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Applied Mathematics 2025年第1期16卷 113-142页

作者： Boris ter-Avanesov Gunter Meissner Mathematics of Finance program Math Department for Gunter Meissner & MS OR Methods in Finance Program IEOR Department Columbia Engineering Columbia University New York USA

Quanto options allow the buyer to exchange the foreign currency payoff into the domestic currency at a fixed exchange rate. We investigate quanto options with multiple underlying assets valued in different foreign currencies each with a different strike price in the payoff function. We carry out a comparative performance analysis of different stochastic volatility (SV), stochastic correlation (SC), and stochastic exchange rate (SER) models to determine the best combination of these models for Monte Carlo (MC) simulation pricing. In addition, we test the performance of all model variants with constant correlation as a benchmark. We find that a combination of GARCH-Jump SV, Weibull SC, and Ornstein Uhlenbeck (OU) SER performs best. In addition, we analyze different discretization schemes and their results. In our simulations, the Milstein scheme yields the best balance between execution times and lower standard deviations of price estimates. Furthermore, we find that incorporating mean reversion into stochastic correlation and stochastic FX rate modeling is beneficial for MC simulation pricing. We improve the accuracy of our simulations by implementing antithetic variates variance reduction. Finally, we derive the correlation risk parameters Cora and Gora in our framework so that correlation hedging of quanto options can be performed.

关键词： Quanto Option Multi-Strike Option Stochastic Volatility (SV) Stochastic Correlation (SC) Stochastic Exchange Rates (SER) Cora Gora Correlation Risk

The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health

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Journal of Environmental Sciences 2025年第1期147卷 294-309页

作者： Juan p.Munoz Laboratorio de Bioquímica Departamento de QuímicaFacultad de CienciasUniversidad de TarapacáArica 1000007Chile

Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine *** is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disorders,neurological alterations,and increased risk of hormone-dependent *** cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC *** review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and cancer *** mechanisms through which EDCs may influence the phenotype of SCs are also ***,the possible implications of these effects on human health are *** available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epigenetic changes,reactive oxygen species production and alterations in the gene expression *** disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,reproductive abnormalities,and ***,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.

关键词： Endocrine-disrupting chemicals Stem cells Cancer stem cells Epigenetic Hormones

Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review

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World Journal of Gastroenterology 2020年第40期26卷 6270-6278页

作者： Márk Félix Juhász Klementina Ocskay Szabolcs Kiss p.ter hegyi Andrea párniczky Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedSzeged 6720Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of pediatrics Heim Pál National Institute for PediatricsBudapest 1089Hungary

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 could be an etiological factor in acute pancreatitis(Ap).AIM To assess all the available evidence in the literature relating to coronavirus disease 2019(COVID-19) and *** We performed a systematic review of the available literature on the topic. The systematic search was conducted on 15 May 2020 on MEDLINE, EMBASE, CENTRAL, Web of Science and Scopus with a search key using the terms "amylase," "lipase," "pancr*," "COVID-19" and synonyms. Due to the low quality and poor comparability of the studies, a meta-analysis was not *** Six case reports and two retrospective cohorts were included, containing data on eleven COVID-19 patients with Ap. Five patients had Ap according to the Atlanta classification. Other publications did not provide sufficient information on the diagnostic criteria. Most cases were considered SARS-CoV-2-induced, while several established etiological factors were not investigated. We were able to identify other possible causes in most of *** We strongly highlight the need for adherence to the guidelines during a diagnostic and etiological workup, which could alter therapy.

关键词： pancreas COVID-19 pancreatic involvement pancreatitis Amylase Lipase

An L-band emitter with quantum memory in silicon

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npj Computational Materials 2022年第1期8卷 2498-2503页

作者： p.ter Udvarhelyi Anton pershin p.ter Deák Adam Gali Wigner Research Centre for physics P.O.Box 49H-1525BudapestHungary Budapest University of Technology and Economics Institute of PhysicsDepartment of Atomic PhysicsMűegyetem rakpart 3.1111BudapestHungary

Fluorescent centres in silicon have recently attracted great interest,owing to their remarkable properties for quantum ***,we demonstrate that the C-centre in silicon can realise an optically readable quantum register in the L-band wavelength region where the transmission losses in commercial optical fibres are *** in-depth theoretical characterisation confirms the assignment of the C-centre to the carbon-oxygen interstitial pair *** further explore its magneto-optical properties,such as hyperfine and spin-orbit coupling constants from first principles calculations,which are crucial for tight control of the quantum states of the triplet electron *** on this data,we set up quantum optics protocols to initialise and read out the quantum states of the electron spin,and realise a quantum memory by transferring quantum information from the electron spin to proximate ^(29)Si nuclear *** findings establish an optically readable long-living quantum memory in silicon where the scalability of qubits may be achieved by CMOS-compatible technology.

关键词： quantum centre optics

Restoration of energy level in the early phase of acute pediatric pancreatitis

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World Journal of Gastroenterology 2017年第6期23卷 957-963页

作者： Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus p.ter Varjú p.ter hegyi Andrea párniczky First Department of pediatrics Semmelweis University Institute for Translational Medicine University of Pécs Institute for Bioanalyses University of Pécs Department of Gastroenterology First Department of MedicineUniversity of Pécs Department of Translational Medicine First Department of MedicineUniversity of Pécs First Department of Surgery Semmelweis University Hungarian Academy of Sciences-University of Szeged Momentum Gastroenterology Multidisciplinary Research Group Heim pál Children’s Hospital

Acute pancreatitis (Ap) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of Ap. Moreover, it has been revealed that restoration of intracellular ATp level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric Ap. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(pRISMA-p) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: p: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe Ap, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, p = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. prospective studies and better pres

关键词： pediatric pancreatitis enteral nutrition nil per os diet ATp restoration length of hospitalization

IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis

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World Journal of Gastroenterology 2017年第3期23卷 447-454页

作者： Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh p.ter hegyi patrícia Sarlós Division of Gastroenterology 1st Department of Internal MedicineUniversity of Pécs7624 PécsHungary Department of Medical Genetics University of Pécs7624 PécsHungary Szentágothai Research Centre 7624 PécsHungary Institute for Translational Medicine University of Pécs7624 PécsHungary

AIM To investigate the association of seven single nucleotide polymorphisms(SNps) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNps of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNps had statistically significant influence on the clinical picture of UC. Two SNps were associated with greater colonic extension(rs2201841 p = 0.0084; rs10489629 p = 0.0405). For two of the SNps, there was more frequently need for operations (rs2201841 p = 0.0348, OR = 8.0; rs10889677 p = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (p = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(p = 0.0116, OR = 6.1707). patients with rs10489629 SNp had a lower risk for weight loss(p = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (p = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNps demonstrated no statistically significant influence on any examined clinical features of *** We demonstrated susceptible or protective character of the investigated IL23 R SNps on the phenotype of UC, confirming the genetic association.

关键词： IL23R gene Ulcerative colitis phenotype polymorphism Hungarian

Synergistic effects of constituents in rare earth-based composites:Enhanced structural,electrical and magnetic properties for water splitting applications

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Journal of Rare Earths 2025年第1期43卷 105-114,I0005页

作者： Chitralekha S.Shankar A.p.Singh Functional Materials Research Laboratory Department of PhysicsARSD CollegeUniversity of Delhi1021India Department of physics Multanimal Modi CollegeCh.Charan Singh UniversityMeerutU.PIndia

Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric application in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics composites were investigated.X-ray diffraction analyses confirm the pure-phase formation of BLFO:NMO composites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)spectra of BLFO:NMO composites reveal peak shifts with rising NMO content,indicating composite *** composites exhibit robust Maxwell-Wagner polarization and a pronounced composition-dependent *** addition of NMO to BLFO results in a rise in dielectric permittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** spectroscopy facilitates a clearer understanding of how charge carriers contribute to these composites and the impact of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the composite's enhanced suitability for microelectronics and hydropower cells,showing improved hydroelectric cell performance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.

关键词： Composites X-ray diffraction Relative permittivity Hydroelectric cell Rare earths

Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第11期30卷 1621-1635页

作者： Armand Csontos Alíz Fazekas Lajos Szakó Nelli Farkas Csenge papp Szilárd Ferenczi Szabolcs Bellyei p.ter hegyi András papp Department of Surgery University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Institute of Bioanalysis University of PécsMedical SchoolPécs H-7624BaranyaHungary Institute for Translational Medicine University of PécsMedical SchoolPécs H-7624BaranyaHungary Department of Emergency Medicine Clinical CenterUniversity of PécsMedical SchoolPécs 7624BaranyaHungary Department of Oncotherapy University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute of pancreatic Diseases Semmelweis UniversityBudapest H-1083Hungary

BACKGROUND Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is ***,a discussion of these two modalities is *** To investigate the benefits and complications of neoadjuvant *** To address this concern,predefined criteria were established using the pICO *** independent authors performed comprehensive searches using predetermined *** analyses were performed to identify significant differences between *** publication bias was visualized using funnel *** quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRADE *** Ten articles,including 1928 patients,were included for the *** difference was detected in pathological complete response(pCR)[pp=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(p=0.039;OR:1.04;95%CI:0.66-1.64)favoring the *** significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical *** result of RoB2 was moderate,and that of the GRADE approach was low or very low in almost all *** Although nCRT may have a higher pCR rate,it does not translate to greater long-term ***,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be *** the case of nCT,toxic side effects are suspected,which can reduce the quality of *** the quality of available studies,further randomized trials are required.

关键词： Neoadjuvant Chemotherapy Chemoradiotherapy Esophageal cancer Adenocarcinoma

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis

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World Journal of Gastroenterology 2017年第47期23卷 8415-8425页

作者： Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross p.ter Csécsei Andrea Vasas Zsolt Szakács László Szapáry p.ter hegyi Alexandra Mikó Department of Gastroenterology First Department of MedicineUniversity of Pécs Institute of Bioanalysis University of Pécs Department of public Health Medicine University of Pécs Department of pharmacognosy Faculty of PharmacyUniversity of Szeged Institute for Translational Medicine University of Pécs Department of Neurology University of Pécs

AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding *** A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were ***1063 articles(EMBASE: 589; pubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, p p(OR = 2.530, 95%CI: 1.386-4.616, p = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, p patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, p pent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, p patients. prospective patient registries and observational clinical trials are crucially needed.

关键词： Gastrointestinal bleeding Chronic kidney disease Mortality Blood transfusion Rebleeding

Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis

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World Journal of Gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai p.ter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi p.ter hegyi on behalf of the Hungarian pancreatic Study Group Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical Medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of public Health Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of pharmacognosy University of SzegedSzeged 6720Hungary Division of Gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Center University of PécsPécs 7624 Hungary MTA-SZTE Momentum Translational Gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(Ap) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the *** To quantify the association between subgroups of BMI and the severity and mortality of *** A meta-analysis was performed using the preferred Reporting Items for Systematic Review and Meta-Analysis(pRISMA) protocols. Three databases(pubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for Ap. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all Ap cases with no restriction on the etiology of the disease. Only studies that classified Ap cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in pROSpERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between Ap severity and BMI. BMI 25 had an almost three-fold increased risk for severe Ap in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, p portantly,the mean BMI of patients with severe Ap is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, p p patients are the highest in the underweight and obese subgroups. A BMI pared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, p < 0.001). However, the chance of mortality

关键词： Acute pancreatitis Body-mass index Obesity Severity Mortality prognostic Meta-analysis