检索结果-南通市图书馆

作者： Selected and edited by maxwell S. Luria [and] Richard L. Hoffman.

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WHAT HE WAS LIKE

英语学习 1999年第12期 23-24页

作者：君泽 William maxwell

他是怎样一个人是人们记忆中的那个友善、乐观、近乎完美的大"好人",还是日记中那个刻薄、消沉、时有邪念的"坏人"?怎样才能了解一个人好人坏人的划分标准是否就那样清楚明了、非此即彼?孰是孰非、留待读者自己去判断吧!

关键词： WHAT HE WAS LIKE HE WAS

Towards a primate single-cell atlas

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Zoological Research 2022年第4期43卷 691-694页

作者： Xiao Zhang Guang-Yao Lai Giacomo Volpe Lei Han Patrick H.maxwell Long-Qi Liu Miguel A.Esteban Yi-Wei Lai Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchunJilin 130062China Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical UniversityGuangzhouGuangdong 511436China Hematology and Cell Therapy Unit IRCCS-Istituto Tumori‘Giovanni Paolo II’Bari 70124Italy BGI-Shenzhen ShenzhenGuangdong 518103China Cambridge Institute for Medical Research Department of MedicineUniversity of CambridgeCambridge CB20XYUK Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdong 510530China

Biology in the 21st century is shifting substantially towards single-cell *** tissues are highly heterogeneous and contain multiple cell types in different states whose tight coordination determines overall *** measurements,including RNA sequencing,provide average values,which may dilute cell-specific effects or overlook rare effects of functional *** greatly limits our understanding of mammalian physiology and *** example,the histological structures of the cortical and medullary regions of the kidney differ substantially,and their cells exhibit distinct characteristics related to environmental gradients such as oxygenation,glomerular filtrate-induced shear stress,and solute concentrations within the ***,not all nephrons,mesenchymal cells,or vascular cells function in the same way,especially in the context of disease and aging.

关键词： analysis histological shifting

Non Selective Inhibition of COX Activity Reversed Inflammation and Reactive Oxygen Radicals Mediated Prostate Cancer Risk and Decreased Disease Progression in Preclinical Model

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Journal of Cancer Therapy 2016年第1期7卷 41-49页

作者： maxwell Omabe Kenneth Nwobini Omabe Clement Ademola Famurewa Alberta Egwu Okorocha Grace maxwell Omabe Tumor Immunology Group Division of Oncology Cancer Research Division Department of Pathology and Laboratory Medicine University of Saskatchewan Saskatoon Canada Molecular Pathology and Cancer Biology Research Group Chemical Pathology Division Department of Medical Laboratory Sciences Faculty of Health Science Ebonyi State University Ebonyi Nigeria Department of Biochemistry and Molecular Biology Faculty of Natural Sciences Federal University Ndufu Alike Ikwo Nigeria Department of Medical Biochemistry Faculty of Basic Medical Sciences Federal University Ndufu Alike Ikwo Nigeria Department of Physiology Faculty of Basic Medical Sciences Ebonyi State University Ebonyi Nigeria

Prostate cancer (PCa) represents the most frequent urologic diagnosis in elderly males. We have previously shown that exposure of prostate to lipopolysaccharide (LPS) promotes cancer risk. We investigated the effect of non-selective cyclooxygenase (COX) inhibition on prostate inflammation-mediated cancer risk in vivo. The prostates of male rats were inoculated with E. coli as sources of inflammatory molecules (LPS) and were treated with COX inhibitor, aspirin 2 mg/Kg orally for 14 days or PBS. Oxidative stress was induced with two 2 mls of hydrogen peroxide orally twice daily or PBS for 14 days;they were either treated with COX inhibitor or PBS for another 14 days. Blood was collected and analyzed for acid phosphatase and PSA. Data showed presences of LPS in the prostate of the rats resulted in gradual increase in PSA when compared to control (P 2O2 had 2.5 fold increase in acid phosphatase (ACP) compared control (P < 0.0001), and by inhiting COX activity, a statistically significant reduction in ACP from 11.2 IU/L ± 0.67 to 5.7 IU/L ± 0.347 (P < 0.0034) was observed. Thus since increased in PSA was associated to cancer risk, our data suggested that inflammation mediated prostate cancer risk was reversible by Inhibition of COX Activity in rats.

关键词： Inflammation Prostate Cancer Reactive Oxygen Species

Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3045-3053页

作者： Keith Al-Hasani Ishant Khurana Lina Mariana Thomas Loudovaris Scott maxwell K.N.Harikrishnan Jun Okabe Mark ECooper Assam El-Osta Department of Diabetes Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroyVictoriaAustralia Department of Clinical Pathology The University of MelbourneParkvilleVictoriaAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32 Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Faculty of Health Department of TechnologyBiomedical Laboratory ScienceUniversity College CopenhagenCopenhagenDenmark

Type 1 diabetes(T1D)is an autoimmune disease that selectively destroys insulin-producingβ-cells in the *** unmet need in diabetes management,current therapy is focussed on *** the reprogramming of progenitor cells into functional insulin-producingβ-cells has also been proposed this remains controversial and poorly *** challenge is determining why default transcriptional suppression is refractory to exocrine *** the death of a 13-year-old girl with established insulin-dependent T1D,pancreatic cells were harvested in an effort to restore and understand exocrine *** pancreas showed classic silencing ofβ-cell progenitor genes with barely detectable insulin(Ins)***126,a highly selective inhibitor of EZH2 methyltransferase activity influenced H3K27me3 chromatin content and transcriptional control resulting in the expression of coreβ-cell markers and ductal progenitor ***126 also reinstated Ins gene expression despite absoluteβ-cell *** studies show the refractory nature of chromatin characterises exocrine suppression influencingβ-cell *** regeneration studies are warranted to determine if the approach of this n-of-1 study generalises to a broader T1D population.

关键词： EZH2 progenitor donor

创业教育对学生创业激情的影响——以加纳发展大学为例

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创业教育对学生创业激情的影响——以加纳发展大学为例

作者： maxwell Anaba 江苏大学

学位级别：硕士

本研究旨在探讨创业教育对学生创业激情的影响,并探讨感知可行性的中介作用和目标导向的调节作用。本研究的研究方法为定量研究方法和问卷调查法。本研究采用分层抽样的方法,收集了加纳340名学生的资料,采用结构方程模型对假设进行检验... 详细信息

本研究旨在探讨创业教育对学生创业激情的影响,并探讨感知可行性的中介作用和目标导向的调节作用。本研究的研究方法为定量研究方法和问卷调查法。本研究采用分层抽样的方法,收集了加纳340名学生的资料,采用结构方程模型对假设进行检验。本研究结果显示,创业教育对创业激情要显著的正向影响。感知可行性对创业教育和创业热情有显著的正向影响。此外,研究结果还显示,在创业教育与创业激情之间,感知可行性具有部分中介作用。此外,研究还发现目标导向调节了创业教育与创业激情的关系。

关键词：创业教育创业激情感知可行性目标导向加纳

Development of a telehealth monitoring service after colorectal surgery:A feasibility study

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World Journal of Gastrointestinal Surgery 2017年第9期9卷 193-199页

作者： Damian D Bragg Helena Edis Sian Clark Simon L Parsons Binoy Perumpalath Dileep N Lobo Charles A maxwell-Armstrong Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute of Health Research(NIHR)Nottingham Biomedical Research CentreNottingham University Hospitals and University of NottinghamQueen’s Medical CentreNottingham NG7 2UHUnited Kingdom

AIM To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery,within an enhanced recovery *** Florence(FLO) is a National Health Service telehealth solution utilised for monitoring chronic health conditions,such as hypertension,using *** were designed to monitor the well-being,basic physiological observations and any patient-reported symptoms,and provide support messages to patients undergoing colorectal surgery within an enhanced recovery after surgery protocol for 30 d after *** interactions with FLO and physiological readings were recorded and patients were invited to provide *** Over a four-week period,16 out of 17 patients used the FLO telehealth service at *** patients did not receive telephone follow-up at three days,as per our standard protocol,unless they reported being unwell or did not make use of the *** patients were readmitted within 30 d,and two of these were identified as being unwell by FLO prior to *** adverse events attributable to the use of the technology were *** The utilisation of telehealth in the early follow-up of patients who have undergone major colorectal surgery after discharge is *** use of this technology may assist in the early recognition and management of complications after discharge.

关键词： Telehealth Remote monitoring Colorectalsurgery Telephone follow up Readmission

Phone skills for the Information Age / 3rd ed.

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Doped graphene/carbon black hybrid catalyst giving enhanced oxygen reduction reaction activity with high resistance to corrosion in proton exchange membrane fuel cells

2006年

作者： Dorothy maxwell.

来源：畅想之星图书光盘版（南... 评论

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Journal of Energy Chemistry 2022年第5期31卷 143-153页

作者： Zhaoqi Ji Jianuo Chen María Pérez-Page Zunmin Guo Ziyu Zhao Rongsheng Cai maxwell T.P.Rigby Sarah J.Haigh Stuart M.Holmes School of Automotive Engineering Harbin Institute of TechnologyWeihai264209ShandongChina Department of Chemical Engineering and Analytical Science The University of ManchesterManchester M139PLUK Department of Materials The University of ManchesterManchester M139PLUK

Nitrogen doping of the carbon is an important method to improve the performance and durability of catalysts for proton exchange membrane fuel cells by platinum–nitrogen and carbon–nitrogen bonds. This study shows that p-phenyl groups and graphitic N acting bridges linking platinum and the graphene/carbon black(the ratio graphene/carbon black = 2/3) hybrid support materials achieved the average size of platinum nanoparticles with(4.88 ± 1.79) nm. It improved the performance of the lower-temperature hydrogen fuel cell up to 0.934 W cm^(-2) at 0.60 V, which is 1.55 times greater than that of commercial Pt/C. Doping also enhanced the interaction between Pt and the support materials, and the resistance to corrosion, thus improving the durability of the low-temperature hydrogen fuel cell with a much lower decay of 10 mV at 0.80 A cm^(-2) after 30 k cycles of an in-situ accelerated stress test of catalyst degradation than that of 92 mV in Pt/C, which achieves the target of Department of Energy(<30 mV). Meanwhile,Pt/Nr EGO_(2)-CB_(3) remains 78% of initial power density at 1.5 A cm^(-2) after 5 k cycles of in-situ accelerated stress test of carbon corrosion, which is more stable than the power density of commercial Pt/C, keeping only 54% after accelerated stress test.

关键词： Nitrogen doped graphene Low-temperature hydrogen fuel cell Catalyst degradation Carbon corrosion

Ethnostudy and Usage of Edible and Medicinal Mushrooms in Some Parts of Anambra State, Nigeria

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Natural Resources 2015年第1期6卷 79-89页

作者： Raphael Nnajiofor Okigbo Chijioke maxwell Nwatu Department of Botany Faculty of Biosciences Nnamdi Azikiwe University Awka Nigeria

Indigenous knowledge and use of edible and medicinal mushrooms in some parts of Anambra state were investigated. Eleven local government areas of the state (Anambra) were randomly surveyed in which six hundred and fifty-six households were interviewed. A well-structured questionnaire was designed to obtain crucial information from the respondents. Residents of Anambra State had indigenous knowledge of mushrooms and their use. Findings revealed that residents of Anambra State consumed edible mushrooms as food and medicine equivalent to USD 7.70. The study showed that more than 85% of respondents interviewed had eaten edible mushrooms as food. Only 2% of them used some of the mushrooms as medicine for treatment of diseases. It was clearly observed that respondents who consumed edible mushrooms because their medicinal importance was significantly (P 0.05) difference among the respondents who used edible mushrooms as an alternative to meat and fish when compared with those who did not use them in a similar manner. Investigation indicated that mushrooms served as an alternative source of income to rural people of Anambra State. Information gathered from respondents on the use of edible and medicinal mushrooms would form a baseline for further studies on ethnomedicinal practices among people of Nigeria and other nations of Africa.

关键词： Edible and Medicinal Mushrooms Ethnostudy Anambra State Nigeria