteroides thetaiotaomicron:in response to starvation Rho phase separated,which triggered an increase in Rho activity and expression changes.1 These results demonstrate that a highly conserved protein can acquire new regulatory properties in evolution by gaining an IDR that leads to protein phase separation.

关键词： al. disordered separating