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ELECTROACTIVE AND NANOSTRUCTURED pOLYMERS AS SCAFFOLD MATERIALS FOR NEURONAL AND CARDIAC TISSUE ENGINEERING

Chinese Journal of polymer Science 2007年第4期25卷 331-339页

作者： p.ul bidez Elizabeth Guterman-Tretter Alan G. MacDiarmid peter I. Lelkes 危岩 School of Biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA School of Biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of ChemistryDrexel UniversityPhiladelphiaPA 19104USA Department of Chemistry University of PennsylvaniaPhiladelphiaPA 19104USA

Conducting polymer, polyaniline （pANI）, has been studied as a novel electroactive and electrically conductive material for tissue engineering applications. The biocompatibility of the conductive polymer can be improved by （i） covalently grafting various adhesive peptides onto the surface of prefabricated conducting polymer films or into the polymer structures during the synthesis, （ii） co-electrospinning or blending with natural proteins to form conducting nanofibers or films, and （iii） preparing conducting polymers using biopolymers, such as collagen, as templates. In this paper, we mainly describe and review the approaches of covalently attaching oligopeptides to pANI and electrospinning pANI-gelatin blend nanofibers. The employment of such modified conducting polymers as substrates for enhanced cell attachment, proliferation and differentiation has been investigated with neuronal pC-12 cells and H9c2 cardiac myoblasts. For the electrospun pANI- gelatin fibers, depending on the concentrations of pANI, H9c2 cells initially displayed different morphologies on the fibrous substrates, but after one week all cultures reached confluence of similar densities and morphologies. Furthermore, we observed, that conductive pANI, when maintained in an aqueous physiologic environment, retained a significant level of electrical conductivity for at least 100 h, even though this conductivity was decreasing over time. preliminary data show that the application of micro-current stimulates the differentiation of pC-12 cells. All the results demonstrate the potential for using pANI as an electroactive polymer in the culture of excitable cells and open the possibility of using this material as an electroactive scaffold for cardiac and/or neuronal tissue engineering applications that require biocompatibility of conductive polymers.

关键词： polyaniline Conductive polymer Biocompatibility Tissue engineering.

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电活性导电聚合物组织工程支架材料研究进展

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中国医学科学院学报 2006年第6期28卷 845-848页

作者：李梦燕 p.ul bidez Elizabeth Guterman-Tretter 郭毅 Alan G.MacDiarmid peter I.Lelkes 原续波袁晓燕盛京李华宋存先危岩 School of Biomedical Engineering Science &Health SystemsDrexel University PhiladelphiaPA19104 School of Biomedical Engineering Science &Health Systems Drexel University PhiladelphiaPA19104 Departmentof Chemistry University of PennsylvaniaPhiladelphia PA19104 USA Departmentof poly-mer Materials Science &Engineering School of Materials Science &EngineeringTianjin University Tianjin 300072 Tianjin Biomedical Materials KeyLaboratory Institute of Biomedical EngineeringCAMS and PUMCTianjin 300192

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺... 详细信息

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺(pANi)在组织工程支架方面的研究进展,并特别阐述短肽与pANi的共价键合和电纺pA-Ni/明胶共混纳米纤维的研究。

关键词：导电聚合物聚吡咯聚苯胺生物相容性组织工程

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