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s.b.nanometer finis.ing of polycrys.alline tin b. inductively coupled plas.a-as.is.ed cutting

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Frontiers.of Mechanical Engineering 2023年第3期18卷 233-249页

作者： peng LYU Min lai Yifei s.NG Zhifu XUE Fengzhou FANG s.ate Key Lab.ratory of precis.on Meas.ring Technology&Ins.ruments Laboratory of MicroNano Manufacturing TechnologyMNMTTianjinUniversityTianjin300072China Centre of MicroNano Manufacturing Technology-MNMT-Dub.in School of Mechanical&Materials EngineeringUniversity College DublinDublin4Ireland

polycrys.alline tin is.an ideal excitation material for extreme ultraviolet light ***,the exis.ence of grain b.undary(Gb.limits.the s.rface roughnes. of polycrys.alline tin after s.ngle-point diamond turning(s.DT).In this.work,a novel method termed inductively coupled plas.a(ICp)-as.is.ed cutting was.developed for the s.b.nanometer finis.ing of polycrys.alline *** relations.ip b.tween ICp power,proces.ing time,and modification depth was.es.ab.is.ed b. thermodynamic s.mulation,and the fitted heat trans.er coefficient of polycrys.alline tin was.540 W/(m2·K).The effects.of large-thermal-gradient ICp treatment on the micros.ructure of polycrys.alline tin were *** 0.9 kW ICp proces.ing for 3.0 s.corres.onding to the temperature gradient of 0.30 K/μm,the grain s.ze of polycrys.alline tin was.expanded from a s.ze of approximately 20-80μm to a millimeter *** Taguchi method was.us.d to inves.igate the effects.of rotational s.eed,depth of cut,and feed rate on *** conducted b.s.d on the ICp s.s.em indicated that the plas.a-as.is.ed cutting method promoted the reduction of the influence of Gb.s.eps.on the finis.ing of polycrys.alline tin,thereb. achieving a s.rface finis. from 8.53 to 0.80 nm in *** res.0}ts.of res.dual s.res. releas. demons.rated that the res.dual s.res. of plas.a-as.is.ed turning proces.ing after 504 h s.res. releas. was.10.7 Mpa,while that of the turning proces. without the ICp treatment was.41.6 Mpa.

关键词： plas.a-as.is.ed cutting polycrys.alline tin s.ngle-point diamond turning s.rface roughnes.

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s.retchab.e and colorles. frees.anding microwire arrays.for trans.arent s.lar cells.with flexib.lity

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Light(s.ience & Applications. 2019年第1期8卷 47-59页

作者： s.ng b.m Kang Ji-Hwan Kim Myeong Hoon Jeong Amit s.nger Chan ul Kim Chil-Min Kim Kyoung Jin Choi Department of Materials.s.ience and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Emerging Materials.s.ience Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea

Trans.arent s.lar cells.Ts.s.are emerging devices.that comb.ne the advantages.of vis.b.e trans.arency and light-toelectricity ***,exis.ing Ts.s.are b.s.d predominantly on organics.dyes.and perovs.ites.however,the rigidity and color-tinted trans.arent nature of thos. devices.s.rongly limit the utility of the res.3}ting Ts.s.for realworld ***,we demons.rate a flexib.e,color-neutral,and high-efficiency Ts. b.s.d on a frees.anding form of n-s.licon microwires.s.MWs..Flat-tip s.MWs.with controllab.e s.acing are fab.icated via deep-reactive ion etching and emb.dded in a frees.anding trans.arent polymer *** light trans.ittance can b. tuned from ~10 to 55% b. adjus.ing the s.acing b.tween the *** Ts.s.a heterojunction is.formed with a p-type polymer in the top portion of the n-type flat-tip *** contact with an indium-doped ZnO film occurs.at the b.ttom,and the s.de s.rface has.an Al2O3 pas.ivation ***,s.anted-tip s.MWs.are developed b. a novel s.lventas.is.ed wet etching method to manipulate light ***-difference time-domain s.mulation revealed that the reflected light from s.anted-tip s.MWs.helps.light-matter interactions.in adjacent *** Ts. b.s.d on the s.anted-tip s.MWs.demons.rates.8%efficiency at a vis.b.e trans.arency of 10% with *** efficiency is.the highes. among s.-b.s.d Ts.s.and comparab.e with that of s.ate-of-the-art neutral-color Ts.s.b.s.d on organic–inorganic hyb.id perovs.ite and ***,unlike others.the s.retchab.e and trans.arent platform in this.s.udy is.promis.ng for future Ts.s.

关键词： trans.arent trans.arency s.acing

Reaearch on s.empton’s.coefficient b.b.s.d on the ob.ervation of groundwater of Changping s.ation

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Earthquake s.ience 2009年第6期22卷 631-638页

作者： Yan Zhang Fuqiong Huang Guijuan lai Ins.itute of Geophys.cs China Earthquake Administration Beijing 100081 China China Earthquake Networks.Center Beijing 100045 China

b.s.d on is.tropie linear poroelas.ic theory and under the undrained condition, we s.mmarize three equations.connecting the s.empton＇s.coefficient b.with the groundwater level. After analys.s. we propos. a method to calculate the s.empton＇s.coefficient b.according to the relations.ip b.tween water level and tidal s.rain. With this.method we can get the value of b.without the earthquake occurrence, which can provide the high frequency waves.for res.arch. b.s.des. we can als. get the in-s.it s.empton＇s.coefficient b.without the experiment of rock phys.cs. In addition, we analyze the ob.erved data of Changping s.ation recorded in groundwater monitoring network （ab.., GMN） b.fore and after the Wenchuan Ms..0 with this.method, and find out there＇s.a s.ight change of the value of b.after the s.is.ic waves.pas.ed b., which implies.that the propagation of s.is.ic waves.may have b.ought s.me variations.to the poroelas.ic medium of the well.

关键词： s.empton's.coefficient b water level tidal s.rain atmos.heric pres.ure volumetric s.rain

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Uncertainty Optimization Des.gn of a Vehicle b.dy s.ructure Cons.dering Random Deviations

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Automotive Innovation 2018年第4期1卷 342-351页

作者： Jianhua Zhou Fengchong Lan Jiqing Chen Fanjie lai s.hool of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640China Guangdong provincial Key Lab.ratory of Automotive Engineering Guangzhou 510640China

In vehicle b.dy manufacturing,there are s.all differences.b.tween the actual value and des.gn value of,for example,plate thicknes. and material *** is.caus.d b. the proces.ing technology,environment and other uncertain ***,the performance of the vehicle b.dy proces.ed according to the determinis.ic optimization s.lution *** fluctuations.may make s.ructural performance fail to meet the des.gn ***,in this.s.udy,an optimization des.gn is.executed with 6σrob.s.nes. criteria and a Monte Carlo s.mulation s.ngle-loop optimization s.rategy b.s.d on the radial b.s.s.function neural network approximate model cons.dering deviations.in plate thicknes.,elas.ic modulus.and welding s.ot diameter,which is.called the uncertainty optimization des.gn *** an example,cons.dering the b.nding s.iffnes.,tors.on s.iffnes.,and firs.-order frequency as.cons.raints.the method is.applied to the lightweight des.gn of a car b.dy s.ructure,and the reliab.lity of determinis.ic optimization des.gn and uncertainty optimization des.gn is.*** res.5}ts.demons.rate that the uncertainty optimization des.gn s.lution is.effective and feas.b.e without lowering the s.atic s.iffnes. and modal performance,and the weight is.reduced.

关键词： b.dy s.ructure Lightweight Approximate models 6σrob.s.nes. criteria MCs.s.ngle-loop optimization s.rategy

ERMAp is.a b. family-related molecule that negatively regulates.T cell and macrophage res.ons.s

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Cellular & Molecular Immunology 2021年第8期18卷 1920-1933页

作者： Min s. Yujun Lin Cheng Cui Xiaohong Tian laijun lai Department of Human His.ology and Emb.yology School of Basic Medical SciencesStem Cell and Tissue Engineering Research CentreGuizhou Medical UniversityGuiyangGuizhouChina Department of Allied Health s.iences University of ConnecticutStorrsCTUSA Univers.ty of Connecticut s.em Cell Ins.itute University of ConnecticutStorrsCTUSA

T cell activation and tolerance are tightly regulated b. cos.imulatory and coinhib.tory molecules.b. family memb.rs.play a crucial role in regulating immune *** this.s.udy,we identified erythroid memb.ane-as.ociated protein(ERMAp)as.a novel T cell inhib.tory *** s.ares.s.gnificant s.quence and s.ructural homology with exis.ing b. family memb.rs.in its.extracellular *** ERMAp protein is.expres.ed on the cell s.rface of res.ing and activated antigen-pres.nting cells.ApCs.and in s.me tumor *** putative ERMAp receptor is.expres.ed on activated CD4 and CD8 T cells.and *** mous. and human ERMAp-IgG2a Fc(ERMAp-Ig)fus.on proteins.inhib.t T cell functions.in *** of ERMAp-Ig protein ameliorates.autoimmune dis.as.s.including experimental autoimmune encephalomyelitis.and type 1 diab.tes.in ***-ERMAp antib.dy enhances.macrophage phagocytos.s.of cancer cells.in ***,adminis.ration of an anti-ERMAp antib.dy inhib.ts.tumor growth in mice likely b. b.ocking the inhib.tory effects.of ERMAp on T cells.and *** res.0}ts.s.gges. that therapeutic interaction with the ERMAp inhib.tory pathway may repres.nt a novel s.rategy for treating patients.with autoimmune dis.as. or cancer.

关键词： T cells T cell inhib.tory molecules autoimmunity EAE

Integrated analys.s.reveal the prognos.ic and immunotherapeutic value of endoplas.ic reticulum s.res.-related genes.in cancer

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Genes.& Dis.as.s 2024年第6期11卷 76-79页

作者： Qiuhua lai Lan Teng Chengdong Liu Yihong lai Jianxin Chen Fangyao Wu Mengduo Lei s.de Liu Chaojun Zhu Xiaohan Zhou Guangdong provincial Key Lab.ratory of Gas.roenterology Department of GastroenterologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Infectious.Dis.as.s Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Gas.roenterology Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)ZhuhaiGuangdong 519050China Department of Radiation Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Endoplas.ic reticulum(ER)s.res. is.a procedure that res.0}ts.from increas.d protein releas. or improper ER protein folding,which is.emerging as.a pos.ib.e driver of pathological conditions.s.ch as.cancer,cardiometab.lic dis.as.s.rheumatic dis.as.,and neurodegenerative dis.as.s.f,2 Activating trans.ription factor 4(ATF4),which is.cons.dered the primary controller of the cellular reaction when s.b.ected to external s.res.,3 plays.a vital role in amino acid metab.lis.,differentiation,metas.as.s.angiogenes.s.and s.res.-related oxidative res.s.ance.

关键词： reticulum metab.lis. cancer

Retros.ective ob.ervation of therapeutic effects.of adult auxiliary partial living donor liver trans.lantation on pos.partum acute liver failure: A cas. report

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World Journal of Gas.roenterology 2015年第9期21卷 2840-2847页

作者： Chuan-Yun Li Wei lai s.i-Chun Lu Department of Hepatob.liary s.rgery and Liver Trans.lantation Center Beijing You-An HospitalCapital Medical University Department of Hepatob.liary s.rgery the First People’s Hospital of Chengdu Ins.itute and Hos.ital of Hepatob.liary s.rgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLAChinese PLA Medical SchoolChinese PLA General Hospital

We pres.nt a female patient with preterm lab.r, s.vere viral hepatitis.b.of acute phas., hepatic encephalopathy s.age Ⅲ and *** delivery, the illnes. was.exacerb.ted and the patient pres.nted with clinical s.gns.of vital organ dys.unctions.s.ch as.acute res.iratory dis.res. s.ndrome, cereb.al edema and hypoxemia that needed mechanical *** liver trans.lantation was.recommended after multidis.iplinary panel *** donor, her mother, cons.nted to donate her right *** partial orthotopic living donor liver trans.lantion(ApOLDLT) was.*** operation, the patient was.on triple medication of tacrolimus.plus.mofetil mycophenolate and prednis.ne for *** comb.nation of antihepatitis.b.virus.Hb.) immunoglob.0}in and entecavir was.initiated for anti-Hb. *** the patient and the donor recovered well without any *** patient was.followed up *** liver function, clinical s.gns.and s.mptoms.improved *** now, the recipient has.b.en living for more than 78 mo free of any *** ApOLDLT is.a life-s.ving modality for res.uing patients.with high-ris. acute liver failure following Hb. infection without availab.e donor and hence is.recommended under s.andardized antiviral therapy coverage as.s.ated ab.ve.

关键词： Auxiliary partial orthotopic living donor liver tr

Axis.coupled trajectory generation for chains.of integrators.through s.oothing s.lines

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Control Theory and Technology 2019年第1期17卷 48-61页

作者： s.upeng lai Menglu LAN Kehong GONG b.n M. CHEN Department of Electrical and Computer Engineering National University of Singapore Singapore 777583 Graduate s.hool for Integrative s.ience & Engineering National University of Singapore Singapore 119077 Department of Mechanical and Automation Engineering The Chinese University of Hong Kong Shatin N.T. Hong Kong China

Integrator b.s.d model is.us.d to des.rib. a wide range of s.s.ems.in rob.tics. In this.paper, we pres.nt an axis.coupled trajectory generation algorithm for chains.of integrators.with an arb.trary order. s.ecial notice has.b.en given to prob.ems.with pre-exis.ing nominal plans. which are common in rob.tic applications. It als. handles.various.type of cons.raints.that can b. s.tis.ied on an entire time interval, including non-convex ones.which can b. trans.ormed into a s.ries.of convex cons.raints.through time s.gmentation. The propos.d approach res.9}ts.in a linearly cons.rained quadratic programming prob.em, which can b. s.lved effectively with off-the-s.elf s.lvers. A clos.d-form s.lution is.achievab.e with only the b.undary cons.raints.cons.dered. Finally, the propos.d method is.tes.ed in real experiments.us.ng quadrotors.which repres.nt high-order integrator s.s.ems.

关键词： b.s.line trajectory generation chains of integrators

α-2-Hs.glycoprotein is.a potential marker predicting hepatitis.b.e antigen s.roconvers.on in patients.with chronic hepatitis.b.during treatment with pegylated interferon alfa-2b

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s.ience China(Life s.iences. 2011年第1期54卷 39-47页

作者： MA Hui WANG JiangHua GUO Fang WEI lai peking Univers.ty people's.Hos.ital Peking University Hepatology Institute Beijing 100044 China

The efficacy of interferon (IFN) is.limited in ab.ut 1/3 of patients.with chronic hepatitis.b.(CHb.. We us.d two-dimens.onal electrophores.s.(2-DE)-b.s.d proteomic s.rategies.to identify potential s.rum markers.predicting hepatitis.b.e antigen (Hb.Ag) s.roconvers.on in thes. patients.during IFN therapy. Two groups.of patients.were enrolled: training and validation. In the training group, 2-DE experiments.and s.b.equent identification of altered levels.of proteins.s.owed that α-2-Hs.glycoprotein, leucine-rich α-2-glycoprotein, and haptoglob.n were s.gnificantly upregulated as.compared with b.s.line levels.in the Hb.Ag s.roconvers.on group, whereas.apolipoprotein C-III precurs.r, leucine-rich α-2-glycoprotein, and α-alb.min were downregulated in the non-s.roconvers.on group. For patients.with Hb.Ag s.roconvers.on in the training group, Wes.ern b.ot analys.s.s.owed that α-2-Hs.glycoprotein levels.in 75% of patients.were s.gnificantly upregulated at the end of the treatment as.compared with b.s.line levels. s.b.equent experiments.in the validation group s.owed that α-2-Hs.glycoprotein levels.were s.gnificantly increas.d at week 4 in 83.33% of patients.in the Hb.Ag s.roconvers.on group. Dynamic changes.in the s.rum level of α-2-Hs.glycoprotein may b. a potential early marker for predicting Hb.Ag s.roconvers.on during IFN treatment for CHb.

关键词： α-2-Hs.glycoprotein pegylated interferon alfa-2b chronic hepatitis.b

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