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Versatile tape-drive target for high-repetition-rate laser-driven proton acceleration

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High power Laser Science and Engineering 2023年第4期11卷 59-69页

作者： N.Xu M.J.V.Streeter O.C.Ettlinger H.Ahmed S.Astbury M.Borghesi N.Bourgeois C.B.Curry S.J.D.Dann N.p.Dover T.Dzelzainis V.Istokskaia M.Gauthier L.Giuffrida G.D.Glenn S.H.Glenzer R.J.Gray J.S.Green G.S.Hicks C.Hyland M.King B.Loughran D.Margarone O.McCusker p.McKenna C.parisuaña p.parsons C.Spindloe D.R.Symes F.Treffert C.A.J.palmer Z.Najmudin John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondonUK School of Maths and physics Queen’s University BelfastBelfastUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK SLAC National Accelerator Laboratory Menlo ParkUSA ELI Beamlines Centre Institute of PhysicsCASDolni BrezanyCzech Republic Faculty of Nuclear Sciences and physical Engineering Czech Technical University in PraguePragueCzech Republic Department of physics SUPAUniversity of StrathclydeGlasgowUK Department of Mechanical Engineering Stanford UniversityStanfordUSA Department of Applied physics Stanford UniversityStanfordUSA Department of Electrical and Computer Engineering University of AlbertaEdmontonCanada Institut für Kernphysik Technische Universität DarmstadtDarmstadtGermany

We present the development and characterization of a high-stability,multi-material,multi-thickness tape-drive target for laser-driven acceleration at repetition rates of up to 100 *** tape surface position was measured to be stable on the sub-micrometre scale,compatible with the high-numerical aperture focusing geometries required to achieve relativistic intensity interactions with the pulse energy available in current multi-Hz and near-future higher repetition-rate lasers(>kHz).Long-term drift was characterized at 100 Hz demonstrating suitability for operation over extended *** target was continuously operated at up to 5 Hz in a recent experiment for 70,000 shots without intervention by the experimental team,with the exception of tape replacement,producing the largest data-set of relativistically intense laser–solid foil measurements to *** tape drive provides robust targetry for the generation and study of high-repetitionrate ion beams using next-generation high-power laser systems,also enabling wider applications of laser-driven proton sources.

关键词： high-repetition-rate laser target laser-plasma acceleration proton generation tape-drive target

Automated control and optimization of laser-driven ion acceleration

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High power Laser Science and Engineering 2023年第3期11卷 32-40页

作者： B.Loughran M.J.V.Streeter H.Ahmed S.Astbury M.Balcazar M.Borghesi N.Bourgeois C.B.Curry S.J.D.Dann S.DiIorio N.p.Dover T.Dzelzainis O.C.Ettlinger M.Gauthier L.Giuffrida G.D.Glenn S.H.Glenzer J.S.Green R.J.Gray G.S.Hicks C.Hyland V.Istokskaia M.King D.Margarone O.McCusker p.McKenna Z.Najmudin C.parisuaña p.parsons C.Spindloe D.R.Symes A.G.R.Thomas F.Treffert N.Xu C.A.J.palmer School of Mathematics and physics Queen’s University BelfastBelfastUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Gérard Mourou Center for Ultrafast Optical Science University of MichiganAnn ArborMIUSA SLAC National Accelerator Laboratory Menlo ParkCAUSA Department of Electrical and Computer Engineering University of AlbertaEdmontonABCanada The John Adams Institute for Accelerator Science Imperial College LondonLondonUK ELI Beamlines Centre Institute of PhysicsCzech Academy of SciencesDolníBˇrežanyCzech Republic Department of Applied physics Stanford UniversityStanfordCAUSA Department of physics SUPAUniversity of StrathclydeGlasgowUK Faculty of Nuclear Sciences and physical Engineering Czech Technical University in PraguePragueCzech Republic Department of Mechanical Engineering Stanford UniversityStanfordCAUSA Institut für Kernphysik Technische Universität DarmstadtDarmstadtGermany

The interaction of relativistically intense lasers with opaque targets represents a highly non-linear,multi-dimensional parameter *** limits the utility of sequential 1D scanning of experimental parameters for the optimization of secondary radiation,although to-date this has been the accepted methodology due to low data acquisition *** repetition-rate(HRR)lasers augmented by machine learning present a valuable opportunity for efficient source ***,an automated,HRR-compatible system produced high-fidelity parameter scans,revealing the influence of laser intensity on target pre-heating and proton generation.A closed-loop Bayesian optimization of maximum proton energy,through control of the laser wavefront and target position,produced proton beams with equivalent maximum energy to manually optimized laser pulses but using only 60%of the laser *** demonstration of automated optimization of laser-driven proton beams is a crucial step towards deeper physical insight and the construction of future radiation sources.

关键词： Bayesian optimization high repetition-rate laser-target interaction laser-driven particle acceleration proton generation

The evolution of a geoscience standard:An instructive tale of science keyword development and adoption

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Geoscience Frontiers 2023年第5期14卷 396-401页

作者： Mark A.parsons Ruth Duerr Øystein Godøy University of Alabama in Huntsville AlabamaUSA Ronin Institute BroomfieldCOUSA Norwegian Meteorological Institute OsloNorway

In 1987,NASA sponsored an international workshop that inspired the Directory Interchange Format or DIF–a metadata format to enable“catalog interoperability”.The DIF formed the basis of the International Directory Network(IDN)and the Global Change Master Directory(GCMD)and included a set of science *** primary intent was to catalog NASA Earth science and related data,but the keywords have been implemented in many different systems and adopted in varying ways by many different organizations around the *** review provides an ethnographic examination of how the keywords have evolved and been managed and how they have been adopted over the last 35 *** illustrates how semantic approaches have evolved over time and provides insights on how standards and associated processes can be sustained and *** institutional commitment is essential,but so is transparency and technical *** and empowering the different roles involved in standards creation,maintenance,and use of standards as well as the services that standards enable is also *** is apparent that semantic representations need to be mindful of different contexts and carefully define verbs as well as nouns and *** and representing relationships is central to interdisciplinary interoperability.

关键词： Data management Standards Digital earth Semantic web Information science

Hydrophilic surface modification of pDMS for droplet microfluidics using a simple,quick,and robust method via pVA deposition

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Microsystems & Nanoengineering 2017年第1期3卷 323-331页

作者： Tatiana Trantidou Yuval Elani Edward parsons Oscar Ces Department of Chemistry Imperial College LondonLondon SW72AZUK Institute of Chemical Biology Imperial College LondonLondon SW72AZUK London Centre for Nanotechnology University College LondonLondon WC1E 6BTUK

polydimethylsiloxane(pDMS)is a dominant material in the fabrication of microfluidic devices to generate water-in-oil droplets,particularly lipid-stabilized droplets,because of its highly hydrophobic ***,its key property of hydrophobicity has hindered its use in the microfluidic generation of oil-in-water droplets,which requires channels to have hydrophilic surface *** this article,we developed,optimized,and characterized a method to produce pDMS with a hydrophilic surface via the deposition of polyvinyl alcohol following plasma treatment and demonstrated its suitability for droplet *** proposed method is simple,quick,effective,and low cost and is versatile with respect to surfactants,with droplets being successfully generated using both anionic surfactants and more biologically relevant *** method also allows the device to be selectively patterned with both hydrophilic and hydrophobic regions,leading to the generation of double emulsions and inverted double emulsions.

关键词： double emulsions droplet microfluidics hydrophobic hydrophilic pDMS surface modification

The penile tourniquet

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Asian Journal of Andrology 2013年第3期15卷 364-367页

作者： Brian A parsons Odunayo Kalejaiye Mustafa Mohammed Raj A persad Bristol Urological Institute Southmead Hospital Bristol BSIO 5NB UK plymouth Hospitals NHS Trust Plymouth PL6 8DH UK

Tourniquets are commonly used in penile surgery to achieve a bloodless operating field or produce artificial erections intraoperatively. Several techniques have been described, but there is a paucity of data and a lack of guidelines to direct their safe use. In penile surgery, it is the local rather than systemic effects of tourniquet use that are the main concern. Tourniquet time should be kept to a minimum, as the limited data available suggests that reperfusion injury can occur even after short periods of ischaemia. High risk groups such as diabetics and arteriopaths are at particular risk. Further studies are needed to determine safe tourniquet times and pressures.

关键词： hypospadia ischaemia penile surgery reperfusion injury tourniquet

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EXTRA DIMENSIONS

Chinese physics C 2016年第10期40卷 890-898页

作者： John parsons Alex pomarol Columbia University Universitat Autbnoma de Barcelona

I Introduction proposals for a spacetime with more than three spatial dimensions date back to the 1920＇s, mainly through the work of Kaluza and Klein, in an attempt to unify the forces of nature [1]. Although their initial idea failed, the formalism that they and others developed is still useful nowadays. Around 1980, string theory proposed again to enlarge the number of space dimensions, this time as a requirement for describing a consistent theory of quantum gravity. The extra dimensions were supposed to be compactified at a scale close to the planck scale, and thus not testable experimentally in the near future.

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Saluenolide A,A Novel Eremophilanolide from Senecio saluenensis

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Chinese Chemical Letters 2002年第4期13卷 333-334页

作者： Yu ZHAO peng WANG Simon parsons David W.H. RANKIN DepartmentofNaturalDrugResearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031

From Senecio saluenensis, a novel eremophilanolide Saluenolide A was isolated. Its structure was elucidated by 2D-NMR technique and X-ray diffraction.

关键词： Sesquiterpene eremophilanolide Senecio X-ray cytotoxicity.

THE EFFECT OF MINE TAILINGS ON THE pRODUCTION OF pLANKTON

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Acta Oceanologica Sinica 1986年第3期5卷 417-423页

作者： T.R.parsons,p.THOMpSON,WUYONG,C.M.LALLI,HOU SHUMIN,AND XU HUAISHU Department of Oceanography University of British Columbia Canado Department of Oceanography University of British Columbia Canado Department of Oceanography University of British Columbia Canado Department of Zoology University of British Colunbia Canada Third Institute of Oceanography State Oceanic Administration Xiamen China Shandong College of Oceanology Qingdao China

Mine tailings at levels of ca 30 and 300 ppm were added to two plankton communities contained in 60 ton Controlled Experimental Ecosystems (CEE); a third CEE was used as a control. The mine tailings caused (1) a delay in the primary productivity and chlorophyll a maxima; (2) a shift in the size spectrum of primary producers towards autotrophic flagellates compared with diatoms in the control; (3) a suppression of heterotrophic microflagellates; and (4) an increased production of zooplankton compared with the control. Zooplankton were observed to have consumed tailings but no changes were observed in the structure of the zooplankton community as a result of tailings additions.

关键词： THE EFFECT OF MINE TAILINGS ON THE pRODUCTION OF pLANKTON

ALKALINE pHOSpHATASE EXpRESSION IN THREE TUMOUR CELL LINES

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山东大学学报(医学版) 1989年第4期 67-74页

作者：邓景惕,p.G.parsons Dept.of Biochemistry Shandong Medical University Queensland Institute of Medical Research Brisbane Australia

The alkaline phosphatases(Aps)in three cell lines(GG,MM138,293)have been characterized by inhibition,thermostability,elec-trophoretic mobility,neuraminidase treatment,molecular mass and immu-nological studies,All three cell lines contained the bone-like Aps,they areheat sensitive,homoarginine,EDTA sensitive,and L-phenylalanine *** of electrophoretic mobility by neuraminidase digestion and lectinaffinity electrophoresis showed that all three cell line Aps contain terminalsialic acid and N-acetylglycosamine residues in their carbohydrate sidechains,but they appear to contain more sialic acid and N-acetylglycosa-mine residues than bone *** abserved between three cell line Apsand bone Ap or within three cell line Aps may be explained by differencesin post translational modifications or by mutations of the cell lines.

关键词： Alkaline phosphatase Cell lines Tumors Sialic acids Molecular weight