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prostate health index can stratify patients with prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen ng Chi-Ho Ip Ada Tsui-Lin ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health indexprostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(png the patients,26.9%could have avoided a biopsy with a prostate health indexpense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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RepDNet:A re-parameterization despeckling network for autonomous underwater side-scan sonar imaging with prior-knowledge customized convolution

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Defence Technology（防务技术） 2024年第5期35卷 259-274页

作者： Zhuoyi Li Zhisen Wang Deshan Chen Tsz leung Yip Angelo p.Teixeira Department of Logistics and Maritime Studies The Hong Kong Polytechnic UniversityChina State Key Laboratory of Maritime Technology and Safety Wuhan University of TechnologyChina School of Transportation and Logistics Engineering Wuhan University of TechnologyChina National Engineering Research Center for Water Transport Safety Wuhan University of TechnologyChina Centre for Marine Technology and Ocean Engineering(CENTEC) Instituto Superior TecnicoUniversidade de LisboaPortugal

Side-scan sonar(SSS)is now a prevalent instrument for large-scale seafloor topography measurements,deployable on an autonomous underwater vehicle(AUV)to execute fully automated underwater acoustic scanning imaging along a predetermined ***,SSS images often suffer from speckle noise caused by mutual interference between echoes,and limited AUV computational resources further hinder noise *** approaches for SSS image processing and speckle noise reduction rely heavily on complex network structures and fail to combine the benefits of deep learning and domain *** address the problem,Rep DNet,a novel and effective despeckling convolutional neural network is *** DNet introduces two re-parameterized blocks:the pixel Smoothing Block(pSB)and Edge Enhancement Block(EEB),preserving edge information while attenuating speckle *** training,pSB and EEB manifest as double-layered multi-branch structures,integrating first-order and secondorder derivatives and smoothing *** inference,the branches are re-parameterized into a 3×3 convolution,enabling efficient inference without sacrificing *** DNet comprises three computational operations:3×3 convolution,element-wise summation and Rectified Linear Unit *** on benchmark datasets,a real SSS dataset and Data collected at Lake Mulan aestablish Rep DNet as a well-balanced network,meeting the AUV computational constraints in terms of performance and latency.

关键词： Side-scan sonar Sonar image despeckling Domain knowledge Re-parameterization

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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben chung-Lap Chan Grace Gar-Lee Yue LI pei-ting Sharon Sze-Man Hon HUAng Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau p.ng-chung leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal plants The Chinese University of Hong KongHong KongChina Department of Chemical pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyp.ng,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(ppoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(p<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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A Simple Embedding Method for the Laplace-Beltrami Eigenvalue problem onImplicit Surfaces

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1189-1216页

作者： Young Kyu Lee Shingyu leung Department of Mathematics The Hong Kong University of Science and TechnologyClear Water BayHong KongChina

We propose a simple embedding method for computing the eigenvalues and eigenfunctions of the Laplace-Beltrami operator on implicit *** approach follows an embedding approach for solving the surface eikonal *** replace the differential operator on the interface with a typical Cartesian differential operator in the surface *** proposed algorithm is easy to implement and *** will give some two-and three-dimensional numerical examples to demonstrate the effectiveness of our proposed approach.

关键词： Laplace-Beltrami operator Level set method Implicit representation Eigenvalues Numerical pDEs

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Changes of tropical cyclone size in three oceanic basins of the northern hemisphere from 2001 to 2021

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Frontiers of Earth Science 2024年第2期18卷 312-323页

作者： Banglin ZHAng Jeremy Cheuk-Hin leung Shengyuan LIU Jianjun XU Guangzhou Institute of Tropical and Marine Meteorology/Guangdong provincial Key Laboratory of Regional Numerical Weather prediction CMAGuangzhou 510640China College of Atmospheric Science Lanzhou UniversityLanzhou 730020China College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China CMA-GDOU Joint Laboratory for Marine Meteorology&South China Sea Institute of Marine Meteorology Guangdong Ocean UniversityZhanjiang 524088China

In this study the changes of tropical cyclone(TC)size from 2001 to 2021 are analyzed based on linear and quadratic curve fittings of the National Hurricane Center(NHC)/Joint Typhoon Warning Center(JTWC)best track data,based on the radius of maximum wind(RMW)and the average radius of 34-kt wind(AR34),in three oceanic basins of the North Atlantic(NATL),the Western North pacific(WpAC)and the Eastern North pacific(EpAC).The computations are done separately for two categories of tropical cyclones:tropical storms(TS)and hurricanes(HT).Size changes of landfalling and non-landfalling TCs are also *** show that there is a great inter-basin variability among the changes in TC *** conclusions include:1)overall,the inner cores of TSs have become larger in all three basins,with the increasing tendencies being significant in the NATL and WApC,while those of HTs mostly get smaller or remain similar;2)meanwhile,comparatively large inter-basin differences are observed for the TC outer core sizes,and the sizes of landfalling TCs;3)particularly,a significant decrease in landfalling HT outer core size is observed over the EpAC;4)in contrast,significant increases in landfalling TS inner core size are found over the NATL and *** presented analysis results could benefit future research about TC forecasts,storm surge studies,and the cyclone climate and its changes.

关键词： tropical cyclone storm size frequency intensity duration

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Translating bacteriophage-derived depolymerases into antibacterial therapeutics:Challenges and prospects

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Acta pharmaceutica Sinica B 2024年第1期14卷 155-169页

作者： Honglan Wang Yannan Liu Changqing Bai Sharon Shui Yee leung School of pharmacy the Chinese University of Hong KongHong Kong SARChina Emergency Medicine Clinical Research Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory Shenzhen University General HospitalShenzhen University Clinical Medical AcademyGuangdong 518055China

predatory bacteriophages have evolved a vast array of depolymerases for bacteria capture and *** depolymerases are enzymes responsible for degrading diverse bacterial surface *** are exploited as antibiofilm agents and antimicrobial adjuvants while rarely inducing bacterial resistance,making them an invaluable asset in the era of antibiotic *** depolymerases have been investigated preclinically,with evidence indicating that depolymerases with appropriate dose regimens can safely and effectively combat different multidrug-resistant pathogens in animal infection ***,some formulation approaches have been developed for improved stability and activity of ***,depolymerase formulation is limited to liquid dosage form and remains in its infancy,posing a significant hurdle to their clinical translation,compounded by challenges in their applicability and *** development must address these obstacles for clinical ***,after unravelling the history,diversity,and therapeutic use of depolymerases,we summarized the preclinical efficacy and existing formulation findings of recombinant ***,the challenges and perspectives of depolymerases as therapeutics for humans were assessed to provide insights for their further development.

关键词： phage-derived polysaccharide depolymerases Bacteriophage proteins Bacterial capsules polysaccharide capsules Antibiotic resistance Biofilms Antibacterial therapy Antimicrobial adjuvants Combination treatment

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Spatiotemporal variations of sand hydraulic conductivity by microbial application methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 268-278页

作者： Viroon Kamchoom Thiti Khattiwong Treesukon Treebupachatsakul Suraparb Keawsawasvong Anthony Kwan leung Excellent Centre for Green and Sustainable Infrastructure Department of Civil EngineeringSchool of EngineeringKing Mongkut’s Institute of Technology Ladkrabang(KMITL)Bangkok10520Thailand Department of Biomedical Engineering School of EngineeringKing Mongkut’s Institute of Technology Ladkrabang(KMITL)Bangkok10520Thailand Department of Civil Engineering Thammasat School of EngineeringThammasat UniversityPrathumthani10200Thailand Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology(HKUST)Hong KongChina

The spatiotemporal distributions of microbes in soil by different methods could affect the efficacy of the microbes to reduce the soil hydraulic *** this study,the specimens of bio-mediated sands were prepared using three different methods,***,mixing,and pouring a given microbial so-lution onto compacted sand *** hydraulic conductivity was measured by constant-head tests,while any soil microstructural changes due to addition of the microbes were observed by scan-ning electron microscope(SEM)and mercury intrusion porosimetry(MIp)*** amount of dextran concentration produced by microbes in each type of specimen was quantified by a *** show that dextran production increased exponentially after 5-7 d of microbial settling with the supply of culture *** injection and mixing methods resulted in a similar amount and uniform dis-tribution of dextran in the *** pouring method,however,produced a nonuniform distri-bution,with a higher concentration near the specimen *** the supply of culture medium discontinued,the dextran content near the surface produced by the pouring method decreased dramatically due to high competition for nutrients with foreign *** dextran concentration was negatively and correlated with hydraulic conductivity of bio-mediated soils exponentially,due to the clogging of large soil pores by *** hydraulic conductivity of the injection and mixing cases did not change significantly when the supply of culture medium was absent.

关键词： Bio-mediated soil Dextran Hydraulic conductivity Leuconostoc mesenteroides Microbial application Microstructure

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Modelling smear effect of vertical drains using a diameter reduction method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 279-290页

作者： Zhichao Shen Siau Chen Chian Siew Ann Tan Chun Fai leung School of Marine Science and Engineering South China University of TechnologyGuangzhouChina Department of Civil and Environmental Engineering National University of SingaporeSingapore

Vertical drains are used to accelerate consolidation of clays in ground improvement *** zones exist around these drains,where permeability is reduced due to soil disturbance caused by the installation *** solution is widely used in practice to consider the effects of drain discharge capacity and smear on the consolidation *** this study,a computationally efficient diameter reduction method(DRM)obtained from the Hansbo solution is proposed to consider the smear effect without the need to model the smear zone *** by analytical and numerical results,a diameter reduction factor is analytically derived to reduce the diameter of the drain,while achieving similar solutions of pore pressure dissipation profile as the classical full model of the smear zone and *** the DRM,the excess pore pressure u obtained from the reduced drain in the original un-disturbed soil zone is accurate enough for practical applications in numerical *** performance of DRM is independent of soil material *** also show equally accurate performance of DRM under conditions of multi-layered soils and coupled radial-vertical groundwater flow.

关键词： Consolidation Vertical drain Smear effect pore pressure Soil improvement

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Deep sea mineral resources and underground space as well as infrastructure for sustainable and liveable cities

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Deep Underground Science and Engineering 2024年第2期3卷 129-130页

作者： Jianguo Wang Hep.ng Xie Chunfai leung Xiaozhao Li School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina Institute of Deep Earth Sciences and Green Energy Shenzhen UniversityShenzhenChina College of Water Resource and Hydropower Sichuan UniversityChengduChina Center for Offshore Research and Engineering National University of SingaporeSingaporeSingapore State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhouChina

This issue covers the papers on two special themes:(1)Mineral resources from deep sea—Science and Engineering and(2)planning and development of underground space and infrastructure for sustainable and liveable cities.

关键词： underground sustainable Deep

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes S.Y.leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of public Health and primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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