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Hepatitis A vaccine associated with autoimmune hepatitis

World Journal of Gastroenterology 2007年第15期13卷 2238-2239页

作者： pa berry G Smith-Laing Medway Maritime Hospital Windmill Road GillinghamKentUnited Kingdom

To describe a case of probable relapsing autoimmune hepatitis associated with vaccination against hepatitis A virus （HAV）. A case report and review of literature were written concerning autoimmune hepatitis in association with hepatitis A and other hepatotropic viruses. Soon a^er the administration of formalin-inactivated hepatitis A vaccine, a man who had recently recovered from an uncharacterized but self-limiting hepatitic illness, experienced a severe deterioration （AST 1687 U/L, INR 1.4）. Anti-nuclear antibodies were detectable, and liver biopsy was compatible with autoimmune hepatitis. The observation supports the role of HAV as a trigger of autoimmune hepatitis. Studies in helper T-cell activity and antibody expression against hepatic proteins in the context of hepatitis A infection are summarized, and the concept of molecular mimicry with regard to other forms of viral hepatitis and autoimmunity is briefly explored.

关键词： Hepatitis A virus Vaccine Autoimmune hepatitis Helper T-cell Molecular mimicry

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Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

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Nano Research 2015年第10期8卷 3281-3292页

作者： Mark McCully Yulan Hernandez Joao Conde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling Catherine C. berry CentreforCellEngineering UniversityofGlasgowGlasgowG128QQScotlandUK InstituteofNanoscienceofAragon UniversityofZaragozaZaragoza50018Spain MassachusettsInstituteofTechnology InstituteforMedicalEngineeringandScienceHarvard-MITDivisionforHealthSciencesandTechnologyCambridgeMassachusetts02139USA UCIBIO DepartamentodeCienciasdaVidaFaculdadedeCienciaseTecnologiaUniversidadeNovadeLisboaCampusdeCaparicaCaparica2829-516Portugal InstitutodeCienciadeMaterialesdeAragon(ICMA) CSIC-UniversidaddeZaragozac/PedroCerbuna12Zaragoza50009Spain InstituteofNanoBiomedicineandEngineering KeyLaboratoryforThinFilmandMicrofabricationTechnologyoftheMinistryofEducationResearchInstituteofTranslationMedicineShanghaiJiaoTongUniversityDongchuanRoad800Shanghai200240China SchoolofScience UniversityoftheWestofScotlandPaisleyPA12BEScotlandUK

The therapeutic promise of small interfering RNAs （siRNAs） for specific gene silencing is dependent on the successful delivery of functional siRNAs to the cytoplasm. Their conjugation to an established delivery platform, such as gold nanoparticles, offers tremendous potential for treating diseases and advancing our understanding of cellular processes. Their success or failure is dependent on both the uptake of the nanoparticles into the cells and subsequent intracellular release of the functional siRNA. In this study, utilizing gold nanoparticle siRNA-mediated delivery against C-MYC, we aimed to determine if we could achieve knockdown in a cancer cell line with low levels of intracellular glutathione, and determine the influence, if any, of polyethylene glycol （PEG） ligand density on knockdown, with a view to determining the optimal nanoparticle design to achieve C-MYC knockdown. We demonstrate that, regardless of the PEG density, knockdown in cells with relatively low glutathione levels can be achieved, as well as the possible effect of steric hindrance of PEG on the availability of the siRNA for cleavage in the intracellular environment. Gold nanoparticle uptake was demonstrated via transmission electron microscopy and mass spectroscopy, while knockdown was determined at the protein and physiological levels （cells in S-phase） by in-cell westerns and BrdU incorporation, respectively.

关键词： gold nanoparticles PEG glutathione siRNA drug delivery

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高磷喂食诱导运动不耐受并损害小鼠的脂肪酸代谢

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中华高血压杂志 2019年第2期27卷 148-148页

作者：刘青叶鹏 Peri-Okonny pa Baskin KK Iwamoto G Mitchell JH Smith SA Kim HK Szweda LI Bassel-Duby R Fujikawa T Castorena CM Richardson J Shelton JM Ayers C berry JD Malladi VS Hu MC Moe OW Scherer PE Vongpatanasin W

无机磷酸盐(inorganic phosphate,Pi)广泛用作西方饮食中的防腐剂和增味剂。缺乏身体活动是西方社会的共同特征,与心血管病的发病率和死亡率增加有关。目前尚不清楚饮食中Pi过量是否会导致运动不耐受和身体活动缺乏。为了确定人体中Pi... 详细信息

无机磷酸盐(inorganic phosphate,Pi)广泛用作西方饮食中的防腐剂和增味剂。缺乏身体活动是西方社会的共同特征,与心血管病的发病率和死亡率增加有关。目前尚不清楚饮食中Pi过量是否会导致运动不耐受和身体活动缺乏。为了确定人体中Pi过量和体力活动之间的关联,研究者在调整了相关变量后,评估DHS-2(达拉斯心脏研究第2阶段)参与者的血清Pi与活动记录测定的身体活动水平以及心脏磁共振成像的左心室功能之间的关系。

关键词：无机磷酸盐不耐受脂肪酸代谢运动小鼠损害喂食身体活动

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RACIAL DIFFERENCES OF OPTIC DISC TOPOGRAPHY IN OCULAR HYPERTEN- SIVE EYES: RESULTS FROM THE CON- FOCAL SCANNING LASER OPHTHAL- MOSCOPY ANCILLARY STUDY TO THE OCULAR HYPERTENSION TREATMENT STUDY

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国际眼科杂志 2003年第1期3卷 92-92页

作者： L.M.Zangwill R.N.Weinreb C.C.berry A.R.Smith K.A.Dirkes A.L.Coleman J.R.Piltz-Sevmour J.L.Liebmann G.A.Cioffi G.Trick J.D.Brandt M.O.Gordon M.A.Kass University of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at Los Angeles CAUniversity of Pennsyl-vania PANew York Eye and Ear Infirmary NY.Devers Eye Institute ORHenry Ford Medical Center MIUniversity of California St Davis CAWashington University School of Medicine MI USAWashington University School of Medicine MI USA

Purpose: To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study (OHTS). Methods: 436 participants

关键词：高眼压视神经盘地形图人种差异共聚焦扫描激光眼科显微镜治疗

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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