检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

二恶英类活性在成人体内相对效应潜能的估计

环境与职业医学 2013年第11期30卷 838-838页

作者： Tomá? Trnovec Todd A. Jusko Eva?ovíková Kinga Lancz Jana Chovancová Henrieta Patayová L'ubica Palkoviová Beata Drobná pavel Langer Martin Van den Berg Ladislav Dedik Sǒna Wimmerová

[背景]毒性当量因子(TEF)是二恶英类物质人体暴露风险评估的重要组成部分。目前,这一概念主要基于使用口服制剂的动物体内实验。因此,目前来自哺乳动物实验的人类TEF仅适用于在口服情况下发生的暴露。然而,这些"摄入量"的TEF通常——但... 详细信息

[背景]毒性当量因子(TEF)是二恶英类物质人体暴露风险评估的重要组成部分。目前,这一概念主要基于使用口服制剂的动物体内实验。因此,目前来自哺乳动物实验的人类TEF仅适用于在口服情况下发生的暴露。然而,这些"摄入量"的TEF通常——但非正确——被监管部门用于计算"系统性"毒性当量(TEQs),这些计算是基于人体血液和组织中的浓度,它们被作为暴露或效应的生物标志物。[目的]试图使用甲状腺体积或血清游离甲状腺素(FT4)浓度作为研究结果,来确定二恶英类混合物组分人体系统浓度的相对效应潜能(REP)。[方法]使用基准浓度和基于回归的方法,比较居住在斯洛伐克东部被一种有机氯污染的地区内320名成人体内各二恶英类化合物和甲状腺终点之间的关联强度。[结果]基于甲状腺体积和FT4计算的REP相似。从甲状腺体积和FT4水平得到的REP数据的回归系数(β)与世界卫生组织(WHO)的TEF值的呈正相关(Spearman相关分析,r=0.69,P=0.01和r=0.62,P=0.03)。计算的REP大多介于其他研究者体内试验REP的最小值和最大值之间。[结论]基于甲状腺终点计算的REP真实地反映了人体暴露场景,因为它们是基于慢性、低剂量的人体暴露和反映身体负担的生物标志物。与先前的结果相比,本文的REP显示出对二恶英类化合物效应有较高的灵敏度。

关键词：二恶英类多氯联苯(DL-PCB) 游离甲状腺素多氯二苯并二恶英(PCDDs) 多氯二苯并呋喃(PCDFs) 相对效应潜能(REP) 甲状腺体积毒性当量因子(TEF)

仅在永久性脑缺血后短暂出现的星形胶质细胞样NG2胶质细胞亚群

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2021年第8期16卷 F0003-F0003页

作者： Denisa Kirdajova Lukas Valihrach Martin Valny Jan Kriska Daniela Krocianova Sarka Benesova pavel Abaffy Daniel Zucha Ruslan Klassen Denisa Kolenicova pavel Honsa Mikael Kubista Miroslava Anderova 杜一星(编译) Department of Cellular Neurophysiology Institute of Experimental MedicineCzech Academy of SciencesPragueCzech Republic Second Faculty of Medicine Charles UniversityCzech Republic Laboratory of Gene Expression Institute of Biotechnology CASBIOCEVVestecCzech Republic Faculty of Chemical Technology Laboratory of Informatics and ChemistryUniversity of Chemistry and TechnologyPragueCzech Republic Faculty of Science Charles UniversityPragueCzech Republic 不详

NG2神经胶质细胞在生理和病理条件下显示出较强的增殖和分化潜力。本研究用3月龄Cspg4启动子下由tdTomato标记NG2神经胶质细胞的小鼠,在不同类型的脑疾病模型(局灶性脑缺血、皮质刺伤和脱髓鞘)中研究NG2细胞的增殖和分化潜力,研究首先... 详细信息

NG2神经胶质细胞在生理和病理条件下显示出较强的增殖和分化潜力。本研究用3月龄Cspg4启动子下由tdTomato标记NG2神经胶质细胞的小鼠,在不同类型的脑疾病模型(局灶性脑缺血、皮质刺伤和脱髓鞘)中研究NG2细胞的增殖和分化潜力,研究首先采用单细胞RT-qPCR和Kohonen自组织映射图分析从未损伤和特定损伤后的皮质/胼胝体分离的tdTomato阳性细胞,比较不同损伤后NG2神经胶质细胞表达概况。这种方法使我们能够区分NG2神经胶质细胞和少突胶质细胞,每个细胞群都包含4个不同的亚群。基因表达谱显示,表达GFAP(反应性星形胶质细胞的标志物)的NG2胶质细胞亚群仅在局灶性脑缺血后短暂出现。然而,在较轻的损伤后(皮质刺伤和脱髓鞘),反映少突胶质细胞成熟不同阶段的亚群明显占优势。免疫组织化学也证实了不同亚群的损伤依赖性发生率。本研究使用单细胞RNA测序分析这种独特的短暂星形胶质细胞样NG2胶质细胞亚群,并采用膜片钳技术揭示了其基本的细胞膜特性。综上所述,我们证明了星形胶质细胞样NG2神经胶质细胞是仅在局灶性脑缺血后短暂出现的NG2神经胶质细胞的特定亚群。这些位于缺血后神经胶质瘢痕中的细胞处于活跃的细胞周期,并显示出与皮质星形胶质细胞相似的电流模式,可能是缺血后胶质瘢痕形成和修复过程中的重要参与者。

关键词：星形胶质细胞脱髓鞘缺血 NG2胶质细胞少突胶质细胞刺伤

在线全文

学校读者我要写书评

暂无评论

任天堂用3DS掌机追求铁杆玩家

商业周刊（中文版） 2010年第12期 44-45页

作者：帕维尔·阿尔皮耶夫（pavel Alpeyev）约什诺里·艾基（Yoshinori Eki）克利夫·爱德华兹（Cliff Edwards）杨鸣娟（译）

任天狗（Nintendog）是一个在任天堂DS掌上游戏机上玩的系列游戏，玩家可以训练、打扮和喂养一只虚拟的小狗。如果你不在乎你的任天狗，它会变得又脏又臭．并且离家出走；但是如果你关爱有加．这只小狗就会在屏幕上嬉戏玩耍，挥舞自己... 详细信息

任天狗（Nintendog）是一个在任天堂DS掌上游戏机上玩的系列游戏，玩家可以训练、打扮和喂养一只虚拟的小狗。如果你不在乎你的任天狗，它会变得又脏又臭．并且离家出走；但是如果你关爱有加．这只小狗就会在屏幕上嬉戏玩耍，挥舞自己的小爪子。任天狗游戏的销量超过2300万，它也因此成为任天堂公司最畅销的系列游戏之一。

关键词：任天堂公司玩家 3DS 掌上游戏机离家出走铁

Dense matter with eXTP

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

蜘蛛咬伤后发生急性泛发性发疹性脓疱病:3例病例报道

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 13-13页

作者： Davidovici B.B. pavel D. Cagnano E. S. Halevy 任建文 Departments of Dermatology Soroka University Medical Center Ben-Gurion University of the Negev Beer-Sheva IsraelDr.

Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction caused mostly by drugs. Three of 22 AGEP cases (13.6%), recruited by us as part of two prospective multinational studies, o... 详细信息

关键词：蜘蛛咬伤皮肤不良反应促发因素

Accretion in strong field gravity with eXTP

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

罕见病主题国际公益文创设计征集——特邀嘉宾作品选登

在线全文

学校读者我要写书评

暂无评论

湖南包装 2021年第1期36卷 174-174页

作者：马青孟育丞李强张大鲁李朝胜苏秀丽黄勇王进华游方舟莫军华梁哲项天平张培源 [俄罗斯]pavel Pisklakov [伊朗]Hossein Abdi 不详

罕见病,指那些发病率极低的疾病,又称"孤儿病"。国际确认的罕见病有7000多种,约80%的罕见病为遗传性疾病,约50%的罕见病在出生时或者儿童期发病,目前只有不到10%的罕见病有治疗方法,据估计我国各类罕见病患者超过2000万人。2020年10月,... 详细信息

罕见病,指那些发病率极低的疾病,又称"孤儿病"。国际确认的罕见病有7000多种,约80%的罕见病为遗传性疾病,约50%的罕见病在出生时或者儿童期发病,目前只有不到10%的罕见病有治疗方法,据估计我国各类罕见病患者超过2000万人。2020年10月,浙大城市学院发起"罕见病主题国际公益文创设计征集"活动,在杭州市文联、浙江医学会罕见病分会指导下。

关键词：罕见病遗传性疾病文创设计医学会公益儿童期发病率征集