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The USDA cucumber (Cucumis sativus L.) collection: genetic diversity, population structure, genome-wide association studies, and core collection development

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Horticulture Research 2018年第1期5卷 236-248页

作者： Xin Wang Kan Bao Umesh K.reddy Yang Bai Sue A.Hammar Chen Jiao Todd C.Wehner Axel O.Ramírez-Madera Yiqun Weng Rebecca Grumet Zhangjun Fei Boyce Thompson Institute Cornell UniversityIthacaNY14853USA Gus R.Douglass Institute and Department of Biology West Virginia State UniversityInstituteVirginiaWV25112USA Department of Horticulture Michigan State UniversityEast LansingMI48824USA Horticultural Science Department North Carolina State UniversityRaleighNC27695USA Horticulture Department University of WisconsinMadisonWI53706USA USDA-ARS Vegetable Crops Research Unit MadisonWI53706USA USDA-ARS Robert W.Holley Center for Agriculture and Health IthacaNY14853USA

Germplasm collections are a crucial resource to conserve natural genetic diversity and provide a source of novel traits essential for sustained crop *** collection,preservation and utilization of these materials depends upon knowledge of the genetic variation present within the *** we use the high-throughput genotyping-by-sequencing(GBS)technology to characterize the United States National plant Germplasm System(NpGS)collection of cucumber(Cucumis sativus L.).The GBS data,derived from 1234 cucumber accessions,provided more than 23 K high-quality single-nucleotide polymorphisms(SNps)that are well distributed at high density in the genome(~1 SNp/10.6 kb).The SNp markers were used to characterize genetic diversity,population structure,phylogenetic relationships,linkage disequilibrium,and population differentiation of the NpGS cucumber *** results,providing detailed genetic analysis of the *** collection,complement NpGS descriptive information regarding geographic origin and phenotypic *** also identified genome regions significantly associated with 13 horticulturally important traits through genome-wide association studies(GWAS).Finally,we developed a molecularly informed,publicly accessible core collection of 395 accessions that represents at least 96%of the genetic variation present in the ***,the information obtained from the GBS data enabled deep insight into the diversity present and genetic relationships among accessions within the collection,and will provide a valuable resource for genetic analyses,gene discovery,crop improvement,and germplasm preservation.

关键词： sustained collection structure

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Global histone post-translational modifications and cancer:Biomarkers for diagnosis,prognosis and treatment?

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World Journal of Biological Chemistry 2015年第4期6卷 333-345页

作者： Shafqat Ali Khan Divya reddy Sanjay Gupta Epigenetics and Chromatin Biology Group Gupta LaboratoryCancer Research CentreAdvanced Centre for Treatment Research and Education in CancerTata Memorial Centre

Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanismssuch as DNA methylation,histone modifications,nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular,covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further,histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review,we will explore and discuss how histone modifications are involved in cancer diagnosis,prognosis and treatment.

关键词： Epigenetics Cancer Diagnosis prognosis Histone pos

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Recent advances in the diagnosis and treatment of acute myocardial infarction

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World Journal of Cardiology 2015年第5期7卷 243-276页

作者： Koushik reddy Asma Khaliq Robert J Henning Department of Medicine James A Haley Veterans Administration Hospital and the University of South Florida College of Medicine

The Third Universal Definition of Myocardial Infarction(MI) requires cardiac myocyte necrosis with an increase and/or a decrease in a patient's plasma of cardiac troponin(cT n) with at least one cT n measurement greater than the 99 th percentile of the upper normal reference limit during:(1) symptoms of myocardialischemia;(2) new significant electrocardiogram(ECG) ST-segment/T-wave changes or left bundle branch block;(3) the development of pathological ECG Q waves;(4) new loss of viable myocardium or regional wall motion abnormality identified by an imaging procedure; or(5) identification of intracoronary thrombus by angiography or *** infarction,when diagnosed,is now classified into five *** of a rise and a fall of troponin are essential to the diagnosis of acute ***,high sensitivity troponin assays can increase the sensitivity but decrease the specificity of MI *** ECG remains a cornerstone in the diagnosis of MI and should be frequently repeated,especially if the initial ECG is not diagnostic of *** have been significant advances in adjunctive pharmacotherapy,procedural techniques and stent technology in the treatment of patients with *** routine use of antiplatelet agents such as clopidogrel,prasugrel or ticagrelor,in addition to aspirin,reduces patient morbidity and *** coronary intervention(pCI) in a timely manner is the primary treatment of patients with acute ST segment elevation *** eluting coronary stents are safe and beneficial with primary coronary *** with direct thrombin inhibitors during pCI is non-inferior to unfractionated heparin and glycoprotein Ⅱb/Ⅲa receptor antagonists and is associated with a significant reduction in *** intra-coronary use of a glycoprotein Ⅱb/Ⅲa antagonist can reduce infarct ***- and post-conditioning techniques can provide additional ***,the incidence and mortality due to MI continues to be high d

关键词： Myocardial necrosis Type 1-5 myocardial infarctions Troponin assays percutaneous coronary intervention Fibrinolytic therapy Thienopyridines Cardioprotection Bone marrow stem cells Cardiac stem cells

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聚酯混纺纱的高速纺纱

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国际纺织导报 2007年第7期35卷 32-32,34-36页

作者： B．S．reddy S．Y．Nanal 薛文良（译）李毓陵（校） priyadarshini纺纱厂印度印度不详

阐述了印度priyadarshini纺纱厂六七年来在Lakshmi6环锭纺设备上以最大速度24500r/min生产9.7tex和7.7tex涤棉纱线的情况。分析了高速纺纱的优势和缺点,并着重讨论了其他厂家希望提高纺纱速度时可能碰到的问题。

关键词：纺纱棉聚酯纤维

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我国南方花生发生一种由蕃茄斑萎病毒引起的新病害

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病毒学报 1986年第3期 271-274+295页

作者：许泽永,reddy D.V.R.,Rajeshwari R,张宗义,黄立新中国农业科学院油料作物研究所国际半干旱热带地区作物研究所国际半干旱热带地区作物研究所中国农业科学院油料作物研究所广西农业科学院经济作物研究室

我们于1984和1985年6月上、中旬,在广州市郊、县,湛江市郊以及广西南宁市郊、县,北海市郊和合蒲县等花生产区,调查花生病毒病时,除了发现花生轻斑驳病毒病外,还发现一种新的病毒病害。其症状特征是:病株顶端叶片上出现很多褪绿黄斑或环... 详细信息

我们于1984和1985年6月上、中旬,在广州市郊、县,湛江市郊以及广西南宁市郊、县,北海市郊和合蒲县等花生产区,调查花生病毒病时,除了发现花生轻斑驳病毒病外,还发现一种新的病毒病害。其症状特征是:病株顶端叶片上出现很多褪绿黄斑或环斑,有的环斑变

关键词：花生病毒病蕃茄斑萎病毒

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phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John p.Hamilton Sai reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.p.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers Department of plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative plant Science Cornell UniversityIthacaNY 14853-1901USA Department of plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZpC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA present address:GenNovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

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腹膜内^(32)p放射治疗和阴道近距离放射治疗作为子宫内膜浆液性乳头状癌和透明细胞癌的辅助治疗:一项Ⅱ期印第安肿瘤学会(HOG97-01)研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 43-44页

作者： Fakiris A.J. Moore D.H. reddy S.R. 耶隶晓静 Indiana University School of Medicine RT 041 535 Barnhill Drive Indianapolis IN 46202- 5289 United States

Objective. A phase II study was conducted to evaluate the role of adjuvant intraperitoneal radioactive phosphorus (32p) and vaginal brachytherapy in patients with uterine papillary serous carcinoma （UpSC） and clear cell carcinoma （CCC）, after complete surgical staging. Methods. patients were required to have undergone complete surgical staging including maximal surgical resection. Residual ≤ 3 mm intraperitoneal disease, and pelvic and para- aortic lymph node dissection with negative nodes, were required. A dose of 15 mCi of intraperitoneal 32p was administered within 8 weeks of surgery. Vaginal brachytherapy was delivered using either high dose rate, total dose of 2100 cGy in 3 fractions （700 cGy per fraction prescribed to 0.5 cm depth from the vaginal surface） or low dose rate to 6500 cGy （prescribed to the vaginal surface） in 1- 2 fractions. Results. For the 21 evaluable patients, distribution by FIGO stage was as follows: Stages I- IIB （17）, Stages III- IV （4）. The median follow- up was 39.6 months （range: 5- 63 months）. No patients experienced grade 2- 4 complications from their adjuvant therapy. Five patients suffered a recurrence: intraperitoneal [n = 2], distal vaginal [n = 2], and one at the surgical scar. Following the 2 distal vagina recurrences early in the trial, the entire length of the vagina was treated with intracavitary brachytherapy. No additional vaginal recurrences were observed. The two- year overall survival, cause- specific survival, and disease- free survival for the entire series were 89.2% , 89.2% , and 79.7% , respectively. Conclusions. Adjuvant therapy for UpSC and CCC with intraperitoneal 32p and vaginal brachytherapy after comprehensive surgical staging is feasible, well tolerated, and warrants further study on a larger scale.

关键词：近距离放射治疗透明细胞癌浆液性乳头状 HOG97-01 腹膜内子宫内膜手术分期肿瘤学近距离放疗剂量率

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A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

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Journal of pharmaceutical Analysis 2012年第4期2卷 272-278页

作者： T.Satyanarayana Raju O.Vishweshwari Kutty V.Ganesh p.Yadagiri Swamy Dr.reddy's Laboratories Ltd.Active pharmaceutical Ingredients IPDOBachupallyHyderabad 500072A.PIndia Department of Chemistry University College of EngineeringOsmania University

Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. This method is capable of separating all the related substances of Linezolid along with the chiral impurity. This method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. The method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. The eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.

关键词： HpLC Linezolid Validation polar organic mode Stability-indicating

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迈索尔市13—19岁学生错殆畸形与相关生活质量的横向研究

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中国口腔医学继续教育杂志 2016年第3期19卷 109-114页

作者： Sibyl Siluvai Nandita Kshetrimayum Chavva V.K. reddy Sunitha Siddanna Maurya Manjunath Sushma Rudraswamy 杜静李煌不详南京大学医学院附属口腔医院江苏省南京市鼓楼区中央路30号 210009

目的：评估迈索尔市13-19岁学生错骀畸形与相关生活质量的关系。材料与方法：本横向研究基于多级分层随机抽样法,共纳入了900名13-I9岁的学生。采用预制问卷来记录样本的详细社会信息、口腔卫生状况、个人习惯、错耠畸形及口腔健康相关... 详细信息

目的：评估迈索尔市13-19岁学生错骀畸形与相关生活质量的关系。材料与方法：本横向研究基于多级分层随机抽样法,共纳入了900名13-I9岁的学生。采用预制问卷来记录样本的详细社会信息、口腔卫生状况、个人习惯、错耠畸形及口腔健康相关的生活质量。首先采用牙齿美学指数（DAI）来评价错耠畸形,再采用13腔健康影响程度14号量表（OHIp-14）来评价生活质量，最后综合评估错胎畸形与相关生活质量的相关性。结果：79,2％（n=713）的调查对象咬合正常或仅有轻微的错骀畸形,12,8％的人有明确的错耠畸形,5,7％的人有重度错殆畸形,23％的人有产生不利影响的错耠畸形。研究发现,错耠畸形的总患病率为208％。在900名研究对象中，466％（n=419）调查对象的错殆畸形对口腔健康相关的生活质量有一定影响。采用Logistic回归的统计学分析，结果表明：错耠畸形对生活质量产生的影响具有显著性（OR=1607,C1=9,17～28,17）。结论：在迈索尔市13-19岁的学生中，错耠畸形会影响与口腔健康相关的生活质量。

关键词：青少年牙齿美学指数牙齿美观口腔健康影响程度量表

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红眼在基层医疗中的诊断和治疗

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中国实用乡村医生杂志 2010年第7期17卷 40-44页

作者： HOLLY CRONAU RAMANA reddy KANKANALA THOMAS MAUGER 周洁清(译) 孙允伟(译) 于明军(译) The Ohio State University College of Medicine Columbus Ohio 中国医科大学七年制

红限是基层医疗最常见的眼科问题之一。几乎眼睛任何部位（包括眼睑、泪腺）发炎或流泪障碍，均可能导致红眼。尽管知道转诊病人到眼科医生处是至关重要的，但是初级保健医生经常可以有效地管理红眼。

关键词：手足口病小儿阿昔洛韦清瘟败毒饮治疗

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