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On the Fourth Power Mean of the Character Sums Over Short Intervals

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Acta Mathematica Sinica,English Series 2007年第1期23卷 153-164页

作者： Wen peng ZHANG Xiao ying WANG Research Center for Basic Science Xi'an Jiaotong University Xi'an 710049 P. R. China

The main purpose of this paper is to study the mean value properties of the character sums over the interval [1,p/8） by using the mean value theorems of the Dirichlet L-functions, and give an interesting mean value f... 详细信息

关键词： character sums short intervals fourth power mean asymptotic formula

Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 177-192页

作者： peng Liu ying peng Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Henan Key Laboratory of Biomolecular Recognition and Sensing Shangqiu Normal UniversityShangqiu 476000China

Chemodynamic therapy(CDT)is considered as a promising modality for selective cancer therapy,which is realized via Fenton reaction-mediated decomposition of endogenous H_(2)O_(2) to produce toxic hydroxyl radical(•OH)for tumor *** extensive efforts have been made to develop CDT-based therapeutics,their in vivo efficacy is usually unsatisfactory due to poor catalytic activity limited by tumor microenvironment,such as anti-oxidative systems,insufficient H_(2)O_(2),and mild *** mitigate these issues,we have witnessed a surge in the development of CDT-based combinatorial nanomedicines with complementary or synergistic mechanisms for enhanced tumor *** virtue of their bio-imaging capabilities,Fenton metal nanomedicines(FMNs)are equipped with intrinsic properties of imaging-guided tumor *** this critical review,we summarize recent progress of this field,focusing on FMNs for imaging-guided combinatorial tumor ***,various Fenton metals with inherent catalytic performances and imaging properties,including Fe,Cu and Mn,were introduced to illustrate their possible applications for tumor ***,CDT-based combinatorial systems were reviewed by incorporating many other treatment means,including chemotherapy,photodynamic therapy(PDT),sonodynamic therapy(SDT),photothermal therapy(PTT),starvation therapy and ***,various imaging approaches based on Fenton metals were presented in ***,challenges are discussed,and future prospects are speculated in the field to pave way for future developments.

关键词： combinatorial medicines equipped

The Squeeze & Excitation Normalization Based nnU-Net for Segmenting Head & Neck Tumors

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Chinese Journal of Electronics 2024年第3期33卷 766-775页

作者： Juanying XIE ying peng Mingzhao WANG School of Computer Science Shaanxi Normal University

Head and neck cancer is one of the most common malignancies in the *** propose SE-nnU-Net by adapting SE(squeeze and excitation) normalization into nnU-Net,so as to segment head and neck tumors in PET/CT images by combining advantages of SE capturing features of interest regions and nnU-Net configuring itself for a specific *** basic module referred to convolution-ReLU-SE is designed for *** the encoder it is combined with residual structure while in the decoder without residual *** loss function combines Dice loss and Focal *** specific data preprocessing and augmentation techniques are developed,and specific network architecture is ***,the deep supervised mechanism is introduced to calculate the loss function using the last four layers of the decoder of *** SE-nnU-net is applied to HECKTOR 2020 and HECKTOR 2021 challenges,respectively,using different experimental *** experimental results show that SE-nnU-Net for HECKTOR 2020 obtained 0.745,0.821,and 0.725 in terms of Dice,Precision,and Recall,respectively,while the SE-nnU-Net for HECKTOR 2021 obtains 0.778 and 3.088 in terms of Dice and median HD95,*** SE-nnU-Net for segmenting head and neck tumors can provide auxiliary opinions for doctors diagnoses.

关键词： Image segmentation Head Data preprocessing Artificial neural networks Network architecture Data models Neck

Evaluating genetic insights into ulcerative colitis and anxiety:Limitations and future directions

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World Journal of Gastroenterology 2024年第37期30卷 4156-4159页

作者： ying peng Xi-Dai Long Department of Pathology The First Affiliated HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000Guangdong ProvinceChina Department of Pathology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China

We reviewed the study by He et al,which investigates the genetic correlation between ulcerative colitis(UC)and anxiety using bidirectional Mendelian *** study reveals a genetic link between UC and anxiety,diverging from prior research associating higher anxiety with Crohn’s *** the study's use of large-scale genome-wide association studies data is commendable,it faces limitations such as single nucleotide polymorphism selection biases,lack of multiple testing corrections,and a reliance on European *** research should address these limitations,incorporate diverse populations,and explore psychotherapeutic interventions to improve UC management and patient outcomes.

关键词： Ulcerative colitis Anxiety Mendelian randomization Genome-wide association study Gut-brain axis Instrumental variables Genetic epidemiology Pleiotropy

Properties and Microstructure of One-Step Cold Rolled Steel Strip for Shadow Mask

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Journal of Iron and Steel Research International 2008年第5期15卷 77-80,94页

作者： LIANG Xuan LI Jun peng ying-hong School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China Cold Rolling Mill Baoshan Iron and Steel Co Ltd Shanghai 200941 China

The effect of recrystallization annealing temperature on the properties and microstructure of one-step cold rolled steel strip for shadow mask was studied. The results showed that there was no yield point elongation when the tensile tests were performed on the samples for annealing temperatures ranging from 750 ℃ to 810 ℃. Moreover, increasing annealing temperature resulted in large grains, which was beneficial to the formability and magnetic property of steel strips. On the other hand, when the sample was annealed at 840 ℃, its microstructure showed ununiforrnity with 0.04 % yield point elongation, which was not good for the function of the shadow mask. Therefore, the proper recrystallization annealing temperature was about 810 ℃ for the present steel strip for shadow mask.

关键词： steel strip shadow mask mechanical property microstructure recrystallization annealing

The reaction of substituted ethylα-bromocinnamates with tetrabutyl ammonium fluoride

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Chinese Chemical Letters 2012年第7期23卷 777-780页

作者： Yan Liang ying peng Zhang Wei Yu School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China

The reaction of ethyl α-bromocinnamates with tetrabutyl ammonium fluoride（TBAF） was influenced largely by the position of the substituent at the phenyl *** the substrates without an ortho substituent at the phenyl ring were transformed to the corresponding β-fluoro ethyl cinnamates under the reaction conditions,the presence of an ortho substituent only resulted in the formation of ethyl 3-phenylpropiolate *** reaction of ethyl 2-bromo-3-（4-methoxyphenyl） acrylate also failed to deliver the hydrofluorination product due to the electron-donating effect of the methoxy group.

关键词： Tetrabutyl ammonium fluoride Ethyl α-bromocinnamates Hydrofluorination Elimination

CD103+ lung dendritic cells(LDCs)induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11b^(hi) LDCs

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Cellular & Molecular Immunology 2018年第4期15卷 377-387页

作者： Sudhanshu Shekhar ying peng Shuhe Wang Xi Yang Department of Medical Microbiology Faculty of MedicineUniversity of ManitobaWinnipegMBCanada Department of Immunology Faculty of MedicineUniversity of ManitobaWinnipegMBCanada

Recent studies suggest differential roles for CD103+and CD11bhi lung dendritic cells(LDCs)in host defense against viral and bacterial *** this study,we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection *** found that CD103+LDCs showed higher expression of costimulatory molecules(CD40,CD80 and CD86)and increased production of cytokines(IL-12p70,IL-10,IL-23 and IL-6)compared with CD11bhi LDCs,but the expression of programmed death-ligand 1(PD-L1)was similar between the two *** importantly,we found,in adoptive transfer experiments,that the mice receiving CD103+LDCs from Chlamydia-infected mice exhibited better protection than the recipients of CD11bhi LDCs,which was associated with more robust Th1/Th17 cytokine *** addition,in vitro experiments showed that CD103+LDCs induced stronger IFN-γand IL-17 responses,when cocutured with chlamydial antigen-primed CD4+T cells,than CD11bhi ***,the blockade of PD1 in the culture of CD4+T cells with either CD103+or CD11bhi LDCs enhanced production of IFN-γand *** conclusion,our data provide direct evidence that CD103+LDCs are more potent in promoting Th1/Th17 immunity to chlamydial lung infection than CD11bhi LDCs.

关键词： Chlamydia muridarum lung dendritic cell Th1/Th17 cells

Impact of Qi-invigorating traditional Chinese medicines on intestinal flora:A basis for rational choice of prebiotics

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Chinese Journal of Natural Medicines 2017年第4期15卷 241-254页

作者： WANG Xiao-Meng LI Xiao-Bo peng ying School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

According to the theory of traditional Chinese medicine(TCM), Qi(vital energy) is regarded as a driving force of biological activities in human body, including both nutrient substances and organ functions. Qi-invigorating TCMs are widely used to treat various symptoms and disorders, such as fatigue, obesity, immunosuppression, intestinal flora imbalance, and gastrointestinal diseases, in which Qi is considered to be reduced or depleted. Interestingly, abundant clinical evidences suggest that these disorders are associated with the alternation of intestinal flora, which directly affects disease status. Herein we review the interaction between gut microbiota and Qi-invigorating TCMs under healthy and disease conditions and discuss the mechanisms of action and applications of Qi-invigorating TCMs in enhancing health status through microbial alternation. A better understanding of the role of Qi-invigorating TCMs in modulating microbial composition and the association between intestinal microbiota and diseases would help reveal the clinical consequences of microbiota alteration and explore opportunities to harness this symbiotic relationship to improve public health.

关键词： Gut microbiota Traditional Chinese medicine Qi

Adsorption and Dissociation of Methanol on Pd(111), Pd/Au(111) and Pd/Rh(111) Surfaces

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Chinese Journal of Structural Chemistry 2019年第12期38卷 2057-2069页

作者： peng Xiao-ying FENG Sheng-Lei Nanchang Key Laboratory of Material and Structure Detection Jiangxi University of TechnologyNanchang 33009SChina

The adsorption and dissociation behaviors of methanol on Pd(111), Pd/Au(111) and Pd/Rh(111) surfaces were studied using a periodical slab model and the PW91 generalized gradient approximation(GGA) within the framework of first-principles calculations based on density functional theory(DFT). The adsorption energy and geometric parameters for the three surfaces showed that methanol is preferentially adsorbed onto the top-Pd sites and that the adsorption energy of methanol on these surfaces decreases in the order Pd/Au(111) > Pd/Rh(111) > Pd(111). After adsorption, the C–O, C–H and O–H bonds in methanol adsorbed onto these surfaces are elongated and the vibrational stretching frequency of the O–H bond is obviously redshifted. Furthermore, the first step for the possible dissociation pathway for methanol on these surfaces was calculated. Our results indicate that the O–H bond in methanol decomposes producing methoxy and a hydrogen atom, with the Pd/Au(111) surface exhibiting the smallest dissociation barrier.

关键词： density functional theory methanol metal surface adsorption dissociation