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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.p.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Estimation of above-ground biomass and carbon stock of an invasive woody shrub in the subtropical deciduous forests of Doon Valley,western Himalaya,India

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Journal of Forestry Research 2015年第2期26卷 291-305页

作者： Gautam mandal s.p.Joshi Ecology Research Laboratory Department of BotanyDAV (PG) College Faculty of science The Lawrence School

This study describes the different parameters used to derive the allometric equation for calculating the biomass of an invasive woody shrub Lantana camara *** the subtropical conditions of western *** identifies the most accurate and convenient method for biomass calculation by comparing destructive with nondestructive *** parameters were measured on a wide range of Lantana from different community levels for the non-destructive calculation of total aboveground *** explanatory variables were identified and measured such as basal diameter either as a single independent variable or in combination with plant *** other suitable combinations of available independent variables include crown length,crown width,crown area,crown volume and coverage of the *** the wide range of allometric equations used with different variables,the equation with D2 H as a variable was found to be the most suitable estimator of biomass calculation for ***,being the most disturbed area due to its high tourist activity round the year,showed maximum coverage（58.57 % ha-1）,highest biomass（13,559.60 kg ha-1） and carbon density（6,373.01 kg ha-1）of *** degree of Lantana’s invasiveness in subtropical conditions was also calculated on the basis of importance value index（IVI）.The maximum IVI（22.77）and mean coverage（26.8 % ha-1） was obtained from the areas near Jolly Grant airport,indicating that physically disturbed areas are more suitable for the growth of Lantana,which may significantly increase shrub *** importance of incorporating allometric equations in calculation of shrub biomass,and its role in atmospheric carbon assimilation has thus been highlighted through the findings of this study.

关键词： Above ground carbon pools Allometric regression equations Carbon density Importance value index(IVI) shrub biomass

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.mandal H.Mahapatra s.Biswas s.sahoo Department of physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(Np) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned Np *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted Np coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the Np models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of parkinson’s disease(pD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes pD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Opposition-based differential evolution for IIR system identification problem

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International Journal of Modeling, simulation, and scientific Computing 2014年第4期5卷 49-105页

作者： p.Upadhyay R.Kar D.mandal s.p.Ghoshal Department of ECE NIT Durgapur West BengalIndia Department of EE NIT Durgapur West BengalIndia

Nature inspired optimization algorithms have made substantial step towards solving of various engineering and scientific real-life *** achieved for those evolution-ary optimization techniques are due to simplicity and flexibility of algorithm *** this paper,optimal set of filter coefficients are searched by the evolutionary optimiza-tion technique called Opposition-based Differential Evolution(ODE)for solving infinite impulse response(IIR)system identification ***-based numbering con-cept is embedded into the primary foundation of Differential Evolution(DE)technique metaphorically to enhance the convergence speed and the performance for finding the optimal *** population is generated with the evaluation of a solution and its opposite solution by fitness function for choosing potent solutions for each iteration *** this competent population,faster convergence speed and better solution quality are *** and balanced search in multidimensional problem space is accomplished with judiciously chosen control parameters for mutation,crossover and selection adopted in the basic DE *** tested against standard benchmark examples,for same order and reduced order models,the simulation results establish the ODE as a competent candidate to others in terms of accuracy and convergence speed.

关键词： IIR adaptive filter RGA psO DE ODE evolutionary optimization techniques mean square error coefficient convergence

protected simultaneous quantum remote state preparation scheme by weak and reversal measurements in noisy environments

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Chinese physics B 2024年第2期33卷 169-177页

作者： mandal Manoj Kumar Choudhury Binayak s. samanta soumen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote state preparation noisy environments weak and reversal measurements

Complex Classical Mechanics of a QEs potential

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Communications in Theoretical physics 2015年第10期64卷 425-432页

作者： Bhabani prasad mandal sushant s.Mahajan Department of physics Banaras Hindu University Department of physics Indian Institute of Technology Banaras Hindu University

We study a combined parity(p) and time reversal(T) invariant non-Hermitian quasi-exactly solvable(QEs) potential, which exhibits pT phase transition, in the complex plane classically to demonstrate different quantum effects. The particle with real energy makes closed orbits around one of the periodic wells of the complex potential depending on the initial condition. However interestingly the particle escapes to an open orbits even with real energy if it is placed beyond a certain distance from the center of the well. On the other hand when the particle energy is complex the trajectory is open and the particle tunnels back and forth between two wells which are separated by a classically forbidden path. The tunneling time is calculated for different pair of wells and is shown to vary inversely with the imaginary component of energy. Our study reveals that spontaneous pT symmetry breaking does not affect the qualitative features of the particle trajectories in the analogous complex classical model.

关键词： pT symmetric complex systems quasi-exactly solvabl