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Tik-Tok Usage During Third Wave of COVID-19 and Its Impacts on personal,Academic,and Social Life of Teenagers and Youngsters in Turkey

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Management Studies 2023年第1期11卷 31-43页

作者： Ali Raza Ain Bemisal Alavi Ahsan ul Haque Shaikh Yusra Memon Maham Memon KBSAS University of Sindh Naushahro Feroze CampusPakistan Bath SpA University Ras-al-KhaimaUAE University of Sindh JamshoroPakistan

Tik-Tok is a famous entertainment and art creation app that is used all around the world,which enables everyone to make short video clip ranging from 30 seconds to 1 minute and which is published and shared with family,friends,and *** app is downloaded about 1.5 billion times with 800 million users all around the world,Tik-Tok users from China,India,USA,Russia,and Turkey are at the *** paper explores the usage of Tik-Tok under the pandemic COVID-19 and how does it impact on personal,academic,and social life of youngsters and teenagers in *** collected primary data by using questionnaires from four big provinces:Istanbul,Ankara,Izmir,and Antalya(mainly top tourist provinces),500 samples were collected by using convenience sampling method,data collected in between 1 April 2021 to 2 May 2021,data analyzed by Multiple ANOVA,three times simple regression was used to explore the impact of Tik-Tok on personal,academic,and social life separately,furthermore correlation test was also applied to show strength among *** indicate statistical significance(ppports the hypotheses.

关键词： COVID-19 Tik-Tok personal life academic life social life

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聚磷腈的合成与表征

聚磷腈的合成与表征

第十八届全国波谱学学术年会

作者： Akram Muhammad 王立俞豪杰 Hamad Khalid Nasir M.Abbasi M.Saleem Zain-ul-Abdin 陈永盛化学工程联合国家重点实验室化学工程与生物工程学系浙江大学

＜正＞聚磷腈是结构可调的聚合物,在生物医药领域（例如药物输送、组织工程等）有着广泛的应用。聚磷腈是骨架上磷原子与氮原子交替排布有机-无机杂化材料,两个侧链单元（通常是有机基团）通过共价键接到每个磷原子上。聚二氯磷腈（DpC...

＜正＞聚磷腈是结构可调的聚合物,在生物医药领域（例如药物输送、组织工程等）有着广泛的应用。聚磷腈是骨架上磷原子与氮原子交替排布有机-无机杂化材料,两个侧链单元（通常是有机基团）通过共价键接到每个磷原子上。聚二氯磷腈（DpCp）是合成聚磷腈的重要中间体,DpCp上的氯原子通过亲核试剂取代得到生物稳定或生物可降解的聚合物[1,2]。由六氯三聚磷腈（HCCp）合成pDCp过程中,单体HCCp的纯化非常重要。通过重结晶与升华的方法来纯化HCCp,其纯度可由31p NMR来测定。纯净的HCCp在20 ppm处有

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宠物犬肠道可培养细菌耐药性种类及其分布

福建农业科技 2020年第4期51卷 9-16页

作者： Hafeez ul Haq 张沁怡黎烨陈明波薛海曌罗成松方行刘平平蒋宁成张婷熊娟田宝玉福建师范大学工业微生物教育部工程研究中心/福建师范大学生命科学学院福建福州350108

为探明宠物犬肠道微生物携带抗生素耐药性的流行病学及阐释饲养动物中微生物抗性与人病原微生物抗性基因的关系。采用细菌分离培养鉴定以及影印平板技术对宠物犬肠道可培养肠杆菌携带的耐药性及其种类、多样性和生态分布进行了调查。结... 详细信息

为探明宠物犬肠道微生物携带抗生素耐药性的流行病学及阐释饲养动物中微生物抗性与人病原微生物抗性基因的关系。采用细菌分离培养鉴定以及影印平板技术对宠物犬肠道可培养肠杆菌携带的耐药性及其种类、多样性和生态分布进行了调查。结果表明:宠物犬肠道可培养细菌具有较高的耐药性比例和多重耐药性。其中大肠杆菌对氨苄西林、磺胺类药物、氯霉素、链霉素和四环素等较早使用的药物耐药率较高,反而对进入临床时间较短的头孢菌素类药物相对较敏感。在调查的细菌中几乎所有的细菌至少有1种抗生素抗性,可分离的肠道细菌中一半以上具有5种以上的抗生素抗性。综上所述,肠道微生物抗性的产生与抗生素的使用时间紧密相关,并且宠物犬肠道可培养细菌的抗性广泛分布,表明宠物很可能成为耐药性基因在环境和人类病原细菌间传播的潜在途径。

关键词：宠物犬抗生素肠道可培养细菌耐药性

Modeling of pD Mechanism in Non-uniform Field at High pressure

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高电压技术 2008年第12期34卷 2662-2667页

作者： B. Florkowska M. Florkowski J. Roehrich p. Zydron Department of Electrical power AGH University of Science and Technology 30-059 Krak6w A1. Mickiewicza 30 Poland ABB Corporate Research 31-038 Krakow ul. Starowiglna 13A Poland

partial discharges in air in non-uniform electric field occur in surroundings made of high curvature *** equivalent electrode system,needle-plane refers both to external components of high voltage insulating systems and to micro sharpness in the internal structure of those *** ionization zone,accumulation of space charge and formation of corresponding current pulses depend on electrode configuration,voltage level,pressure,temperature and humidity of *** assessment of pressure influence on discharge mechanism in non-homogenous electric field has been performed on the basis of empirical density distributions of discharge charges at different voltage levels,electrode distance,curvature of high voltage electrode and taking into account solid dielectric barrier in serial *** measurement results obtained at variable voltage level yield the influence of electric field strength in the needle electrode *** increasing voltage,a deviation from normal distribution may be observed that reveals other forms of discharge.

关键词：高压条件非均匀电场局放机制建模

Intervertebral disc degeneration is rescued by TGFβ/BMp signaling modulation in an ex vivo flamin B mouse model

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Bone Research 2022年第3期10卷 524-535页

作者： Jennifer Zieba Kimberly N.Forlenza Kelly Heard Jorge H.Martin Michaela Bosakova Daniel H.Cohn Stephen p.Robertson pavel Krejci Deborah Krakow Department of Orthopedic Surgery Los AngelesCA 90095USA Department of Biology Faculty of MedicineMasaryk University62500 BrnoCzech Republic International Clinical Research Center St.Anne’s University Hospital65691 BrnoCzech Republic Institute of Animal physiology and Genetics Czech Academy of Sciences60200 BrnoCzech Republic Department of Molecular Cell and Developmental Biology University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Women’s and Children’s Health Dunedin School of MedicineUniversity of OtagoDunedinNew Zealand Department of Human Genetics Los AngelesCA 90095USA Department of Obstetrics and Gynecology Los AngelesCA 90095USA Department of pediatrics David Geffen School of Medicine at University of CaliforniaLos AngelesLos AngelesCA 90095USA

Spondylocarpotarsal syndrome(SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B(FLNB). Utilizing a FLNB knockout mouse,we showed that the vertebral fusions in SCT evolved from intervertebral disc(IVD) degeneration and ossification of the annulus fibrosus(AF), eventually leading to full trabecular bone formation. This resulted from alterations in the TGFβ/BMp signaling pathway that included increased canonical TGFβ and noncanonical BMp signaling. In this study, the role of FLNB in the TGFβ/BMp pathway was elucidated using in vitro, in vivo, and ex vivo treatment methodologies. The data demonstrated that FLNB interacts with inhibitory Smads 6 and 7(i-Smads) to regulate TGFβ/BMp signaling and that loss of FLNB produces increased TGFβ receptor activity and decreased Smad 1 ubiquitination. Through the use of small molecule inhibitors in an ex vivo spine model, TGFβ/BMp signaling was modulated to design a targeted treatment for SCT and disc degeneration. Inhibition of canonical and noncanonical TGFβ/BMp pathway activity restored Flnb-/-IVD morphology. These most effective improvements resulted from specific inhibition of TGFβand p38 signaling activation. FLNB acts as a bridge for TGFβ/BMp signaling crosstalk through i-Smads and is key for the critical balance in TGFβ/BMp signaling that maintains the IVD. These findings further our understanding of IVD biology and reveal new molecular targets for disc degeneration as well as congenital vertebral fusion disorders.

关键词： TGFβ vivo BMp treatment

印度河扇水道堤岸外侧更新世沉积物波发育特征与形成过程分析

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古地理学报 2022年第2期24卷 389-404页

作者：浩克纪友亮张胜久刘炎鑫 Khurram Shahzad Saad Ahmed Mashwani 刘笑语姜燕中国石油大学(北京)油气资源与探测国家重点实验室地球科学学院北京102249 汉堡大学地质研究所德国汉堡哈扎拉大学曼塞拉分校地球与环境科学系巴基斯坦开伯尔-普赫图赫瓦省21300 中国石油华北油田工程技术研究院河北任丘062550

印度河扇更新世发育的沉积物波结构复杂、形态多样,其形成过程的认识程度低。本次研究通过高分辨率地震数据和地震解释技术,研究了印度河扇沉积物波的波长、形态、波峰变化等形态特征;阐述了沉积物波与沉积物变形特征的差异、识别了两... 详细信息

印度河扇更新世发育的沉积物波结构复杂、形态多样,其形成过程的认识程度低。本次研究通过高分辨率地震数据和地震解释技术,研究了印度河扇沉积物波的波长、形态、波峰变化等形态特征;阐述了沉积物波与沉积物变形特征的差异、识别了两者的区分标志;总结了水道堤岸斜坡和区域斜坡上沉积物波的分布规律;在此基础上,讨论了沉积物波的形成机理和控制因素,分析了沉积物波的形成过程,并建立了印度河扇沉积物波的形成模式。研究表明:(1)研究区沉积物波波长平均为486.84 m,最大1473 m;波高在10~60 m之间,平均30 m。(2)沉积物波的形态有对称型和非对称型,其迁移方式有上坡迁移型、加积型和下坡迁移型;沉积物波主要发育在水道堤岸的斜坡上,在区域斜坡上也发育少量的沉积物波,这2种沉积物波波脊的走向差异很大,水道堤岸斜坡上的沉积物波主要分布于水道凹岸堤岸的外侧,距离水道越远其规模(波长、波高)越小,波脊走向近于NE-SW方向,与水道的走向平行或斜交;区域斜坡上的沉积物波波脊的走向多为NW-SE向,平行于区域斜坡的走向,离源区越远规模越大。(3)水道堤岸斜坡上的沉积物波是由水道型浊流在离心力的作用下,溢出水道的凹岸,在堤岸外侧的斜坡上沉积形成的,堤岸斜坡的角度对沉积物波的发育规模影响不大,浊流的强度和输沙量对其规模影响大;区域斜坡上发育的沉积物波是由顺坡而下的非水道化的浊流沉积形成;滑塌变形造成的起伏地貌以及早期沉积物波的存在,也都影响了后期沉积物波的发育。

关键词：沉积物波水道堤岸斜坡浊流更新世印度河扇

Microstructure and magnetic properties of Fe-Co-Nd-Y-B alloys obtained by suction casting method

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Journal of Rare Earths 2009年第4期27卷 680-683页

作者： J.Olszewski J.Zbroszczyk M.Hasiak J.Kaleta M.Nabiaek p.Bragiel K.Sobczyk W.Ciurzyńska J.wierczek A.Lukiewska Institute of physics Cz■stochowa University of Technology Al.Armii Krajowej 19 42-200 Cz■stochowa Poland Institute of Materials Science and Applied Mechanics Wroctaw University of Technology ul.Smoluchowskiego 25 50-370 Wroctaw Poland Jan Dtugosz University Al.Armii Krajowej 13/15 42-200 Cz■stochowa Poland

The phase composition, magnetic properties i.e. coercivity and the magnetic polarization at room temperature for the bulk Fe67Co5Nd3Y6B19 and Fe64Co5Nd6Y6B19 alloys were studied. The bulk amorphous Fe67CosNd3Y6B19 alloy, inhomogeneous in the as-quenched state, crystallized after annealing at 948 K for 0.5 h and consisted of Nd2Fe14B-type, Fe2B and paramagnetic phases. The rapidly solidified Fe64Co5Nd6Y6B19 alloy contained the Nd2Fel4B-type and paramagnetic phases. The annealing of the bulk Fe67CosNd3Y6B19 alloy at 948 K for 0.5 h led to hard magnetic properties. However, the bulk Fe64Co5Nd6Y6B19 alloy exhibited good hard magnetic properties directly after preparation.

关键词： Moessbauer spectroscopy bulk alloys rare earth hard magnetic materials

心肺移植患者巨细胞病毒耐更昔洛韦基因突变研究

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中华传染病杂志 2002年第1期20卷 37-40页

作者：周琳钱景蔡挺 TC Harder p Rautenberg 浙江大学医学院微生物教研室杭州310031

目的　建立并应用人巨细胞病毒 (HCMV)行列探针检测 (LipA)技术 ,快速检测心肺移植患者HCMV耐更昔洛韦 (GCV)基因突变。方法　以HCMV ul97基因为靶序列 ,设计 13条特异性寡核苷酸探针 ,用Nested pCR扩增目的基因 ,LipA技术检测与耐药有... 详细信息

目的　建立并应用人巨细胞病毒 (HCMV)行列探针检测 (LipA)技术 ,快速检测心肺移植患者HCMV耐更昔洛韦 (GCV)基因突变。方法　以HCMV ul97基因为靶序列 ,设计 13条特异性寡核苷酸探针 ,用Nested pCR扩增目的基因 ,LipA技术检测与耐药有关的碱基突变。并对Nested pCR产物平行做直接序列测定 ,与LipA结果比较。结果　 16例心肺移植患者 ,LipA技术检测发现 4例患者存在HCMV ul97基因突变 ,突变分别发生在编码子 5 2 0 ,5 95及 6 0 3,与直接序列测定比较 ,两者完全吻合。结论　长期应用GCV预防及治疗HCMV感染可以诱导病毒耐药 ,LipA技术可作为检测HCMV基因突变的一种有效手段。

关键词：人巨细胞病毒更昔洛韦行列探针检测心肺移植

Use of prostate-specific antigen testing in Medicare beneficiaries:Association with previous evaluation

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Family Medicine and Community Health 2017年第2期5卷 109-118页

作者： Gregory S.Cooper Tzuyung Doug Kou Mark D.Schluchter Avi Dor Siran M.Koroukian Simon p.Kim Division of Gastroenterology University Hospitals Cleveland Medical Center11100 Euclid Ave.ClevelandOH 44106USA Department of Urology University Hospitals Cleveland Medical Center11100 Euclid Ave.ClevelandOH 44106USA Case Comprehensive Cancer Center Wearn BuildingCase Western Reserve University11100 Euclid Ave.ClevelandOH 44106USA Department of Epidemiology and Biostatistics School of MedicineWood BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA Department of Health policy and Management Milken Institute School of Public HealthGeorge Washington University950 New Hampshire Ave.NWWashingtonDC 20052USA

Objective:Determine uptake of prostate-specific antigen(pSA)testing in Medicare benefi-ciaries according to previous receipt of pSA ***:A 5%random sample of men aged 67 years or older without a previous diagnosis of prostate cancer was identified through 2009-2012 Medicare *** measured the annualized frequency of pSA screening among men due for pSA testing,stratified by pSA testing use in the previous 2 years,and clustered by ordering ***:Throughout the study period,pSA testing use was consistently higher for men with previous screening than for men without previous *** men without previous screening,there was a decline in testing that was most pronounced in *** with 2009,the cor-responding odds ratios were 0.98[95%confidence interval(CI)(0.96-1.00)]in 2010,0.94[95%CI(0.92-0.95)]in 2011,and 0.66[95%CI(0.65-0.68)]in *** contrast,for men with previous screening,pSA testing frequency was stable from 2009 to 2011,and declined to a lesser extent in 2012[odds ratio 0.80,95%CI(0.79-0.81)].Conclusion:Receipt of pSA testing is highly dependent on whether an individual was tested in the recent *** previously unscreened men,the largest decrease occurred in 2012,which may reflect in part the publication of US preventive Services Task Force guidelines,but there was much less impact among men already being screened.

关键词： prostate-specific antigen Medicare mass screening clinical practice patterns