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地图 1993年第3期 30-32页

作者： John p.snyder 王桥

选择矩形作为地图的图廓是自然的,这导致了世界地图中圆柱投影,特别是墨卡托投影持续的流行。非圆柱投影使用于世界地图也不断地受到鼓励。最近七(?)地图和地理组织还为此通过了决议。设计从社区到大陆的大块地区各种区域的矩形地图是... 详细信息

选择矩形作为地图的图廓是自然的,这导致了世界地图中圆柱投影,特别是墨卡托投影持续的流行。非圆柱投影使用于世界地图也不断地受到鼓励。最近七(?)地图和地理组织还为此通过了决议。设计从社区到大陆的大块地区各种区域的矩形地图是一种较常见的需要。如果地图上所有的部分都是同等重要的,使用新近的等角的或等面积的投影就可以减少总变形,这些新投影能够使外圈的等变形线接近于矩形。

关键词：地图地图投影矩形边界

姜黄素类似物EF25-(GSH)_2抗肝癌作用的研究

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中国细胞生物学学报 2014年第9期36卷 1241-1249页

作者：叶莉莉周桃 James p.snyder 傅海安黄蓓安徽大学生命科学学院合肥230601 美国Emory大学化学院美国Emory大学医学院

在细胞及动物个体水平探讨姜黄素类似物EF25-(GSH)2的抗肝癌作用。用不同浓度的EF25-(GSH)2处理体外培养的肝癌细胞、正常肝细胞以及HepG2荷瘤裸鼠,MTT法检测细胞存活率,电镜及激光共聚焦显微镜观察细胞形态,蛋白质免疫印迹法(Western b... 详细信息

在细胞及动物个体水平探讨姜黄素类似物EF25-(GSH)2的抗肝癌作用。用不同浓度的EF25-(GSH)2处理体外培养的肝癌细胞、正常肝细胞以及HepG2荷瘤裸鼠,MTT法检测细胞存活率,电镜及激光共聚焦显微镜观察细胞形态,蛋白质免疫印迹法(Western blot)检测AMpK/Akt/mTOR相关通路蛋白磷酸化水平的变化。结果显示,EF25-(GSH)2对HepG2作用48 h的IC50为7.2μmol/L,对其生长抑制作用明显优于姜黄素及顺铂,且对正常细胞的杀伤作用较小。形态学观察到细胞中有自噬现象的发生。免疫印迹法结果提示,EF25-(GSH)2可能通过AMpK/Akt/mTOR的相关通路抑制肿瘤细胞生长。对肝癌模型裸鼠的实验显示,给药后的肿瘤体积明显缩小。该实验结果证明,EF25-(GSH)2具有良好的作为肝癌治疗药物的开发前景。

关键词： EF25-(GSH)2 肝癌细胞自噬

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美国地质测量局使用的地图投影

测绘科学 1985年第3期 36-42页

作者： John p.snyder ,苏山舞

数十年来,美国地质测量局(USGS)在其制图生产中一直沿用简单的多圆锥投影。目前,它出版的地图,包括国家地图集的地图在内,使用了多种通用投影。其中,横轴墨卡托投影和兰勃特正形圆锥投影是等角的,另一些投影是等积或等距的,还有一些投影... 详细信息

数十年来,美国地质测量局(USGS)在其制图生产中一直沿用简单的多圆锥投影。目前,它出版的地图,包括国家地图集的地图在内,使用了多种通用投影。其中,横轴墨卡托投影和兰勃特正形圆锥投影是等角的,另一些投影是等积或等距的,还有一些投影,像米勒圆柱投影和格灵登投影是为了使用方便而选用的。某些投影把地球作为圆球,另一些投影则把地球视为圆球或椭球。此外,USGS已经设想和设计出了一些新的投影,其中包括空间斜轴墨卡托投影,这是为卫星图象制图而设计的第一种投影,其连续变形较小。USGS已经为几乎所有这些或另一些投影的正、反算公式编制了程序。这些程序适用于绘图或从一种投影到另一种投影的坐标转换。USGS正准备出版一本综合地图投影手册,它将详细、准确地介绍USGS所使用的全部投影。

关键词：投影中心 USGS 圆柱投影透视中心地图投影圆锥投影斜轴墨卡托投影地图大比例尺基本比例尺中央经线中央子午线

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放大镜式的方位投影

地图 1988年第3期 32-39页

作者： John p.snyder ,胡毓钜 ,潘海群

本文提出了一组新的具有“放大镜”效果的方位投影,它适用于突出重点地区而以其周围地区衬托的地图。在此组投影上,包围重点地区的圆的内部是一个标准等距或兰勃特等面积方位投影。在该圆与外围圆之间,方位角保持正确,而向径或面积比例... 详细信息

本文提出了一组新的具有“放大镜”效果的方位投影,它适用于突出重点地区而以其周围地区衬托的地图。在此组投影上,包围重点地区的圆的内部是一个标准等距或兰勃特等面积方位投影。在该圆与外围圆之间,方位角保持正确,而向径或面积比例尺分别地保持为常数,但缩小了一个定值。在其他四个投影上,其内部是一标准方位投影,可能是球面、球心或上述两者,但该部分之外向径比例尺逐渐缩小到零。带有矩形界线的这类投影也是存在的。

关键词：透视投影向径方位投影平面投影地图投影比例尺量具放大镜

plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for Code Coupling,Data Management and Visualization

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Communications in Computational physics 2008年第8期4卷 675-702页

作者： J.Cummings A.pankin N.podhorszki G.park S.Ku R.Barreto S.Klasky C.S.Chang H.Strauss L.Sugiyama p.snyder D.pearlstein B.Ludascher G.Bateman A.Kritz the CpES Team California Institute of Technology PasadenaCA 91125 Lehigh University BethlehemPA 18015 University of California at Davis DavisCA 95616 Courant Institute of Mathematical Sciences New York UniversityNY 10012 Oak Ridge National Laboratory Oak RidgeTN 37830 Massachusetts Institute of Technology CambridgeMA 02139 General Atomics San DiegoCA 92186 Lawrence Livermore National Laboratory LivermoreCA 94550 SciDAC FSp Center for plasma Edge Simulation

A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localizedmodes(ELMs)is presented in this *** tool brings together,in a coordinated and effective manner,several first-principles physics simulation codes,stability analysis packages,and data processing and visualization tools.A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code,XGC0,with an ideal MHD linear stability analysis code,ELITE,and an extended MHD initial value code such as M3D or ***0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the *** Kepler workflow processes the XGC0 simulation results into simple images that can be selected and displayed via the Dashboard,a monitoring tool implemented in AJAX allowing the scientist to track computational resources,examine running and archived jobs,and view key physics data,all within a standard Web *** XGC0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE *** an ELM crash is triggered,the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the *** process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the ***,the Kepler workflow archives all data outputs and processed images using HpSS,as well as provenance information about the software and hardware used to create the *** complete process of preparing,executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described

关键词： plasma simulation magnetohydrodynamic and fluid equation gyrofluid and gyrokinetic simulations hybrid methods

紫杉烷C-2位改造的化合物的合成、抗癌活性及其与p-糖蛋白和β-微管蛋白的相互作用

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紫杉烷C-2位改造的化合物的合成、抗癌活性及其与P-糖蛋白和β-微...

The new kid on the block in insect pest management:sprayable RNAi goes commercial

中国化学会第二十五届学术年会

作者：方唯硕杨春刚王磊李轩 J.Fernando Diaz Frances Sharom James p.snyder 中国医学科学院药物研究所中国医学科学院药物研究所中国医学科学院药物研究所中国医学科学院药物研究所 CIB CSIC 28040 Madrid Spain University of Guelph Guelph ON N1G 2W1 Canada Emory University Atlanta GA 30322 USA

As a continuing research effort to understand SAR of paclitaxel and its analogs, and to develop new generation of taxanes effective against sensitive and drug-resistant tumors mediated by p-glycoprote

关键词：紫杉烷抗癌活性肿瘤耐药 p-糖蛋白 β-微管蛋白

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Science China(Life Sciences) 2024年第8期67卷 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William E.snyder Angharad M.R.Gatehouse Myron p.Zalucki Bruce E.Tabashnik Yulin Gao State Key Laboratory for Biology of plant Disease and Insect pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Bayer AG Crop Science DivisionR&DPest ControlMonheim 40789Germany Department of Crop and Soil Science Oregon State UniversityOntario 97914USA School of Biology and Ecology University of MaineOrono 04469USA Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Department of Entomology Michigan State UniversityEast Lansing 48864USA Department of plant Medicals Andong National UniversityAndong 36729Republic of Korea Department of Entomology University of KentuckyLexington 40503USA Oregon State University Oregon Integrated Pest Management CenterCorvallis 97838USA Department of Entomology Cornell UniversityCornell AgriTechGeneva 14456USA Department of Entomology and plant pathology University of TennesseeKnoxville 37996USA Department of Entomology and Wildlife Ecology University of DelawareNewark 19716USA Department of Entomology University of GeorgiaAthensGeorgia 30602USA School of Natural and Environmental Sciences Newcastle UniversityNewcastle upon TyneNE17RUUK School of the Environment University of QueenslandBrisbane 4072Australia Shandong Engineering Research Center for Environment-Friendly Agricultural pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China Department of Entomology University of ArizonaTucson 85721USA National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural SciencesBeijing 100081China

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this *** urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

关键词： crops damage pest

睾酮治疗性腺功能减退症男性患者对骨折风险影响的临床研究

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中国临床药理学杂志 2024年第5期40卷 731-731页

作者： snyder p J BAUER D C ELLENBERG S S 孟海峰

男性性腺功能减退症患者的睾酮治疗可以改善骨密度和骨质量,但需要足够大的样本和足够长的持续时间来确定睾酮对骨折发生率的影响。

关键词：骨折发生率性腺功能减退症骨质量骨折风险睾酮治疗骨密度持续时间男性患者

Trilayer anisotropic structure versus randomly oriented structure in heart valve leaflet tissue engineering

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Bio-Design and Manufacturing 2023年第4期6卷 423-438页

作者： Yuriy snyder Soumen Jana Department of Bioengineering University of MissouriColumbiaMO 65211USA

It has been hypothesized that leaflet substrates with a trilayer structure and anisotropicmechanical properties could be useful for the production of functional and long-lasting tissue-engineered *** investigate the influence of the anisotropic structural and mechanical characteristics of a substrate on cells,in this study,we electrospun trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates(used as controls)from polycaprolactone ***,the random substrates had higher radial and lower circumferential tensile properties than the trilayer substrates;however,they had similar flexural *** valvular interstitial cells cultured on both substrates produced random and trilayer cell-cultured constructs,*** trilayer cell-cultured constructs had more anisotropic mechanical properties,17%higher cellular proliferation,14%more extracellular matrix(i.e.,collagen and glycosaminoglycan)production,and superior gene and protein expression,suggesting that more cells were in a growth state in the trilayer constructs than in the random ***,the random and radial layers of the trilayer constructs had more vimentin,collagen,transforming growth factor-beta 1(TGF-ß1),transforming growth factor-beta 3(TGF-ß3)gene expression than in the circumferential layer of the *** study verifies that the differences in structural,tensile,and anisotropic properties of the trilayer and random substrates influence the characteristics of the cells and ECM in the constructs.

关键词： Heart valve leaflet Trilayer Tissue engineering Fiber Electrospinning