检索结果-南通市图书馆

Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver

引用

World Journal of Gastroenterology 2005年第40期11卷 6262-6268页

作者： A Quaglia MA Jutand A Dhillon A Godfrey R Togni p bioulac-sage C Balabaud M Winnock Ap Dhillon Department of Histopathology INSERM U593 Lab pathology

AIM： To design a classification tool for the histological assessment of hepatocellular carcinoma （HCC）, dysplastic nodules （DN）, and macroregenerative nodules （MRN） in cirrhotic liver. METHODS： Two hundred and twelve hepatocellular nodules （106 HCC; 74 IRN, 32 DN） were assessed systematically, quantitatively, and semiquantitatively as appropriate for 10 histological features that have been described as helpful in distinguishing small HCC, DN, and MRN in cirrhotic livers. The data were analyzed by multiple correspondence analysis （MCA）. RESULTS： HCA distributed HCC, DN, and HRN as defined by traditional histological evaluation as well as the individual histological variables, in a ＂malignancy scale＂. Based on the MCA data representation, we created a classification tool, which categorizes an individual nodular lesion as MRN, DN, or HCC based on the balance of all histological features （i.e., vascular invasion, capsular invasion, tumor necrosis, tumor heterogeneity, reticulin loss, capillarization of sinusoids, trabecular thickness, nuclear atypia, and mitotic activity）. The classification tool classified most （83%） of a validation set of 47 nodules in the same way as the routine histological assessment. No discrepandes were present for DN and MRN between the routine histological assignment and the dassification tool. Of 25 HCC assigned by routine assessment in the validation set, 8 were assigned to the DN category by the classification tool. CONCLUSION： We have designed a classification tool for the histological assessment of HCC and its putative precursors in cirrhotic liver. Application of this toolsystematically records histological features of diagnostic importance in the evaluation of small HCC.

关键词： Hepatocellular carcinoma Cirrhosis Multiplecorrespondence analysis Large regenerative nodule Dysplastic nodule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unexpected discovery of 2 cases of hepatocyte nuclear factor 1α-mutated infracentimetic adenomatosis

引用

World Journal of Gastroenterology 2008年第30期14卷 4830-4833页

作者： Hervé Laumonier Anne Rullier Jean Saric Charles Balabaud p.ulette bioulac-sage Department of Radiology Hpital Saint André CHU Bordeaux Department of pathology Hpital Pellegrin CHU Bordeaux Department of Surgery Hpital Saint André CHU Bordeaux Department of Hepatology Hpital Saint André CHU Bordeaux

We present 2 cases of hepatocyte nuclear factor 1α (HNF1α)-mutated adenomatosis, discovered for reasons unrelated to this disease, and identified using immunohistochemical methods. These new tools may further our understanding of the link between adenomas/adenomatosis subtypes and their complications, and their association with other abnormalities.

关键词： Hepatocellular adenoma Adenomatosis Hepatocyte nuclear factor 1 Hepatocyte nuclear factor 1α mutation β-catenin mutation Focal nodular hyperplasia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence

引用

World Journal of Gastroenterology 2009年第3期15卷 300-309页

作者： Frédérique Caillot Céline Derambure p.ulette bioulac-sage Arnaud Franois Michel Scotte Odile Goria Martine Hiron Maryvonne Daveau Jean-philippe Salier Inserm Unité 905 and Institut Fédératif de Recherches Multidisciplinaires sur les peptides Faculté de Médecine-Pharmacie76183 RouenFrance Service d'Anatomie pathologique Centre Hospitalier Universitaireand Inserm U88933000 BordeauxFrance Département pathologie Centre Hospitalier Universitaire76183 RouenFrance Service de Chirurgie Générale et Digestive Centre Hospitalier Universitaire76183 RouenFrance Service d'Hépato-gastro-entérologie Centre Hospitalier Universitaire76183 RouenFrance

AIM： To search for transcription dysregulation that could （1） differentiate hepatocellular carcinoma （HCC）-free from HCC-related cirrhosis （2） differentiate HCC-free cirrhosis related to HCV from that related to alcohol intake. METHODS： Using microarray analysis, we compared transcript levels in HCC-free cirrhosis （alcoholism： 7; hepatitis C： 7）, HCC-associated cirrhosis （alcoholism： 10; hepatitis C： 10） and eight control livers. The identified transcripts were validated by qRT-pCR in an independent cohort of 45 samples （20 HCC-free cirrhosis; 15 HCC-associated cirrhosis and 10 control livers）. We also confirmed our results by ***： In HCC-free livers, we identified 70transcripts which differentiated between alcoholicrelated-cirrhosis, HCV-related cirrhosis and control livers. They mainly corresponded to down-regulation. Dysregulation of Signal Transduction and Activator of Transcription-3 （STAT-3） was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free cirrhosis. In contrast, in HCC, such transcription dysregulations were not observed. CONCLUSION： We report that transcriptional dysregulations exist in HCC-free cirrhosis, are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition.

关键词： Liver pathology Alcoholism Hepatitis Cvirus Gene expression Carcinogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SYSTEMS ENGINEERING RESEARCH

引用

Journal of Systems Science and Systems Engineering 2008年第3期17卷 319-333页

作者： Abd-El-Kader SAHRAOUI Dennis M.BUEDE Andrew p.sage LAAS-CNRS and Universitéde Toulouse 7 Avenue du Colonel Roche Toulouse31077France Innovative Decisions Inc.2139 Golf Course Dr.RestonVA 20191 USA Dept.of Systems Engineering and Operations Research George Mason UniversityFairfaxVA 22030 USA

In this paper, we propose selected research topics that are believed central to progress and growth in the application of systems engineering （SE）. As a professional activity, and as an intellectual activity, systems engineering has strong links to such associated disciplines as decision analysis, operation research, project management, quality management, and systems design. When focussing on systems engineering research, we should distinguish between subjects that are of systems engineering essence and others that more closely correspond to those that are more relevant for related disciplines.

关键词： Systems engineering systems of systems requirements engineering systems families

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

引用

World Journal of Gastroenterology 2006年第45期12卷 7278-7284页

作者： Laurent Castéra Anne pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont patrice Couzigou p.ulette bioulac-sage Charles Balabaud FrancisMégraud Armelle Ménard Service d'Hépato-Gastroentérologie H?pital St-André Bordeaux France Service d'Hépato-Gastroentérologie H?pital Haut Lévêque Pessac France INSERM ERI 10 Laboratoire deBactériologie Université Victor Segalen Bordeaux 2 BordeauxFrance INSERM E0362Groupe de Recherche pour l'étude du Foie Université VictorSegalen Bordeaux 2 Bordeaux France Service d'Anatomie pathologique H?pital Pellegrin Bordeaux France Service de ChirurgieDigestive H?pital St-André Bordeaux France Laboratoire de Virologie Université VictorSegalen Bordeaux 2 Bordeaux France

AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). polymerase chain reactions (pCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (p =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species.

关键词： Hepatitis C virus Hepatitis Cirrhosis Helicobacter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RNA polymerases in plasma cells trav-ELL2 the beat of a different drum

引用

World Journal of Immunology 2015年第3期5卷 99-112页

作者： sage M Smith Nolan T Carew Christine Milcarek Department of Immunology School of MedicineUniversity of Pittsburgh

There is a major transformation in gene expression between mature B cells （including follicular, marginal zone, and germinal center cells） and antibody secreting cells （ASCs）, i.e. , ASCs, （including plasma blasts, splenic plasma cells, and long-lived bone marrow plasma cells）. This signifcant change-over occurs to accommodate the massive amount of secretory-specific immunoglobulin that ASCs make and the export processes itself. It is well known that there is an up-regulation of a small number of ASC-specific transcription factors prdm1 （B-lymphocyte-induced maturation protein 1）, interferon regulatory factor 4, and Xbp1, and the reciprocal down-regulation of pax5, Bcl6 and Bach2, which maintain the B cell program. Less well appreciated are the major alterations in transcription elongation and RNA proce-ssing occurring between B cells and ASCs. The three ELL family members ELL1, 2 and 3 have different protein sequences and potentially distinct cellular roles in transcription elongation. ELL1 is involved in DNA repair and small RNAs while ELL3 was previously described as either testis or stem-cell specifc. After B cell stimulation to ASCs, ELL3 levels fall precipitously while ELL1 falls off slightly. ELL2 is induced at least 10-fold in ASCs relative to B cells. All of these changes cause the RNA polymerase Ⅱ in ASCs to acquire different properties, leading to differences in RNA processing and histone modifcations.

关键词： Interferon regulatory factor 4 Antibody secreting cells B cell differentiation ELL2 Secretory-specific antibody B-lymphocyte-induced maturation protein 1 OCA-B Super elongation complex Xbp-1 Mammalian target of rapamycin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大量骨溶介(附一例报告)

引用

青岛大学学报(医学版) 1977年第1期 134-136页

作者： M.R.sage p.W.Allen 乐兴祥青岛医学院外科教研组

1.报告一例左足的骨和软组织的大量骨溶介。2.造影显示左足的循环较缓慢,然肿瘤血管无造影剂。3.出现症状四年亦即作膝下截肢后二年病人示痊愈。

关键词：骨骼病例运动器官病理骨折骨皮质血管瘤血管肿瘤硷性磷酸酶

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

系统工程导论

引用

丛书名： SEM译丛.Wiley系统工程与管理系列精选译丛

2006年

作者：（美）塞奇（sage A.p.）（美）阿姆斯特朗（Armstrong J.E.）胡保生彭勤科译

本书主要讨论大规模系统工程的基础和原理，先提出系统的需求和定义，然后给出描述系统工程过程的一种结构并导出生命周期模型，同时强调系统工程方法和利用它来解决问题。

ISBN: (数字)7560522351

ISBN: (纸本)7560522351

关键词：系统工程

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Tp53基因突变参与成人肝脏未分化(胚胎)肉瘤的生成,不同于Wnt和端粒酶途径:3例病例的免疫组化研究及2例病例的基因相关研究

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 54-54页

作者： Lepreux S. Rebouissou S. Le Bail B. p. bioulac- sage 王铮 Service d'Anatomie pathologique Hpital Pellegrin CHU Bordeaux 33076 Bordeaux France

Background/Aims: Hepatic undifferentiated (embryonal) sarcoma (HUS) is an exc eptional hepatic malignant tumor in adults. Genetic studies were never reported in adult cases. Methods: In this study concerning three cases of HUS occurring i n adult, we studied the three classical ways of carcinogenesis i.e. the Tp53 (p5 3), Wnt (CTNNB1/β - catenin and AXIN1) and telomerase (hTERT) pathways. We stu died the expression of p53, β - catenin and telomerase catalytic subunit hTERT by immunohistochemistry in the three cases; we determined Tp53 gene mutation in two cases and the genome- wide allelotype, AXIN1, and CTNNB1/β - catenin gen e mutation in one case. Results: Immunohistochemistry showed an overexpression o f p53 in more than 80% of tumoral cells; furthermore, mutations of Tp53 were o bserved in two cases, involving the sequence- specific DNA binding domain. In c ontrast, no mutation was found in CTNNB1/β - catenin and AXIN1 genes. Tumoral cells did not show hTERT staining nor nuclear expression of β - catenin. In ad dition, allelotype analysis in one case showed loss of heterozygosity of chromos ome 7p, 11p, 17p, 22q, and allelic imbalance of 1p, 8p, 20q. Conclusions: In thi s report of HUS in three adult patients, we emphasize the role of Tp53 pathway i n carcinogenesis of this rare tumor. This point could be of interest for therape utic strategies.

关键词：端粒酶途径 Tp53基因 Wnt 成人肝脏基因突变免疫组化研究肝脏恶性肿瘤 β-连环蛋白等位基因失衡序列特异性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental investigation and prediction of wear behavior of cotton fiber polyester composites

引用

Friction 2017年第2期5卷 183-193页

作者： Hiral H.pARIKH piyush p.GOHIL Department of Mechanical Engineering School of Science and Engineering Navrachana University Vadodara 391410 India Department of Mechanical Engineering Faculty of Technology & Engineering the MS University of Baroda Kalabhavan Vadodara 390001 India

The cotton fiber reinforced polyester composites were fabricated with varying amount of graphite fillers (0,3,5 wt.％) with a hand lay-up *** tests were planned by using a response surface (Box Behnken method) design of experiments and conducted on a pin-on-disc machine (pOD) test *** effect of the weight percentage of graphite content on the dry sliding wear behavior of cotton fiber polyester composite (CFpC) was examined by considering the effect of operating parameters like load,speed,and sliding *** wear test results showed the inclusion of 5 wt.％ of graphite as fillers in CFpC increase wear resistance compared to 3 wt.％ of graphite *** graphite fillers were recommended for CFpC to increase the wear resistance of the material.A scanning electron microscope (SEM) was used to study the wear *** predict the wear behavior of the composite material,comparisons were made between the general regression technique and an artificial neural network (ANN).The conformation test results revealed the predicted wear with the ANN was acceptable when compared with the actual experimental results and the regression mathematical models.

关键词： wear composites cotton fiber reinforced polyester composites artificial neural network pin-on-disc

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：