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Systemic modulation of skeletal mineralization by magnesium implant promoting fracture healing: Radiological exploration enhanced with pCA-based machine learning in a rat femoral model

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Journal of Magnesium and Alloys 2024年第3期12卷 1009-1020页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGermany

The clinical application of magnesium(Mg)and its alloys for bone fractures has been well supported by in vitro and in vivo ***,there were studies indicating negative effects of high dose Mg intake and sustained local release of Mg ions on bone metabolism or repair,which should not be ignored when developing Mg-based ***,it remains necessary to assess the biological effects of Mg implants in animal models relevant to clinical treatment *** primary purpose of this study was to validate the beneficial effects of intramedullary Mg implants on the healing outcome of femoral fractures in a modified rat *** addition,the mineralization parameters at multiple anatomical sites were evaluated,to investigate their association with healing outcome and potential clinical *** to the control group without Mg implantation,postoperative imaging at week 12 demonstrated better healing outcomes in the Mg group,with more stable unions in 3D analysis and high-mineralized bridging in 2D *** bone tissue mineral density(TMD)was higher in the Mg group at the non-operated femur and lumbar vertebra,while no differences between groups were identified regarding the bone tissue volume(TV),TMD and bone mineral content(BMC)in *** the surgical femur,the Mg group presented higher TMD,but lower TV and BMC in the distal metaphyseal region,as well as reduced BMC at the osteotomy *** component analysis(pCA)-based machine learning revealed that by selecting clinically relevant parameters,radiological markers could be constructed for differentiation of healing outcomes,with better performance than 2D *** study provides insights and preclinical evidence for the rational investigation of bioactive materials,the identification of potential adverse effects,and the promotion of diagnostic capabilities for fracture healing.

关键词： Magnesium Implants Bone fracture Mineralization Systemic modulation principal component analysis.

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peri-implant gas accumulation in response to magnesium-based musculoskeletal biomaterials:Reframing current evidence for preclinical research and clinical evaluation

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Journal of Magnesium and Alloys 2024年第1期12卷 59-71页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical *** the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable ***,the optimization aims at slowing down the degradation process,rather than exemption of the gas *** study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(pIGA)after musculoskeletal Mg *** literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to *** Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal *** tissue and intraosseous pIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse *** examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal *** according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with *** still lacks standardized procedures or consensus for both preclinical and clinical evaluation of ***,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal

关键词： Magnesium implant Degradation Hydrogen Gas release postoperative follow-up

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Dielectric size optimization for high power density in large-scale triboelectric nanogenerators

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Nano Research 2024年第9期17卷 8455-8464页

作者： Abdulkerim Karabiber Ömer Dirik Feyyaz Koc Faruk Ozel Department of Electrical and Electronics Engineering Bingol UniversityBingol 12000Turkey Department of Metallurgical and Materials Engineering Karamanoglu Mehmetbey UniversityKaraman 70200Turkey

Triboelectric nanogenerators(TENGs)have emerged as a promising technology to harvest electrical energy from natural motions such as human movement,wind,and water *** TENGs show significant potential in small-scale applications,developing large-scale TENGs capable of generating high power remains a significant *** factors that can affect the performance of large-scale TENGs are being investigated to overcome this challenge,including the size and configuration of dielectric *** study optimizes dielectrics regarding surface area,thickness,and multicell configuration to improve harvested electrical power density in large-scale *** the studies,glass fiber was used as the positive dielectric,and multipurpose white silicone was used as the negative dielectric because of their high tribo-potential,durability,and easy *** the size optimization phase,dielectric thicknesses and surface areas that provide the maximum power density were ***,horizontal and vertical multicell configurations were examined to efficiently integrate size-optimized *** results reveal that large-scale TENGs with vertical multicell configurations can achieve high and usable energy density for *** findings provide valuable insight into the development of large-scale TENGs with advanced power generation capabilities.

关键词： triboelectric nanogenerator dielectric layer size optimization multi-cell structure high power density

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血细胞和内皮细胞相互作用能影响急性白血病的止血平衡吗?

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Oncology and Translational Medicine 1994年第3期11卷 156-156页

作者： T.Südhoff A.Wehmeier B.Bauser p.schlmer W.Schneider 刘立根 Department of Hematology Oncology and Clinical Immunology Heinrieh-Heine-University Moorenstr.5 D-40225 Düsseldorf Germany 同济医科大学附属同济医院

在确诊急性白血病(AL)的患者常伴有止血障碍。在 AL,已证明内皮细胞(EC)和原始细胞参与凝块形成和溶解的调节。近来,通过粘附分子的白细胞-EC 相互作用是一研究热点。如同中性粒细胞一样,原始细胞主要通过 E-选择素和血管粘附分子-1(VCA... 详细信息

在确诊急性白血病(AL)的患者常伴有止血障碍。在 AL,已证明内皮细胞(EC)和原始细胞参与凝块形成和溶解的调节。近来,通过粘附分子的白细胞-EC 相互作用是一研究热点。如同中性粒细胞一样,原始细胞主要通过 E-选择素和血管粘附分子-1(VCAM-1)介导粘附到 EC 上,E-选择素和 VCAM-

关键词：白血病原始细胞 EC AL 血癌内皮细胞

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Device-measured physical activity and sedentary time in the Nordic countries:A scoping review of population-based studies

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Journal of Sport and Health Science 2024年第5期13卷 650-660页

作者： Ing-Mari Dohrn Jakob Tarp Jostein Steene-Johannessen Tommi Vasankari Maria Hagströmer Division of physiotherapy Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet14183 HuddingeSweden Department of Sports Medicine Norwegian School of Sports Sciences0806 OsloNorway UKK Institute for Health promotion Research 33500 TampereFinland Faculty of Medicine and Health Technology Tampere University33100 TampereFinland Academic primary Health Care Centre Region Stockholm13365 StockholmSweden

purpose:The purpose of this scoping review was to summarize and describe the methodology and results from population-based studies of physical activity and sedentary time measured with devices in the Nordic countries(Denmark,Finland,Iceland,Norway,and Sweden)and published in 2000 or ***:A systematic search was carried out in pubMed and Web of Science in June 2023 using predefined search ***:Fourteen unique research projects or surveillance studies were ***,2 surveillance studies published by national agencies were included,resulting in a total of 16 studies for *** surveillance systems exist in Finland and Norway,with regular survey waves in school-aged children/adolescents and *** Denmark,recent nationally representative data have been collected in school children *** far,Sweden has no regular national surveillance system using device-based data *** studies were found from *** first study was conducted in 2001 and the most recent in 2022,with most data collected from 2016 to *** studies included children/adole scents 6-18 years,no study included *** total 11 studies included adults,of which 8 also covered older *** study focused specifically on older *** analytical sample size ranged from 205 to 27,*** methodology is presented,such as information on sampling strategy,device type and placement,wear protocols,and physical activity classification *** of physical activity and sedentary time in children/adolescents,adults,and older adults across the Nordic countries are ***:A growing implementation of device-based population surveillance of physical activity and sedentary behavior in the Nordic countries has been *** variety of devices,placement,and data procedures both within and between the Nordic countries highlights the challenges when it comes to comparing study outcomes as well as the need for more standa

关键词： Accelerometer Light intensity Moderate-vigorous intensity Surveillance Wearable devices

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Evaluation of crustal deformation and associated strong motions induced by the 2022 paktika earthquake,Afghanistan

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Earthquake Science 2024年第6期37卷 546-557页

作者： A.Bari Jahed Ömer Aydan Takashi Ito Naoki Iwata University of Ryukyus Okinawa 903-0213Japan Chuden Engineering Consultants Hiroshima 734-8510Japan

The 2022 paktika earthquake(moment magnitude:6.2) occurred on June 22,2022,near the border between the Khost and paktika provinces of Afghanistan,causing heavy damage and casualties in paktika *** study evaluated the crustal deformation and associated strong motions induced by the paktika *** deformations were determined using the Differential Interferometric Synthetic Aperture Radar(DInSAR) technique and three-dimensional finite element method(3DFEM) and the results were *** permanent ground displacements obtained from the DInSAR and 3D-FEM analyses were similar in terms of amplitude and areal *** motions were estimated using the 3D-FEM with and without considering regional *** estimations of maximum ground acceleration,velocity,and permanent ground deformations were compared among each other as well as with those inferred from failures of some simple structures in the Spera and Gayan *** inferred maximum ground acceleration and velocity from the failed adobe structures were more than 300 Gal and 50 cm/s,respectively,nearly consistent with the estimates obtained using empirical *** empirical method yielded a maximum ground acceleration of 347 Gal,whereas the maximum ground velocity was approximately50 cm/*** light of these findings,some surface expressions of crustal deformations and strong ground motions,such as failures of soil and rock slopes and rockfalls,have been *** rock slope failures in the epicentral area were consistent with those observed during various earthquakes in Afghanistan and worldwide.

关键词： paktika earthquake FEM SAR Afghanistan fault rupture surface deformation slope rockfall

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Surgical treatment of a rare brachial artery aneurysm postarteriovenous fistula closure after kidney transplant:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4755-4761页

作者： Nahit Arda Demirkan Yasemin Keskin Hakan Sevinç Ömer Arda Çetinkaya Department of General Surgery Ankara University School of MedicineAnkara 06100Türkiye Department of General Surgery Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkara 06100Türkiye

BACKGROUND Brachial artery aneurysms are defined as dilations greater than 50%of the normal diameter,which are rare among all peripheral arterial *** they are often present as pseudoaneurysms,true brachial artery aneurysms are also detected *** this case report,the surgical repair method of true brachial artery aneurysms,which is a rare condition,is *** SUMMARY Herein,we present a 61-year-old male patient with complaints of swelling and pain in the right arm antecubital region that had been progressing over 6 *** the diagnosis of a true brachial artery aneurysm associated with arteriovenous fistula,the aneurysm was surgically repaired with an autologous saphenous vein *** patient was discharged without any neurovascular complications *** True brachial artery aneurysms are rare and there are not any recommendations for their management in the current *** though the treatment of true aneurysms in this artery is primarily based on a surgical treatment,endovascular repair also might be an option.

关键词： Brachial artery aneurysm Arteriovenous fistula Kidney transplantation Surgical repair Autologous vein interposition Case report

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Enhanced entropy generation and heat transfer characteristics of magnetic nano-encapsulated phase change materials in latent heat thermal energy storage systems

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： p.S.REDDY p.SREEDEVI Department of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(NEpCMs).The versatile finite element method(FEM)is implemented to numerically solve the governing *** effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of NEpCMs,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity ***,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented *** results indicate that the time taken by the NEpCMs to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf ***,the contours of the heat capacity ratio Cr decrease with the increase in the Stefan number Ste.

关键词： volume fraction of nano-encapsulated phase change material(NEpCM) radiation Stefan number heat capacity ratio entropy generation

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A Hybrid Optimization Approach of Single point Incremental Sheet Forming of AISI 316L Stainless Steel Using Grey Relation Analysis Coupled with principal Component Analysiss

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 160-166页

作者： A Visagan p Ganesh Department of production Technology Madras Institute of TechnologyChennai-600044India

We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with principal Component Analysis(pCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with pCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.

关键词： single point incremental forming AISI 316L taguchi grey relation analysis principal component analysis surface roughness scanning electron microscopy

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Cryogenic and conventional milling of AZ91 magnesium alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2503-2519页

作者： Vikas Marakini Srinivasa pai p Gururaj Bolar Bhaskara p Achar Department of Mechanical Engineering Nitte(Deemed to be University)NMAM Institute of Technology(NMAMIT)Nitte 574110India Department of Mechanical and Industrial Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal 576104India

Use of magnesium is the need of the hour due to its low density as well as its high strength-to-weight and stiffness-to-weight ratio *** study focuses on the effectiveness of liquid nitrogen(LN_(2))assisted cryogenic machining on the surface integrity(SI)characteristics of AZ91 magnesium *** milling using uncoated carbide inserts have been performed under liquid nitrogen(LN_(2))assisted cryogenic condition and compared with conventional(dry)*** are performed using machining parameters in terms of cutting speeds of 325,475,625 m/min,feed rates of 0.05,0.1,0.15 mm/teeth and depth of cuts of 0.5,1,1.5 mm *** significant surface integrity characteristics such as surface roughness,microhardness,microstructure,and residual stresses have been *** of SI characteristics with respect to milling parameters have been identified using statistical technique such as ANOVA and signal-to-noise(S/N)ratio ***,the multi criteria decision making(MCDM)techniques such as additive ratio assessment method(ARAS)and complex proportional assessment(COpRAS)have been utilized to identify the optimal conditions for milling AZ91 magnesium alloy under both dry and cryogenic *** of LN_(2)during machining,resulted in reduction in machining temperature by upto 29%with a temperature drop from 251.2℃under dry condition to 178.5℃in cryogenic *** showed the advantage of performing cryogenic milling in improving the surface integrity to a significant *** machining considerably minimized the roughness by upto 28%and maximised the microhardness by upto 23%,when compared to dry *** speed has caused significant impact on surface roughness(95.33%-dry,92.92%-cryogenic)and surface microhardness(80.33%-dry,82.15%-cryogenic).Due to the reduction in machining temperature,cryogenic condition resulted in compressive residual stresses(maximumσ║=-113 Mpa)on the alloy *** indicate no

关键词： Magnesium alloy Cryogenic machining Roughness Microhardness Microstructure Residual stress Multi criteria decision making

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