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Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China

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Chinese Science bulletin 2008年第4期53卷 501-507页

作者： WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret b. MURPHY LAM paul Kwan Sing Centre for Coastal Pollution and Conservation Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Tong HKSAR China National Institute of Advanced Industrial Science and Technology (AIST) 16-10nogawa Tsukuba Ibaraki 305-8569 Japan

The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much *** human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other *** objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg *** pooled egg samples from eight locations were analyzed for 11 *** results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(boxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/*** results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations.

关键词：中国鸡蛋人体健康风险评估污染物含氟化合物全氟辛烷磺酸

Impact of high-fat diet and vitamin D_3 supplementation on aortic stenosis establishment in waved-2 epidermal growth factor receptor mutant mice

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Journal of Integrative Medicine 2019年第2期17卷 107-114页

作者： bérénice Colleville Nicolas Perzo Guillaume Avinée Ana?s Dumesnil Frederic Ziegler paul billoir Hélène Eltchaninoff Vincent Richard Eric Durand Department of biology Institut National de la Santé et de la Recherche Médicale U1096 (Endothélium Valvulopathies et Insuffisance Cardiaque) Normandie University Fédération Hospitalo-Universitaire REMODeling in Valvulopathy and Heart Failure Department of Cardiology Rouen University Hospital Department of biology Institut National de la Santé et de la Recherche Médicale U1073 (Nutrition Inflammation et Dysfonction de l’axe Intestin-Cerveau) Normandie University Institute for Clinical biology-General biochemistry Unit Rouen University Hospital Department of Vascular Hemostasis Rouen University Hospital

Objective: The use of animal models of aortic stenosis(AS) remains essential to further elucidate its pathophysiology and to evaluate new therapeutic strategies. The waved-2 mouse AS model has been proposed;data have indicated that while aortic regurgitation(AR) is effectively induced, development of AS is *** aimed to evaluate the effect of high-fat diet(HFD) and vitamin D_3 supplementation in this ***: HFD and subcutaneous vitamin D_3 injections were initiated at the age of 6 weeks until the age of 6(n = 16, 6-month treatment group) and 9(n = 11, 9-month treatment group) months. Twelve waved-2 mice without supplementation were used as control. Echocardiography was performed at 3, 6 and 9 months. blood serum analysis(calcium, 1,25(OH)_2D_3 and cholesterol), histology and immunohistochemistry(CD-31, CD-68 and osteopontin) were evaluated at the end of the experiment(6 or 9 months).Results: Total cholesterol and 1,25(OH)_2D_3 were significantly increased relative to the control group. HFD and vitamin D_3 supplementation did result in improvements to the model, since AS was only detected in 6(15.3%) mice(2 in the 3 groups) and AR was developed in the remaining animals. Echocardiographic parameters, fibrosis, thickness, inflammation and valvular calcification, were not significantly different between the 6-month treatment and control groups. Similar results were also observed in the 9-month treatment ***: These results suggest that HFD and vitamin D_3 supplementation have no effect in the waved-2 mouse model. This model essentially mimics AR and rarely AS. Further studies are needed to find a reliable animal model of AS.

关键词： Experimental model Epidermal growth factor receptor Vitamin D3 High-fat diet Aortic stenosis Aortic regurgitation

磁休克治疗对重度抑郁症患者脑功能网络的影响

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生物化学与生物物理进展 2022年第6期49卷 1103-1113页

作者：田树香徐桂芝王龙龙刘向向 FITZGERALD b paul 河北工业大学电气工程学院省部共建电工装备可靠性与智能化国家重点实验室天津310130 河北工业大学电气工程学院河北省生物电磁与神经工程重点实验室天津310130 Epworth Centre for Innovation in Mental Health Epworth Healthcare and Monash Alfred Psychiatry Research CentreMonash UniversityMelbourne 3004Australia

目的磁休克治疗(MST)是一种新兴的神经调节干预技术,在重度抑郁症(MDD)治疗中得到广泛应用,然而其抗抑郁机制尚不清楚。探索MST对不同疗效MDD患者脑功能网络的调控作用,对MST治疗的抗抑郁作用机制研究具有重要意义。方法本文对18例MD... 详细信息

目的磁休克治疗(MST)是一种新兴的神经调节干预技术,在重度抑郁症(MDD)治疗中得到广泛应用,然而其抗抑郁机制尚不清楚。探索MST对不同疗效MDD患者脑功能网络的调控作用,对MST治疗的抗抑郁作用机制研究具有重要意义。方法本文对18例MDD患者MST作用前后的静息态脑电进行记录,基于皮尔逊相关方法构建脑功能网络;应用复杂网络理论对比分析脑功能网络拓扑结构的改变;根据HDRS-17评分变化率进一步区分治疗有效组和无效组,对网络特征进行二次比较。结果 MST后,MDD患者的脑功能网络平均节点度、平均聚类系数和平均全局效率值均比治疗前显著升高,平均路径长度值显著降低,小世界属性显著增大;相比于治疗无效组,治疗有效组的脑功能网络特征参数变化量更大。结论 MST显著改变了MDD患者脑功能网络拓扑结构,对患者的脑功能网络具有一定的调制作用,这些结果为MST治疗的抗抑郁机制研究提供了实验支持和理论依据。

关键词：重度抑郁症磁休克治疗静息态脑电脑功能网络

First Records of Late Triassic Conodont Fauna andδ13Ccarb from the Dengdengqiao Section,Dangchang County,Gansu Province,Northwestern China

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Journal of Earth Science 2021年第3期32卷 646-656页

作者： Hanxiao Li Miaoyan Wang Muhui Zhang paul b.Wignall Manuel Rigo Yanlong Chen Xianlang Wu Zhumin Ouyang baojin Wu Zhaoyang Yi Zaitian Zhang Xulong Lai School of Earth Sciences China University of GeosciencesWuhan 430074China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China State Key Laboratory of biogeology and Environmental Geology China University of GeosciencesWuhan 430078China School of Earth and Environment University of LeedsLeeds LSI 9JT.UK Department of Geosciences University of PadovaVia Gradenigo 635131PadovaItaly Shaanxi Key Laboratory ofEarly Life and Environments State Key Laboratory of Continental Dynamics and Department of GeologyNorthwest UniversityXi'an 710069China Key Laboratory of Orogenic belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China Wuhan Center of Geological Survey Wuhan 430205China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China

based on a study of 49 conodont and 57 geochemical samples from the Upper Triassic,carbonate-dominated Dengdengqiao Formation,Qinling basin,China,the Carnian conodonts and carbon isotope records are first *** genera and four species have been identified amongst 87 conodont elements:Mosherella praebudaensis,*** ***.,***.,and"Misikella"*** presence of *** indicates that the lower part(bed 2)of the formation is attributable to the Julian(lower Carnian)substage.A radiolarian fauna identified in a previous study belongs to the upper Carnian,but the sampling horizon is ***δ13Ccarb curve shows a~1.8‰negative excursion beginning from upper part of bed 3,but its stratigraphic location is *** Dengdengqiao Formation is clearly at least partly of Carnian age but could include younger *** abundant calcareous algae at the section is probably due to some transport rather than preserved in *** unusual ecosystem with rare marine organisms may reflect long-term stressful and unfavorable conditions at Dengdengqiao.

关键词： conodonts Late Triassic Julian Qinling

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Materials property prediction for limited datasets enabled by feature selection and joint learning with MODNet

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npj Computational Materials 2021年第1期7卷 731-738页

作者： Pierre-paul De breuck Geoffroy Hautier Gian-Marco Rignanese UCLouvain Institute of Condensed Matter and Nanosciences(IMCN)Louvain-la-NeuveBelgium Dartmouth College Thayer School of EngineeringHanoverNHUSA

In order to make accurate predictions of material properties,current machine-learning approaches generally require large amounts of data,which are often not available in *** this work,MODNet,an all-round framework,is presented which relies on a feedforward neural network,the selection of physically meaningful features,and when applicable,*** to being faster in terms of training time,this approach is shown to outperform current graph-network models on small *** particular,the vibrational entropy at 305 K of crystals is predicted with a mean absolute test error of 0.009 meV/K/atom(four times lower than previous studies).Furthermore,joint learning reduces the test error compared to single-target learning and enables the prediction of multiple properties at once,such as temperature ***,the selection algorithm highlights the most important features and thus helps to understand the underlying physics.

关键词： learning prediction property

Large-scale industrial manufacturing of carbon nanotubes in a continuous inclined mobile-bed rotating reactor via the catalytic chemical vapor deposition process

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Frontiers of Chemical Science and Engineering 2017年第2期11卷 280-289页

作者： Sophie L. Pirard Sigrid Douven Jean-paul Pirard Laboratory of Chemical Engineering Department of Chemical Engineering University of Liege B-4000 Liege Belgium

This article reports the different steps of the design, development and validation of a process for continuous production of carbon nanotubes （CNTs） via catalytic chemical vapor deposition from the laboratory scale to the industrial production. This process is based on a continuous inclined mobile-bed rotating reactor and very active catalysts using methane or ethylene as carbon source. The importance of modeling taking into account the hydrodynamic, physicochemical and physical phenomena that occur during CNT production in the process analysis is emphasized. The impact of this invention on the environment and human health is taken into consideration too.

关键词： carbon nanotubes catalytic chemical vapor deposition inclined rotating reactor industrial process scaling-up

电休克治疗对重度抑郁症患者脑功能网络的影响研究

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生物医学工程学杂志 2023年第3期40卷 426-433页

作者：田树香徐桂芝杨新生 paul b Fitzgerald Alan Wang 河北工业大学河北省生物电磁与神经工程重点实验室天津300401 河北工业大学天津市生物电工与智能健康重点实验室天津300401 河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300130 北京大学中国药物依赖性研究所北京100191 School of Medicine and Psychology The Australian National UniversityCanberraAustralian Capital Territory 2601Australia Auckland bioengineering Institute The University of AucklandAuckland 1010New Zealand Faculty of Medical and Health Sciences The University of AucklandAuckland 1023New Zealand Centre for brain Research The University of AucklandAuckland 1042New Zealand

电休克治疗(ECT)是一种能够对重度抑郁症(MDD)进行高效神经调节的干预技术,但其抗抑郁作用机制尚不明确。本文通过记录19例MDD患者在ECT前后的静息状态脑电(RS-EEG),从多角度分析了ECT对MDD患者静息态脑功能网络的调制作用:利用Welch算... 详细信息

电休克治疗(ECT)是一种能够对重度抑郁症(MDD)进行高效神经调节的干预技术,但其抗抑郁作用机制尚不明确。本文通过记录19例MDD患者在ECT前后的静息状态脑电(RS-EEG),从多角度分析了ECT对MDD患者静息态脑功能网络的调制作用:利用Welch算法估算自发脑电活动功率谱密度(PSD);基于虚部相干(iCoh)构建脑功能网络并计算功能连通性;利用最小生成树理论探究脑功能网络的拓扑结构特征。结果表明,MDD患者多个节律PSD、功能连通性和拓扑结构在ECT后发生了显著变化。本文研究结果揭示了ECT对MDD患者大脑活动的作用,对MDD的临床治疗和机制解析具有重要参考作用。

关键词：重度抑郁症电休克治疗静息态脑电脑功能网络最小生成树

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MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients

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World Journal of Gastroenterology 2017年第29期23卷 5324-5332页

作者： Swati Valmiki Vineet Ahuja Jaishree paul School of Life Sciences Jawaharlal Nehru University Department of Gastroenterology All India Institute of Medical Sciences

To investigate the miRNA expression in colonic mucosal biopsies from endoscopically inflamed and non inflamed regions of ulcerative colitis (UC) patients. METHODSColonic mucosal pinch biopsies were analyzed from the inflamed and non inflamed regions of same UC patient. Total RNA was isolated and differential miRNA profiling was done using microarray platform. Quantitative Real Time PCR was performed in colonic biopsies from inflamed (n = 8) and non-inflamed (n = 8) regions of UC and controls (n = 8) to validate the differential expression of miRNA. Potential targets of dysregulated miRNA were identified by using in silico prediction tools and probable role of these miRNA in inflammatory pathways were predicted. RESULTSThe miRNA profile of inflamed colonic mucosa differs significantly from the non-inflamed. Real time PCR analysis showed that some of the miRNA were differentially expressed in the inflamed mucosa as compared to non inflamed mucosa and controls (miR-125b, miR-223, miR-138, and miR-155), while (miR-200a) did not show any significant changes. In contrast to microarray, where miR-378d showed downregulation in the inflamed mucosa, qRT-PCR showed a significant upregulation in the inflamed mucosa as compared to the non inflamed. The in silico prediction analysis revealed that the genes targeted by these miRNAs play role in the major signaling pathways like MAPK pathway, NF-κb signaling pathway, cell adhesion molecules which are all assciated with UC. CONCLUSIONThe present study reports disease specific alteration in the expression of miR-125b, miR-155, miR-223 and miR-138 in UC patients and also predict their biological significance.

关键词： Ulcerative colitis Colon mucosa MicroRNA Microarray qRT-PCR In silico analysis

Probing the Impact of Solvent on the Strength of Lewis Acids via Fluorescent Lewis Adducts

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Precision Chemistry 2023年第1期1卷 49-56页

作者： Amy E.Laturski Joshua R.Gaffen paul Demay-Drouhard Christopher b.Caputo Thomas baumgartner Department of Chemistry York UniversityTorontoON M3J 1P3Canada

Various methods have been developed to measure the strength of a Lewis acid.A major challenge for these measurements lies in the complexity that arises from variable solvent interactions and perturbations of Lewis acids as their reaction environment ***,we investigate the impact of solvent effects on Lewis acids for the first time as measured by the fluorescent Lewis adduct(FLA)*** binding of a Lewis acid in various solvents reveals a measurable dichotomy between both polarity and donor ability of the *** not strictly separable,we observe that the influence of solvent polarity on Lewis acid unit(LAU)values is distinctly opposite to the influence of donor *** dichotomy was confirmed by titration data,illustrating that solvation effects can be appropriately and precisely gauged by the FLA method.

关键词： Fluorescence Fluorescent Lewis adducts Lewis acids Effective Lewis acidity Solvent polarity Solvent donor strength