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Damage analysis caused by ^(60)Co ions in functionally graded materials

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Defence Technology(防务技术) 2025年第2期44卷 248-256页

作者： zübeyde Özkan Ugur Gökmen Sema Bilge Ocak Department of Advanced Technologies Graduate School of Natural and Applied SciencesGazi UniversityAnkara06560Turkiye Department of Metallurgical and Materials Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkiye Basic and Engineering Sciences Central Laboratory Application and Research Center Gazi UniversityAnkara 06560Turkiye

Functionally graded composite/hybrid materials(FGCM/FGHCM)were produced by adding B_(4)C,TiO_(2),and B_(4)C+TiO_(2)ceramic materials at various ratios(0-50%)into the AA6082 *** analysis of the damage caused by^(60) ions'(1.173-1.1332 MeV)on the material was examined using the SRIM/TRIM Monte Carlo simulation *** the simulation,the following data regarding the atoms of the target materials were obtained:ion distribution,target ionization,total displacements,surface binding energy,lattice binding energy,and displacement *** the studied four materials,the one with the highest ion range value was found to be AA6082 with ***_(2)was found to be the reinforcement material that reduced the ion range the most in the *** to its high binding energy,B_(4)C reinforced AA6082+(0-50%)B_(4)C FGCM was found to have the least vacancy with 4782/ion.

关键词： SRIM/TRIM Damage analysis AA6082 ^(60)Co ion

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(pDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health

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Journal of Environmental Sciences 2025年第1期147卷 294-309页

作者： Juan p.Munoz Laboratorio de Bioquímica Departamento de QuímicaFacultad de CienciasUniversidad de TarapacáArica 1000007Chile

Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine *** is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disorders,neurological alterations,and increased risk of hormone-dependent *** cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC *** review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and cancer *** mechanisms through which EDCs may influence the phenotype of SCs are also ***,the possible implications of these effects on human health are *** available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epigenetic changes,reactive oxygen species production and alterations in the gene expression *** disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,reproductive abnormalities,and ***,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.

关键词： Endocrine-disrupting chemicals Stem cells Cancer stem cells Epigenetic Hormones

New breakthrough: Building non-markovian environments for single-qubit systems at any time interval

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Science China(physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 193页

作者： H.z.Shen Center for Quantum Sciences and School of physics Northeast Normal University

The proposal of quantum simulation provides a highly effective approach for experimental research on open quantum systems. To date, numerous quantum simulation studies pertaining to open quantum systems have been put forward,including Fanchini et al.’s simulation of a dephasing noise channel utilizing an optical system [1], and Xiong et al.’s realization of a quantum simulation for a non-rotating-wave approximation noise channel, also leveraging an optical system [2].

关键词： quantum system breakthrough

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Synergistic effects of constituents in rare earth-based composites:Enhanced structural,electrical and magnetic properties for water splitting applications

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Journal of Rare Earths 2025年第1期43卷 105-114,I0005页

作者： Chitralekha S.Shankar A.p.Singh Functional Materials Research Laboratory Department of PhysicsARSD CollegeUniversity of Delhi1021India Department of physics Multanimal Modi CollegeCh.Charan Singh UniversityMeerutU.PIndia

Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric application in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics composites were investigated.X-ray diffraction analyses confirm the pure-phase formation of BLFO:NMO composites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)spectra of BLFO:NMO composites reveal peak shifts with rising NMO content,indicating composite *** composites exhibit robust Maxwell-Wagner polarization and a pronounced composition-dependent *** addition of NMO to BLFO results in a rise in dielectric permittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** spectroscopy facilitates a clearer understanding of how charge carriers contribute to these composites and the impact of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the composite's enhanced suitability for microelectronics and hydropower cells,showing improved hydroelectric cell performance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.

关键词： Composites X-ray diffraction Relative permittivity Hydroelectric cell Rare earths

Thermal fracture analysis of two collinear cracks in a functionally graded medium based on the three-phase-lag model

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Applied Mathematics and Mechanics(English Edition) 2025年第3期46卷 501-520页

作者： zhangna XUE Huameng WANG Jianlin LIU Minjie WEN z.T.CHEN College of pipeline and Civil Engineering China University of Petroleum(East China) School of Civil Engineering and Architecture Zhejiang Sci-Tech University Department of Mechanical Engineering University of Alberta

The three-phase-lag(TpL) heat conduction model is an accurate representation of the actual heat transfer process. It would be interesting to investigate how the TpL model affects the thermal fracture behavior when there are defects existing in the medium. This paper aims to analyze the thermoelastic responses of two collinear cracks within a functionally graded half-space under thermal loadings by means of the TpL model. The thermoelastic problem is transformed into a series of singular integral equations using the integral transformation methods. The transient temperature and stress intensity factors(SIFs) are obtained through the application of Chebyshev *** effects of crack spacing and non-homogeneous parameters on the transient thermoelastic responses are presented, and the results of the TpL model are compared with those of the Fourier model, Cattaneo and Vernotte(CV) model, and dual-phase-lag(DpL)model. It is shown that crack spacing and non-homogeneous parameters have important effects on the thermoelastic responses, and the fluctuation phenomenon under the TpL model is the most pronounced due to the existence of the thermal displacement lag term.

关键词： Chebyshev polynomials

Gastric cancer diagnosis and prevention:Detecting precancerous at community level

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 19-28页

作者： Sergey M Kotelevets Sergey z Chukov Department of propaedeutics of Internal Medicine North Caucasus State AcademyCherkessk 369000Russia Department of pathological Anatomy Stavropol State Medical UniversityStavropol 355017Russia

The problem of gastric cancer(GC)prevention remains relevant for a long *** methods of population serological screening of atrophic gastritis and precancerous changes in the gastric mucosa have been created at *** endoscopic and morphological methods of verification of the diagnosis of precancerous diseases and changes in the gastric mucosa have been introduced into the practice of gastroenterologists and *** risk stratification systems allow the formation of risk groups that require population *** hints for population serological screening of atrophic gastritis,endoscopic and morphological verification of precancerous changes and diseases of the stomach recommend using it:When developing state programs for the prevention of stomach cancer;when implementing preventive measures for stomach cancer by doctors of all specialties;the authors also offer the possibility of use by anyone over the age of 40,provided that they seek methodological help from their doctor;in the work of health schools in any medical and preventive *** use of an assessment system of certain risk factor signatures with prognostic value would add significant assistance to preventive measures against GC.

关键词： prevention Gastric cancer Strategy Atrophic gastritis Serological screening precancerous changes