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绝缘铁粉在自行车永磁电动机中的应用

粉末冶金技术 2007年第2期25卷 145-151页

作者： C.Gélinas J.Cros L.-p.Lefebvre A.St-Louis J.-Y.dubé Ray Guo 韩凤麟 Quebec Metal powders Limited Sorel-TracyQuébecCanaela Laval University Ste-FoyQuébecCanada Industrial Materials Institute/NRCC BouchervilleQuébecCanada Maxtech powder Metal Ste-FoyQuébecCanada Energy propulsion System Asbestos QuébecCanada QMp Metal powders(Asia pacific) Hong KongChina

由于可减低成本,可减少每个部件的零件,同时铁粉复合材料具有各向同性,设计适应性大,因此绝缘铁粉正在用来替代用于电动机的钢片叠层材料。本文讲述了由铁粉复合材料定子制造永磁电动机样机所用的系统设计方法。介绍了开发这种定子的各... 详细信息

由于可减低成本,可减少每个部件的零件,同时铁粉复合材料具有各向同性,设计适应性大,因此绝缘铁粉正在用来替代用于电动机的钢片叠层材料。本文讲述了由铁粉复合材料定子制造永磁电动机样机所用的系统设计方法。介绍了开发这种定子的各个阶段,从最初的设计迭代到样品试验、用工业压机试验及生产。中心点是设计、材料及压制方面。

关键词：铁粉自行车永磁电动机 SMC 绝缘铁粉设计

Structural Elucidation of Condensed Tannin from <i>picea mariana</i>Bark

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 1-8页

作者： papa Niokhor Diouf Carmen Mihaela Tibirna Martha-Estrella García-pérez Mariana Royer p.scal dubé Tatjana Stevanovic Centre de Recherche sur le Bois Faculté de Foresterie de Géographie et de Géomatique Université Laval Québec City Canada Département de Génie Chimique Faculté des Sciences et de Génie Université Laval Québec City Canada Institut des Nutraceutiques et des Aliments Fonctionnels Université Laval Québec City Canada Service de Recherche et d’Expertise en Transformation des produits Forestiers (SEREX) Amqui Canada

The aim of this work was to determine the structural characteristics of the condensed tannins isolated from the aqueous extract of black spruce (picea mariana Mill) bark. This is the first report on the structural characterization of condensed tannins from black spruce bark. The condensed tannins from the hot water extract prepared from picea mariana bark were isolated by column chromatography on Sephadex LH-20 media. In this study, UV-visible and 13C-NMR spectroscopic techniques, along with pyrolysis-gas chromatography/mass spectrometry (py-GC/MS) and liquid chromatogramphy analyses were applied to determine the structural characteristics of black spruce bark tannins. We have confirmed for the first time the presence of methoxylated B-rings in the flavanol units of condensed tannins from black spruce bark, which could be regarded as further contribution to the chemotaxonomy of the genus picea. The methoxylation of Norway spruce bark condensed tannins have been demonstrated previously.

关键词： picea mariana Bark Condensed Tannins proanthocyanidins polyphenols Structural Characterization

Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

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Cellular & Molecular Immunology 2022年第2期19卷 222-233页

作者： Stéphane pillet prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot pyone pyone Aye Katharina Röltgen Gabrielle Lehmicke philipe Gobeil Charlotte dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf p.Bohm Jay Rappaport François Villinger Nathalie Landry Bali pulendran Brian J.Ward Medicago Inc. QuébecQCCanada. Institute for Immunity Transplantation and InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA. Tulane National primate Research Center CovingtonLAUSA. New Iberia Research Center University of Louisiana at LafayetteNew IberiaLAUSA. Department of pathology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Department of Microbiology and Immunology Tulane University School of MedicineNew OrleansLAUSA. Department of Microbiology and Immunology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Institute for Immunity Transplantation&InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA Research Institute of the McGill University Health Centre MontrealQCCanada.

Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)***-derived virus-like particle(VLp)vaccine candidates have previously demonstrated immunogenicity and efficacy against ***,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLp bearing a SARS-CoV-2 spike protein(CoVLp)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)*** a single dose of the unadjuvanted CoVLp vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted *** micrograms of CoVLp adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T *** were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of *** viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLp adjuvanted with *** clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated *** CoVLp adjuvanted with AS03 was therefore selected for vaccine development and clinical trials.

关键词： SARS-CoV-2 Virus-like particles Non-humane primates AS03 CpG1018

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压光对纸张表面性能的影响

中国印刷与包装研究 2010年第6期2卷 73-77页

作者： p.Vernhes M.dubé J.-F.Bloch 许英 Art Conservation Research Center Carnegie Mellon University700 Technology DrivePittsburghPA 15219United States Laboratoire de Génié des procedes papetiers(LGp2) CNRS/Institut Polytechnique de Grenoble(Grenoble INP)461rue de la papeterieBP 6538402 Saint-Martin-d'Heres cedex 9France Centre Intégré en ptes et papiers(CIpp) Université du Quebec à Trois-Rivieres3351 boul.Des ForgesTrois-Rivi èresQuebecG9A 6L2 Canada Laboratoire de Génie des procédés papetiers(LGp2) CNRS/Institut Polytechnique de Grenoble(Grenoble INP)461rue de la papeterieBP 6538402 Saint-Martin-d'Heres cedex 9France

纸张压光是一道工业整饰工序,它可以提高纸张表面的平滑度,改善其光泽度和印刷适性。本文讨论了压光对微观和宏观尺度上纸张粗糙度的影响以及这种表面改性与纤维形态之间的关系。实验原料为两种不同的纤维以及它们的混合物,采用光学轮... 详细信息

纸张压光是一道工业整饰工序,它可以提高纸张表面的平滑度,改善其光泽度和印刷适性。本文讨论了压光对微观和宏观尺度上纸张粗糙度的影响以及这种表面改性与纤维形态之间的关系。实验原料为两种不同的纤维以及它们的混合物,采用光学轮廓仪表征纸张表面的性能。实验结果表明,在所测定的尺度范围内,压光均可以改善纸张的表面性能,通过简单的比例转换后,这些变化具有相关性,这一结果也适用于由混合纤维抄造的纸张。

关键词：压光技术尺寸差异天然纤维纸张形貌

A Fourier Companion Matrix (Multiplication Matrix) with Real-Valued Elements: Finding the Roots of a Trigonometric polynomial by Matrix Eigensolving

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Numerical Mathematics(Theory,Methods and Applications) 2013年第4期6卷 586-599页

作者： John p.Boyd Department of Atmospheric Oceanic&Space ScienceUniversity of Michigan2455 Hayward AvenueAnn Arbor MI 48109USA

We show that the zeros of a trigonometric polynomial of degree N with the usual(2N+1)terms can be calculated by computing the eigenvalues of a matrix of dimension 2N with real-valued elements M_(jk).This matrix M is a multiplication matrix in the sense that,after first defining a vector φwhose elements are the first 2N basis functions,Mφ=2cos(t)φ.This relationship is the eigenproblem;the zeros tk are the arccosine function of λ_(k)/2 where theλk are the eigenvalues of *** dub this the“Fourier Division Companion Matrix”,or FDCM for short,because it is derived using trigonometric polynomial *** show through examples that the algorithm computes both real and complex-valued roots,even double roots,to near machine precision accuracy.

关键词： Fourier series trigonometric polynomial rootfinding secular companion matrix

An Event Horizon Imager(EHI) Mission Concept Utilizing Medium Earth Orbit Sub-mm Interferometry

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空间科学学报 2021年第2期41卷 211-233页

作者： KUDRIASHOV V MARTIN-NEIRA M ROELOFS F FALCKE H BRINKERINK C BARYSHEV A HOGERHEIJDE M YOUNG A pOURSHAGHAGHI H KLEIN-WOLT M MOSCIBRODZKA M DAVELAAR J BARAT I DUESMANN B VALENTA V pERDIGUES ARMENGOL J M DE WILDE D MARTIN IGLESIAS p ALAGHA N VAN DER VORST M Department of Astrophysics/IMApp Radboud University NijmegenP.O.Box 90106500 GL Nijmegenthe Netherlands ESTEC/ESA Keplerlaan 12201 A2 Noordurigkthe Netherlands Mar planck Institute for Radio Astrorny Auf dem Higel 69D-53121 Bon(Endenich)Germany University of Groningen Landleven 129747 AD Groningenthe Netherlands Leiden Observatory Leiden UniversityPO Box 95132300 RALeidenthe Netherlands Anton pannekoek Institute for Astronomy University of AmsterdamScience Park 9041098 XHAmsterdamthe Netherlands Center for Computational Astrophysics Flatiron Institute162 Fifth AvenueNew YorkNY 10010USA

Submillimeter interferometry has the potential to image supermassive black holes on event horizon scales,providing tests of the theory of general relativity and increasing our understanding of black hole accretion *** Event Horizon Telescope(EHT) performs these observations from the ground,and its main imaging targets are Sagittarius A~* in the Galactic Center and the black hole at the center of the M87 ***,the EHT is fundamentally limited in its performance by atmospheric effects and sparse terrestrial(u,v)-coverage(Fourier sampling of the image).The scientific interest in quantitative studies of the horizon size and shape of these black holes has motivated studies into using space interferometry which is free of these *** resolution considerations and interstellar scattering effects push the desired observing frequency to bands above 500 *** paper presents the requirements for meeting these science goals,describes the concept of interferometry from polar or Equatorial Medium Earth Orbits(pECMEO) which we dub the Event Horizon Imager(EHI),and utilizes suitable space technology *** this concept,two or three satellites orbit at slightly different orbital radii,resulting in a dense and uniform spiral-shaped(u,v)-coverage over *** local oscillator signals are shared via an inter-satellite link,and the data streams are correlated on-board before final processing on the ***-satellite metrology and satellite positioning are extensively employed to facilitate the knowledge of the instrument position vector,and its time *** European space heritage usable for both the front ends and the antenna technology of such an instrument is *** and future sensors for the required inter-satellite metrology are *** performance estimates and simulation results are given.

关键词： Instrumentation Space VLBI Radio Telescopes

Rad7 E3 Ubiquitin Ligase Attenuates polyubiquitylation of Rpn10 and Dsk2 Following DNA Damage in <i>Saccharomyces cerevisiae</i>

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Advances in Biological Chemistry 2015年第7期5卷 239-254页

作者： Joseph M. Benoun Danielle Lalimar-Cortez Analila Valencia Adriana Granda Destaye M. Moore Eric p. Kelson paula L. Fischhaber Department of Chemistry and Biochemistry California State University Northridge Northridge CA USA

During Nucleotide Excision Repair (NER) in the yeast S. cerevisiae, ubiquitylation of Rad4 is carried out by the E3 ubiquitin ligase that includes Rad7-Elc1-Cul3 and is critical to optimal NER. Rad7 E3 activity targets Rad4 for degradation by the proteaseome but, in principle, could also trigger other DNA damage responses. We observed increased nuclear ubiquitin foci (Ub-RFp) formation in S. cerevisiae containing a Rad7 E3 ligase mutant (rad7SOCS) in response to DNA damage by benzo[a]pyrenediolepoxide (BpDE) in dividing cells. Immunoblots reveal that ubiquitin conjugates of Rpn10 and Dsk2 accumulate in greater abundance in rad7SOCS compared to RAD7 in dividing cells in response to BpDE which makes Rpn10 and Dsk2 candidates for being the ubiquitylated species observed in our microscopy experiments. Microscopy analysis with strains containing Dsk2-GFp shows that Dsk2-GFp and Dsk2-GFp/Ub-RFp colocalized in nuclear foci form to an increased extent in a rad7SOCS mutant background in dividing cells than in a RAD7 wild-type strain. Further, Dsk2-GFp in the rad7SOCS strain formed more foci at the plasma membrane following BpDE treatment in dividing cells relative to strains containing RAD7 or a rad7△?deletion mutant. In response to a different agent, UV irradiation, levels of ubiquitylated proteins were increased in rad7SOCS relative to RAD7, and the proteasomal deubiquitylase subunit, Rpn11 was even monoubiquitylated in the absence of damaging agents. Together these data show that Rad7 E3 activity attenuates ubiq-uitylation of proteins regulating the shuttling of polyubiquitylated proteins to the proteasome (Dsk2 and Rpn10) and removal of ubiquitin chains just prior to degradation (Rpn11). Since Rad7 E3 ligase activity has been shown to increase ubiquitylation of its target proteins, yet our results show increased ubiquitylation in the absence of Rad7 E3, we suggest that Rad7 E3 action regulates ubiquitin ligase and deubiquitylase (dub) activities that act on Rpn10, Dsk2 a

关键词： Ubiquitin Rad7 Rpn10 Rpn11 Dsk2 DNA Damage Response