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骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究

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中国妇幼保健 2017年第11期32卷 2432-2435页

作者：王鹤 Ramesh reddy Ngoc Minh phuong Nguyen Seang L Tan Rima Slim 广西医科大学附属肿瘤医院妇瘤科广西南宁530021 麦吉尔大学人类健康中心人类基因部加拿大蒙特利尔魁北克省H4A 3J1 麦吉尔大学人类健康中心妇产科加拿大蒙特利尔魁北克省H4A 3J1

目的探讨骨形态发生蛋白15(BMp15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显... 详细信息

目的探讨骨形态发生蛋白15(BMp15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMp15基因的多态性,并采用蛋白功能预测软件预测各SNps对BMp15蛋白功能的影响。结果在BMp15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148p,p.A180T,p.H200Y)和1个插入突变,(***263dup)。通过预测,p.L148p突变可能会严重影响BMp15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNps对BMp15蛋白功能基本无影响。结论 BMp15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。

关键词：骨形态发生蛋白15 基因多态性 RHMs 习惯性流产

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霉菌毒素问题的生物解决途径

湖南饲料 2005年第3期 17-21页

作者： G.DEVEGOWDA T.N.K.MURTHY B.N.reddy 农业科学大学兽医学院印度班加罗尔

1霉菌毒素概况世界上已知的真菌有10000多种.幸运的是,其中大部分都是对人类有益的,它们可用来生产面包、奶酪,以及抗生素等.但是,还是有大约50多种真菌对畜禽和人类是有害的,它们可以产生毒素,统称为霉菌毒素.霉菌毒素是真菌在代谢饲... 详细信息

1霉菌毒素概况世界上已知的真菌有10000多种.幸运的是,其中大部分都是对人类有益的,它们可用来生产面包、奶酪,以及抗生素等.但是,还是有大约50多种真菌对畜禽和人类是有害的,它们可以产生毒素,统称为霉菌毒素.霉菌毒素是真菌在代谢饲料和饲料原料中的营养物质的过程中所产生的代谢产物.

关键词：霉菌毒素危害饲料污染最高限量综合控制技术

非心源性胸痛患者的中枢性致敏:一项临床试验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 52-53页

作者： Mohr Drewes A. pedersen J. reddy H. 张红凯 Center for Visceral Biomechanics and pain Department of Medical GastroenterologyAalborg University HospitalDK-9000 AalborgDenmark Dr.

*** with non-cardiac chest pain(NNCp) suffer from unexplained and often intractable pain which can pose a major clinical *** aim of this study was to investigate nociceptive processing in NNCp patients and their response to experimentally acid-induced oeso-phageal hyperalgesia using a multimodal stimulation *** and *** highly selected patients with NCCp(mean age 43 years,1 M) were compared with an age-and gender-matched group of 20 healthy *** preconditioning,the distal oesophagus was painfully distended with a balloon using “ impedance planimetry”.This method assesses the luminal cross-sectional area of the oesophagus based on the electrical impedance of the fluid inside the *** baseline distensions were done before and after pharmacological relaxation of the smooth muscle with 20 mg *** baseline distensions,a series of up to 10 mechanical stimuli was performed(temporal summation) .The stimulations were repeated after sensitization of the oesophagus induced by acid *** sensory intensities were assessed during the stimulations and the referred pain area was *** baseline distensions,no differences were seen between patients and controls before and after relaxation of the smooth *** patients tolerated fewer repeated distensions than controls(4.8± 0.5 versus 9.1± 0.9;p =0.04) and had an increased size of the referred pain areas to the mechanical stimulations(32.9± 6.2 versus 64.9± 18.3 cm2 ;p =0.01) .After sensitization with acid,the patients developed hyperalgesia(p patients showed facilitated central pain mechanisms(temporal summation and visceral hyperalgesia after sensitization) .This could be used in the diagnosis and understanding of the symptoms in these patients.

关键词：非心源性胸痛临床试验中枢性食管痛致敏食管酸灌注痛觉敏感健康受试者刺激法时间总和

A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds

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Journal of Cancer Metastasis and Treatment 2019年第2期4卷 77-86页

作者： Matthew Kaufman Ana Cruz Janese Thompson Srinivasa reddy Nisha BansaI Joshua GCohen Yanyuan Wu Jay Vadgama Robin Farias-Eisner Obstetrics and Gynecology University of CaliforniaLos AngelesCA 90024USA School of Medicine Meharry Medical CollegeNashvilleTN 37208USA Internal Medicine Charles Drew UniversityLos AngelesCA 90059USA

Ovarian cancer (OC) is a serious condition that often presents at advanced stages and has high mortality rates, with the current mode of early-stage screening lacking sensitivity and specificity. OC often presents asymptomatically, which renders early diagnosis difficult. Furthermore, many patients lack significant risk factors or family history of the disease. Five-year survival rates differ between patients with OC among racial, ethnic, and social groups as a result of different social barriers. This review article aims to present the currently existing data regarding health care disparities among OC patients of different ethnic, demographic, and socioeconomic backgrounds, and what next steps should be taken to better understand and eventually eliminate these potentially devastating health care disparities. Increasing data support the notion that a combination of genomic, socioeconomic status, social factors, and cultural differences lead to differential treatments and therefore health care disparities. While genomic and biological factors are important, language barriers, geographic and travel barriers, differences in comorbidity likelihood between populations, and different treatment plans seem to have a greater impact on 5-year survival rates of patients from diverse backgrounds. Language barriers limit a shared-decision model of care. Transportation limitations and geographic differences can lead to limited follow-up and insufficient care in resource and equipment restrictive settings. patients with these barriers also tend to have a higher incidence of comorbidities that raise the mortality rate of OC. Further research needs to explore effective ;solutions to bridge health care disparities and understand why they occur.

关键词： Ovarian cancer healthcare disparities public health racial disparities epidemiology literature review

Five “Ds” of plastic surgery

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plastic and Aesthetic Research 2017年第1期4卷 13-14页

作者： preethitha Babu Ravi Kumar Chittoria Sudhanva Hemanth Kumar Senthil Kumaran Marimuthu Elan Kumar Subbarayan Konda Sireesha reddy Vinayak Chavan Devi prasad Mohapatra Meethale Thiruvoth Friji Dinesh Kumar Sivakumar Department of plastic Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

Although there are a variety of definitions that describe plastic surgery,confusion persists in the minds of both the lay public and doctors.A common lay misconception is that actual pieces of plastic are used to repair injured tissues or placed over defects to make them appear *** the other hand,resident doctors from specialities such as ear-nose-throat and general surgery fail to appreciate the vast scope that plastic surgery specialty *** recognition of this,trainee plastic surgeons are often asked to briefly define our specialty in their final exams,so that subsequent misconceptions are minimized.

关键词： Definitions plastic surgery Confusion persists

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抗磷脂综合征表现为视乳头水肿1例(英文)

国际眼科杂志 2007年第6期7卷 1522-1525页

作者： Nadir A M Ali I Tajunisah V Subrayan S C reddy K J Goh 马来亚大学医学院眼科马来亚大学医学院神经科

目的:报告1例罕见抗磷脂综合征的患者,由于上矢状窦血栓形成而表现为双眼视乳头水肿及右眼第六颅神经麻痹,经抗凝和乙酰唑胺治疗后视乳头水肿恢复。方法:病例报告:一44岁中国男性,主诉为头痛、复视及轻度的视物模糊。临床检查发现右眼第... 详细信息

目的:报告1例罕见抗磷脂综合征的患者,由于上矢状窦血栓形成而表现为双眼视乳头水肿及右眼第六颅神经麻痹,经抗凝和乙酰唑胺治疗后视乳头水肿恢复。方法:病例报告:一44岁中国男性,主诉为头痛、复视及轻度的视物模糊。临床检查发现右眼第6神经麻痹和双眼视乳头水肿,双眼视野盲点扩大和红绿色觉缺失,计算机断层摄影及核磁共振扫描显示上矢状窦血栓形成,血液学检查证实抗磷脂综合征是其潜在原因。结果:在联合应用抗凝和口服乙酰唑胺治疗3mo后,视乳头水肿恢复至正常的解剖,扩大的视野盲点降至正常水平,双眼红绿色觉恢复正常,伴随右眼视乳头水肿消退和视力改善表明这个患者视功能得以恢复。结论:抗磷脂综合征应与视乳头水肿鉴别诊断;对于顽固性的视乳头水肿,口服乙酰唑胺是抗凝治疗的重要辅助治疗,它可以保护视神经免受有可能导致失明后果的视神经损害。

关键词：抗磷脂综合征上矢状窦血栓形成视乳头水肿乙酰唑胺第6颅神经麻痹

High-throughput proteomic Analysis in Chicken Lung with Avian Influenza Virus Infection by MASS Spectrometry

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High-throughput Proteomic Analysis in Chicken Lung with Avia...

活检及组织学病理学在诊断银屑病甲中的重要性

第五届中国畜牧科技论坛

作者： Ying Wang Yue Shi Yaling Song Yixiang Zhang Joshua Yuan Susie Dai Vinayak Brahmakshatriya Blanca Lupiani Sanjay reddy Susan J.Lamont Huaiiun Zhou Department of poultry Science Texas A &M University College StationTX 77843-2472USA Department of plant pathology and Microbiology Texas A&M UniversityCollege StationTX 77843USA Department of Veterinary pathobiology College of Veterinary MedicineTexas A&M UniversityCollege StationTX 77843-4467 USA Department of Animal Science Iowa State UniversityAmesIA 50011USA

Avian influenza virus(AIV) not only causes significant economic losses in poultry production,but also is of big concern to human *** objective of this study was to identify proteins associated with AIV infections in two genetically distinct,highly inbred chicken lines that differ in AIV resistance(Fayoumi is resistant and Leghorn is susceptible to AIV infection).Chickens were inoculated with 10 EID of H5N3 AIV or pBS at three weeks of *** lungs were collected at 4 days post *** with equal amount of cytosolic, membrane,nuclear and cytoskeletal fractions were extracted by differential detergent fractionation followed by

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 39-40页

作者： Grover C. reddy B.S.N. Chaturvedi K.U. 焦婷 11/15 Nehru Nagar New Delhi- 110065 India

Background: Involvement of the nail is quite common in psoriasis and at times may be the sole diagnostic clue. However, the histopathology of nail psoriasis has not been adequately evaluated. A confirmation of the diagnosis is required in cases suspected to have nail psoriasis in order to plan longterm therapy. Objectives: To assess the diagnostic significance and safety profile of nail biopsy in cases with nail psoriasis. Methods: Clinical and mycological features were studied in 42 patients with nail psoriasis. Of these, 22 patients gave consent for nail biopsies to be taken and the histopathological changes were assessed. Results: Males were affected more commonly (57% ) with a peak incidence in the age group of 10- 20 years (29% ). Distal onycholysis, discoloration of nail plate, subungual hyperkeratosis and fine nail pitting were the predominant clinical features. In the 22 biopsies done, hyperkeratosis with parakeratosis (91% ) was found to be the most common and hypergranulosis was the least common histological finding (36% ). Clinicohistological correlation was possible only in 55% cases. periodic acid-Schiff (pAS) stainingwas done for all biopsies. Conclusions: Histopathological examination of nails is a valuable diagnostic aid, especially in the absence of skin lesions. Examination of the pAS-stained sections is necessary before making a histological diagnosis of nail psoriasis because onychomycosis and psoriasis may show similar histology.

关键词：组织病理学改变银屑病甲诊断价值活检术组织学组织病理改变临床特征长期治疗患者安全性